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The Molecular Biology of Susceptibility to Post-Traumatic Stress Disorder: Highlights of Epigenetics and Epigenomics

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The interactions between host genome and gut microbiome increase the risk of psychiatric disorders: Mendelian randomization and biological annotation

Xiao, L., Liu, S., Wu, Y., Huang, Y., Tao, S., Liu, Y., Tang, Y., Xie, M., Ma, Q., Yin, Y., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.08.003 · Cited by 45 · see citing works

Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social support

Carvalho, C. M., Wendt, F. R., Maihofer, A. X., Stein, D. J., Stein, M. B., Sumner, J. A., Hemmings, S. M. J., Nievergelt, C. M., Koenen, K. C., Gelernter, J. E., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0655-6 · Cited by 46 · see citing works

PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus

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Polygenic prediction and GWAS of depression, PTSD, and suicidal ideation/self-harm in a Peruvian cohort

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Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy

Seligowski, A. V., Misganaw, B., Duffy, L., Ressler, K. J., & Guffanti, G. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.21111113 · Cited by 42 · see citing works

Assessment of Posttraumatic Stress Disorder and Educational Achievement in Sweden

Vilaplana-Pérez, A., Sidorchuk, A., Pérez-Vigil, A., Brander, G., Isoumura, K., Hesselmark, E., Sevilla‐Cermeño, L., Valdimarsdóttir, U. A., Song, H., Jangmo, A., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.28477 · Cited by 40 · see citing works

Stability of polygenic scores across discovery genome-wide association studies

Schultz, L. M., Merikangas, A. K., Ruparel, K., Jacquemont, S., Glahn, D. C., Gur, R. E., Barzilay, R., & Almasy, L. A. (2022) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2022.100091 · Cited by 40 · see citing works

Machine learning within the Parkinson’s progression markers initiative: Review of the current state of affairs

Gerraty, R. T., Provost, A. C., Li, L., Wagner, E. A., Haas, M., & Lancashire, L. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1076657 · Cited by 42 · see citing works

Genome-wide association study identifies four pan-ancestry loci for suicidal ideation in the Million Veteran Program

Ashley‐Koch, A. E., Kimbrel, N. A., Qin, X., Lindquist, J. H., Garrett, M. E., Dennis, M. F., Hair, L. P., Huffman, J. E., Jacobson, D., Madduri, R., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010623 · Cited by 39 · see citing works

Investigating the impact of poverty on mental illness in the UK Biobank using Mendelian randomization

Marchi, M., Alkema, A., Xia, C., Thio, C. H. L., Chen, L.-Y., Schalkwijk, W., Galeazzi, G. M., Ferrari, S., Pingani, L., Kweon, H., et al. (2024) · Nature Human Behaviour · doi:10.1038/s41562-024-01919-3 · Cited by 42 · see citing works

PTSD: Past, present and future implications for China

Zhou, Y., Shang, Z., Zhang, F., Wu, L., Sun, L., Jia, Y., Yu, H., & Liu, W. (2021) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2021.04.011 · Cited by 41 · see citing works

Integration of peripheral transcriptomics, genomics, and interactomics following trauma identifies causal genes for symptoms of post-traumatic stress and major depression

Wuchty, S., Myers, A., Ramirez‐Restrepo, M., Huentelman, M. J., Richolt, R., Gould, F., Harvey, P. D., Michopolous, V., Steven, J. S., Wingo, A. P., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01084-3 · Cited by 39 · see citing works

General v. specific vulnerabilities: polygenic risk scores and higher-order psychopathology dimensions in the Adolescent Brain Cognitive Development (ABCD) Study

Waszczuk, M. A., Miao, J., Docherty, A. R., Shabalin, A. A., Jonas, K. G., Michelini, G., & Kotov, R. (2021) · Psychological Medicine · doi:10.1017/s0033291721003639 · Cited by 39 · see citing works

Shared molecular genetic risk of alcohol dependence and posttraumatic stress disorder (PTSD).

Sheerin, C. M., Bountress, K. E., Meyers, J. L., de Viteri, S. S., Shen, H., Maihofer, A. X., Duncan, L. E., & Amstadter, A. B. (2020) · Psychology of Addictive Behaviors · doi:10.1037/adb0000568 · Cited by 40 · see citing works

Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorder

Wingo, T. S., Gerasimov, E. S., Liu, Y., Duong, D. M., Vattathil, S., Lori, A., Gockley, J., Breen, M. S., Maihofer, A. X., Nievergelt, C. M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01544-4 · Cited by 37 · see citing works

Genetic architecture distinguishes tinnitus from hearing loss

Clifford, R. E., Maihofer, A. X., Chatzinakos, C., Coleman, J. R. I., Daskalakis, N. P., Gasperi, M., Hogan, K., Mikita, E. A., Stein, M. B., Tcheandjieu, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44842-x · Cited by 38 · see citing works

Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons

Goes, F. S., Collado‐Torres, L., Zandi, P. P., Huuki-Myers, L. A., Tao, R., Jaffe, A. E., Pertea, G. M., Shin, J. H., Weinberger, D. R., Kleinman, J. E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59115-4 · Cited by 37 · see citing works

Posttraumatic Stress Disorder and Chronic Pain Conditions in Men: A Twin Study

Gasperi, M., Panizzon, M. S., Goldberg, J. H., Buchwald, D., & Afari, N. (2020) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000899 · Cited by 38 · see citing works

Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder

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Asthma and posttraumatic stress disorder (PTSD): Emerging links, potential models and mechanisms

Allgire, E., McAlees, J. W., Lewkowich, I. P., & Sah, R. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.06.001 · Cited by 36 · see citing works

Transcriptome-wide association study of post-trauma symptom trajectories identified GRIN3B as a potential biomarker for PTSD development

Lori, A., Schultebraucks, K., Galatzer‐Levy, I. R., Daskalakis, N. P., Katrinli, Ş., Smith, A. K., Myers, A., Richholt, R., Huentelman, M. J., Guffanti, G., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01073-8 · Cited by 37 · see citing works

PTSD is associated with increased DNA methylation across regions of HLA-DPB1 and SPATC1L

Katrinli, Ş., Zheng, Y., Gautam, A., Hammamieh, R., Yang, R., Venkateswaran, S., Kilaru, V., Lori, A., Hinrichs, R. C., Powers, A. D., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.10.023 · Cited by 35 · see citing works

Causal influences of neuropsychiatric disorders on Alzheimer’s disease

Baranova, A. V., Zhao, Q., Cao, H., Chandhoke, V., & Zhang, F. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02822-1 · Cited by 36 · see citing works

Parsing inter- and intra-individual variability in key nervous system mechanisms of stress responsivity and across functional domains

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Prevalence and Characterization of Psychological Trauma in Patients with Fibromyalgia: A Cross-Sectional Study

Gardoki-Souto, I., Redolar-Ripoll, D., Fontana, M., Hogg, B., Castro, M. J., Blanch, J. M., Ojeda, F., Solanes, A., Radua, J., Valiente-Gómez, A., et al. (2022) · Pain Research and Management · doi:10.1155/2022/2114451 · Cited by 36 · see citing works

Chronic overlapping pain conditions and nociplastic pain

Johnston, K. J. A., Signer, R., & Huckins, L. M. (2025) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2024.100381 · Cited by 35 · see citing works

Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non‐perinatal depression

Kiewa, J., Meltzer-Brody, S. E., Milgrom, J., Guintivano, J., Hickie, I. B., Whiteman, D. C., Olsen, C. M., Colodro‐Conde, L., Medland, S. E., Martin, N. G., et al. (2022) · Depression and Anxiety · doi:10.1002/da.23232 · Cited by 36 · see citing works

Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies

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Modulation of fear behavior and neuroimmune alterations in house dust mite exposed A/J mice, a model of severe asthma

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Phenome risk classification enables phenotypic imputation and gene discovery in developmental stuttering

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Molecular Signatures of Post-Traumatic Stress Disorder in War-Zone Exposed Veteran and Active Duty Soldiers

Muhie, S. Y., Gautam, A., Yang, R., Misganaw, B., Daigle, B. J., Mellon, S. H., Flory, J. D., Amara, D. A., Lee, I., Wang, K., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101045 · Cited by 35 · see citing works

Association between microbiome and the development of adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure

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Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

Okhuijsen‐Pfeifer, C., van der Horst, M. Z., Bousman, C., Lin, B. D., van Eijk, K. R., Ripke, S., Ayhan, Y., Babaoglu, M. O., Bak, M., Alink, W., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01884-3 · Cited by 33 · see citing works

Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder

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Polygenic prediction of PTSD trajectories in 9/11 responders

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Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathwaysPreprint

Nievergelt, C. M., Maihofer, A. X., Klengel, T., Atkinson, E. G., Chen, C., Choi, K. W., Coleman, J. R. I., Dalvie, S., Duncan, L. E., Logue, M. W., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/458562 · Cited by 24 · see citing works

Large-Scale Genetic Characterization of PTSD Across Ancestry, Gender and Trauma-Type

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First Wave Genome Wide Study In Ptsd: Genetic Overlap And Sex Differences In Heritability

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Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability

Duncan, L. E., Ratanatharathorn, A., Aiello, A. E., Almli, L. M., Amstadter, A. B., Ashley-Koch, A. E., Baker, D. G., Beckham, J. C., Bierut, L. J., Bisson, J., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.77 · Cited by 425 · see citing works

PTSD Genome-Wide Association Study Identifies Novel Loci and Informs Future Expectations

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