Human β-Cell Proliferation and Intracellular Signaling: Part 3
Open accessAbstract
This is the third in a series of Perspectives on intracellular signaling pathways coupled to proliferation in pancreatic β-cells. We contrast the large knowledge base in rodent β-cells with the more limited human database. With the increasing incidence of type 1 diabetes and the recognition that type 2 diabetes is also due in part to a deficiency of functioning β-cells, there is great urgency to identify therapeutic approaches to expand human β-cell numbers. Therapeutic approaches might include stem cell differentiation, transdifferentiation, or expansion of cadaver islets or residual endogenous β-cells. In these Perspectives, we focus on β-cell proliferation. Past Perspectives reviewed fundamental cell cycle regulation and its upstream regulation by insulin/IGF signaling via phosphatidylinositol-3 kinase/mammalian target of rapamycin signaling, glucose, glycogen synthase kinase-3 and liver kinase B1, protein kinase Cζ, calcium-calcineurin–nuclear factor of activated T cells, epidermal growth factor/platelet-derived growth factor family members, Wnt/β-catenin, leptin, and estrogen and progesterone. Here, we emphasize Janus kinase/signal transducers and activators of transcription, Ras/Raf/extracellular signal–related kinase, cadherins and integrins, G-protein–coupled receptors, and transforming growth factor β signaling. We hope these three Perspectives will serve to introduce these pathways to new researchers and will encourage additional investigators to focus on understanding how to harness key intracellular signaling pathways for therapeutic human β-cell regeneration for diabetes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activation of both the JAK-STAT and antiviral pathways was previously reported in beta cells in response to IFN-γ.
“The activation of both of these pathways was previously reported in beta cells in response to IFN-γ42,43.”
From Quantifying the effect of experimental perturbations at single-cell resolution (2021) · cites this paper as [43]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,370 · see citing works
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,037 · see citing works
Massagué, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3434 · Cited by 3,130 · see citing works
Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,712 · see citing works
RAS oncogenes: the first 30 years
Malumbres, M., & Barbacid, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1097 · Cited by 1,902 · see citing works
Jiao, Y., Shi, C., Edil, B. H., de Wilde, R. F., Klimstra, D. S., Maitra, A., Schulick, R. D., Tang, L. H., Wolfgang, C. L., Choti, M. A., et al. (2011) · Science · doi:10.1126/science.1200609 · Cited by 1,717 · see citing works
The JAK-STAT Pathway at Twenty
Stark, G. R., & Darnell, J. E., Jr. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.013 · Cited by 1,523 · see citing works
Pharmacology, physiology, and mechanisms of incretin hormone action.
Campbell, J. E., & Drucker, D. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.008 · Cited by 1,500 · see citing works
Ras oncogenes: split personalities
Karnoub, A. E., & Weinberg, R. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2438 · Cited by 1,467 · see citing works
JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease
O’Shea, J. J., & Plenge, R. M. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.014 · Cited by 1,152 · see citing works
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
