Selective Targeting of TGF-β Activation to Treat Fibroinflammatory Airway Disease
Open accessAbstract
Therapeutic targeting of an extended-closed conformation of the integrin αvβ8 inhibits TGF-β activation and ameliorates symptoms of experimental airway disease in mice.
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IL-17A signaling has a confirmed role in fibrosis development in multiple tissues, based on IL-17A- and IL-17RA-deficient mice and neutralizing monoclonal antibodies.
“Experiments with IL-17A- and IL-17RA-deficient mice, as well as therapeutic studies with IL-17A neutralizing monoclonal antibodies confirmed a role for IL-17A signaling in the development of fibrosis in multiple tissues110–112,116–118”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [116]
IL-17A promotes TGF-β production.
“In addition to promoting TGF-β production116,119”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [116]
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- Authors
- Minagawa, S., Lou, J., Seed, R. I., Cormier, A., Wu, S., Cheng, Y., Murray, L., Tsui, P., Connor, J., Herbst, R., Govaerts, C., Barker, T., Cambier, S., Yanagisawa, H., Goodsell, A., Hashimoto, M., Brand, O. J., Cheng, R., Ma, R., McKnelly, K. J., Wen, W., Hill, A., Jablons, D., Wolters, P., Kitamura, H., Araya, J., Barczak, A. J., Erle, D. J., Reichardt, L. F., Marks, J. D., Baron, J. L., & Nishimura, S. L.
- Affiliations
- University of California, San Francisco (US)
- Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Gaithersburg, MD 20878, USA.
- Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Cambridge CB21 6GH, UK.
- Jikei University School of Medicine (JP)
- Corresponding author
- Minagawa, Shunsuke
- Lou, Jianlong
- Seed, Robert I.
- Nishimura, Stephen L.
- ORCID
- Minagawa, Shunsuke
- Lou, Jianlong
- Seed, Robert I.
- Cormier, Anthony
- Wu, Shenping
- Cheng, Yifan
- Murray, Lynne
- Herbst, Ronald
- Yanagisawa, Haruhiko
- Goodsell, Amanda
- Hashimoto, Mitsuo
- Brand, Oliver J.
- Ma, Royce
- McKnelly, Kate J.
- Hill, Arthur
- Wolters, Paul
- Kitamura, Hideya
- Araya, Jun
- Barczak, Andrea J.
- Erle, David J.
- Reichardt, Louis F.
- Marks, James D.
- Baron, Jody L.
- Nishimura, Stephen L.
- Venue
- Science Translational Medicine
- Published
- 2014-06-18
- Volume
- 6
- Issue
- 241
- Pages
- 241ra79-241ra79
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4341974
- OpenAlex
- W2144222001
- Cited by
- 90
- References
- 62
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 11 · 2019: 9 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 2
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL063993, HL113032, R01HL090662, R01HL113032, HL090662, R01HL063993)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK026743)
- National Institute of Neurological Disorders and Stroke (P01NS044155, NS044155)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- TGF-beta activation, integrin αvβ8, ITGB8, airway remodeling, chronic obstructive pulmonary disease, engineered antibodies, allosteric inhibition, integrin conformation, airway fibrosis, tobacco smoke, allergens, epitope mapping, transgenic mice
- MeSH terms
- Animals, Humans, Mice, Transgenic, Tracheitis, Transforming Growth Factor beta, Mice
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