Mossman, Brooke T.

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 2,658

Mechanisms in the Pathogenesis of Asbestosis and Silicosis

MOSSMAN, B. T., & CHURG, A. (1998) · American Journal of Respiratory and Critical Care Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisOccupational and environmental lung diseases

Cited by 971

Redox-based regulation of signal transduction: principles, pitfalls, and promises

Janssen-Heininger, Y. M. W., Mossman, B. T., Heintz, N. H., Forman, H. J., Kalyanaraman, B., Finkel, T., Stamler, J. S., Rhee, S. G., & van der Vliet, A. (2008) · Free Radical Biology and Medicine

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 784

Differential regulation of antioxidant enzymes in response to oxidants.

Shull, S., Heintz, N. H., Periasamy, M., Manohar, M., Janssen, Y. M., Marsh, J. P., & Mossman, B. T. (1991) · Journal of Biological Chemistry

Redox biology and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 403

TNF-α Inhibits Asbestos-Induced Cytotoxicity via a NF-ΚB-Dependent Pathway, a Possible Mechanism for Asbestos-Induced Oncogenesis

Yang, H., Bocchetta, M., Kroczynska, B., Elmishad, A. G., Chen, Y., Liu, Z., Bubici, C., Mossman, B. T., Pass, H. I., Testa, J. R., et al. (2006) · Proceedings of the National Academy of Sciences

Occupational and environmental lung diseasesNF-κB Signaling Pathways

Cited by 322

Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases

Shukla, A., Gulumian, M., Hei, T. K., Kamp, D., Rahman, Q., & Mossman, B. T. (2003) · Free Radical Biology and Medicine

Occupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 288

Diseases caused by asbestos: mechanisms of injury and disease development

Manning, C. B., Vallyathan, V., & Mossman, B. T. (2002) · International Immunopharmacology

Occupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 228

Persistent induction of c-fos and c-jun expression by asbestos.

Heintz, N. H., Janssen, Y. M., & Mossman, B. T. (1993) · Proceedings of the National Academy of Sciences

Occupational and environmental lung diseasesCarcinogens and Genotoxicity Assessment

Cited by 205

Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis

Mossman, B. T., Marsh, J. P., Sesko, A., Hill, S., Shatos, M. A., Doherty, J., Petruska, J., Adler, K. B., Hemenway, D., Mickey, R., et al. (1990) · American Review of Respiratory Disease

Occupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 163

Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases

Mossman, B. T., Borm, P. J., Castranova, V., Costa, D. L., Donaldson, K., & Kleeberger, S. R. (2007) · Particle and Fibre Toxicology

Occupational and environmental lung diseasesAir Quality and Health Impacts

Cited by 150

Cell signaling and transcription factor activation by asbestos in lung injury and disease

Shukla, A., Ramos-Nino, M., & Mossman, B. (2003) · The International Journal of Biochemistry & Cell Biology

Occupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 87

Novel Cell Imaging Techniques Show Induction of Apoptosis and Proliferation in Mesothelial Cells by Asbestos

Goldberg, J. L., Zanella, C. L., Janssen, Y. M. W., Timblin, C. R., Jimenez, L. A., Vacek, P., Taatjes, D. J., & Mossman, B. T. (1997) · American Journal of Respiratory Cell and Molecular Biology

Occupational and environmental lung diseasesCell death mechanisms and regulation

Cited by 78

Increased Phosphorylated Extracellular Signal-Regulated Kinase Immunoreactivity Associated with Proliferative and Morphologic Lung Alterations after Chrysotile Asbestos Inhalation in Mice

Robledo, R. F., Buder-Hoffmann, S. A., Cummins, A. B., Walsh, E. S., Taatjes, D. J., & Mossman, B. T. (2000) · The American Journal of Pathology

Occupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 77

Gene Expression Profiles Reveal Increased mClca3 (Gob5) Expression and Mucin Production in a Murine Model of Asbestos-Induced Fibrogenesis

Sabo-Attwood, T., Ramos-Nino, M., Bond, J., Butnor, K. J., Heintz, N., Gruber, A. D., Steele, C., Taatjes, D. J., Vacek, P., & Mossman, B. T. (2005) · The American Journal of Pathology

Occupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 72

Cellular and molecular parameters of mesothelioma

Ramos‐Nino, M. E., Testa, J. R., Altomare, D. A., Pass, H. I., Carbone, M., Bocchetta, M., & Mossman, B. T. (2006) · Journal of Cellular Biochemistry

Occupational and environmental lung diseasesIntraperitoneal and Appendiceal Malignancies

Cited by 71

Bioreactivity of the crystalline silica polymorphs, quartz and cristobalite, and implications for occupational exposure limits (OELs)

Mossman, B. T., & Glenn, R. E. (2013) · Critical Reviews in Toxicology

Occupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 63

Airway Epithelial NF-κB Activation Modulates Asbestos-Induced Inflammation and Mucin Production In Vivo

Haegens, A., Barrett, T. F., Gell, J., Shukla, A., MacPherson, M., Vacek, P., Poynter, M. E., Butnor, K. J., Janssen-Heininger, Y. M., Steele, C., et al. (2007) · The Journal of Immunology

Occupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 48

Patterns of c-fosand c-junProto-oncogene Expression, Apoptosis, and Proliferation in Rat Pleural Mesothelial Cells Exposed to Erionite or Asbestos Fibers

Timblin, C. R., Guthrie, G. D., Janssen, Y. W. M., Walsh, E. S., Vacek, P., & Mossman, B. T. (1998) · Toxicology and Applied Pharmacology

Occupational and environmental lung diseasesCarcinogens and Genotoxicity Assessment

Cited by 42

In vitro studies on the biologic effects of fibers: Correlation with in vivo Bioassays

Mossman, B. T. (1990) · Environmental Health Perspectives

Occupational and environmental lung diseasesCarcinogens and Genotoxicity Assessment

Cited by 41

Targeting the MEK1 Cascade in Lung Epithelium Inhibits Proliferation and Fibrogenesis by Asbestos

Manning, C. B., Sabo-Attwood, T., Robledo, R. F., MacPherson, M. B., Rincón, M., Vacek, P., Hemenway, D., Taatjes, D. J., Lee, P. J., & Mossman, B. T. (2008) · American Journal of Respiratory Cell and Molecular Biology

Occupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 20

Molecular Responses to Asbestos: Induction of Cell Proliferation and Apoptosis Through Modulation of Redox-Dependent Cell Signaling Pathways

Heintz, N. H., & Mossman, B. T. (2008) · Asbestos and Its Diseases

Occupational and environmental lung diseasesRedox biology and oxidative stress

Cited by 6