Tomlinson, Ian

Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations

Pollard, P. J., Brière, J. J., Alam, N. A., Barwell, J., Barclay, E., Wortham, N. C., Hunt, T., Mitchell, M., Olpin, S., Moat, S. J., et al. (2005) · Human Molecular Genetics

Cancer, Hypoxia, and MetabolismAdrenal and Paraganglionic Tumors

Cited by 865

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

the CORGI Consortium, Tomlinson, I., Webb, E., Carvajal-Carmona, L., Broderick, P., Kemp, Z., Spain, S., Penegar, S., Chandler, I., Gorman, M., et al. (2007) · Nature Genetics

Genetic Associations and EpidemiologyGenetic factors in colorectal cancer

Cited by 808

Associations of breast cancer risk factors with tumor subtypes: A pooled analysis from the breast cancer association consortium studies

Yang, X. R., Chang-Claude, J., Goode, E. L., Couch, F. J., Nevanlinna, H., Milne, R. L., Gaudet, M., Schmidt, M. K., Broeks, A., Cox, A., et al. (2011) · JNCI: Journal of the National Cancer Institute

Cancer Risks and FactorsBreast Cancer Treatment Studies

Cited by 691

Deep learning for prediction of colorectal cancer outcome: a discovery and validation study

Skrede, O.-J., De Raedt, S., Kleppe, A., Hveem, T. S., Liestøl, K., Maddison, J., Askautrud, H. A., Pradhan, M., Nesheim, J. A., Albregtsen, F., et al. (2020) · The Lancet

AI in cancer detectionRadiomics and Machine Learning in Medical Imaging

Cited by 627

Colorectal cancer and genetic alterations in the Wnt pathway

Segditsas, S., & Tomlinson, I. (2006) · Oncogene

Wnt/β-catenin signaling in development and cancerGenetic factors in colorectal cancer

Cited by 591

Whole-genome sequencing of patients with rare diseases in a national health system

Turro, E., Astle, W. J., Megy, K., Gräf, S., Greene, D., Shamardina, O., Allen, H. L., Sanchis-Juan, A., Frontini, M., Thys, C., et al. (2020) · Nature

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 554

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

Frezza, C., Zheng, L., Folger, O., Rajagopalan, K. N., MacKenzie, E. D., Jerby, L., Micaroni, M., Chaneton, B., Adam, J., Hedley, A., et al. (2011) · Nature

Cancer, Hypoxia, and MetabolismHeme Oxygenase-1 and Carbon Monoxide

Cited by 503

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

The PRACTICAL Consortium, Day, F. R., kConFab Investigators, AOCS Investigators, Scotland, G., EPIC-InterAct Consortium, Study, L. C., Ruth, K. S., Thompson, D. J., Lunetta, K. L., et al. (2015) · Nature Genetics

Genetic Associations and EpidemiologyBRCA gene mutations in cancer

Cited by 402

SDH mutations in cancer

Bardella, C., Pollard, P. J., & Tomlinson, I. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Adrenal and Paraganglionic TumorsCancer, Hypoxia, and Metabolism

Cited by 395

Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer

Mouradov, D., Sloggett, C., Jorissen, R. N., Love, C. G., Li, S., Burgess, A. W., Arango, D., Strausberg, R. L., Buchanan, D., Wormald, S., et al. (2014) · Cancer Research

Genetic factors in colorectal cancerCancer Genomics and Diagnostics

Cited by 375

Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

The COGENT Consortium, Houlston, R. S., The CORGI Consortium, The COIN Collaborative Group, The COINB Collaborative Group, Cheadle, J., Dobbins, S. E., Tenesa, A., Jones, A. M., Howarth, K., et al. (2010) · Nature Genetics

Genetic Associations and EpidemiologyGenetic factors in colorectal cancer

Cited by 360

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

Kovac, M., Blattmann, C., Ribi, S., Smida, J., Mueller, N. S., Engert, F., Castro-Giner, F., Weischenfeldt, J., Kovacova, M., Krieg, A., et al. (2015) · Nature Communications

