Mitochondrial Dysfunction in Type 2 Diabetes and Obesity

Højlund, Kurt; Mogensen, Martin; Sahlin, Kent; Beck-Nielsen, Henning

doi:10.1016/j.ecl.2008.06.006

Cited by 135Metabolism, Diabetes, and CancerMitochondrial Function and PathologyAdipose Tissue and Metabolism

Mitochondrial Dysfunction in Type 2 Diabetes and Obesity

Højlund, Kurt, Mogensen, Martin, Sahlin, Kent, Beck-Nielsen, Henning·2008·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2008.06.006

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Abstract

Insulin resistance in skeletal muscle is a major hallmark of type 2 diabetes mellitus (T2D) and obesity that is characterized by impaired insulin-mediated glucose transport and glycogen synthesis and by increased intramyocellular content of lipid metabolites. Several studies have provided evidence for mitochondrial dysfunction in skeletal muscle of type 2 diabetic and prediabetic subjects, primarily due to a lower content of mitochondria (mitochondrial biogenesis) and possibly to a reduced functional capacity per mitochondrion. This article discusses the latest advances in the understanding of the molecular mechanisms underlying insulin resistance in human skeletal muscle in T2D and obesity, with a focus on possible links between insulin resistance and mitochondrial dysfunction.

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A mitochondrial oxidative phosphorylation defect in skeletal muscle may contribute to increased intramyocellular fat content.
“suggest that this mitochondrial defect contributes to the increased intramyocellar fat content.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [19]
Recent studies have reported a defect in mitochondrial oxidative phosphorylation in skeletal muscle in several insulin-resistant states.
“Recent studies have reported a mitochondrial defect in oxidative phosphorylation in skeletal muscle in variety of insulin resistant states.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [19]

