Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence
Abstract
Somatic stem cells are ultimately responsible for mediating appropriate organ homeostasis and have therefore been proposed to represent a cellular origin of the ageing process-a state often characterized by inappropriate homeostasis. Specifically, it has been suggested that ageing stem cells might succumb to replicative senescence by a mechanism involving the cyclin-dependent kinase inhibitor p16(INK4A). Here, we tested multiple functional and molecular parameters indicative of p16(INK4A) activity in primary aged murine hematopoietic stem cells (HSCs). We found no evidence that replicative senescence accompanies stem cell ageing in vivo, and in line with p16(INK4A) being a critical determinant of such processes, most aged HSCs (>99%) failed to express p16(INK4A) at the mRNA level. Moreover, whereas loss of epigenetically guided repression of the INK4A/ARF locus accompanied replicative senescent murine embryonic fibroblasts, such repression was maintained in aged stem cells. Taken together, these studies indicate that increased senescence as mediated by the p16(INK4A) tumor suppressor has only a minor function as an intrinsic regulator of steady-state HSC ageing in vivo.
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Certain laboratories could not find p16INK4a expression in freshly isolated HSCs from young or old mice.
“Whether the impact of p16INK4a deficiency reflects a direct role in HSCs themselves remains somewhat controversial, however, as some groups have failed to detect p16INK4a expression in HSCs freshly isolated from young or aged mice129.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [129]
Cites
Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168 · see citing works
Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E. W., Burger, P. C., Baylin, S. B., & Sidransky, D. (1995) · Nature Medicine · doi:10.1038/nm0795-686 · Cited by 1,978 · see citing works
Stability and flexibility of epigenetic gene regulation in mammalian development
Reik, W. (2007) · Nature · doi:10.1038/nature05918 · Cited by 1,963 · see citing works
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871 · see citing works
Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature · doi:10.1038/16476 · Cited by 1,580 · see citing works
Cell intrinsic alterations underlie hematopoietic stem cell aging
Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · see citing works
Self-citationStem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106 · see citing works
Stems Cells and the Pathways to Aging and Cancer
Rossi, D. J., Jamieson, C. H. M., & Weissman, I. L. (2008) · Cell · doi:10.1016/j.cell.2008.01.036 · Cited by 895 · see citing works
Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J.-C., et al. (2007) · Genes & Development · doi:10.1101/gad.415507 · Cited by 850 · see citing works
How stem cells age and why this makes us grow old
Sharpless, N. E., & DePinho, R. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2241 · Cited by 843 · see citing works
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes
Schneider, R., Bannister, A. J., Myers, F. A., Thorne, A. W., Crane‐Robinson, C., & Kouzarides, T. (2003) · Nature Cell Biology · doi:10.1038/ncb1076 · Cited by 792 · see citing works
Bryder, D., Rossi, D. J., & Weissman, I. L. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060312 · Cited by 733 · see citing works
Self-citationAge-Associated Characteristics of Murine Hematopoietic Stem Cells
Sudo, K., Ema, H., Morita, Y., & Nakauchi, H. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1273 · Cited by 722 · see citing works
Pronk, C. J. H., Rossi, D. J., Månsson, R., Attema, J. L., Norddahl, G. L., Chan, C. K. F., Sigvardsson, M., Weissman, I. L., & Bryder, D. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.07.005 · Cited by 671 · see citing works
Self-citationOpposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
