Knowles, Tuomas P. J.

The amyloid state and its association with protein misfolding diseases.

Knowles, T. P. J., Vendruscolo, M., & Dobson, C. M. (2014) · Nature Reviews Molecular Cell Biology

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 2,382

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

Galvagnion, C., Buell, A. K., Meisl, G., Michaels, T. C. T., Vendruscolo, M., Knowles, T. P. J., & Dobson, C. M. (2015) · Nature Chemical Biology

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 661

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

Liao, Y.-C., Fernandopulle, M. S., Wang, G., Choi, H., Hao, L., Drerup, C. M., Patel, R., Qamar, S., Nixon-Abell, J., Shen, Y., et al. (2019) · Cell

RNA Research and SplicingCellular transport and secretion

Cited by 550

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

De, S., Wirthensohn, D. C., Flagmeier, P., Hughes, C., Aprile, F. A., Ruggeri, F. S., Whiten, D. R., Emin, D., Xia, Z., Varela, J. A., et al. (2019) · Nature Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 448

Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering

Sandberg, A., Luheshi, L. M., Söllvander, S., Pereira de Barros, T., Macao, B., Knowles, T. P. J., Biverstål, H., Lendel, C., Ekholm-Petterson, F., Dubnovitsky, A., et al. (2010) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 358

Surface electrostatics govern the emulsion stability of biomolecular condensates

Welsh, T. J., Krainer, G., Espinosa, J. R., Joseph, J. A., Sridhar, A., Jahnel, M., Arter, W. E., Saar, K. L., Alberti, S., Collepardo-Guevara, R., et al. (2020) · Nano Letters

RNA Research and SplicingElectrostatics and Colloid Interactions

Cited by 168

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

Tóth, G., Gardai, S. J., Zago, W., Bertoncini, C. W., Cremades, N., Roy, S. L., Tambe, M. A., Rochet, J.-C., Galvagnion, C., Skibinski, G., et al. (2014) · PLoS ONE

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 151

Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses

Geiger, F., Acker, J., Papa, G., Wang, X., Arter, W. E., Saar, K. L., Erkamp, N. A., Qi, R., Bravo, J. P., Strauss, S., et al. (2021) · The EMBO Journal

Viral gastroenteritis research and epidemiologyRNA Research and Splicing

Cited by 130

In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease

Meisl, G., Hidari, E., Allinson, K., Rittman, T., DeVos, S. L., Sanchez, J. S., Xu, C. K., Duff, K. E., Johnson, K. A., Rowe, J. B., et al. (2021) · Science Advances

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 127

Diffusing protein binders to intrinsically disordered proteins

Liu, C., Wu, K., Choi, H., Han, H. L., Zhang, X., Watson, J. L., Ahn, G., Zhang, J. Z., Shijo, S., Good, L. L., et al. (2025) · Nature

Protein Structure and DynamicsChemical Synthesis and Analysis

Cited by 79

Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms.

Iljina, M., Garcia, G. A., Dear, A. J., Flint, J., Narayan, P., Michaels, T. C. T., Dobson, C. M., Frenkel, D., Knowles, T. P. J., & Klenerman, D. (2016) · Scientific Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 68

Design of amyloidogenic peptide traps

Sahtoe, D. D., Andrzejewska, E. A., Han, H. L., Rennella, E., Schneider, M. M., Meisl, G., Ahlrichs, M., Decarreau, J., Nguyen, H., Kang, A., et al. (2024) · Nature Chemical Biology

Alzheimer's disease research and treatmentsProtein Structure and Dynamics

Cited by 48

Design of amyloidogenic peptide traps

Sahtoe, D. D., Andrzejewska, E. A., Han, H. L., Rennella, E., Schneider, M. M., Meisl, G., Ahlrichs, M., Decarreau, J., Nguyen, H., Kang, A., et al. (2023) · Nature Chemical Biology

Alzheimer's disease research and treatmentsProtein Structure and Dynamics

Cited by 48

Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity

Dworzak, J., Renvoisé, B., Habchi, J., Yates, E. V., Combadière, C., Knowles, T. P., Dobson, C. M., Blackstone, C., Paulsen, O., & Murphy, P. M. (2015) · PLOS ONE

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 30

The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus**

Zhu, H., Narita, M., Joseph, J. A., Krainer, G., Arter, W. E., Olan, I., Saar, K. L., Ermann, N., Espinosa, J. R., Shen, Y., et al. (2023) · ChemBioChem

Genomics and Chromatin DynamicsProtein Structure and Dynamics

Cited by 23

The role of N-terminal acetylation on biomolecular condensation

G. Oliveira, C., Silva, M. T. S., Kava, E., Agarwal, T., Cereghetti, G., F. Vicente, E., Knowles, T. P. J., Costa-Filho, A. J., & Mendes, L. F. S. (2026) · Communications Chemistry

Protein Structure and DynamicsRNA Research and Splicing

Cited by 2

Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates

Chris Ng, T. L., Hoare, M. P., Maristany, M. J., Wilde, E. J., Sneideris, T., Huertas, J., Agbetiameh, B. K., Furukawa, M., Joseph, J. A., Knowles, T. P. J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory)

RNA Research and SplicingProtein Structure and Dynamics

Cited by 1