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Increased Phosphorylation of Skeletal Muscle Glycogen Synthase at NH2-Terminal Sites During Physiological Hyperinsulinemia in Type 2 Diabetes
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Højlund, K., Yi, Z., Hwang, H., Bowen, B. P., Lefort, N., Flynn, C. R., Langlais, P. R., Weintraub, S. T., & Mandarino, L. J. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700304-mcp200 · Cited by 119 · see citing works
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Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulin-sensitive and insulin-resistant Pima Indians
Yang, X., Pratley, R. E., Tokraks, S., Bogardus, C., & Permana, P. A. (2002) · Diabetologia · doi:10.1007/s00125-002-0905-7 · Cited by 113 · see citing works
Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with Type II diabetes
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Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes
Misu, H., Takamura, T., Matsuzawa, N., Shimizu, A., Ota, T., Sakurai, M., Ando, H., Arai, K., Yamashita, T., Honda, M., et al. (2007) · Diabetologia · doi:10.1007/s00125-006-0489-8 · Cited by 102 · see citing works
AMP-Activated Protein Kinase Is Not Down-Regulated in Human Skeletal Muscle of Obese Females
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Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training
Burns, N. C., Finucane, F. M., Hatunic, M., Gilman, M., Murphy, M. S., Gasparro, D., Mari, A., Gastaldelli, A., & Nolan, J. J. (2007) · Diabetologia · doi:10.1007/s00125-007-0655-7 · Cited by 96 · see citing works
Insulin resistance in relatives of NIDDM patients: The role of physical fitness and muscle metabolism
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Proteome Analysis of Skeletal Muscle From Obese and Morbidly Obese Women
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Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects.
Kruszynska, Y. T., Mulford, M. I., Baloga, J., Yu, J., & Olefsky, J. M. (1998) · Diabetes · doi:10.2337/diabetes.47.7.1107 · Cited by 93 · see citing works
Pioglitazone Enhances Mitochondrial Biogenesis and Ribosomal Protein Biosynthesis in Skeletal Muscle in Polycystic Ovary Syndrome
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Cardiopulmonary Impairment in Young Women with Polycystic Ovary Syndrome
Orio, F., Giallauria, F., Palomba, S., Cascella, T., Manguso, F., Vuolo, L., Russo, T., Tolino, A., Lombardi, G., Colao, A., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0216 · Cited by 84 · see citing works
AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes
Højlund, K., Mustard, K. J., Stæhr, P., Hardie, D. G., Beck‐Nielsen, H., Richter, E. A., & Wojtaszewski, J. F. P. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00326.2003 · Cited by 80 · see citing works
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Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes.
Timmons, J. A., Norrbom, J., Schéele, C., Thonberg, H., Wahlestedt, C., & Tesch, P. (2006) · Genomics · doi:10.1016/j.ygeno.2005.09.007 · Cited by 79 · see citing works
Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects—experiences from relatives and twin studies
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Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes
Højlund, K., Frystyk, J., Levin, K., Flyvbjerg, A., Wojtaszewski, J. F. P., & Beck‐Nielsen, H. (2006) · Diabetologia · doi:10.1007/s00125-006-0240-5 · Cited by 67 · see citing works
Self-citation
Normalization of Plasma Glucose Concentration by Insulin Therapy Improves Insulin-Stimulated Glycogen Synthesis in Type 2 Diabetes
Pratipanawatr, T., Cusi, K., Ngo, P., Pratipanawatr, W., Mandarino, L. J., & DeFronzo, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.2.462 · Cited by 61 · see citing works
Impaired Glycogen Synthase Activity and Mitochondrial Dysfunction in Skeletal Muscle: Markers or Mediators of Insulin Resistance in Type 2 Diabetes?
Publisher, B. S. P. B. S. (2006) · Current Diabetes Reviews · doi:10.2174/1573399810602040375 · Cited by 59 · see citing works
Reduced Skeletal Muscle Oxygen Uptake and Reduced β-Cell Function
Thamer, C., Stümvoll, M., Niess, A. M., Tschritter, O., Haap, M. M., Becker, R., Shirkavand, F., Bachmann, O. P., Kristian, R. E. T. T., Volk, A., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.7.2126 · Cited by 59 · see citing works
Impaired mitochondrial activity and insulin-resistant offspring of patients with type 2 diabetes
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Two‐dimensional protein map of human vastus lateralis muscle
Gelfi, C., Palma, S. D., Cerretelli, P., Begum, S. B., & Wait, R. (2003) · Electrophoresis · doi:10.1002/elps.200390025 · Cited by 44 · see citing works
The effect of exercise, training, and inactivity on insulin sensitivity in diabetics and their relatives: what is new?
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Skeletal muscle mitochondrial protein metabolism and function in ageing and type 2 diabetes
Barazzoni, R. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200401000-00015 · Cited by 34 · see citing works