Ohtani, N., Zebedee, Z., Huot, T. J. G., Stinson, J. A., Sugimoto, M., Ohashi, Y., Sharrocks, A. D., Peters, G., & Hara, E. (2001) · Nature · doi:10.1038/35059131 · Cited by 654 · see citing works
Zindy, F., Quelle, D. E., Roussel, M. F., & Sherr, C. J. (1997) · Oncogene · doi:10.1038/sj.onc.1201178 · Cited by 574 · see citing works
Polycomb/Trithorax response elements and epigenetic memory of cell identity
Ringrose, L., & Paro, R. (2007) · Development · doi:10.1242/dev.02723 · Cited by 515 · see citing works
Månsson, R., Hultquist, A., Luc, S., Yang, L., Anderson, K., Kharazi, S., Al-Hashmi, S., Liuba, K., Thorén, L., Adolfsson, J., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.013 · Cited by 353 · see citing works
Kotake, Y., Cao, R., Viatour, P., Sage, J., Zhang, Y., & Xiong, Y. (2007) · Genes & Development · doi:10.1101/gad.1499407 · Cited by 314 · see citing works
Oguro, H., Iwama, A., Morita, Y., Kamijo, T., van Lohuizen, M., & Nakauchi, H. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052477 · Cited by 227 · see citing works
Attema, J. L., Papathanasiou, P., Forsberg, E. C., Xu, J., Smale, S. T., & Weissman, I. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704468104 · Cited by 134 · see citing works
Self-citationRandall, T. D., & Weissman, I. L. (1998) · Stem Cells · doi:10.1002/stem.160038 · Cited by 103 · see citing works
Signer, R. A. J., Montecino-Rodriguez, E., Witte, O. N., & Dorshkind, K. (2008) · Genes & Development · doi:10.1101/gad.1715808 · Cited by 102 · see citing works
Pearce, D. J., Anjos‐Afonso, F., Ridler, C. M., Eddaoudi, A., & Bonnet, D. A. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0405 · Cited by 77 · see citing works
Nygren, J., & Bryder, D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003710 · Cited by 49 · see citing works
Self-citationPatel, A. C., Anna, C. H., Foley, J. F., Stockton, P. S., Tyson, F. L., Barrett, J. C., & Devereux, T. R. (2000) · Carcinogenesis · doi:10.1093/carcin/21.9.1691 · Cited by 45 · see citing works
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Esplin, B. L., Shimazu, T., Welner, R. S., Garrett, K. P., Nie, L., Zhang, Q., Humphrey, M. B., Yang, Q., Borghesi, L., & Kincade, P. W. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003438 · Cited by 327 · see citing works
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Schultz, M. B., & Sinclair, D. A. (2016) · Development · doi:10.1242/dev.130633 · Cited by 331 · see citing works
Norddahl, G. L., Pronk, C. J., Wahlestedt, M., Sten, G., Nygren, J. M., Ugale, A., Sigvardsson, M., & Bryder, D. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.03.009 · Cited by 249 · see citing works
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Alessio, N., Bohn, W., Rauchberger, V., Rizzolio, F., Cipollaro, M., Rosemann, M., Irmler, M., Beckers, J., Giordano, A., & Galderisi, U. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1224-x · Cited by 61 · see citing works
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Sun, Y., Lin, X., Liu, B., Zhang, Y.-X., Li, W., Zhang, S., He, F., Tian, H., Zhu, X., Liu, X.-M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj6877 · Cited by 34 · see citing works
Hilpert, M., Legrand, C., Bluteau, D., Balayn, N., Betems, A., Bluteau, O., Villeval, J., Louache, F., Gonin, P., Debili, N., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.10.005 · Cited by 31 · see citing works
Zhuang, L., Hulin, J.-A., Gromova, A., Nguyen, T. D. T., Yu, R. T., Liddle, C., Downes, M., Evans, R. M., Makarenkova, H. P., & Meech, R. (2014) · Stem Cells · doi:10.1002/stem.1674 · Cited by 30 · see citing works
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Self-citationWang, C., Oshima, M., Sashida, G., Tomioka, T., Hasegawa, N., Mochizuki‐Kashio, M., Nakajima‐Takagi, Y., Kusunoki, Y., Kyoizumi, S., Imai, K., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132041 · Cited by 21 · see citing works
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Wang, Z., Zhang, C., Warden, C., Liu, Z., Yuan, Y., Guo, C., Wang, C., Wang, J., Wu, X., Ermel, R. W., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03340-w · Cited by 18 · see citing works
