Kulkarni, Rohit N.

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 1,296

TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

Du, K., Herzig, S., Kulkarni, R. N., & Montminy, M. (2003) · Science

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 842

Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk

Handschin, C., Choi, C. S., Chin, S., Kim, S., Kawamori, D., Kurpad, A. J., Neubauer, N., Hu, J., Mootha, V. K., Kim, Y.-B., et al. (2007) · Journal of Clinical Investigation

Pancreatic function and diabetesAdipose Tissue and Metabolism

Cited by 335

Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo

Kawamori, D., Kurpad, A. J., Hu, J., Liew, C. W., Shih, J. L., Ford, E. L., Herrera, P. L., Polonsky, K. S., McGuinness, O. P., & Kulkarni, R. N. (2009) · Cell Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 316

Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic β Cells

Leibiger, B., Leibiger, I. B., Moede, T., Kemper, S., Kulkarni, R. N., Kahn, C. R., de Vargas, L. M., & Berggren, P.-O. (2001) · Molecular Cell

Pancreatic function and diabetesMetabolism, Diabetes, and Cancer

Cited by 267

Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets

Cheng, K., Ho, K., Stokes, R., Scott, C., Lau, S. M., Hawthorne, W. J., O’Connell, P. J., Loudovaris, T., Kay, T. W., Kulkarni, R. N., et al. (2010) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 230

High glucose inhibits glucose‐6‐phosphate dehydrogenase, leading to increased oxidative stress and β‐cell apoptosis

Zhang, Z., Liew, C. W., Handy, D. E., Zhang, Y., Leopold, J. A., Hu, J., Guo, L., Kulkarni, R. N., Loscalzo, J., & Stanton, R. C. (2010) · The FASEB Journal

Pancreatic function and diabetesRedox biology and oxidative stress

Cited by 226

Skeletal Muscle-Selective Knockout of LKB1 Increases Insulin Sensitivity, Improves Glucose Homeostasis, and Decreases TRB3

Koh, H.-J., Arnolds, D. E., Fujii, N., Tran, T. T., Rogers, M. J., Jessen, N., Li, Y., Liew, C. W., Ho, R. C., Hirshman, M. F., et al. (2006) · Molecular and Cellular Biology

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 202

Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

Otani, K., Kulkarni, R. N., Baldwin, A. C., Krutzfeldt, J., Ueki, K., Stoffel, M., Kahn, C. R., & Polonsky, K. S. (2004) · American Journal of Physiology-Endocrinology and Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 185

Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis

Bates, S. H., Kulkarni, R. N., Seifert, M., & Myers, M. G. (2005) · Cell Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 173

Human β-Cell Proliferation and Intracellular Signaling: Part 3

Stewart, A. F., Hussain, M. A., García-Ocaña, A., Vasavada, R. C., Bhushan, A., Bernal-Mizrachi, E., & Kulkarni, R. N. (2015) · Diabetes

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 142

Sex differences underlying pancreatic islet biology and its dysfunction

Gannon, M., Kulkarni, R. N., Tse, H. M., & Mauvais-Jarvis, F. (2018) · Molecular Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 133

Accurate measurement of pancreatic islet β-cell mass using a second-generation fluorescent exendin-4 analog

Reiner, T., Thurber, G., Gaglia, J., Vinegoni, C., Liew, C. W., Upadhyay, R., Kohler, R. H., Li, L., Kulkarni, R. N., Benoist, C., et al. (2011) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 120

Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells

Morgan, D. G., Kulkarni, R. N., Hurley, J. D., Wang, Z. L., Wang, R. M., Ghatei, M. A., Karlsen, A. E., Bloom, S. R., & Smith, D. M. (1998) · Diabetologia

Pancreatic function and diabetesNeuropeptides and Animal Physiology

Cited by 79

Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

De Jesus, D. F., Zhang, Z., Brown, N. K., Li, X., Xiao, L., Hu, J., Gaffrey, M. J., Fogarty, G., Kahraman, S., Wei, J., et al. (2024) · Nature Cell Biology

Diabetes and associated disordersRNA modifications and cancer

Cited by 56

Redox Regulation of m 6 A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes

De Jesus, D. F., Zhang, Z., Brown, N. K., Li, X., Gaffrey, M. J., Kahraman, S., Wei, J., Hu, J., Basile, G., Xiao, L., et al. (2023) · Nature Cell Biology

Diabetes and associated disordersRNA modifications and cancer

Cited by 56

HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells

Ng, N. H. J., Jasmen, J. B., Lim, C. S., Lau, H. H., Krishnan, V. G., Kadiwala, J., Kulkarni, R. N., Ræder, H., Vallier, L., Hoon, S., et al. (2019) · iScience

Pluripotent Stem Cells ResearchPancreatic function and diabetes

Cited by 54