Luttrell, L. M., & Lefkowitz, R. J. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.3.455 · Cited by 1,123 · see citing works
The regulation of TGFβ signal transduction
Moustakas, A., & Heldin, C. (2009) · Development · doi:10.1242/dev.030338 · Cited by 830 · see citing works
Serotonin regulates pancreatic beta cell mass during pregnancy
Kim, H., Toyofuku, Y., Lynn, F. C., Chak, E., Uchida, T., Mizukami, H., Fujitani, Y., Kawamori, R., Miyatsuka, T., Kosaka, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2173 · Cited by 586 · see citing works
PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis
Seino, S., & Shibasaki, T. (2005) · Physiological Reviews · doi:10.1152/physrev.00001.2005 · Cited by 558 · see citing works
cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2Preprint
Jhala, U. S., Canettieri, G., Screaton, R. A., Kulkarni, R., Krajewski, S., Reed, J. C., Walker, J. R., Lin, X., White, M. F., & Montminy, M. (2003) · Genes & Development · doi:10.1101/gad.1097103 · Cited by 544 · see citing works
Self-citationBiology and significance of the JAK/STAT signalling pathways
Kiu, H., & Nicholson, S. E. (2012) · Growth Factors · doi:10.3109/08977194.2012.660936 · Cited by 470 · see citing works
Regulation of gene-activation pathways by PIAS proteins in the immune system
Shuai, K., & Liu, B. (2005) · Nature reviews. Immunology · doi:10.1038/nri1667 · Cited by 447 · see citing works
Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy
Butler, A. E., Cao-Minh, L., Galasso, R., Rizza, R. A., Corradin, A., Cobelli, C., & Butler, P. C. (2010) · Diabetologia · doi:10.1007/s00125-010-1809-6 · Cited by 435 · see citing works
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
Shibasaki, T., Takahashi, H., Miki, T., Sunaga, Y., Matsumura, K., Yamanaka, M., Zhang, C., Tamamoto, A., Satoh, T., Miyazaki, J.-I., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707054104 · Cited by 425 · see citing works
Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor
Brooks, A. J., Dai, W. H., O’Mara, M. L., Abankwa, D., Chhabra, Y., Pelekanos, R., Gardon, O., Tunny, K. A., Blucher, K. M., Morton, C. J., et al. (2014) · Science · doi:10.1126/science.1249783 · Cited by 421 · see citing works
Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
Åhrén, B. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2782 · Cited by 417 · see citing works
Jourdan, T., Godlewski, G., Cinar, R., Bertola, A., Szanda, G., Liu, J., Tam, J., Han, T., Mukhopadhyay, B., Skarulis, M. C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3265 · Cited by 388 · see citing works
Expansion of β-cell mass in response to pregnancy
Rieck, S., & Kaestner, K. H. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.11.001 · Cited by 358 · see citing works
Karnik, S. K., Chen, H., McLean, G. W., Heit, J. J., Gu, X., Zhang, A. Y., Fontaine, M., Yen, M. H., & Kim, S. K. (2007) · Science · doi:10.1126/science.1146812 · Cited by 353 · see citing works
Multiple endocrine neoplasia type 1.
Pannett, A. A. J., & Thakker, R. V. (1999) · Endocrine Related Cancer · doi:10.1677/erc.0.0060449 · Cited by 350 · see citing works
Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes
Tang, C., Ahmed, K., Gille, A., Lu, S. Y., Gröne, H., Tunaru, S., & Offermanns, S. (2015) · Nature Medicine · doi:10.1038/nm.3779 · Cited by 332 · see citing works
New regulatory mechanisms of TGF-β receptor function
Kang, J. S., Liu, C., & Derynck, R. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.05.008 · Cited by 329 · see citing works
M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7
