Frydman, Judith

Misfolded proteins partition between two distinct quality control compartments

Kaganovich, D., Kopito, R., & Frydman, J. (2008) · Nature

Heat shock proteins researchAutophagy in Disease and Therapy

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Protein misfolding in neurodegenerative diseases: Implications and strategies

Sweeney, P., Park, H., Baumann, M., Dunlop, J., Frydman, J., Kopito, R., McCampbell, A., Leblanc, G., Venkateswaran, A., Nurmi, A., et al. (2017) · Translational Neurodegeneration

Heat shock proteins researchAlzheimer's disease research and treatments

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Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

Leeman, D. S., Hebestreit, K., Ruetz, T., Webb, A. E., McKay, A., Pollina, E. A., Dulken, B. W., Zhao, X., Yeo, R. W., Ho, T. T., et al. (2018) · Science

Neurogenesis and neuroplasticity mechanismsAutophagy in Disease and Therapy

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Diverse Cellular Functions of the Hsp90 Molecular Chaperone Uncovered Using Systems Approaches

McClellan, A. J., Xia, Y., Deutschbauer, A. M., Davis, R. W., Gerstein, M., & Frydman, J. (2007) · Cell

Heat shock proteins researchFungal and yeast genetics research

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Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

Escusa-Toret, S., Vonk, W. I. M., & Frydman, J. (2013) · Nature Cell Biology

Heat shock proteins researchEndoplasmic Reticulum Stress and Disease

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Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease

Chou, C.-C., Vest, R., Prado, M. A., Wilson-Grady, J., Paulo, J. A., Shibuya, Y., Moran-Losada, P., Lee, T.-T., Luo, J., Gygi, S. P., et al. (2025) · Nature Cell Biology

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

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Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network

Vonk, W. I. M., Rainbolt, T. K., Dolan, P. T., Webb, A. E., Brunet, A., & Frydman, J. (2020) · Molecular Cell

Heat shock proteins researchNeurogenesis and neuroplasticity mechanisms

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Fragment-based computational design of antibodies targeting structured epitopes

Aguilar Rangel, M., Bedwell, A., Costanzi, E., Taylor, R. J., Russo, R., Bernardes, G. J. L., Ricagno, S., Frydman, J., Vendruscolo, M., & Sormanni, P. (2022) · Science Advances

Monoclonal and Polyclonal Antibodies Researchvaccines and immunoinformatics approaches

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