Unsupervised clustering of gene expression data points at hypoxia as possible trigger for metabolic syndrome
Ptitsyn, A. A., Hulver, M. W., Cefalu, W. T., York, D. A., & Smith, S. R. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-318 · Cited by 32 · see citing works
Mitochondrial function: use it or lose it.
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Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies
Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655 · see citing works
Pathogenesis of insulin resistance in skeletal muscle
Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670 · see citing works
Comprehensive review on lactate metabolism in human health
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Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
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Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents
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Human genetics illuminates the paths to metabolic disease
O’Rahilly, S. (2009) · Nature · doi:10.1038/nature08532 · Cited by 324 · see citing works
The Role of Adipose Tissue and Lipotoxicity in the Pathogenesis of Type 2 Diabetes
Cusi, K. J. (2010) · Current Diabetes Reports · doi:10.1007/s11892-010-0122-6 · Cited by 294 · see citing works
The membrane receptor CD44: novel insights into metabolism
Weng, X., Maxwell-Warburton, S., Hasib, A., Ma, L., & Kang, L. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2022.02.002 · Cited by 254 · see citing works
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆
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Insulin Resistance in Obesity as the Underlying Cause for the Metabolic Syndrome
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Mitochondrial Translation and Beyond: Processes Implicated in Combined Oxidative Phosphorylation Deficiencies
Smits, P., Smeitink, J., & van den Heuvel, L. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/737385 · Cited by 202 · see citing works
Phosphoproteome Analysis of Functional Mitochondria Isolated from Resting Human Muscle Reveals Extensive Phosphorylation of Inner Membrane Protein Complexes and Enzymes
Zhao, X., León, I. R., Bak, S. Y., Mogensen, M., Wrzesinski, K., Højlund, K., & Jensen, O. N. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.000299 · Cited by 169 · see citing works
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Characteristics of Mitochondrial Transformation into Human Cells
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Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor
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TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model
Ti, Y., Xie, G.-L., Wang, Z., Bi, X., Ding, W., Wang, J., Jiang, G.-H., Bu, P. L., Zhang, Y., Zhong, M., et al. (2011) · Diabetes · doi:10.2337/db11-0549 · Cited by 143 · see citing works
Lipid droplets interact with mitochondria using SNAP23
Jägerström, S., Polesie, S., Wickström, Y., Johansson, B. R., Schrøder, H. D., Højlund, K., & Boström, P. (2009) · Cell Biology International · doi:10.1016/j.cellbi.2009.06.011 · Cited by 141 · see citing works
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Pathomechanisms of Type 2 Diabetes Genes
Staiger, H., Machicao, F. E., Fritsche, A., & Häring, H.-U. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0017 · Cited by 133 · see citing works
Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration
Mendizabal‐Zubiaga, J., Melser, S., Bénard, G., Ramos, A., Reguero, L., Arrabal, S., Elezgarai, I., Gerrikagoitia, I., Suárez, J., de Fonseca, F. R., et al. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00476 · Cited by 130 · see citing works
Dietary stearic acid regulates mitochondria in vivo in humans
Senyilmaz, D., Pfaff, D. H., Virtue, S., Schwarz, K. V., Fleming, T., Altamura, S., Muckenthaler, M. U., Okun, J. G., Vidal‐Puig, A., Nawroth, P. P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05614-6 · Cited by 132 · see citing works
Mitochondrial stress: A bridge between mitochondrial dysfunction and metabolic diseases?
Hu, F., & Liu, F. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.008 · Cited by 112 · see citing works
The role of cardiolipin concentration and acyl chain composition on mitochondrial inner membrane molecular organization and function
Pennington, E. R., Funai, K., Brown, D. A., & Shaikh, S. R. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.03.012 · Cited by 107 · see citing works
The transition from fetal growth restriction to accelerated postnatal growth: a potential role for insulin signalling in skeletal muscle
Mühlhäusler, B. S., Duffield, J. A., Ozanne, S. E., Pilgrim, C., Turner, N. A., Morrison, J. L., & McMillen, I. C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173161 · Cited by 100 · see citing works
IL-6 induces lipolysis and mitochondrial dysfunction, but does not affect insulin-mediated glucose transport in 3T3-L1 adipocytes
Ji, C., Chen, X., Gao, C., Jiao, L., Wang, J., Xu, G., Fu, H., Guo, X., & Zhao, Y. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9361-8 · Cited by 99 · see citing works
