Cited by 135Pancreatic function and diabetesDiabetes and associated disordersSex and Gender in Healthcare

Sex differences underlying pancreatic islet biology and its dysfunction

Open access
Gannon, Maureen, Kulkarni, Rohit N., Tse, Hubert M., Mauvais-Jarvis, Franck·2018·Molecular Metabolism

Abstract

BACKGROUND: The sex of an individual affects glucose homeostasis and the pathophysiology, incidence, and prevalence of diabetes as well as the response to therapy. SCOPE OF THE REVIEW: This review focuses on clinical and experimental sex differences in islet cell biology and dysfunction during development and in adulthood in human and animal models. We discuss sex differences in β-cell and α-cell function, heterogeneity, and dysfunction. We cover sex differences in communication between gonads and islets and islet-cell immune interactions. Finally, we discuss sex differences in β-cell programming by nutrition and other environmental factors during pregnancy. MAJOR CONCLUSIONS: Important sex differences exist in islet cell function and susceptibility to failure. These differences represent sex-related biological factors that can be harnessed for gender-based prevention of and therapy for diabetes.

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Crossref · 10.1016/j.molmet.2018.05.017

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  • Increased methylation of the DUSP9 gene could act as a risk factor for insulin resistance and T2DM.

    “and thus increased methylation of the DUSP9 gene could act as a risk factor for insulin resistance and T2DM [83].”

    From Sex Differences in Response to Treatment with Glucagon-like Peptide 1 Receptor Agonists: Opportunities for a Tailored Approach to Diabetes and Obesity Care (2022) · cites this paper as [83]

    The Islet and β-cell heterogeneity section (page not provided) reports increased DUSP9 methylation in male islets and describes DUSP9 as associated with insulin resistance and type 2 diabetes. It does not establish that increased methylation itself is a risk factor for either condition. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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1 of the 120 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [44]Klein S.L. Roberts C.W. Sex hormones and immunity to infection 2010 Springer Verlag Berlin

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Authors
Gannon, M., Kulkarni, R. N., Tse, H. M., & Mauvais-Jarvis, F.
Affiliations
  • VA Tennessee Valley Healthcare System (US)
  • Joslin Diabetes Center (US)
  • University of Alabama at Birmingham (US)
Venue
Molecular Metabolism
Publisher
Elsevier BV
Published
2018-09
Volume
15
Pages
82-91
ISSN
2212-8778 (ISSN-L)
OpenAlex
W2806507802
Cited by
133
References
120
Citations by year
2026: 13 · 2025: 18 · 2024: 14 · 2023: 17 · 2022: 23 · 2021: 27 · 2020: 10 · 2019: 7 · 2018: 3
FWCI
2.61
Type
journal article
Language
en
Open access
Locations
  • Molecular Metabolism (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Juvenile Diabetes Research Foundation United States of America (BX003725, 2 -SRA-2016-270-S-B, R01 DK107444, R01 DK074970, 2-PNF-2016-322-S-B)
  • National Institutes of Health (R01 DK105689, 2R24 DK090964-06)
  • U.S. Department of Veterans Affairs (BX003744, R01 DK099550, R01 DK103215, R01 DK67536)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Keywords
sex differences, pancreatic islets, beta-cell dysfunction, alpha-cell dysfunction, islet heterogeneity, pregnancy, nutrition, diabetes susceptibility, glucose homeostasis
MeSH terms
Animals, Diabetes Mellitus, Humans, Islets of Langerhans, Sex Characteristics, Gonadal Hormones

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