An ancient system of host defense
Open accessAbstract
Research over the past few years has begun to provide significant advances in our understanding of the interplay between the innate and adaptive immune systems. New findings in several model systems reveal remarkable parallels and conservation of ancient host defense pathways in organisms separated by over a billion years of evolution.
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TLR2 and TLR4 signals as well as vitamin D2 are linked to induction of autophagy as an anti-microbial effector mechanism.
“TLR2 and TLR4 signals as well as vitamin D2 have been linked to induction autophagy as an anti-microbial effector mechanism (81).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [81]
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- Authors
- Medzhitov, R., & Janeway, C. A.
- Affiliations
- Yale University (US)
- Howard Hughes Medical Institute (US)
- ORCID
- Medzhitov, Ruslan
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 1998-02
- Volume
- 10
- Issue
- 1
- Pages
- 12-15
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W1968061454
- Cited by
- 327
- References
- 32
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 12 · 2012: 10
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Opinion in Immunology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01ai026810-06)
- National Institute of Allergy and Infectious Diseases (AI26810)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Keywords
- innate immunity, adaptive immunity, evolutionary conservation, innate-adaptive immune interaction
- MeSH terms
- Animals, Drosophila, Biological Evolution, Humans, Immunity, Innate, Mammals, Plants
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