Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo

Generalized lacZ expression with the ROSA26 Cre reporter strain

Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237 · see citing works

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Kulkarni, R., Brüning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., & Kahn, C. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80546-2 · Cited by 1,139 · see citing works

The Glucagon-Like Peptides

Kieffer, T. J., & Habener, J. F. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.6.0385 · Cited by 1,056 · see citing works

Autonomic regulation of islet hormone secretion – Implications for health and disease

Bo, A.-R. (2000) · Diabetologia · doi:10.1007/s001250051322 · Cited by 843 · see citing works

Studies of pancreatic alpha cell function in normal and diabetic subjects

Unger, R. H., Aguilar-Parada, E., Müller, W. A., & Eisentraut, A. M. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106297 · Cited by 837 · see citing works

Hypoglycemia in the Diabetes Control and Complications Trial

The Diabetes Control and Complications Trial Research Group (1997) · Diabetes · doi:10.2337/diab.46.2.271 · Cited by 746 · see citing works

Lack of Glucagon Response to Hypoglycemia in Diabetes: Evidence for an Intrinsic Pancreatic Alpha Cell Defect

Gerich, J. E., Langlois, M., Noacco, C., Karam, J. H., & Forsham, P. H. (1973) · Science · doi:10.1126/science.182.4108.171 · Cited by 688 · see citing works

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

Herrera, P. L. (2000) · Development · doi:10.1242/dev.127.11.2317 · Cited by 674 · see citing works

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

Yoon, K., Ko, S., Cho, J., Lee, J. M., Ahn, Y., Song, K. H., Yoo, S. J., Kang, M. I., Cha, B. Y., Lee, K. W., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020735 · Cited by 645 · see citing works

Opposing actions of Arx and Pax4 in endocrine pancreas developmentPreprint

Collombat, P., Mansouri, A., Hecksher‐Sørensen, J., Serup, P., Krull, J., Gradwohl, G., & Gruß, P. (2003) · Genes & Development · doi:10.1101/gad.269003 · Cited by 598 · see citing works

Diabetes Control and Complications Trial

Yue, D. K., Colagiuri, S., McElduff, A., & Silink, M. (1993) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1993.tb141357.x · Cited by 575 · see citing works

α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains

Gromada, J., Franklin, I., & Wollheim, C. B. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0007 · Cited by 574 · see citing works

Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice

Gelling, R. W., Du, X. Q., Dichmann, D. S., Rømer, J., Huang, H., Cui, L., Obici, S., Tang, B., Holst, J. J., Fledelius, C., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0237106100 · Cited by 563 · see citing works

Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans.

Heller, S. R., & Cryer, P. E. (1991) · Diabetes · doi:10.2337/diab.40.2.223 · Cited by 531 · see citing works

Novel concepts in insulin regulation of hepatic gluconeogenesis

Barthel, A., & Schmoll, D. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00253.2003 · Cited by 514 · see citing works

New Perspectives on the Microvasculature of the Islets of Langerhans in the Rat

Bonner‐Weir, S., & Orci, L. (1982) · Diabetes · doi:10.2337/diab.31.10.883 · Cited by 482 · see citing works

Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels

Rorsman, P., Berggren, P., Bokvist, K. B., Ericson, H., Möhler, H., Östenson, C., & Smith, P. A. (1989) · Nature · doi:10.1038/341233a0 · Cited by 460 · see citing works

Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release.

Amiel, S. A., Sherwin, R. S., Simonson, D. C., & Tamborlane, W. V. (1988) · Diabetes · doi:10.2337/diab.37.7.901 · Cited by 393 · see citing works

Islet β-cell secretion determines glucagon release from neighbouring α-cells

Ishihara, H., Maechler, P., Gjinovci, A., Herrera, P. L., & Wollheim, C. B. (2003) · Nature Cell Biology · doi:10.1038/ncb951 · Cited by 380 · see citing works

β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass

Kulkarni, R. N., Holzenberger, M., Shih, D. Q., Özcan, U., Stoffel, M., Magnuson, M. A., & Kahn, C. R. (2002) · Nature Genetics · doi:10.1038/ng872 · Cited by 363 · see citing works

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.

