Cited by 90Cell Adhesion Molecules ResearchChronic Obstructive Pulmonary Disease (COPD) ResearchTGF-β signaling in diseases

Selective Targeting of TGF-β Activation to Treat Fibroinflammatory Airway Disease

Open access
Minagawa, Shunsuke, Lou, Jianlong, Seed, Robert I., Cormier, Anthony, Wu, Shenping, Cheng, Yifan, Murray, Lynne, Tsui, Ping +24 more·2014·Science Translational Medicine

Abstract

Therapeutic targeting of an extended-closed conformation of the integrin αvβ8 inhibits TGF-β activation and ameliorates symptoms of experimental airway disease in mice.

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Crossref · 10.1126/scitranslmed.3008074

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62 of 62 references verified0 citation errors · 0 not checkable

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  • IL-17A signaling has a confirmed role in fibrosis development in multiple tissues, based on IL-17A- and IL-17RA-deficient mice and neutralizing monoclonal antibodies.

    “Experiments with IL-17A- and IL-17RA-deficient mice, as well as therapeutic studies with IL-17A neutralizing monoclonal antibodies confirmed a role for IL-17A signaling in the development of fibrosis in multiple tissues110–112,116–118”

    From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [116]

  • IL-17A promotes TGF-β production.

    “In addition to promoting TGF-β production116,119”

    From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [116]

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Research works printed but not linked: 1

  1. [52]Finkbeiner WE The Lung: Scientific Foundations Crystal RG Lippincott-Raven Publishers Philadelphia, PA 1997 415 433

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Authors
Minagawa, S., Lou, J., Seed, R. I., Cormier, A., Wu, S., Cheng, Y., Murray, L., Tsui, P., Connor, J., Herbst, R., Govaerts, C., Barker, T., Cambier, S., Yanagisawa, H., Goodsell, A., Hashimoto, M., Brand, O. J., Cheng, R., Ma, R., McKnelly, K. J., Wen, W., Hill, A., Jablons, D., Wolters, P., Kitamura, H., Araya, J., Barczak, A. J., Erle, D. J., Reichardt, L. F., Marks, J. D., Baron, J. L., & Nishimura, S. L.
Affiliations
  • University of California, San Francisco (US)
  • Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Gaithersburg, MD 20878, USA.
  • Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Cambridge CB21 6GH, UK.
  • Jikei University School of Medicine (JP)
Corresponding author
  • Minagawa, Shunsuke
  • Lou, Jianlong
  • Seed, Robert I.
  • Nishimura, Stephen L.
Venue
Science Translational Medicine
Published
2014-06-18
Volume
6
Issue
241
Pages
241ra79-241ra79
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2144222001
Cited by
90
References
62
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 11 · 2019: 9 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 2
FWCI
7.43
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL063993, HL113032, R01HL090662, R01HL113032, HL090662, R01HL063993)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK026743)
  • National Institute of Neurological Disorders and Stroke (P01NS044155, NS044155)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
TGF-beta activation, integrin αvβ8, ITGB8, airway remodeling, chronic obstructive pulmonary disease, engineered antibodies, allosteric inhibition, integrin conformation, airway fibrosis, tobacco smoke, allergens, epitope mapping, transgenic mice
MeSH terms
Animals, Humans, Mice, Transgenic, Tracheitis, Transforming Growth Factor beta, Mice

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