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Cited by 577Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesDementia and Cognitive Impairment Research

The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

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Vassar, Robert, Kovacs, Dora M., Yan, Riqiang, Wong, Philip C.·2009·The Journal of Neuroscience
DOI 10.1523/jneurosci.3657-09.2009PMC PMC2879048
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Abstract

The β-amyloid (Aβ) peptide is the major constituent of amyloid plaques in Alzheimer's disease (AD) brain and is likely to play a central role in the pathogenesis of this devastating neurodegenerative disorder. The β-secretase, β-site amyloid precursor protein cleaving enzyme (BACE1; also called Asp2, memapsin 2), is the enzyme responsible for initiating Aβ generation. Thus, BACE is a prime drug target for the therapeutic inhibition of Aβ production in AD. Since its discovery 10 years ago, much has been learned about BACE. This review summarizes BACE properties, describes BACE translation dysregulation in AD, and discusses BACE physiological functions in sodium current, synaptic transmission, myelination, and schizophrenia. The therapeutic potential of BACE will also be considered. This is a summary of topics covered at a symposium held at the 39th annual meeting of the Society for Neuroscience and is not meant to be a comprehensive review of BACE.

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Authors
Vassar, R., Kovacs, D. M., Yan, R., & Wong, P. C.
Affiliations
  • Northwestern University (US)
  • Harvard University (US)
  • Cleveland Clinic (US)
ORCID
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2009-10-14
Volume
29
Issue
41
Pages
12787-12794
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.3657-09.2009
PMC
PMC2879048
OpenAlex
W2042600422
Cited by
577
References
7
Citations by year
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FWCI
4.60
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (RF1AG022560, R01AG022560)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
BACE1, beta-secretase, Alzheimer's disease, amyloid-beta, amyloid plaques, sodium current, synaptic transmission, myelination, schizophrenia, BACE inhibitors, therapeutic target
MeSH terms
Alzheimer Disease, Animals, Humans, Models, Biological, Protease Inhibitors, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, Amyloid Precursor Protein Secretases

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