Nishimura, Stephen L.

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

Mu, D., Cambier, S., Fjellbirkeland, L., Baron, J. L., Munger, J. S., Kawakatsu, H., Sheppard, D., Broaddus, V. C., & Nishimura, S. L. (2002) · The Journal of Cell Biology

TGF-β signaling in diseasesCell Adhesion Molecules Research

Cited by 729

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

Minagawa, S., Araya, J., Numata, T., Nojiri, S., Hara, H., Yumino, Y., Kawaishi, M., Odaka, M., Morikawa, T., Nishimura, S. L., et al. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTelomeres, Telomerase, and Senescence

Cited by 323

Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients

Araya, J., Cambier, S., Markovics, J. A., Wolters, P., Jablons, D., Hill, A., Finkbeiner, W., Jones, K., Broaddus, V. C., Sheppard, D., et al. (2007) · Journal of Clinical Investigation

Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseases

Cited by 257

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β

Kitamura, H., Cambier, S., Somanath, S., Barker, T., Minagawa, S., Markovics, J., Goodsell, A., Publicover, J., Reichardt, L., Jablons, D., et al. (2011) · Journal of Clinical Investigation

Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseases

Cited by 189

Integrin αvβ8–expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells

Takasaka, N., Seed, R. I., Cormier, A., Bondesson, A. J., Lou, J., Elattma, A., Ito, S., Yanagisawa, H., Hashimoto, M., Ma, R., et al. (2018) · JCI Insight

TGF-β signaling in diseasesCancer Immunotherapy and Biomarkers

Cited by 119

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

Stockis, J., Liénart, S., Colau, D., Collignon, A., Nishimura, S. L., Sheppard, D., Coulie, P. G., & Lucas, S. (2017) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyTGF-β signaling in diseases

Cited by 111

Selective Targeting of TGF-β Activation to Treat Fibroinflammatory Airway Disease

Minagawa, S., Lou, J., Seed, R. I., Cormier, A., Wu, S., Cheng, Y., Murray, L., Tsui, P., Connor, J., Herbst, R., et al. (2014) · Science Translational Medicine

Cell Adhesion Molecules ResearchChronic Obstructive Pulmonary Disease (COPD) Research

Cited by 90

Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

Fenton, T. M., Kelly, A., Shuttleworth, E. E., Smedley, C., Atakilit, A., Powrie, F., Campbell, S., Nishimura, S. L., Sheppard, D., Levison, S., et al. (2017) · Mucosal Immunology

TGF-β signaling in diseasesInflammatory Bowel Disease

Cited by 64

Latent-TGF-β has a domain swapped architecture

Jin, M., Seed, R. I., Shing, T., Wang, L., Li, J., Cheng, Y., & Nishimura, S. L. (2025) · Nature Communications

TGF-β signaling in diseasesProtease and Inhibitor Mechanisms

Cited by 3