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A ROS-Responsive nanoparticle for nuclear gene delivery and autophagy restoration in Parkinson's disease therapy

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Isolation, Bioactivity, and Molecular Docking of a Rare Gastrodin Isocitrate and Diverse Parishin Derivatives from Gastrodia elata Blume

Zhou, J., Chen, J., Gong, S., Ban, Y., Li, Z., Liu, Y., Wu, J., & Li, N. (2024) · ACS Omega · doi:10.1021/acsomega.4c00436 · Cited by 9 · see citing works

Daphnetin protects neurons in an Alzheimer disease mouse model and normal rat neurons by inhibiting BACE1 activity and activating the Nrf2/HO-1 pathway

Zhang, X., Ma, W., Liu, H., Liu, Y., Zhang, Y., He, S., Ding, X., Li, B., & Yan, Y. (2024) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlae043 · Cited by 8 · see citing works

ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer’s disease

Demetriou, A., Lindqvist, B., Ali, H. G., Shamekh, M. M., Maioli, S., Inzunza, J., Maioli, S., Nilsson, P., & Nalvarte, I. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00711-w · Cited by 11 · see citing works

PM2.5 exposure exacerbates Alzheimer's disease pathology through lysosomal dysfunction in APP/PS1 mice

Wei, M., Li, W., Bao, G., Yang, Z., Li, S., & Le, W. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118918 · Cited by 8 · see citing works

Network Proximity Analysis Deciphers the Pharmacological Mechanism of Osthole against D-Galactose Induced Cognitive Disorder in Rats

Wang, X., Fu, X., Luo, X., Lai, Y., Cai, C., Liao, Y., Dai, Z., Fang, S., & Fang, J. (2023) · Molecules · doi:10.3390/molecules29010021 · Cited by 8 · see citing works

HDAC Inhibitors recapitulate Human Disease-Associated Microglia Signatures in vitroPreprint

Haage, V. C., Tuddenham, J. F., Bautista, A. R., White, C. C., Garcia, F. G., Patel, R., Comandante-Lou, N., Marshe, V. S., Soni, R. K., Sims, P. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.11.617544 · Cited by 8 · see citing works

Chitosan Oligosaccharide Attenuates Neuroinflammation by Regulating Microglial Immunometabolic Reprogramming via the mTOR Signaling Pathway

Chen, H., Cai, M., He, Y., Sun, Y., & Dai, X. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c05010 · Cited by 7 · see citing works

Recent advances in nanotechnology for combating Alzheimer's disease

Hu, C., Wu, B., Wu, Y., Shi, M., Ma, J., Gao, H., & Zhang, J. (2023) · Materials Chemistry Frontiers · doi:10.1039/d3qm00493g · Cited by 6 · see citing works

TAMing Gliomas: Unraveling the Roles of Iba1 and CD163 in Glioblastoma

Fuse, H., Zheng, Y., Alzoubi, I., & Graeber, M. B. (2025) · Cancers · doi:10.3390/cancers17091457 · Cited by 6 · see citing works

ZuoGui Pill Ameliorates Alzheimer’s Disease–Like Pathology in 3xTg-AD Mice by Targeting Aβ Production, Tau Phosphorylation, Synaptic Loss, and Neuroinflammation

Li, S., Wang, D., Li, A., Wang, T., Chen, X., Li, H., Wang, T., Xie, Y., Liang, J., & Cai, X. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05336-z · Cited by 4 · see citing works

The manipulator behind “Scissors”: γ -secretase and its modulators in Alzheimer’s disease

Ning, G., Fan, X., Du, J., wenxue, Z., Sijia, W., Meinei, C., Xiaolong, D., & Yiming, Q. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1637671 · Cited by 4 · see citing works

Laminaria japonica fucoidan ameliorates D-galactose-induced cognitive impairment via the regulation of tryptophan metabolism along the gut-brain axis

Wang, L., Lu, C., Li, S., Wu, T., Ren, X., Song, S., & Ai, C. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150151 · Cited by 3 · see citing works

A Question of Origins: Non-neuronal Sources of Amyloid-β

Sasmita, A. O., & Depp, C. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-025-01572-4 · Cited by 3 · see citing works

