Yan, Riqiang

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashler, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., et al. (1999) · Nature

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,438

Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

Yang, L.-B., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X.-L., Beach, T., Sue, L., Wong, P., Price, D., et al. (2003) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 729

The β-Secretase BACE1 in Alzheimer’s Disease

Hampel, H., Vassar, R., De Strooper, B., Hardy, J., Willem, M., Singh, N., Zhou, J., Yan, R., Vanmechelen, E., De Vos, A., et al. (2021) · Biological Psychiatry

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Cited by 694

Bace1 modulates myelination in the central and peripheral nervous system

Hu, X., Hicks, C. W., He, W., Wong, P., Macklin, W. B., Trapp, B. D., & Yan, R. (2006) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 608

The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

Vassar, R., Kovacs, D. M., Yan, R., & Wong, P. C. (2009) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Cited by 577

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

Wen, L., Tang, F.-L., Hong, Y., Luo, S.-W., Wang, C.-L., He, W., Shen, C., Jung, J.-U., Xiong, F., Lee, D.-H., et al. (2011) · Journal of Cell Biology

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 270

BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration

Hu, X., Zhou, X., He, W., Yang, J., Xiong, W., Wong, P., Wilson, C. G., & Yan, R. (2010) · Journal of Neuroscience

Alzheimer's disease research and treatmentsEpilepsy research and treatment

Cited by 162

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice

Sasmita, A. O., Depp, C., Nazarenko, T., Sun, T., Siems, S. B., Ong, E. C., Nkeh, Y. B., Böhler, C., Yu, X., Bues, B., et al. (2024) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 125

APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner

Cui, S., Xiong, F., Hong, Y., Jung, J.-U., Li, X.-S., Liu, J.-Z., Yan, R., Mei, L., Feng, X., & Xiong, W.-C. (2011) · Journal of Bone and Mineral Research

Bone Metabolism and DiseasesAlzheimer's disease research and treatments

Cited by 101

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

Singh, N., Das, B., Zhou, J., Hu, X., & Yan, R. (2022) · Science Advances

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 95

Sequential formation of different layers of dystrophic neurites in Alzheimer’s brains

Sharoar, M. G., Hu, X., Ma, X.-M., Zhu, X., & Yan, R. (2019) · Molecular Psychiatry

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 87

Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains

Sharoar, M. G., Palko, S., Ge, Y., Saido, T. C., & Yan, R. (2021) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 78

Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction

Fan, Q., He, W., Gayen, M., Benoit, M. R., Luo, X., Hu, X., & Yan, R. (2020) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanisms

Cited by 58

The sterol regulatory element‐binding protein 2 is dysregulated by tau alterations in Alzheimer disease

Wang, C., Zhao, F., Shen, K., Wang, W., Siedlak, S. L., Lee, H., Phelix, C. F., Perry, G., Shen, L., Tang, B., et al. (2019) · Brain Pathology

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 18