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An NRF2 Perspective on Stem Cells and Ageing

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The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress

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Come Together: Protein Assemblies, Aggregates and the Sarcostat at the Heart of Cardiac Myocyte Homeostasis

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Human platelet lysate stimulates neurotrophic properties of human adipose-derived stem cells better than Schwann cell-like cells

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RNA-binding protein dysfunction in neurodegeneration

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Is Aging an Inevitable Characteristic of Organic Life or an Evolutionary Adaptation?

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Aptamer Reduces Aggregation of Mutant Huntingtin and Rescues Proteostasis Network in Non-Neuronal and Neuronal Cells

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Turnover and replication analysis by isotope labeling (TRAIL) reveals the influence of tissue context on protein and organelle lifetimes

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Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruptionPreprint

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UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation

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Temporal Quantitative Proteomic and Phosphoproteomic Profiling of SH-SY5Y and IMR-32 Neuroblastoma Cells during All-Trans-Retinoic Acid-Induced Neuronal Differentiation

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Senataxin deficiency disrupts proteostasis through nucleolar ncRNA-driven protein aggregation

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Proteostatic tuning underpins the evolution of novel multicellular traits

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Analysis of the Expression and Subcellular Distribution of eEF1A1 and eEF1A2 mRNAs during Neurodevelopment

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Oxidized SOD1 accelerates cellular senescence in neural stem cells

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Amyloid β accelerates age-related proteome-wide protein insolubility

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CHIP mutations affect the heat shock response differently in human fibroblasts and iPSC-derived neurons

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Protein homeostasis imprinting across evolution

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Phosphorylation of CRYAB induces a condensatopathy to worsen post–myocardial infarction left ventricular remodeling

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The San1 Ubiquitin Ligase Avidly Recognizes Misfolded Proteins through Multiple Substrate Binding Sites

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Chaperonin‐containing tailless complex polypeptide 1 subunit 6A correlates with increased World Health Organization grade, less isocitrate dehydrogenase mutation, and deteriorative survival of astrocytoma patients

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Ascorbic acid mitigates the impact of oxidative stress in a human model of febrile seizure and mesial temporal lobe epilepsy

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Research advances on antioxidation, neuroprotection, and molecular mechanisms of Lycium barbarum polysaccharides

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HLH-1 Modulates Muscle Proteostasis During Caenorhabditis elegans Larval Development

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Epigenetic regulation of neural stem cell aging in the mouse hippocampus by Setd8 downregulation

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Polyalanine Expansion in PABPN1 Alters the Structure and Dynamics of Its Nuclear Aggregates in Differentiated Muscle Cells

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Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis

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Sustaining Brain Youth by Neural Stem Cells: Physiological and Therapeutic Perspectives

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Distinct patterns of proteostasis network gene expression are associated with different prognoses in melanoma patients

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Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption

Yong, J., Villalta, J. E., Vu, N., Kukurugya, M. A., Olsson, N., López, M. P., Lazzari-Dean, J. R., Hake, K., McAllister, F. E., Bennett, B. D., et al. (2024) · eLife · doi:10.7554/elife.86194.3 · Cited by 3 · see citing works

Treating hippocampal neural stem cells with nano-pulsed laser therapy generates neurons resilient against amyloid-β oligomer toxicity

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Pseudophosphorylation of single residues of the J‐domain of DNAJA2 regulates the holding/folding balance of the Hsc70 system

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Protein Aggregation Triggered by Rewired Protein Homeostasis during Neuronal Differentiation

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Enhanced Response of ZnO Nanorod-Based Flexible MEAs for Recording Ischemia-Induced Neural Activity in Acute Brain Slices

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Human clearance systems have a layered architecture across tissues and cell types that supports varied proteome compositions

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Impairment of lipid homoeostasis causes accumulation of protein aggregates in the lysosomePreprint

Yong, J., Villalta, J. E., Vu, N., Kukurugya, M. A., Bennett, B. D., López, M. P., Lazzari-Dean, J. R., Hake, K., & Jan, C. H. (2023) · eLife · doi:10.7554/elife.86194.1 · Cited by 2 · see citing works

Dysregulated proteostasis

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Genome-wide screens identify core regulators of cell surface prion protein expression

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Proteostasis function and dysfunction in Huntington's disease

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Correlating Protein Aggregate Structure with Cellular Function in Differentiated Muscle Cells: Discriminating Pathogenic from Non-Pathogenic FormsPreprint

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Molecular and clinical determinants of pathogenic protein aggregation

de Mattos, E. P. (2022) · doi:10.33612/diss.220760500

UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation independently of the p97 ATPasePreprint

Ahlstedt, B. A., Ganji, R., Mukkavalli, S., Paulo, J. A., Gygi, S. P., & Raman, M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.16.520763

The ubiquitin-proteasome system in neurodegenerative diseases

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Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by agingPreprint

Molzahn, C. M., Kuechler, E. R., Nierves, L. A., Cole, G., Wang, J., Cashman, N. R., Karsan, A., Lange, P. F., Gsponer, J. A., & Mayor, T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.28.582597

Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruptionPreprint

Yong, J., Villalta, J. E., Vu, N., Kukurugya, M. A., Olsson, N., López, M. P., Lazzari-Dean, J. R., Hake, K., McAllister, F. E., Bennett, B. D., et al. (2024) · eLife · doi:10.7554/elife.86194.2

Structural Features of Pathogenic Aggregates Correlate with Cell Pathology in Differentiated CellsPreprint

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