Efficacy and mechanisms of Icariin in the treatment of Alzheimer's disease: a systematic review and meta-analysis of a preclinical study

Cui, J., Huang, R., & Dong, X. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178706 · Cited by 3 · see citing works

Role of non-neuronal cells in neurorepair: a focus on proteinopathy and neurodegeneration

Rodríguez-Carreiro, S., Nogales, M. D. C., Jiménez-Galán, D., Carmona-Lorenzo, S., Caro-Martín, A., Navarro, E., & Esteras, N. (2024) · Regenerative medicine reports . · doi:10.4103/regenmed.regenmed-d-24-00005 · Cited by 3 · see citing works

Pharmacological effects of herbal ingredients of Manasamitra vatakam in the treatment of Alzheimer's disease: A review

Nair, A. C., Kuriakose, B. B., Biju, A., Surendran, S., Sudheesh, M. S., & Lakshmi, P. K. (2025) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2024.101041 · Cited by 3 · see citing works

Microglia-derived sEV: Friend or foe in the pathogenesis of cognitive impairment

Chen, L., & Wang, W. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111287 · Cited by 3 · see citing works

Recent advances in traditional Chinese medicine-mediated regulation of microglial metabolic reprogramming in neurological disease therapy

Wu, Z., Lv, F., Shao, S., Chen, Y., Weng, N., & Xia, Y. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121355 · Cited by 2 · see citing works

Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis

Yang, R., He, Y., Pan, Y., Geng, A., Huang, F., Guo, K., & Zhang, H. (2026) · Immunity & Ageing · doi:10.1186/s12979-026-00565-9 · Cited by 2 · see citing works

ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer’s diseasePreprint

Demetriou, A., Lindqvist, B., Ali, H. G., Shamekh, M. M., Maioli, S., Inzunza, J., Varshney, M., Nilsson, P., & Nalvarte, I. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.22.604543 · Cited by 2 · see citing works

Mechanism insight into selenium-rich tea mediates the neuroprotective effect on the treatment of Alzheimer’s disease

He, Z., Li, X., Cao, Y., Wang, Z., Liu, Y., Ye, Y., Luo, C., Qiao, Y., Du, X., Ni, J., et al. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250635 · Cited by 1 · see citing works

Computational and Experimental Validation of Anti-LPS-Induced Alzheimer’s Disease Effects of Pterocarpus mildbraedii and its Compounds: Combining Network Pharmacology, Molecular Docking, In Vitro , and In Vivo Approaches

Sandrine, M. N. Y., Owona, P. E., Ella, F. A., Bilanda, D. C., Julie, A. O. J., Cynthia, B. Y. P., Michel, B. G., Dzeufiet, P. D. D., Binsaleh, A. Y., Alwethaynani, M. S., et al. (2025) · Journal of Computational Biophysics and Chemistry · doi:10.1142/s2737416525501248 · Cited by 1 · see citing works

β-amyloid and β-amyloid precursor protein synthesis and processing: effects of exercise and exercise-related injury

Zhen, W., Xing, Y., Li, Y., Hao, J., Kong, L., & Zhen, H. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1735542 · Cited by 1 · see citing works

HMC3 revealed: how much do these “Microglia” really tell us?

Buccarello, L., Privitera, A., Partsinevelos, K., Serwa, K., Carota, G., Pietro, L. D., Cardaci, V., Mangione, R., Sibbitts, J., Lazzarino, G., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1778798 · Cited by 1 · see citing works

Chrysin reprograms microglial metabolism and function via targeting SYK to alleviate the symptoms of Alzheimer's disease

Li, L., Gu, Y., Luo, X., Wang, J., Jia, Y., & Yan, T. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122056 · Cited by 1 · see citing works

Phytochemicals in Alzheimer’s Disease Prevention and Management: Molecular Mechanisms, Therapeutic Potential, Translational Challenges, and Emerging Research Directions

Khan, M. S., Zafar, I., & Bopassa, J. C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146329 · Cited by 1 · see citing works

QKL injection ameliorates Alzheimer's disease-like pathology by regulating expression of RAGE

Dou, J., Zhang, X., Hu, C., Gao, Y., Zhao, Y., Hei, M., Wang, Z., Guo, N., & Zhu, H. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112422 · Cited by 1 · see citing works