Leucine in Obesity: Therapeutic Prospects
Yao, K., Duan, Y., Li, F., Tan, B., Hou, Y., Wu, G., & Yin, Y. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.05.004 · Cited by 89 · see citing works
Mitochondrial function in ageing: coordination with signalling and transcriptional pathways
Yin, F., Sancheti, H., Liu, Z., & Cadenas, E. (2015) · The Journal of Physiology · doi:10.1113/jp270541 · Cited by 92 · see citing works
Normal mitochondrial function and increased fat oxidation capacity in leg and arm muscles in obese humans
Ara, I., Larsen, S., Stallknecht, B. M., Guerra, B., Morales‐Álamo, D., Andersen, J. L., Ponce‐González, J. G., Guadalupe‐Grau, A., Galbo, H., Calbet, J. A. L., et al. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.123 · Cited by 88 · see citing works
Testosterone therapy increased muscle mass and lipid oxidation in aging men
Frederiksen, L., Højlund, K., HOUGAARD, D. M., Brixen, K., & Andersen, M. (2011) · AGE · doi:10.1007/s11357-011-9213-9 · Cited by 84 · see citing works
Self-citation
Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation
Guedouari, H., Daigle, T., Scorrano, L., & Hébert-Chatelain, É. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.10.015 · Cited by 83 · see citing works
Agonism of the 5-Hydroxytryptamine 1F Receptor Promotes Mitochondrial Biogenesis and Recovery from Acute Kidney Injury
Garrett, S., Whitaker, R., Beeson, C., & Schnellmann, R. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.214700 · Cited by 70 · see citing works
New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms
Schäfer, S., Machicao, F. E., Fritsche, A., Häring, H., & Kantartzis, K. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(11)70008-0 · Cited by 78 · see citing works
Dietary Quercetin Supplementation in Mice Increases Skeletal Muscle PGC1α Expression, Improves Mitochondrial Function and Attenuates Insulin Resistance in a Time-Specific Manner
Henagan, T. M., Lenard, N. R., Gettys, T. W., & Stewart, L. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089365 · Cited by 72 · see citing works
Human ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insulin-resistant muscle
Højlund, K., Yi, Z., Lefort, N., Langlais, P. R., Bowen, B. P., Levin, K., Beck‐Nielsen, H., & Mandarino, L. J. (2009) · Diabetologia · doi:10.1007/s00125-009-1624-0 · Cited by 65 · see citing works
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Effects of Exercise on AMPK Signaling and Downstream Components to PI3K in Rat with Type 2 Diabetes
Cao, S., Li, B., Yi, X., Chang, B., Zhu, B., Lian, Z., Zhang, Z., Zhao, G., Liu, H., & Zhang, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051709 · Cited by 66 · see citing works
Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy
Malik, A. N., Shahni, R., & Iqbal, M. M. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.07.002 · Cited by 65 · see citing works
Mitochondrial bioenergetics is not impaired in nonobese subjects with type 2 diabetes mellitus
Chattopadhyay, M., GuhaThakurta, I., Behera, P., Ranjan, K. R., Khanna, M., Mukhopadhyay, S., & Chakrabarti, S. (2011) · Metabolism · doi:10.1016/j.metabol.2011.04.015 · Cited by 64 · see citing works
Metabolic Abnormalities, Dietary Risk Factors and Nutritional Management in Amyotrophic Lateral Sclerosis
D’Amico, E., Grosso, G., Nieves, J. W., Zanghì, A., Factor-Litvak, P. R., & Mitsumoto, H. (2021) · Nutrients · doi:10.3390/nu13072273 · Cited by 64 · see citing works
Effects of Coenzyme Q 10 on Arterial Stiffness, Metabolic Parameters, and Fatigue in Obese Subjects: A Double-Blind Randomized Controlled Study
Lee, Y., Cho, W.-J., Kim, J.-K., & Lee, D. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.1202 · Cited by 61 · see citing works
Therapeutic Strategies for Mitochondrial Dysfunction and Oxidative Stress in Age-Related Metabolic Disorders
Bhatti, J. S., Kumar, S., Vijayan, M., Bhatti, G. K., & Reddy, P. H. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.012 · Cited by 60 · see citing works
Mitochondrial Dysfunction and Mitophagy in Type 2 Diabetes: Pathophysiology and Therapeutic Targets
Apostolova, N., Vezza, T., Muntané, J., Rocha, M., & Víctor, V. M. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0016 · Cited by 59 · see citing works
The associations of adiposity, physical activity and inflammation with fatigue in older adults
Valentine, R. J., Woods, J. A., McAuley, E., Dantzer, R., & Evans, E. M. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.06.002 · Cited by 57 · see citing works
Porcine muscle sensory attributes associate with major changes in gene networks involving CAPZB, ANKRD1, and CTBP2
Ponsuksili, S., Muráni, E., Phatsara, C., Schwerin, M., Schellander, K., & Wimmers, K. (2009) · Functional & Integrative Genomics · doi:10.1007/s10142-009-0131-1 · Cited by 57 · see citing works
Vitamin D Ameliorates Fat Accumulation with AMPK/SIRT1 Activity in C2C12 Skeletal Muscle Cells
Chang, E., & Kim, Y. (2019) · Nutrients · doi:10.3390/nu11112806 · Cited by 54 · see citing works
Comparative analyses of cell disruption methods for mitochondrial isolation in high-throughput proteomics study
