Cited by 327Invertebrate Immune Response MechanismsImmune Response and InflammationAntimicrobial Peptides and Activities

An ancient system of host defense

Open access
Medzhitov, Ruslan, Janeway, Charles A·1998·Current Opinion in Immunology

Abstract

Research over the past few years has begun to provide significant advances in our understanding of the interplay between the innate and adaptive immune systems. New findings in several model systems reveal remarkable parallels and conservation of ancient host defense pathways in organisms separated by over a billion years of evolution.

Integrity signals

Registry

Crossref · 10.1016/s0952-7915(98)80024-1

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32 of 32 references verified0 citation errors · 0 not checkable

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  • TLR2 and TLR4 signals as well as vitamin D2 are linked to induction of autophagy as an anti-microbial effector mechanism.

    “TLR2 and TLR4 signals as well as vitamin D2 have been linked to induction autophagy as an anti-microbial effector mechanism (81).”

    From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [81]

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Authors
Medzhitov, R., & Janeway, C. A.
Affiliations
  • Yale University (US)
  • Howard Hughes Medical Institute (US)
Venue
Current Opinion in Immunology
Publisher
Elsevier BV
Published
1998-02
Volume
10
Issue
1
Pages
12-15
ISSN
0952-7915 (ISSN-L)
OpenAlex
W1968061454
Cited by
327
References
32
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 12 · 2012: 10
FWCI
3.26
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Immunology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2r01ai026810-06)
  • National Institute of Allergy and Infectious Diseases (AI26810)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Keywords
innate immunity, adaptive immunity, evolutionary conservation, innate-adaptive immune interaction
MeSH terms
Animals, Drosophila, Biological Evolution, Humans, Immunity, Innate, Mammals, Plants

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