Xiao, X., Gaffar, I. M., Guo, P., Wiersch, J. C., Fischbach, S., Peirish, L., Song, Z., El‐Gohary, Y., Prasadan, K. L., Shiota, C., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321347111 · Cited by 311 · see citing works
PDGF signalling controls age-dependent proliferation in pancreatic β-cells
Chen, H., Gu, X., Liu, Y., Wang, J., Wirt, S. E., Bottino, R., Schorle, H., Sage, J., & Kim, S. K. (2011) · Nature · doi:10.1038/nature10502 · Cited by 278 · see citing works
Huang, C., Snider, F., & Cross, J. C. (2009) · Endocrinology · doi:10.1210/en.2008-1003 · Cited by 275 · see citing works
Freemark, M. (2002) · Endocrinology · doi:10.1210/en.143.4.1378 · Cited by 258 · see citing works
Human β-Cell Proliferation and Intracellular Signaling
Kulkarni, R., Mizrachi, E.-B., Garcı́a-Ocaña, A., & Stewart, A. F. (2012) · Diabetes · doi:10.2337/db12-0018 · Cited by 237 · see citing works
Self-citationProliferation of sorted human and rat beta cells
Parnaud, G., Bosco, D., Berney, T., Pattou, F., Kerr-Conte, J., Donath, M. Y., Bruun, C., Mandrup-Poulsen, T., Billestrup, N., & Halban, P. A. (2007) · Diabetologia · doi:10.1007/s00125-007-0855-1 · Cited by 232 · see citing works
Vasavada, R. C., Garcia-Ocaña, A., Zawalich, W. S., Sorenson, R. L., Dann, P., Syed, M., Ogren, L., Talamantes, F., & Stewart, A. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15399 · Cited by 212 · see citing works
Self-citationRegulation of STAT signaling by acetylation
Zhuang, S. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.05.007 · Cited by 199 · see citing works
An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans
Amisten, S., Salehi, A. A., Rorsman, P., Jones, P. M., & Persaud, S. J. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.05.004 · Cited by 196 · see citing works
Human SH2B1 mutations are associated with maladaptive behaviors and obesity
Doche, M. E., Bochukova, E. G., Su, H.-W., Pearce, L. R., Keogh, J. M., Henning, E., Cline, J. M., Dale, A., Cheetham, T. D., Barroso, I., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62696 · Cited by 194 · see citing works
Anchoring of protein kinase A facilitates hormone-mediated insulin secretion
Lester, L. B., Langeberg, L. K., & Scott, J. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14942 · Cited by 193 · see citing works
Suppression of cytokine signaling: The SOCS perspective
Linossi, E. M., Babon, J. J., Hilton, D. J., & Nicholson, S. E. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.03.005 · Cited by 192 · see citing works
Presence of functional cannabinoid receptors in human endocrine pancreas
Bermúdez‐Silva, F. J., Suárez, J., Baixerás, E., Čobo, N., Bautista, D., Cuesta-Muñoz, A. L., Fuentes, E., Juan-Picó, P., Castro, M. J., Milman, G., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0890-y · Cited by 191 · see citing works
Lin, H., Lee, J.-H., Yadav, H., Kamaraju, A. K., Liu, E. V., Zhigang, D., Vieira, A., Kim, S., Collins, H. W., Matschinsky, F. M., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805379200 · Cited by 189 · see citing works
Quoyer, J., Longuet, C., Broca, C., Linck, N., Costes, S., Varin, E. M., Bockaert, J., Bertrand, G., & Dalle, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.067207 · Cited by 187 · see citing works
Aberrant Hypermethylation of Tumor Suppressor Genes in Pancreatic Endocrine Neoplasms
House, M. G., Herman, J. G., Guo, M. Z., Hooker, C. M., Schulick, R. D., Lillemoe, K. D., Cameron, J. L., Hruban, R. H., Maitra, A., & Yeo, C. J. (2003) · Annals of Surgery · doi:10.1097/01.sla.0000086659.49569.9e · Cited by 178 · see citing works
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic β-cell mass