Pontoglio, M., Sreenan, S., Roe, M., Pugh, W., Ostrega, D., Doyen, A., Pick, A. J., Baldwin, A., Velho, G., Froguel, P., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2548 · Cited by 321 · cited 2× · see citing works

Hypoglycemia: The Limiting Factor in the Management of IDDM

Cryer, P. E. (1994) · Diabetes · doi:10.2337/diab.43.11.1378 · Cited by 307 · see citing works

Insulin within islets is a physiologic glucagon release inhibitor

Maruyama, H., Hisatomi, A., Orci, L., Grodsky, G. M., & Unger, R. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111658 · Cited by 303 · see citing works

β-Cell Secretory Products Activate α-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release

Franklin, I., Gromada, J., Gjinovci, A., Theander, S., & Wollheim, C. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1808 · Cited by 291 · see citing works

Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system

Xu, E., Kumar, M., Zhang, Y., Ju, W., Obata, T., Zhang, N., Liu, S., Wendt, A., Deng, S., Ebina, Y., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2005.11.015 · Cited by 283 · see citing works

Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines

Kulkarni, R., Winnay, J. N., Daniels, M. S., Brüning, J. C., Flier, S. N., Hanahan, D., & Kahn, C. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8339 · Cited by 266 · see citing works

Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic α-Cells

Ravier, M. A., & Rutter, G. A. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1789 · Cited by 264 · see citing works

The Forkhead Transcription Factor Foxo1 Bridges the JNK Pathway and the Transcription Factor PDX-1 through Its Intracellular Translocation

Kawamori, D., Kaneto, H., Nakatani, Y., Matsuoka, T., Matsuhisa, M., Hori, M., & Yamasaki, Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508510200 · Cited by 254 · see citing works

Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes.

Orci, L., Baetens, D., Rufener, C., AMHERDT, M., Ravazzola, M., Studer, P., MALAISSE-LAGAE, F., & Unger, R. H. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1338 · Cited by 254 · see citing works

Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors

Marty, N. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26309 · Cited by 246 · see citing works

Disruption of leptin receptor expression in the pancreas directly affects β cell growth and function in mice

Morioka, T., Asilmaz, E., Hu, J., Dishinger, J. F., Kurpad, A. J., Elias, C. F., Li, H., Elmquist, J. K., Kennedy, R. T., & Kulkarni, R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30910 · Cited by 244 · see citing works

Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells

Vieira, E., Salehi, A., & Gylfe, E. (2007) · Diabetologia · doi:10.1007/s00125-006-0511-1 · Cited by 218 · see citing works

Role of glucagon in the pathogenesis of diabetes: The status of the controversy

Unger, R. H. (1978) · Metabolism · doi:10.1016/0026-0495(78)90291-3 · Cited by 216 · see citing works

Gluconeogenesis in the perfused liver

Exton, J. H., Jefferson, L. S., Butcher, R. W., & Park, C. R. (1966) · The American Journal of Medicine · doi:10.1016/0002-9343(66)90151-3 · Cited by 200 · see citing works

Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations

Salehi, A., Vieira, E., & Gylfe, E. (2006) · Diabetes · doi:10.2337/db06-0080 · Cited by 159 · see citing works

Hypothalamic ATP-sensitive K + Channels Play a Key Role in Sensing Hypoglycemia and Triggering Counterregulatory Epinephrine and Glucagon Responses

Evans, M. L., McCrimmon, R. J., Flanagan, D., Keshavarz, T., Fan, X., McNay, E. C., Jacob, R. J., & Sherwin, R. S. (2004) · Diabetes · doi:10.2337/diabetes.53.10.2542 · Cited by 154 · see citing works

Postprandial Suppression of Glucagon Secretion Depends on Intact Pulsatile Insulin Secretion

Meier, J. J., Kjems, L. L., Veldhuis, J. D., Lefèbvre, P., & Butler, P. C. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1449 · Cited by 144 · see citing works

Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gsα deficiency

Chen, M., Gavrilova, O., Zhao, W., Nguyen, A., Lorenzo, J., Shen, L., Nackers, L. M., Pack, S., Jou, W., & Weinstein, L. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24196 · Cited by 141 · see citing works

Glucagon Secretion from the Perfused Pancreas of Streptozotocin-treated Rats

Weir, G. C., Knowlton, S. D., Atkins, R. F., McKennan, K. X., & Martin, D. B. (1976) · Diabetes · doi:10.2337/diab.25.4.275 · Cited by 122 · see citing works

Zinc, Not Insulin, Regulates the Rat α-Cell Response to Hypoglycemia In Vivo

Zhou, H., Zhang, T., Harmon, J. S., Bryan, J., & Robertson, R. P. (2007) · Diabetes · doi:10.2337/db06-1454 · Cited by 122 · see citing works

Basic Principles of Quantitative PCR

Raeymaekers, L. (2000) · Molecular Biotechnology · doi:10.1385/mb:15:2:115 · Cited by 122 · see citing works

In vivo inhibition of glucagon secretion by paracrine beta cell activity in man.