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Smurf2 regulates hematopoietic stem cell self‐renewal and aging
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Wang, Y., Zang, X., Wang, Y., & Chen, P. (2012) · PubMed Central · Cited by 15 · see citing works
Zhao, X., Huang, Y., Wang, Y., Chen, P., Yu, Y., & Song, Z. (2013) · Europe PMC (PubMed Central) · Cited by 14 · see citing works
Chandra, A., Law, S. F., & Pignolo, R. J. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112059 · Cited by 13 · see citing works
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Self-citationMarrow failure and aging: The role of “Inflammaging”
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Zhou, Y., Yang, B., Yao, X., & Wang, Y. (2010) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-010-9372-5 · Cited by 11 · see citing works
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Liu, L. A., & Rando, T. A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00006-3 · Cited by 5 · see citing works
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Weishaupt, H., & Attema, J. L. (2010) · Biological Procedures Online · doi:10.1007/s12575-010-9031-y · Cited by 6 · see citing works
Self-citationSim, H., Kook, S., Yun, C.-Y., Bhattarai, G., Cho, E., & Lee, J. (2016) · Stem Cells · doi:10.1002/stem.2425 · Cited by 5 · see citing works
Loss of P2Y14 results in an arresting response to hematological stress
Garrison, B. S., & Rossi, D. J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76626 · Cited by 3 · see citing works
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Siu, K. T., & Minella, A. C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2095-2_9 · Cited by 1 · see citing works
Hematopoiesis: Functional Insights by Cell Fate Conversion
Wahlestedt, M. (2014) · Lund University Publications (Lund University)
OPINION Aging of the hematopoietic system
Snoeck, H. (2013)
and low expression of Bmi1 are associated with endothelial cellular senescence in the human cornea
Wang, Y., Zang, X., Wang, Y., & Chen, P. (2012)
Twisting mice move the dystonia field forward
Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J. G. J., Rossi, D. J., Hayflick, L., & Ps, M. (2014)
Self-citationAging of Murine Hematopoietic Stem Cells
Wojtowicz, E. E., Verovskaya, E. V., & de Haan, G. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_6
Dynamics and Aging of Hematopoietic Stem Cells
van Os, R. P., & de Haan, G. (2014) · CRC Press eBooks · doi:10.1201/b16962-3
Basic Hematopoiesis and Leukemia Stem Cells
Hwang, W. Y. K., Bari, S., Ng, L. G., Itahana, K., Li, S., Koh, J. Y. P., & Than, H. (2023) · Springer eBooks · doi:10.1007/978-981-99-3810-0_1
Multiple Functions of Cables1 in Hematopoiesis
He, L. (2018) · theses.fr (ABES) · doi:10.70675/15f425d0zd56fz476bz8344z0f5ca38773ca
- Authors
- Attema, J. L., Pronk, C. J. H., Norddahl, G. L., Nygren, J. M., & Bryder, D.
- Affiliations
- Lund University (SE)
- Corresponding author
- Bryder, D
- Venue
- Oncogene
- Published
- 2009-04-27
- Volume
- 28
- Issue
- 22
- Pages
- 2238-2243
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2001407037
- Cited by
- 72
- References
- 26
- Citations by year
- 2025: 3 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 12 · 2013: 7 · 2012: 6
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Fondation pour la Recherche Médicale
- Crafoordska Stiftelsen
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- hematopoietic stem cells, stem cell aging, replicative senescence, p16INK4a, INK4a/ARF locus, epigenetic repression, tumour suppressor, embryonic fibroblasts
- MeSH terms
- Animals, Cell Line, DNA, Hematopoietic Stem Cells, Histones, Methylation, Promoter Regions, Genetic, Up-Regulation, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Epigenesis, Genetic, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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