Buteau, J., Spatz, M. L., & Accili, D. (2006) · Diabetes · doi:10.2337/db05-0825 · Cited by 178 · see citing works
Renner, S., Fehlings, C., Herbach, N., Hofmann, A., von Waldthausen, D. C., Keßler, B., Ulrichs, K. F. A., Chodnevskaja, I., Moskalenko, V., Amselgruber, W. M., et al. (2010) · Diabetes · doi:10.2337/db09-0519 · Cited by 172 · see citing works
Bernal‐Mizrachi, E., Kulkarni, R., Scott, D. K., Mauvais‐Jarvis, F., Stewart, A. F., & Garcı́a-Ocaña, A. (2014) · Diabetes · doi:10.2337/db13-1146 · Cited by 171 · see citing works
Self-citationYamauchi, T., Kaburagi, Y., Ueki, K., Tsuji, Y., Stark, G. R., Kerr, I. M., Tsushima, T., Akanuma, Y., Komuro, I., Tobe, K., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15719 · Cited by 169 · see citing works
Differential Activation Mechanisms of Erk-1/2 and p70S6K by Glucose in Pancreatic β-Cells
Briaud, I., Lingohr, M. K., Dickson, L. M., Wrede, C. E., & Rhodes, C. J. (2003) · Diabetes · doi:10.2337/diabetes.52.4.974 · Cited by 168 · see citing works
Expansion of adult β-cell mass in response to increased metabolic demand is dependent on HNF-4α
Gupta, R. K., Gao, N., Gorski, R. K., White, P., Hardy, O. T., Rafiq, K., Brestelli, J. E., Chen, G., Stoeckert, C. J., & Kaestner, K. H. (2007) · Genes & Development · doi:10.1101/gad.1535507 · Cited by 161 · see citing works
FSTL3 deletion reveals roles for TGF-β family ligands in glucose and fat homeostasis in adults
Mukherjee, A., Sidis, Y., Mahan, A. L., Raher, M. J., Xia, Y. Y., Rosen, E. D., Bloch, K. D., Thomas, M. K., & Schneyer, A. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607966104 · Cited by 157 · see citing works
Lingohr, M. K., Dickson, L. M., McCuaig, J. F., Hügl, S., Twardzik, D. R., & Rhodes, C. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.966 · Cited by 147 · see citing works
Friedrichsen, B. N., Neubauer, N., Lee, Y. C., Gram, V. K., Blume, N., Petersen, J. S., Nielsen, J. H., & Møldrup, A. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06160 · Cited by 147 · see citing works
Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy
Schraenen, A., Lemaire, K., de Faudeur, G., Hendrickx, N., Granvik, M., Lommel, L. V., Mallet, J. J., Vodjdani, G., Gilon, P., Binart, N., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1913-7 · Cited by 142 · see citing works
Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway
Blum, B., Roose, A. N., Barrandon, O., Maehr, R., Arvanites, A. C., Davidow, L. S., Davis, J. C., Peterson, Q. P., Rubin, L. L., & Melton, D. A. (2014) · eLife · doi:10.7554/elife.02809 · Cited by 133 · see citing works
Erythropoietin protects against diabetes through direct effects on pancreatic β cells
Choi, D., Schroer, S. A., Lu, S. Y., Wang, L., Wu, X., Liu, Y., Zhang, Y., Gaisano, H. Y., Wagner, K., Wu, H., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100665 · Cited by 128 · see citing works
Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells
Kim, W., Doyle, M. E., Liu, Z., Lao, Q., Shin, Y., Carlson, O. D., Kim, H. S., Thomas, S., Napora, J. K., Lee, E. K., et al. (2011) · Diabetes · doi:10.2337/db10-1550 · Cited by 126 · see citing works
Self-citationSmart, N. G., Apelqvist, Å., Gu, X., Harmon, E. B., Topper, J. N., MacDonald, R. J., & Kim, S. K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040039 · Cited by 123 · see citing works
Impact of prolactin receptor isoforms on reproduction
Binart, N., Bachelot, A., & Bouilly, J. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.01.008 · Cited by 119 · see citing works
