Spillantini, Maria Grazia

α-Synuclein in Lewy bodies

Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 8,382

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., & Crowther, R. A. (1989) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 2,492

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

Spillantini, M. G., Murrell, J. R., Goedert, M., Farlow, M. R., Klug, A., & Ghetti, B. (1998) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,474

100 years of Lewy pathology

Goedert, M., Spillantini, M. G., Del Tredici, K., & Braak, H. (2013) · Nature Reviews Neurology

Parkinson's Disease Mechanisms and TreatmentsNeurology and Historical Studies

Cited by 1,190

Tau pathology and neurodegeneration

Spillantini, M. G., & Goedert, M. (2013) · The Lancet Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,133

Cloning and sequencing of the cDNA encoding an isoform of microtubule‐associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

Goedert, M., Spillantini, M. G., Potier, M. C., Ulrich, J., & Crowther, R. A. (1989) · The EMBO Journal

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,037

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

Skibinski, G., Parkinson, N. J., Brown, J. M., Chakrabarti, L., Lloyd, S. L., Hummerich, H., Nielsen, J. E., Hodges, J. R., Spillantini, M. G., Thusgaard, T., et al. (2005) · Nature Genetics

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 822

Tau protein pathology in neurodegenerative diseases

Spillantini, M. G., & Goedert, M. (1998) · Trends in Neurosciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 683

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Van Deerlin, V. M., Sleiman, P. M. A., Martinez-Lage, M., Chen-Plotkin, A., Wang, L.-S., Graff-Radford, N. R., Dickson, D. W., Rademakers, R., Boeve, B. F., Grossman, M., et al. (2010) · Nature Genetics

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 579

Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice

Pan-Montojo, F., Anichtchik, O., Dening, Y., Knels, L., Pursche, S., Jung, R., Jackson, S., Gille, G., Spillantini, M. G., Reichmann, H., et al. (2010) · PLoS ONE

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 524

Frontotemporal Dementia and Corticobasal Degeneration in a Family with a P301S Mutation in Tau

Bugiani, O., Murrell, J. R., Giaccone, G., Hasegawa, M., Ghigo, G., Tabaton, M., Morbin, M., Primavera, A., Carella, F., Solaro, C., et al. (1999) · Journal of Neuropathology and Experimental Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 450

Frontotemporal dementia and its subtypes: a genome-wide association study

Ferrari, R., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B. J., Dobson-Stone, C., Brooks, W. S., Schofield, P. R., Halliday, G. M., et al. (2014) · The Lancet Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 383

α‐Synuclein metabolism and aggregation is linked to ubiquitin‐independent degradation by the proteasome

Tofaris, G. K., Layfield, R., & Spillantini, M. G. (2001) · FEBS Letters

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 363

Proteasomal degradation of tau protein

David, D. C., Layfield, R., Serpell, L., Narain, Y., Goedert, M., & Spillantini, M. G. (2002) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsUbiquitin and proteasome pathways

Cited by 327

Tau Mutations Cause Frontotemporal Dementias

Goedert, M., Crowther, R. A., & Spillantini, M. G. (1998) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 268

Depletion of Perineuronal Nets Enhances Recognition Memory and Long-Term Depression in the Perirhinal Cortex

Romberg, C., Yang, S., Melani, R., Andrews, M. R., Horner, A. E., Spillantini, M. G., Bussey, T. J., Fawcett, J. W., Pizzorusso, T., & Saksida, L. M. (2013) · The Journal of Neuroscience

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 231

Propagation of Tau aggregates

Goedert, M., & Spillantini, M. G. (2017) · Molecular Brain

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 213

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

Brelstaff, J., Tolkovsky, A. M., Ghetti, B., Goedert, M., & Spillantini, M. G. (2018) · Cell Reports

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 195

Hereditary Frontotemporal Dementia Caused by Tau Gene Mutations

Van Swieten, J., & Spillantini, M. G. (2007) · Brain Pathology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 195

Tau Proteins and Neurofibrillary Degeneration

Goedert, M., Spillantini, M. G., & Crowther, R. A. (1991) · Brain Pathology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 178

Comparison of the neurofibrillary pathology in Alzheimer’s disease and familial presenile dementia with tangles

Spillantini, M. G., Crowther, R. A., & Goedert, M. (1996) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 160

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations

Iovino, M., Agathou, S., González-Rueda, A., Del Castillo Velasco-Herrera, M., Borroni, B., Alberici, A., Lynch, T., O’Dowd, S., Geti, I., Gaffney, D., et al. (2015) · Brain

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 155

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

Yang, S., Cacquevel, M., Saksida, L. M., Bussey, T. J., Schneider, B. L., Aebischer, P., Melani, R., Pizzorusso, T., Fawcett, J. W., & Spillantini, M. G. (2015) · Experimental Neurology

Alzheimer's disease research and treatmentsMemory and Neural Mechanisms

Cited by 138

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Swarup, V., Hinz, F. I., Rexach, J. E., Noguchi, K.-I., Toyoshiba, H., Oda, A., Hirai, K., Sarkar, A., Seyfried, N. T., Cheng, C., et al. (2019) · Nature Medicine

Alzheimer's disease research and treatmentsBioinformatics and Genomic Networks

Cited by 136