A Brain-Targeting Nanoprobe for On-Site BACE1 Detection and Reversal of Microglia-Derived Neuroinflammation

Liu, X., Cao, R., Dang, Y., Xu, Z., & Zhang, W. (2025) · ACS Applied Nano Materials · doi:10.1021/acsanm.5c00123 · Cited by 1 · see citing works

Unlocking the neuroprotective potential of peptide nucleic acids 5 (PNA5) in neurological diseases: molecular mechanisms to therapeutic approaches

Porel, P., Hunjan, G., Kaur, N., Sharma, V., Kaur, M., Mittal, Y., Kaur, R., & Aran, K. R. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01629-3 · Cited by 1 · see citing works

Bace1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptidesPreprint

Yan, R., Zhou, J., Singh, N., Galske, J., Hudobenko, J., & Hu, X. (2022) · Research Square · doi:10.21203/rs.3.rs-2042855/v1

Reduction of cerebral lactate level is correlated with increased Aβ quantity in Alzheimer’s disease model micePreprint

Zhang, M., Wang, Y., Guan, X., Chen, X., & Guo, H. (2024) · Research Square · doi:10.21203/rs.3.rs-3848505/v1

Up-regulation of the IL-1 signaling pathway enhances gene expression of transcription factors (Jun, Junb, Jund, Fos, and Fosb)

Mao, J. (2024) · MedScien · doi:10.61173/9fk4yy06

The contribution of oligodendrocytes to amyloid and tau pathologies in mouse models of Alzheimer’s disease

Sasmita, A. O. (2024) · doi:10.53846/goediss-10403

Microglia - a vital marker in early Alzheimer’s disease

Ma, L. (2024) · E3S Web of Conferences · doi:10.1051/e3sconf/202455305035

Up-regulation of IL-1 signaling pathway enhances gene expression of transcription factors (Jun, Junb, Jund, and Fos)

Li, X. (2024) · Theoretical and Natural Science · doi:10.54254/2753-8818/45/20240582

Systems Pharmacology Approach and Experiment Evaluation Reveal Pterocarpus Mildbraedii (Fabaceae) Intervention for Counteracting Behavioral Changes and Neuroinflammatory and Oxidative Stress Markers Against Lps-Induced Alzheimer's Disease in RatsPreprint

Ngadena, Y. S. M., Owona, P. E., Ella, F. A., Bilanda, D. C., Yandja, P. C. B., Bindzi, G. M., & Dzeufiet, P. D. D. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5066541

The Role of Microglial Polarization in Adult Hippocampal Neurogenesis and Possible Depression Therapy

Zhang, X. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2025.24213

Role of BDNF Expression Through Microglial Polarization in Adult Hippocampal Neurogenesis in Depression and the Therapeutics

Gao, S. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2025.24204

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization

Wang, X., Zhang, Q., Zhang, X., Liu, J., Zhang, J., Liu, C., Cui, Y., Qs, S., Hou, Y., Wang, Y., et al. (2026) · Aging Cell · doi:10.1111/acel.70379

ApoE-directed CpG nano-immunoadjuvant ameliorates Alzheimer's-like pathology in mice

Huang, X., Sun, Y.-Y., Qin, Y.-R., Chen, H., Pan, T.-T., Zhao, S., Cai, Q., Zhang, X., Nie, X.-D., Feng, L., et al. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114687

Computational fragment-based design of chemically modified oligonucleotides for selective protein inhibition : BACE1 as a case study

González‐Alemán, R. (2023) · doi:10.70675/d579a173zeee9z409fzaf5ez64ae20859f75

The SHIP1-inflammatory-lipid axis in Alzheimer’s disease: from genetic risk to spatiotemporal mechanistic insights

Xi, R., Zheng, X., Zhao, J., & Fu, Y. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03819-x · Cited by 1 · see citing works

CRISPR-Based Gene Therapy for Brain Disease

Khajouei, F., Ghaemi, A., Abnous, K., Taghdisi, S. M., Ramezani, M., & Alibolandi, M. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05966-x

Vitamin K2 Promotes Mitochondrial Structural and Functional Homeostasis to Ameliorate Alzheimer Pathology by Targeting the EGFR-Ras-ERK Signaling Axis