Sarcoma Diagnosis and TreatmentCancer Genomics and Diagnostics

Cited by 353

Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: A retrospective, pooled biomarker study

Domingo, E., Freeman-Mills, L., Rayner, E., Glaire, M., Briggs, S., Vermeulen, L., Fessler, E., Medema, J. P., Boot, A., Morreau, H., et al. (2016) · The Lancet Gastroenterology & Hepatology

Genetic factors in colorectal cancerColorectal Cancer Treatments and Studies

Cited by 308

Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status

Bardella, C., El‐Bahrawy, M., Frizzell, N., Adam, J., Ternette, N., Hatipoglu, E., Howarth, K., O'Flaherty, L., Roberts, I., Turner, G., et al. (2011) · The Journal of Pathology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 281

Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study

Wagner, S. J., Reisenbüchler, D., West, N. P., Niehues, J. M., Zhu, J., Foersch, S., Veldhuizen, G. P., Quirke, P., Grabsch, H. I., van den Brandt, P. A., et al. (2023) · Cancer Cell

AI in cancer detectionRadiomics and Machine Learning in Medical Imaging

Cited by 275

Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning

Sirinukunwattana, K., Domingo, E., Richman, S. D., Redmond, K. L., Blake, A., Verrill, C., Leedham, S. J., Chatzipli, A., Hardy, C., Whalley, C. M., et al. (2021) · Gut

AI in cancer detectionRadiomics and Machine Learning in Medical Imaging

Cited by 264

KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer

Tie, J., Lipton, L., Desai, J., Gibbs, P., Jorissen, R. N., Christie, M., Drummond, K. J., Thomson, B. N. J., Usatoff, V., Evans, P. M., et al. (2011) · Clinical Cancer Research

Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancer

Cited by 217

Age- and Tumor Subtype–Specific Breast Cancer Risk Estimates for CH EK 2 *1100delC Carriers

Schmidt, M. K., Hogervorst, F., van Hien, R., Cornelissen, S., Broeks, A., Adank, M. A., Meijers, H., Waisfisz, Q., Hollestelle, A., Schutte, M., et al. (2016) · Journal of Clinical Oncology

BRCA gene mutations in cancerBreast Lesions and Carcinomas

Cited by 173

Increased somatic mutation burdens in normal human cells due to defective DNA polymerases

Robinson, P. S., Coorens, T. H. H., Palles, C., Mitchell, E., Abascal, F., Olafsson, S., Lee, B. C. H., Lawson, A. R. J., Lee-Six, H., Moore, L., et al. (2021) · Nature Genetics

Cancer Genomics and DiagnosticsDNA Repair Mechanisms

Cited by 173

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

EMBRACE, Dunning, A. M., Collaborators, G. S., HEBON, kConFab Investigators, Michailidou, K., Kuchenbaecker, K. B., Thompson, D., French, J. D., Beesley, J., et al. (2016) · Nature Genetics

Genetic Associations and EpidemiologyEstrogen and related hormone effects

Cited by 161

The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase

Pollard, P., Wortham, N., & Tomlinson, I. (2003) · Annals of Medicine

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 159

A Polymorphic p53 Response Element in KIT Ligand Influences Cancer Risk and Has Undergone Natural Selection

Zeron-Medina, J., Wang, X., Repapi, E., Campbell, M. R., Su, D., Castro-Giner, F., Davies, B., Peterse, E. F. P., Sacilotto, N., Walker, G. J., et al. (2013) · Cell

Cancer-related Molecular PathwaysGenetic Associations and Epidemiology

Cited by 118

The effects of mutational processes and selection on driver mutations across cancer types

Temko, D., Tomlinson, I. P. M., Severini, S., Schuster-Böckler, B., & Graham, T. A. (2018) · Nature Communications

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 115

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres

Jones, A. M., Beggs, A. D., Carvajal-Carmona, L., Farrington, S., Tenesa, A., Walker, M., Howarth, K., Ballereau, S., Hodgson, S. V., Zauber, A., et al. (2012) · Gut

Telomeres, Telomerase, and SenescenceGenetic Associations and Epidemiology

Cited by 113