Asplin, C. M., Paquette, T. L., & Palmer, J. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110251 · Cited by 119 · see citing works

Ablation of the Glucagon Receptor Gene Increases Fetal Lethality and Produces Alterations in Islet Development and Maturation

Vuguin, P. M., Kedees, M. H., Cui, L., Guz, Y., Gelling, R. W., Nejathaim, M., Charron, M. J., & Teitelman, G. (2006) · Endocrinology · doi:10.1210/en.2005-1410 · Cited by 116 · see citing works

Hypoglycemia Unawareness in IDDM

Cryer, P. E. (1993) · Diabetes Care · doi:10.2337/diacare.16.3.40 · Cited by 113 · see citing works

Regulation of α-Cell Function by the β-Cell in Isolated Human and Rat Islets Deprived of Glucose: the “Switch-off” Hypothesis

Hope, K. M., Tran, P. O. T., Zhou, H., Oseid, E. A., Leroy, E., & Robertson, R. P. (2004) · Diabetes · doi:10.2337/diabetes.53.6.1488 · Cited by 110 · see citing works

Activation of ATP-Sensitive K+ Channels in the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses to Hypoglycemia in Normal and Recurrently Hypoglycemic Rats

McCrimmon, R. J., Evans, M. L., Fan, X., McNay, E. C., Chan, O. T. M., Ding, Y., Zhu, W., Gram, D. X., & Sherwin, R. S. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3169 · Cited by 106 · see citing works

Intra-islet insulin permits glucose to directly suppress pancreatic A cell function.

Greenbaum, C. J., Havel, P. J., Taborsky, G. J., & Klaff, L. J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115375 · Cited by 106 · see citing works

Hypoglycemia Unawareness in IDDM

Mokáň, M., Mitrakou, A., Veneman, T. F., Ryan, C. M., Korytkowski, M., Cryer, P., & Gerich, J. E. (1994) · Diabetes Care · doi:10.2337/diacare.17.12.1397 · Cited by 106 · see citing works

Inhibition of Pancreatic Glucagon Responses to Arginine by Somatostatin in Normal Man and in Insulin-Dependent Diabetics

Gerich, J. E., Lorenzi, M., Schneider, V. B., Kwan, C. W., Karam, J. H., Guillemin, R., & Forsham, P. H. (1974) · Diabetes · doi:10.2337/diab.23.11.876 · Cited by 104 · see citing works

Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line.

Philippé, J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114214 · Cited by 101 · see citing works

Regulation of α-Cell Function by the β-Cell During Hypoglycemia in Wistar Rats: the “Switch-off” Hypothesis

Zhou, H., Tran, P. O. T., Yang, S., Zhang, T., LeRoy, E., Oseid, E. A., & Robertson, R. P. (2004) · Diabetes · doi:10.2337/diabetes.53.6.1482 · Cited by 99 · see citing works

Assessment of residual insulin secretion in diabetic patients using the intravenous glucagon stimulatory test: methodological aspects and clinical applications.

Scheen, A. J., Castillo, M. J., & Lefèbvre, P. J. (1996) · PubMed · Cited by 87 · see citing works

Glucose-regulated Glucagon Secretion Requires Insulin Receptor Expression in Pancreatic α-Cells

Diao, J., Shyr, Z. A., Chan, C. B., & Wheeler, M. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506276200 · Cited by 86 · see citing works

The role of the autonomic nervous system in the control of glucagon, insulin and pancreatic polypeptide release from the pancreas.

Bloom, S. R., Edwards, A. V., & Hardy, R. N. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012369 · Cited by 86 · see citing works

Intra-islet regulation.