Nyga, R., Pecquet, C., Harir, N., Gu, H., Duthille, I., Régnier, A., Gouilleux‐Gruart, V., Lassoued, K., & Gouilleux, F. (2005) · Biochemical Journal · doi:10.1042/bj20041523 · Cited by 118 · see citing works
Saleem, S., Li, J., Yee, S., Fellows, G. F., Goodyer, C. G., & Wang, R. (2009) · The Journal of Pathology · doi:10.1002/path.2577 · Cited by 118 · see citing works
Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes
Marzo, V. D., Piscitelli, F., & Mechoulam, R. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_4 · Cited by 114 · see citing works
Snapin Mediates Incretin Action and Augments Glucose-Dependent Insulin Secretion
Song, W., Seshadri, M. R., Ashraf, U., Mdluli, T., Mondal, P., Keil, M. F., Azevedo, M. F., Kirschner, L. S., Stratakis, C. A., & Hussain, M. A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.002 · Cited by 113 · see citing works
Self-citationAmaral, M. E. C., Cunha, D. A., Anhê, G. F., Ueno, M., Carneiro, E. M., Velloso, L. A., Bordin, S., & Boschero, A. C. (2004) · Journal of Endocrinology · doi:10.1677/joe.1.05547 · Cited by 110 · see citing works
Insulin Stimulates Primary β-Cell Proliferation via Raf-1 Kinase
Beith, J. L., Alejandro, E. U., & Johnson, J. D. (2008) · Endocrinology · doi:10.1210/en.2007-1557 · Cited by 109 · see citing works
Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans
Banks, A. S., Li, J., McKeag, L., Hribal, M. L., Kashiwada, M., Accili, D., & Rothman, P. B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23853 · Cited by 104 · see citing works
Ras‐GRF1 signaling is required for normal β‐cell development and glucose homeostasis
de Mora, J. F., Esteban, L. M., Burks, D. J., Núñez, A., Garcés, C., García‐Barrado, M. J., Osma, M. D. C. I., Moratinos, J., Ward, J. M., & Santos, E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg280 · Cited by 94 · see citing works
Morris, D. L., Cho, K. W., Zhou, Y., & Rui, L. (2009) · Diabetes · doi:10.2337/db08-1388 · Cited by 93 · see citing works
Cornu, M., Modi, H., Kawamori, D., Kulkarni, R., Joffraud, M., & Thorens, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091116 · Cited by 92 · see citing works
Self-citationCannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation
Kim, W., Lao, Q., Shin, Y., Carlson, O. D., Lee, E. K., Gorospe, M., Kulkarni, R., & Egan, J. M. (2012) · Science Signaling · doi:10.1126/scisignal.2002519 · Cited by 90 · see citing works
Self-citationβ1 integrin is a crucial regulator of pancreatic β-cell expansion
Diaferia, G. R., Jiménez‐Caliani, A. J., Ranjitkar, P., Yang, W., Hardiman, G., Rhodes, C. J., Crisá, L., & Cirulli, V. (2013) · Development · doi:10.1242/dev.098533 · Cited by 87 · see citing works
Laubner, K., Kieffer, T. J., Lam, N. T., Niu, X., Jakob, F., & Seufert, J. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3410 · Cited by 85 · see citing works
Protein Kinase C-ζ Activation Markedly Enhances β-Cell Proliferation
Vasavada, R. C., Wang, L., Fujinaka, Y., Takane, K. K., Rosa, T. C., Mellado‐Gil, J. M., Friedman, P. A., & Garcı́a-Ocaña, A. (2007) · Diabetes · doi:10.2337/db07-0461 · Cited by 83 · see citing works
Self-citationKaihara, K. A., Dickson, L. M., Jacobson, D. A., Tamarina, N., Roe, M. W., Philipson, L. H., & Wicksteed, B. (2013) · Diabetes · doi:10.2337/db12-1013 · Cited by 80 · see citing works
A smad signaling network regulates islet cell proliferation
El-Gohary, Y., Tulachan, S., Wiersch, J., Guo, P., Welsh, C., Prasadan, K., Paredes, J., Shiota, C., Xiao, X., Wada, Y., et al. (2014) · Diabetes · doi:10.2337/db13-0432 · Cited by 77 · see citing works
