Bryder, David

Cell intrinsic alterations underlie hematopoietic stem cell aging

Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 1,152

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature

Hematopoietic Stem Cell TransplantationDNA Repair Mechanisms

Cited by 1,115

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

Beerman, I., Bhattacharya, D., Zandi, S., Sigvardsson, M., Weissman, I. L., Bryder, D., & Rossi, D. J. (2010) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 711

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy

Pronk, C. J. H., Rossi, D. J., Månsson, R., Attema, J. L., Norddahl, G. L., Chan, C. K. F., Sigvardsson, M., Weissman, I. L., & Bryder, D. (2007) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 671

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9

Mandal, P. K., Ferreira, L. M. R., Collins, R., Meissner, T. B., Boutwell, C. L., Friesen, M., Vrbanac, V., Garrison, B. S., Stortchevoi, A., Bryder, D., et al. (2014) · Cell stem cell

CRISPR and Genetic EngineeringCAR-T cell therapy research

Cited by 475

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

Weischenfeldt, J., Damgaard, I., Bryder, D., Theilgaard-Mönch, K., Thoren, L. A., Nielsen, F. C., Jacobsen, S. E. W., Nerlov, C., & Porse, B. T. (2008) · Genes & Development

RNA Research and SplicingHematopoietic Stem Cell Transplantation

Cited by 288

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging

Norddahl, G. L., Pronk, C. J., Wahlestedt, M., Sten, G., Nygren, J. M., Ugale, A., Sigvardsson, M., & Bryder, D. (2011) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationMitochondrial Function and Pathology

Cited by 249

Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-Initiating Cells in C/EBPα Mutant AML

Bereshchenko, O., Mancini, E., Moore, S., Bilbao, D., Månsson, R., Luc, S., Grover, A., Jacobsen, S. E. W., Bryder, D., & Nerlov, C. (2009) · Cancer Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 147

Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

Säwen, P., Eldeeb, M., Erlandsson, E., Kristiansen, T. A., Laterza, C., Kokaia, Z., Karlsson, G., Yuan, J., Soneji, S., Mandal, P. K., et al. (2018) · eLife

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 120

Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

Porse, B. T., Bryder, D., Theilgaard-Mönch, K., Hasemann, M. S., Anderson, K., Damgaard, I., Jacobsen, S. E. W., & Nerlov, C. (2005) · The Journal of Experimental Medicine

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 117

An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state

Wahlestedt, M., Norddahl, G. L., Sten, G., Ugale, A., Frisk, M.-A. M., Mattsson, R., Deierborg, T., Sigvardsson, M., & Bryder, D. (2013) · Blood

Hematopoietic Stem Cell TransplantationPluripotent Stem Cells Research

Cited by 106

Self-Renewal of Multipotent Long-Term Repopulating Hematopoietic Stem Cells Is Negatively Regulated by FAS and Tumor Necrosis Factor Receptor Activation

Bryder, D., Ramsfjell, V., Dybedal, I., Theilgaard-Mönch, K., Högerkorp, C.-M., Adolfsson, J., Borge, O. J., & Jacobsen, S. E. W. (2001) · The Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 98

Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence

Attema, J. L., Pronk, C. J. H., Norddahl, G. L., Nygren, J. M., & Bryder, D. (2009) · Oncogene

Telomeres, Telomerase, and SenescenceHematopoietic Stem Cell Transplantation

Cited by 72

Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property

Nygren, J. M., Bryder, D., & Jacobsen, S. E. W. (2006) · The Journal of Immunology

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 72

Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate

Wahlestedt, M., Erlandsson, E., Kristiansen, T., Lu, R., Brakebusch, C., Weissman, I. L., Yuan, J., Martin-Gonzalez, J., & Bryder, D. (2017) · Nature Communications

Hematopoietic Stem Cell TransplantationPluripotent Stem Cells Research

Cited by 59