Klengel, Torsten

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience

Epigenetics and DNA MethylationStress Responses and Cortisol

Cited by 1,447

Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation

Yehuda, R., Daskalakis, N. P., Bierer, L. M., Bader, H. N., Klengel, T., Holsboer, F., & Binder, E. B. (2016) · Biological Psychiatry

Epigenetics and DNA MethylationPosttraumatic Stress Disorder Research

Cited by 782

The transcriptional landscape of age in human peripheral blood

Peters, M. J., Joehanes, R., Pilling, L. C., Schurmann, C., Conneely, K. N., Powell, J., Reinmaa, E., Sutphin, G. L., Zhernakova, A., Schramm, K., et al. (2015) · Nature Communications

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 725

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Nievergelt, C. M., Maihofer, A. X., Klengel, T., Atkinson, E. G., Chen, C.-Y., Choi, K. W., Coleman, J. R. I., Dalvie, S., Duncan, L. E., Gelernter, J., et al. (2019) · Nature Communications

Posttraumatic Stress Disorder ResearchGenetic Associations and Epidemiology

Cited by 635

Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder

Mehta, D., Klengel, T., Conneely, K. N., Smith, A. K., Altmann, A., Pace, T. W., Rex-Haffner, M., Loeschner, A., Gonik, M., Mercer, K. B., et al. (2013) · Proceedings of the National Academy of Sciences

Child Abuse and TraumaPosttraumatic Stress Disorder Research

Cited by 548

DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain

Smith, A. K., Kilaru, V., Klengel, T., Mercer, K. B., Bradley, B., Conneely, K. N., Ressler, K. J., & Binder, E. B. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 355

Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions

Klengel, T., & Binder, E. B. (2015) · Neuron

Epigenetics and DNA MethylationStress Responses and Cortisol

Cited by 353

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O’Leary, J. C., Fontaine, S. N., Breydo, L., Zhang, B., Li, P., Wang, L., et al. (2013) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsHeat shock proteins research

Cited by 322

Sensitive periods for the effect of childhood adversity on DNA methylation: results from a prospective, longitudinal study

Dunn, E. C., Soare, T. W., Zhu, Y., Simpkin, A. J., Suderman, M. J., Klengel, T., Smith, A. D. A. C., Ressler, K. J., & Relton, C. L. (2019) · Biological Psychiatry

Epigenetics and DNA MethylationChild Abuse and Trauma

Cited by 315

The role of DNA methylation in stress-related psychiatric disorders

Klengel, T., Pape, J., Binder, E. B., & Mehta, D. (2014) · Neuropharmacology

Epigenetics and DNA MethylationStress Responses and Cortisol

Cited by 309

Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation

Provençal, N., Arloth, J., Cattaneo, A., Anacker, C., Cattane, N., Wiechmann, T., Röh, S., Ködel, M., Klengel, T., Czamara, D., et al. (2020) · Proceedings of the National Academy of Sciences

Epigenetics and DNA MethylationStress Responses and Cortisol

Cited by 209

Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients

Menke, A., Arloth, J., Pütz, B., Weber, P., Klengel, T., Mehta, D., Gonik, M., Rex-Haffner, M., Rubel, J., Uhr, M., et al. (2012) · Neuropsychopharmacology

Stress Responses and CortisolTreatment of Major Depression

Cited by 177

Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression

Menke, A., Klengel, T., Rubel, J., Brückl, T., Pfister, H., Lucae, S., Uhr, M., Holsboer, F., & Binder, E. B. (2013) · Genes, Brain and Behavior

Stress Responses and CortisolGenetic Associations and Epidemiology

Cited by 151

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

Arloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K. V., Balsevich, G., Schmidt, M. V., Karbalai, N., Czamara, D., et al. (2015) · Neuron

Stress Responses and CortisolGenetic Associations and Epidemiology

Cited by 142

Epigenetic and genetic variation at SKA2 predict suicidal behavior and post-traumatic stress disorder

Kaminsky, Z., Wilcox, H. C., Eaton, W. W., Van Eck, K., Kilaru, V, Jovanovic, T., Klengel, T., Bradley, B., Binder, E. B., Ressler, K. J., et al. (2015) · Translational Psychiatry

Suicide and Self-Harm StudiesStress Responses and Cortisol

Cited by 128

Epigenetic mechanisms underlying learning and the inheritance of learned behaviors

Dias, B. G., Maddox, S. A., Klengel, T., & Ressler, K. J. (2015) · Trends in Neurosciences

Epigenetics and DNA MethylationMemory and Neural Mechanisms

Cited by 125

Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5

Hartmann, J., Bajaj, T., Klengel, C., Chatzinakos, C., Ebert, T., Dedic, N., McCullough, K. M., Lardenoije, R., Joëls, M., Meijer, O. C., et al. (2021) · Cell Reports

Stress Responses and CortisolEstrogen and related hormone effects

Cited by 119

Differential genetic and epigenetic regulation of catechol-O-methyltransferase is associated with impaired fear inhibition in posttraumatic stress disorder

Norrholm, S. D., Jovanovic, T., Smith, A. K., Binder, E., Klengel, T., Conneely, K., Mercer, K. B., Davis, J. S., Kerley, K., Winkler, J., et al. (2013) · Frontiers in Behavioral Neuroscience

Posttraumatic Stress Disorder ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 104

DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression

Wingo, A. P., Almli, L. M., Stevens, J. S., Klengel, T., Uddin, M., Li, Y., Bustamante, A. C., Lori, A., Koen, N., Stein, D. J., et al. (2015) · Nature Communications

Posttraumatic Stress Disorder ResearchMicroRNA in disease regulation

Cited by 98

Intergenerational Effects of Maternal Holocaust Exposure on FKBP5 Methylation

Bierer, L. M., Bader, H. N., Daskalakis, N. P., Lehrner, A., Provençal, N., Wiechmann, T., Klengel, T., Makotkine, I., Binder, E. B., & Yehuda, R. (2020) · American Journal of Psychiatry

Epigenetics and DNA MethylationPosttraumatic Stress Disorder Research

Cited by 86

FKBP5 allele-specific epigenetic modification in gene by environment interaction

Klengel, T., & Binder, E. B. (2015) · Neuropsychopharmacology

Stress Responses and CortisolPosttraumatic Stress Disorder Research

Cited by 84

Allele-specific epigenetic modification: a molecular mechanism for gene-environment interactions in stress-related psychiatric disorders

Klengel, T., & Binder, E. B. (2013) · Epigenomics

Epigenetics and DNA MethylationStress Responses and Cortisol

Cited by 52

Transcriptomic Network Analysis Reveals Trauma Type– and Ancestry-Related Heterogeneity in Posttraumatic Stress Disorder

Jiang, W., Bronk, G., Lake, M. T., Hoffman, N., Zar, H. J., Breen, M. S., Stein, D. J., Koen, N., Ressler, K. J., & Klengel, T. (2026) · American Journal of Psychiatry

Posttraumatic Stress Disorder ResearchChild Abuse and Trauma

Cited by 0