Inada, A., Hamamoto, Y., Tsuura, Y., Miyazaki, J., Toyokuni, S., Ihara, Y., Nagai, K., Yamada, Y., Bonner‐Weir, S., & Seino, Y. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2831-2841.2004 · Cited by 75 · see citing works
Anchored phosphatases modulate glucose homeostasis
Hinke, S. A., Navedo, M. F., Ulman, A., Whiting, J. L., Nygren, P. J., Tian, G., Jiménez‐Caliani, A. J., Langeberg, L. K., Cirulli, V., Tengholm, A., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.244 · Cited by 72 · see citing works
Menin determines K-RAS proliferative outputs in endocrine cells
Chamberlain, C. E., Scheel, D. W., McGlynn, K., Kim, H., Miyatsuka, T., Wang, J., Nguyen, V. Q., Zhao, S., Mavropoulos, A., Abraham, A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci69004 · Cited by 69 · see citing works
Kondegowda, N. G., Joshi-Gokhale, S., Harb, G., Williams, K., Zhang, X. Y., Takane, K. K., Zhang, P., Scott, D. K., Stewart, A. F., Garcı́a-Ocaña, A., et al. (2010) · Diabetes · doi:10.2337/db09-1796 · Cited by 68 · see citing works
Self-citationXu, J., Zhang, Y., Berry, P. A., Jiang, J., Lobie, P. E., Langenheim, J. F., Chen, W. Y., & Frank, S. J. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0255 · Cited by 65 · see citing works
Cadherin Engagement Improves Insulin Secretion of Single Human β-Cells
Parnaud, G., Lavallard, V., Bédat, B., Matthey-Doret, D., Morel, P., Berney, T., & Bosco, D. (2014) · Diabetes · doi:10.2337/db14-0257 · Cited by 64 · see citing works
Stout, L. E., Svensson, A. M., & Sorenson, R. L. (1997) · Endocrinology · doi:10.1210/endo.138.4.5089 · Cited by 63 · see citing works
Emerging roles for the TGFβ family in pancreatic β-cell homeostasis
Brown, M. L., & Schneyer, A. L. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.02.008 · Cited by 63 · see citing works
Jackerott, M., Møldrup, A., Thams, P., Galsgaard, E. D., Knudsen, J. G., Lee, Y. C., & Nielsen, J. H. (2006) · Diabetes · doi:10.2337/db06-0244 · Cited by 63 · see citing works
Gastrointestinal hormones and the regulation of β‐cell mass
Lavine, J. A., & Attie, A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05802.x · Cited by 61 · see citing works
Conditional β1‐integrin‐deficient mice display impaired pancreatic β cell function
Riopel, M., Krishnamurthy, M., Li, J., Liu, S., Leask, A., & Wang, R. (2011) · The Journal of Pathology · doi:10.1002/path.2849 · Cited by 60 · see citing works
ICA512 signaling enhances pancreatic β-cell proliferation by regulating cyclins D through STATs
Mziaut, H., Kersting, S., Knoch, K.-P., Fan, W.-H., Trajkovski, M., Erdmann, K., Bergert, H., Ehehalt, F., Saeger, H., & Solimena, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710931105 · Cited by 59 · see citing works
β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice
Ravier, M. A., Leduc, M., Richard, J., Linck, N., Varrault, A., Pirot, N., Roussel, M., Bockaert, J., Dalle, S., & Bertrand, G. (2013) · Diabetologia · doi:10.1007/s00125-013-3130-7 · Cited by 58 · see citing works
Odori, S., Hosoda, K., Tomita, T., Fujikura, J., Kusakabe, T., Kawaguchi, Y., Doi, R., Takaori, K., Ebihara, K., Sakai, Y., et al. (2012) · Metabolism · doi:10.1016/j.metabol.2012.06.010 · Cited by 57 · see citing works
Regulation of pancreatic β-cell mass and proliferation by SOCS-3
Lindberg, K., Rønn, S. G., Tornehave, D., RICHTER, H. E., Hansen, J. A., Rømer, J., Jackerott, M., & Billestrup, N. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01840 · Cited by 55 · see citing works
In Vitro Proliferation of Adult Human Beta-Cells
Rütti, S., Sauter, N. S., Bouzakri, K., Prazak, R., Halban, P. A., & Donath, M. Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035801 · Cited by 54 · see citing works