Samols, E., & Stagner, J. (1988) · American Journal of Medicine · doi:10.1016/0002-9343(88)90395-6 · Cited by 84 · see citing works

Insulin Regulates Islet α-Cell Function by Reducing KATP Channel Sensitivity to Adenosine 5′-Triphosphate Inhibition

Leung, Y., Ahmed, I., Sheu, L., Gao, X., Hara, M., Tsushima, R. G., Diamant, N. E., & Gaisano, H. Y. (2006) · Endocrinology · doi:10.1210/en.2005-1249 · Cited by 83 · see citing works

Glucagon Is Required for Early Insulin-Positive Differentiation in the Developing Mouse Pancreas

Prasadan, K. L., Daume, E., Preuett, B. L., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3229 · Cited by 80 · see citing works

Functional Genomics of the Endocrine Pancreas

Scearce, L. M., Brestelli, J. E., McWeeney, S. K., Lee, C. S., Mazzarelli, J. M., Pinney, D. F., Pizarro, A., Stoeckert, C. J., Clifton, S. W., Permutt, M. A., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.7.1997 · Cited by 78 · see citing works

NORMALIZATION OF FASTING HYPERGLUCAGONEMIA AND EXCESSIVE GLUCAGON RESPONSES TO INTRAVENOUS ARGININE IN HUMAN DIABETES MELLITUS BY PROLONGED INFUSION OF INSULIN

Gerich, J. E., Tsalikian, E., Lorenzi, M., Schneider, V. B., Bohannon, N. V., Gustafson, G. M., & Karam, J. H. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-41-6-1178 · Cited by 74 · see citing works

Impaired hormonal responses to hypoglycemia in spontaneously diabetic and recurrently hypoglycemic rats. Reversibility and stimulus specificity of the deficits.

Powell, A. M., Sherwin, R. S., & Shulman, G. I. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116883 · Cited by 73 · see citing works

Retrograde perfusion as a model for testing the relative effects of glucose versus insulin on the A cell.

Stagner, J. I., & Samols, E. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112356 · Cited by 54 · see citing works

Counterregulatory deficits occur within 24 h of a single hypoglycemic episode in conscious, unrestrained, chronically cannulated mice

Jacobson, L., Ansari, T., & McGuinness, O. P. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00383.2005 · Cited by 51 · see citing works

Proglucagon Gene Expression and Posttranslational Processing in a Hamster Islet Cell Line*

Drucker, D. J., Philippé, J., & Mojsov, S. (1988) · Endocrinology · doi:10.1210/endo-123-4-1861 · Cited by 49 · see citing works

The Role of Glucagon in the Endogenous Hyperglycemia of Diabetes Mellitus

Unger, R. H. (1977) · Annual Review of Medicine · doi:10.1146/annurev.me.28.020177.001003 · Cited by 46 · see citing works

Loss of insulin-induced inhibition of glucagon gene transcription in hamster pancreatic islet alpha cells by long-term insulin exposure

González, M., Böer, U., Dickel, C., Quentin, T., Cierny, I., Oetjen, E., & Knepel, W. (2008) · Diabetologia · doi:10.1007/s00125-008-1134-5 · Cited by 14 · see citing works

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works

Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease

Sandoval, D. A., & D'Alessio, D. A. (2015) · Physiological Reviews · doi:10.1152/physrev.00013.2014 · Cited by 498 · see citing works

A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives

Reed, J., Bain, S., & Kanamarlapudi, V. (2021) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s319895 · Cited by 441 · see citing works

Resolving the paradox of hepatic insulin resistance

Santoleri, D., & Titchenell, P. M. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.10.016 · Cited by 336 · see citing works

Islet α cells and glucagon--critical regulators of energy homeostasis

Campbell, J. E., & Drucker, D. J. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.51 · Cited by 266 · see citing works

Minireview: Glucagon in the Pathogenesis of Hypoglycemia and Hyperglycemia in Diabetes

Cryer, P. E. (2012) · Endocrinology · doi:10.1210/en.2011-1499 · Cited by 242 · see citing works

Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes

Zhang, Q., Ramracheya, R., Lahmann, C., Tarasov, A., Bengtsson, M., Braha, O., Braun, M., Brereton, M., Collins, S., Galvanovskis, J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.014 · Cited by 225 · see citing works