Li, Y., Zhao, H., Wu, J., Hu, Y., Pan, J., Frimpong, A. O., Xie, B. B., Yang, W. Z., Sun, M., Chen, W., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27135708

Effects of traditional Chinese medicine on microglia immunometabolism: A new frontier in the treatment of neurodegenerative diseases

Li, Q., Ding, M., He, R., Cheng, J., & Yuan, Z. (2026) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2026.100179

PrPC modulates BACE1-dependent amyloid pathology under chronic cerebral hypoperfusion: Implications for vascular cognitive impairment

Sun, Q., Yin, X., Lang, Y., Zhang, B., Shao, J., Zhang, Y., Wang, Y., Wang, Y., & Cui, L. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e00957

Magnolol as a promising multitarget agent for Alzheimer's disease: Evidence from a systematic evidence synthesis, network pharmacology, and molecular dynamics simulations

Qin, Y., Dong, X., Zhang, C., & Nao, J. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158586

Development of a Novel AAV-Mediated microRNA Gene Therapy for Spatial Suppression of BACE1 to Improve Cognitive Function in Alzheimer’s Disease Model Mice

Zhou, Y., Diao, Y., Yan, Z., Shui, X., Huang, Z., Sun, Y., Wang, S. W., Xia, Y., Lee, T. H., & Wang, L. (2026) · Biomolecules · doi:10.3390/biom16081075

THERAPY FOR ALZHEIMER’S DISEASE - FOCUS ON LECANEMAB

Jońca, M., Majchrowicz, G., Kurys, N., Piekarska, W., Litke, S., & Gołacka, K. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.3(51).2026.5795

The role of microglia glucose metabolism reprogramming in Alzheimer's disease treatment

Cao, Q., Shen, M., Liu, Y., Li, C., Liu, L., Zhou, J., Yue, R., Niu, D., Ren, Y., Pan, L., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261478594

Metabolic reallocation in spinal cord oligodendrocytes drives chronic pain in mice through neuronal Aβ 42 production

Fotio, Y., Masri, S. A., Shi, Z., Le, J., Das, S., Rubtsova, V. I., Tagne, A. M., Jang, C., Swarup, V., & Piomelli, D. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.aea8738

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Chen, J., Zhang, W., Song, L., Liao, Y., Zhang, H., Xia, Y., & Cui, D. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70839

Targeting the BACE1–GSK-3β Signaling Axis in Alzheimer’s Disease: From Molecular Crosstalk to Nanotechnology-Based Translational Strategies

Marimuthu, A., Singh, M. T., Balasubramanian, S., & Krishnamurthy, P. T. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06203-1

Early post-sepsis innate behavioral changes in aged mice occur independently of detectable neuroinflammation

Lee, H. N. R., Lin, J., Baer, B., Haffizulla, A., Ware, L. B., Harrison, F. E., & Bastarache, J. A. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.107062

Effectiveness of exercise training on hippocampal mitochondrial regulation in Alzheimer’s disease: A mechanistic systematic review

Kao, S., Yousaf, F., Ishaq, S., Shah, I. A., Wu, B.-T., & Lee, S.-D. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.116070

Inhibition of BACE1 in glial cells for enhancing clearance of amyloid plaques

Yan, R. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.083297

BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1

Singh, N., Benoit, M., Zhou, J., Das, B., Dávila-Velderrain, J., Kellis, M., Tsai, L., Hu, X., & Yan, R. (2022) · Science Advances · doi:10.1126/sciadv.abo1286 · Cited by 69 · see citing works

Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice

Thakker, D. R., Sankaranarayanan, S., Weatherspoon, M. R., Harrison, J., Pierdomenico, M., Heisel, J., Thompson, L. A., Haskell, R. J., Grace, J. E., Taylor, S. J., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2262-14.2015 · Cited by 32 · see citing works

BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions

Hu, X., Das, B., Hou, H., He, W., & Yan, R. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20171831 · Cited by 127 · see citing works

Reducing β-Amyloid by Inhibition of BACE1: How Low Should You Go?

Killick, R., Hardy, J., & Simons, J. P. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.001 · Cited by 3 · see citing works