Chaiyarit, S., & Thongboonkerd, V. (2009) · Analytical Biochemistry · doi:10.1016/j.ab.2009.07.026 · Cited by 55 · see citing works
Skeletal Muscle Nucleo-Mitochondrial Crosstalk in Obesity and Type 2 Diabetes
Devarshi, P. P., McNabney, S. M., & Henagan, T. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040831 · Cited by 55 · see citing works
Cafeteria diet-induced insulin resistance is not associated with decreased insulin signaling or AMPK activity and is alleviated by physical training in rats
Brandt, N., Bock, K. D., Richter, E. A., & Hespel, P. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00098.2010 · Cited by 50 · see citing works
Role and clinical significance of lymphocyte mitochondrial dysfunction in type 2 diabetes mellitus
Khan, S., Raghuram, G. V., Bhargava, A., Pathak, N., Chandra, D. H., Jain, S. K., & Mishra, P. K. (2011) · Translational research · doi:10.1016/j.trsl.2011.08.007 · Cited by 49 · see citing works
Tetramethylpyrazine protects palmitate-induced oxidative damage and mitochondrial dysfunction in C2C12 myotubes
Gao, X., Zhao, X., Zhu, Y., Li, X.-M., Xu, Q., Lin, H., & Wang, M. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.02.025 · Cited by 49 · see citing works
Exercise-Regulated Mitochondrial and Nuclear Signalling Networks in Skeletal Muscle
Reisman, E. G., Hawley, J. A., & Hoffman, N. J. (2024) · Sports Medicine · doi:10.1007/s40279-024-02007-2 · Cited by 50 · see citing works
Allicin induces beige-like adipocytes via KLF15 signal cascade
Lee, C. G., Rhee, D. K., Kim, B. O., Um, S. H., & Pyo, S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.09.014 · Cited by 48 · see citing works
Interleukin‐15 in obesity and metabolic dysfunction: current understanding and future perspectives
Duan, Y., Li, F., Wang, W., Guo, Q., Wen, C., Li, Y., & Yin, Y. (2017) · Obesity Reviews · doi:10.1111/obr.12567 · Cited by 47 · see citing works
Lack of β, β‐carotene‐9′, 10′‐oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice
Wu, L., Guo, X., Hartson, S. D., Davis, M. A., He, H., Medeiros, D. M., Wang, W., Clarke, S. L., Lucas, E. A., Smith, B. J., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600576 · Cited by 45 · see citing works
Autophagy, Myocardial Protection, and the Metabolic Syndrome
Giricz, Z., Mentzer, R. M., & Gottlieb, R. A. (2012) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318256ce10 · Cited by 43 · see citing works
β2-adrenergic receptor-mediated mitochondrial biogenesis improves skeletal muscle recovery following spinal cord injury
Scholpa, N. E., Simmons, E. C., Tilley, D. G., & Schnellmann, R. G. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113064 · Cited by 43 · see citing works
Drivers for the comorbidity of type 2 diabetes mellitus and epilepsy: A scoping review
Shlobin, N. A., & Sander, J. W. A. S. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107043 · Cited by 39 · see citing works
Exercise, mitochondrial dysfunction and inflammasomes in skeletal muscle
Slavin, M. B., Khemraj, P., & Hood, D. A. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100636 · Cited by 41 · see citing works
Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders
Sorriento, D., Pascale, A. V., Finelli, R., Carillo, A. L., Annunziata, R., Trimarco, B., & Iaccarino, G. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/604685 · Cited by 38 · see citing works
Retracted
Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration
Khan, G., Galazis, N., Docheva, N., Layfield, R., & Atiomo, W. (2014) · Human Reproduction · doi:10.1093/humrep/deu268 · Cited by 40 · see citing works
Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function
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Authors: Højlund, K., Mogensen, M., Sahlin, K., & Beck-Nielsen, H.
Affiliations: Odense University Hospital (DK)
University of Southern Denmark (DK)
Corresponding author: Højlund, Kurt
ORCID: Højlund, Kurt
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2008-09
Volume: 37
Issue: 3
Pages: 713-731
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2008.06.006
OpenAlex: W2107088422
Semantic Scholar: 31431014b8af686b99bb75eb8c7c784d89c4fca3
Cited by: 135
References: 102
Citations by year: 2026: 3 · 2025: 4 · 2024: 6 · 2023: 12 · 2022: 8 · 2021: 3 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 10 · 2016: 8 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 7
FWCI: 0.95
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders: Diabetesforeningen
Sundhed og Sygdom, Det Frie Forskningsråd
Novo Nordisk UK Research Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: mitochondrial dysfunction, type 2 diabetes, obesity, insulin resistance, skeletal muscle, mitochondrial biogenesis, glucose transport, glycogen synthesis, intramyocellular lipid, prediabetes
MeSH terms: Organelle Biogenesis, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Mitochondria, Obesity, Oxidation-Reduction, Proteomics

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Mitochondrial Dysfunction in Type 2 Diabetes and Obesity

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