Højlund, Kurt

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 4,810

Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes

Mogensen, M., Sahlin, K., Fernström, M., Glintborg, D., Vind, B. F., Beck-Nielsen, H., & Højlund, K. (2007) · Diabetes

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 573

Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes

Hwang, H., Bowen, B. P., Lefort, N., Flynn, C. R., De Filippis, E. A., Roberts, C., Smoke, C. C., Meyer, C., Højlund, K., Yi, Z., et al. (2010) · Diabetes

Metabolism, Diabetes, and CancerMuscle Physiology and Disorders

Cited by 255

Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

Lefort, N., Glancy, B., Bowen, B., Willis, W. T., Bailowitz, Z., De Filippis, E. A., Brophy, C., Meyer, C., Højlund, K., Yi, Z., et al. (2010) · Diabetes

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 174

Mitochondrial Dysfunction in Type 2 Diabetes and Obesity

Højlund, K., Mogensen, M., Sahlin, K., & Beck-Nielsen, H. (2008) · Endocrinology and Metabolism Clinics of North America

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 135

A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene.

Højlund, K., Hansen, T., Lajer, M., Henriksen, J. E., Levin, K., Lindholm, J., Pedersen, O., & Beck-Nielsen, H. (2004) · Diabetes

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 130

Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.

Vind, B. F., Pehmøller, C., Treebak, J. T., Birk, J. B., Hey-Mogensen, M., Beck-Nielsen, H., Zierath, J. R., Wojtaszewski, J. F. P., & Højlund, K. (2011) · Diabetologia

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 129

Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution

Kolnes, K. J., Petersen, M. H., Lien-Iversen, T., Højlund, K., & Jensen, J. (2021) · Frontiers in Physiology

Cardiovascular and exercise physiologyAdipose Tissue and Metabolism

Cited by 112

Effect of Calorie-Unrestricted Low-Carbohydrate, High-Fat Diet Versus High-Carbohydrate, Low-Fat Diet on Type 2 Diabetes and Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial

Hansen, C. D., Gram-Kampmann, E.-M., Hansen, J. K., Hugger, M. B., Madsen, B. S., Jensen, J. M., Olesen, S., Torp, N., Rasmussen, D. N., Kjærgaard, M., et al. (2023) · Annals of Internal Medicine

Diet and metabolism studiesDietary Effects on Health

Cited by 110

Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: evidence for an intrinsic oxidative enzyme defect

Ørtenblad, N., Mogensen, M., Petersen, I., Højlund, K., Levin, K., Sahlin, K., Beck-Nielsen, H., & Gaster, M. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 101

Testosterone therapy decreases subcutaneous fat and adiponectin in aging men

Frederiksen, L., Højlund, K., Hougaard, D. M., Mosbech, T. H., Larsen, R., Flyvbjerg, A., Frystyk, J., Brixen, K., & Andersen, M. (2012) · European Journal of Endocrinology

Hormonal and reproductive studiesNutrition and Health in Aging

Cited by 93

Transcriptional and epigenetic changes influencing skeletal muscle metabolism in women with polycystic ovary syndrome

Nilsson, E., Benrick, A., Kokosar, M., Krook, A., Lindgren, E., Källman, T., Martis, M. M., Højlund, K., Ling, C., & Stener-Victorin, E. (2018) · The Journal of Clinical Endocrinology & Metabolism

Ovarian function and disordersEpigenetics and DNA Methylation

Cited by 93

Once-weekly semaglutide doubles the five-year risk of nonarteritic anterior ischemic optic neuropathy in a Danish cohort of 424,152 persons with type 2 diabetes

Grauslund, J., Taha, A. A., Molander, L. D., Kawasaki, R., Möller, S., Højlund, K., & Stokholm, L. (2024) · International Journal of Retina and Vitreous

Diabetes Treatment and ManagementDrug-Induced Ocular Toxicity

Cited by 79

Markers of autophagy are adapted to hyperglycaemia in skeletal muscle in type 2 diabetes

Kruse, R., Vind, B. F., Petersson, S. J., Kristensen, J. M., & Højlund, K. (2015) · Diabetologia

Autophagy in Disease and TherapyMuscle Physiology and Disorders

Cited by 67

Steady-State Pharmacokinetics of Metformin Is Independent of the OCT1 Genotype in Healthy Volunteers

Christensen, M. M. H., Højlund, K., Hother-Nielsen, O., Stage, T. B., Damkier, P., Beck-Nielsen, H., & Brøsen, K. (2015) · European Journal of Clinical Pharmacology

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 62

Transcriptional profiling of myotubes from patients with type 2 diabetes: no evidence for a primary defect in oxidative phosphorylation genes.

Frederiksen, C. M., Højlund, K., Hansen, L., Oakeley, E. J., Hemmings, B., Abdallah, B. M., Brusgaard, K., Beck-Nielsen, H., & Gaster, M. (2008) · Diabetologia

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 57

Dysregulation of muscle glycogen synthase in recovery from exercise in type 2 diabetes.

Pedersen, A. J. T., Hingst, J. R., Friedrichsen, M., Kristensen, J. M., Højlund, K., & Wojtaszewski, J. F. P. (2015) · Diabetologia

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 28

The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

Sylow, L., Pham, T. C. P., Raun, S., Havula, E., Henriquez-Olguín, C., Rubalcava-Gracia, D., Frank, E., Fritzen, A., Jannig, P., Andersen, N., et al. (2024) · Nature Communications

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 19

The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

Pham, T. C. P., Raun, S. H., Havula, E., Henriquez-Olguín, C., Rubalcava-Gracia, D., Frank, E., Fritzen, A. M., Jannig, P. R., Andersen, N. R., Kruse, R., et al. (2024) · Nature Communications

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 19

The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

Pham, T. C. P., Raun, S. H., Havula, E., Henriquez-Olguín, C., Rubalcava-Gracia, D., Frank, E., Fritzen, A. M., Jannig, P. R., Andersen, N. R., Kruse, R., et al. (2023) · Nature Communications

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 19

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake

Kjærgaard, J., Lindqvist, C. B., Quesada, J. P., Jessen, S., Schlabs, F., Ehrlich, A. M., Yonamine, C. Y., García-Ureña, M., Schmalbruch, J. H., Small, L., et al. (2025) · Cell Reports Medicine

Metabolism, Diabetes, and CancerMuscle metabolism and nutrition

Cited by 11