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

Titchenell, P. M., Chu, Q., Monks, B. R., & Birnbaum, M. J. (2015) · Nature Communications · doi:10.1038/ncomms8078 · Cited by 169 · see citing works

δ‐cells and β‐cells are electrically coupled and regulate α‐cell activity via somatostatin

Briant, L. J. B., Reinbothe, T. M., Spiliotis, I., Miranda, C., Rodriguez, B., & Rorsman, P. (2018) · The Journal of Physiology · doi:10.1113/jp274581 · Cited by 155 · see citing works

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Vergari, E., Knudsen, J. G., Ramracheya, R., Salehi, A., Zhang, Q., Adam, J., Asterholm, I. W., Benrick, A., Briant, L. J. B., Chibalina, M. V., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08193-8 · Cited by 152 · see citing works

The α-cell in diabetes mellitus

Gromada, J., Chabosseau, P., & Rutter, G. A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0097-y · Cited by 143 · see citing works

β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

Robson-Doucette, C. A., Sultan, S., Allister, E. M., Wikstrom, J. D., Koshkin, V., Bhattacharjee, A., Prentice, K. J., Sereda, S. B., Shirihai, O. S., & Wheeler, M. B. (2011) · Diabetes · doi:10.2337/db11-0132 · Cited by 136 · see citing works

GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca ²⁺ channels

Ramracheya, R., Chapman, C., Chibalina, M., Dou, H., Miranda, C., González, A., Moritoh, Y., Shigeto, M., Zhang, Q., Braun, M., et al. (2018) · Physiological Reports · doi:10.14814/phy2.13852 · Cited by 128 · see citing works

Intranasal Insulin Suppresses Endogenous Glucose Production in Humans Compared With Placebo in the Presence of Similar Venous Insulin Concentrations

Dash, S., Xiao, C., Morgantini, C., Koulajian, K., & Lewis, G. F. (2015) · Diabetes · doi:10.2337/db14-0685 · Cited by 108 · see citing works

Obesity dysregulates fasting-induced changes in glucagon secretion

Stern, J. H., Smith, G. I., Chen, S., Unger, R. H., Klein, S., & Scherer, P. E. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0201 · Cited by 84 · see citing works

The physiology and pathophysiology of the neural control of the counterregulatory response

Beall, C., Ashford, M. L., & McCrimmon, R. J. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00531.2011 · Cited by 63 · see citing works

Pancreatic α-Cell Dysfunction in Type 2 Diabetes: Old Kids on the Block

Moon, J. S., & Won, K. C. (2015) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2015.39.1.1 · Cited by 61 · see citing works

Functional identification of islet cell types by electrophysiological fingerprinting

Briant, L. J. B., Zhang, Q., Vergari, E., Kellard, J. A., Rodriguez, B., Ashcroft, F. M., & Rorsman, P. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2016.0999 · Cited by 59 · see citing works

Hypothalamic Brain‐Derived Neurotrophic Factor Regulates Glucagon Secretion Mediated by Pancreatic Efferent Nerves

Gotoh, K., Masaki, T., Chiba, S., Ando, H., Fujiwara, K., Shimasaki, T., Mitsutomi, K., Katsuragi, I., Kakuma, T., Sakata, T., et al. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12003 · Cited by 22 · see citing works

Glucagon: Structure-Function Relationships Investigated by Sequence Deletions

Frandsen, E., Grønvald, F. C., Hedïng, L. G., et al. (1981) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1981.362.1.665 · Cited by 41 · see citing works

Biological Activities of Deshistidine-glucagon

Ikeda, Y., OBAYASHI, N., Saito, H., et al. (1971) · Folia Endocrinologica Japonica · doi:10.1507/endocrine1927.47.9_605

Direct Evidence of a Glucagon-Dependent Regulation of the Concentration of Glucagon Receptors in the Liver

Santos, Á., & Blázquez, E. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb05838.x · Cited by 29 · see citing works

Relationship between plasma glucagon disappearance and tissue uptake in rats

Balage, M., Grizard, J., HOULIER, M.-L., et al. (1986) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19860103 · Cited by 5 · see citing works

Changes of glucagon structure and function by ~(21)Ala site-directed mutagenesis

Jingyu, M., Shijie, Y., Zhang, P., et al. (2001) · Zhongguo shengwu huaxue yu fenzi shengwu xuebao