Medzhitov, Ruslan

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation

Wang, A., Huen, S. C., Luan, H. H., Yu, S., Zhang, C., Gallezot, J.-D., Booth, C. J., & Medzhitov, R. (2016) · Cell

Immune Response and InflammationDietary Effects on Health

Cited by 579

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

Luan, H. H., Wang, A., Hilliard, B. K., Carvalho, F., Rosen, C. E., Ahasic, A. M., Herzog, E. L., Kang, I., Pisani, M. A., Yu, S., et al. (2019) · Cell

GDF15 and Related BiomarkersSepsis Diagnosis and Treatment

Cited by 527

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

Kleinridders, A., Schenten, D., Könner, A. C., Belgardt, B. F., Mauer, J., Okamura, T., Wunderlich, F. T., Medzhitov, R., & Brüning, J. C. (2009) · Cell Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 483

Circuit Design Features of a Stable Two-Cell System

Zhou, X., Franklin, R. A., Adler, M., Jacox, J. B., Bailis, W., Shyer, J. A., Flavell, R. A., Mayo, A., Alon, U., & Medzhitov, R. (2018) · Cell

Gene Regulatory Network AnalysisMathematical Biology Tumor Growth

Cited by 430

Tissue homeostasis and inflammation

Meizlish, M. L., Franklin, R. A., Zhou, X., & Medzhitov, R. (2021) · Annual Review of Immunology

Immune Response and InflammationT-cell and B-cell Immunology

Cited by 364

Age-Associated Defect in Human TLR-1/2 Function

van Duin, D., Mohanty, S., Thomas, V., Ginter, S., Montgomery, R. R., Fikrig, E., Allore, H. G., Medzhitov, R., & Shaw, A. C. (2007) · The Journal of Immunology

Immune Response and InflammationImmune responses and vaccinations

Cited by 352

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

Bondar, T., & Medzhitov, R. (2010) · Cell Stem Cell

Cancer-related Molecular PathwaysHematopoietic Stem Cell Transplantation

Cited by 342

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

Kopp, E., Medzhitov, R., Carothers, J., Xiao, C., Douglas, I., Janeway, C. A., & Ghosh, S. (1999) · Genes & Development

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 334

An ancient system of host defense

Medzhitov, R., & Janeway, C. A. (1998) · Current Opinion in Immunology

Invertebrate Immune Response MechanismsImmune Response and Inflammation

Cited by 327

Influenza Virus-Induced Glucocorticoids Compromise Innate Host Defense against a Secondary Bacterial Infection

Jamieson, A. M., Yu, S., Annicelli, C. H., & Medzhitov, R. (2010) · Cell Host & Microbe

Stress Responses and CortisolInfluenza Virus Research Studies

Cited by 180

Principles of Cell Circuits for Tissue Repair and Fibrosis

Adler, M., Mayo, A., Zhou, X., Franklin, R. A., Meizlish, M. L., Medzhitov, R., Kallenberger, S. M., & Alon, U. (2020) · iScience

Wound Healing and TreatmentsLiver physiology and pathology

Cited by 177

An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis

Wang, S., Li, K., Pickholz, E., Dobie, R., Matchett, K. P., Henderson, N. C., Carrico, C., Driver, I., Borch Jensen, M., Chen, L., et al. (2023) · Science Translational Medicine

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 176

Prevaccine Determination of the Expression of Costimulatory B7 Molecules in Activated Monocytes Predicts Influenza Vaccine Responses in Young and Older Adults

van Duin, D., Allore, H. G., Mohanty, S., Ginter, S., Newman, F. K., Belshe, R. B., Medzhitov, R., & Shaw, A. C. (2007) · The Journal of Infectious Diseases

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 159

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense

Luan, H. H., & Medzhitov, R. (2016) · Cell Metabolism

Immune cells in cancerImmune responses and vaccinations

Cited by 130

Confronting risks of mirror life

Adamala, K. P., Agashe, D., Belkaid, Y., Bittencourt, D. M. D. C., Cai, Y., Chang, M. W., Chen, I. A., Church, G. M., Cooper, V. S., Davis, M. M., et al. (2024) · Science

Space Science and Extraterrestrial LifeOrigins and Evolution of Life

Cited by 125

Mechanosensing regulates tissue repair program in macrophages

Meizlish, M. L., Kimura, Y., Pope, S. D., Matta, R., Kim, C., Philip, N. H., Meyaard, L., Gonzalez, A., & Medzhitov, R. (2024) · Science Advances

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

Cited by 114

Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice

Wang, A., Pope, S. D., Weinstein, J. S., Yu, S., Zhang, C., Booth, C. J., & Medzhitov, R. (2019) · Proceedings of the National Academy of Sciences

Autoimmune and Inflammatory Disorders ResearchInflammasome and immune disorders

Cited by 67

Two-signal requirement for growth-promoting function of Yap in hepatocytes

Su, T., Bondar, T., Zhou, X., Zhang, C., He, H., & Medzhitov, R. (2015) · eLife

Hippo pathway signaling and YAP/TAZLiver physiology and pathology

Cited by 64

The origins of tumor-promoting inflammation

Bondar, T., & Medzhitov, R. (2013) · Cancer Cell

Telomeres, Telomerase, and SenescenceImmune cells in cancer

Cited by 47

Tissue Biology: In Search of a New Paradigm

Adler, M., Chavan, A. R., & Medzhitov, R. (2023) · Annual Review of Cell and Developmental Biology

Developmental Biology and Gene RegulationCellular Mechanics and Interactions

Cited by 40

Training the next generation of biomedical investigators in glycosciences

Agre, P., Bertozzi, C., Bissell, M., Campbell, K. P., Cummings, R. D., Desai, U. R., Estes, M., Flotte, T., Fogleman, G., Gage, F., et al. (2016) · Journal of Clinical Investigation

Glycosylation and Glycoproteins ResearchHealth and Medical Research Impacts

Cited by 34

Technical Report on Mirror Bacteria: Feasibility and Risks

Adamala, K., Agashe, D., Binder, D., Cai, Y., Cooper, V., Duncombe, R., Esvelt, K., Glass, J., Hand, T., Inglesby, T., et al. (2025) · Stanford Digital Repository

Origins and Evolution of LifeGlobal Security and Public Health

Cited by 9