Bastien-Dionne, P.-O., Valenti, L. V. C., Kon, N., Gu, W., & Buteau, J. (2011) · Diabetes · doi:10.2337/db11-0101 · Cited by 53 · see citing works
Schuppin, G. T., Pons, S., Hügl, S., Aiello, L. P., King, G. L., White, M. F., & Rhodes, C. J. (1998) · Diabetes · doi:10.2337/diabetes.47.7.1074 · Cited by 51 · see citing works
Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts
Tian, L., Gao, J., Weng, G., Yi, H., Tian, B., O’Brien, T. D., & Guo, Z. (2011) · Transplant International · doi:10.1111/j.1432-2277.2011.01275.x · Cited by 47 · see citing works
Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin
Wakae-Takada, N., Xuan, S., Watanabe, K., Meda, P., & Leibel, R. L. (2013) · Diabetologia · doi:10.1007/s00125-012-2824-6 · Cited by 47 · see citing works
Partial functional overlap of the three ras genes in mouse embryonic development
Nakamura, K., Ichise, H., Nakao, K., Hatta, T., Otani, H., Sakagami, H., Kondo, H., & Katsuki, M. (2007) · Oncogene · doi:10.1038/sj.onc.1210956 · Cited by 44 · see citing works
Cadherin Engagement Protects Human β-Cells from Apoptosis
Parnaud, G., Gonelle‐Gispert, C., Morel, P., Giovannoni, L., Müller, Y. D., Meier, R. P. H., Borot, S., Berney, T., & Bosco, D. (2011) · Endocrinology · doi:10.1210/en.2011-1286 · Cited by 43 · see citing works
Stimulating beta cell replication and improving islet graft function by GPR119 agonists
Gao, J., Tian, L., Weng, G., Bhagroo, N. V., Sorenson, R. L., O’Brien, T. D., Luo, J., & Guo, Z. (2011) · Transplant International · doi:10.1111/j.1432-2277.2011.01332.x · Cited by 41 · see citing works
Talbot, J., Joly, E. C., Prentki, M., & Buteau, J. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.08.010 · Cited by 40 · see citing works
The transcription factor Stat3 is dispensable for pancreatic β-cell development and function
Lee, J., & Hennighausen, L. G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.162 · Cited by 40 · see citing works
Kelly, P., Bailey, C. L., Fueger, P. T., Newgard, C. B., Casey, P. J., & Kimple, M. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.069112 · Cited by 39 · see citing works
Activation of Elk-1, an Ets transcription factor, by glucose and EGF treatment of insulinoma cells
Bernal‐Mizrachi, E., Wu, W., Srinivasan, S., Klenk, A. S., Cohen, D., & Permutt, M. A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1286 · Cited by 39 · see citing works
Self-citationMultiple endocrine neoplasia type 1
Thakker, R. V. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.104058 · Cited by 38 · see citing works
Lee, J., Gavrilova, O., Davani, B., Na, R., Robinson, G. W., & Hennighausen, L. G. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.05.010 · Cited by 35 · see citing works
Ma, F., Wei, Z., Shi, C., Gan, Y. X., Lu, J., Frank, S. J., Balducci, J., & Huang, Y. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1052 · Cited by 34 · see citing works
Skp2 Is Required for Incretin Hormone-Mediated β-Cell Proliferation
Tschen, S.-I., Georgia, S. K., Dhawan, S., & Bhushan, A. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1119 · Cited by 33 · see citing works
Self-citationInhibition of beta cell growth and function by bone morphogenetic proteins
Bruun, C., Christensen, G. L., Jacobsen, M. L. B., Kanstrup, M. B., Jensen, P. R., Fjordvang, H., Mandrup-Poulsen, T. R., & Billestrup, N. (2014) · Diabetologia · doi:10.1007/s00125-014-3384-8 · Cited by 33 · see citing works
Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokines
Santangelo, C., Scipioni, A., Marselli, L., Marchetti, P., & Dotta, F. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01856 · Cited by 33 · see citing works
Williams, K. R., Abanquah, D., Joshi-Gokhale, S., Otero, P. A., Lin, H. Y., Guthalu, N. K., Zhang, X., Mozar, A., Bisello, A., Stewart, A. F., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2260-z · Cited by 30 · see citing works
Self-citationTriiodothyronine Induces Proliferation of Pancreatic β-cells through the MAPK/ERK Pathway
Kim, T., Lee, J. H., Jung, H. S., Ha, T. Q., Kim, T. N., Han, N., Lee, E., Kim, T., Kwon, M. J., Lee, S., et al. (2014) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0034-1367060 · Cited by 30 · see citing works
Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1
Xie, J., El-Sayed, N. M., Cheng, Q., Zhao, X., Moore, C. E., & Herbert, T. P. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0200 · Cited by 29 · see citing works
Ahlkvist, L., Brown, K., & Åhrén, B. (2013) · Endocrine Connections · doi:10.1530/ec-12-0079 · Cited by 28 · see citing works
Differential synthesis and action of TGFβ superfamily ligands in mouse and rat islets
Brown, M., Kimura, F., Bonomi, L. M., Ungerleider, N., & Schneyer, A. L. (2011) · Islets · doi:10.4161/isl.3.6.18013 · Cited by 25 · see citing works
Wu, H., Mezghenna, K., Mármol, P., Guo, T., Moliner, A., Yang, S.-N., Berggren, P., & Ibáñez, C. F. (2013) · Diabetologia · doi:10.1007/s00125-013-3079-6 · Cited by 25 · see citing works
Expression and Function of Monoacylglycerol Lipase in Mouse β-cells and Human Islets of Langerhans
Li, C., Vilches-Flores, A., Zhao, M., Amiel, S., Jones, P. M., & Persaud, S. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000339069 · Cited by 22 · see citing works
Loss of β-arrestin2 mediates pancreatic-islet dysfunction in mice
Zhang, M., Zhu, Y., Mu, K., Li, L., Lu, J., Zhao, J., Huang, X., Wang, C., & Jia, W. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.04.079 · Cited by 20 · see citing works
Jiao, Y., Rieck, S., Lay, J. E. L., & Kaestner, K. H. (2013) · Diabetologia · doi:10.1007/s00125-013-3014-x · Cited by 17 · see citing works
Multiple Endocrine Neoplasia Type 1
Thakker, R. V. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00150-7 · Cited by 17 · see citing works
No non-redundant function of suppressor of cytokine signaling 2 in insulin producing β-cells
Puff, R., Dames, P., Weise, M., Göke, B., Parhofer, K. G., & Lechner, A. (2010) · Islets · doi:10.4161/isl.2.4.12556 · Cited by 13 · see citing works
Zhang, M., Feng, Y., Wang, J., Zhao, J., Li, T., He, M., Yang, D., Nosjean, O., Boutin, J. A., Renard, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063861 · Cited by 12 · see citing works
Mozar, A., Kondegowda, N. G., Pollack, I., Fenutría, R., & Vasavada, R. C. (2014) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-014-9168-3 · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Molecular pathways associated with oxidative stress in diabetes mellitus
Ighodaro, O. M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.058 · Cited by 560 · see citing works
Zhou, Q., & Melton, D. A. (2018) · Nature · doi:10.1038/s41586-018-0088-0 · Cited by 384 · see citing works
SerpinB1 Promotes Pancreatic β-Cell Proliferation
Ouaamari, A. E., Dirice, E., Gedeon, N., Hu, J., Zhou, J.-Y., Shirakawa, J., Hou, L., Goodman, J. L., Karampelias, C., Qiang, G., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.001 · Cited by 207 · see citing works
Self-citationQuantifying the effect of experimental perturbations at single-cell resolution
Burkhardt, D. B., Stanley, J. S., Tong, A., Perdigoto, A. L., Gigante, S. A., Herold, K. C., Wolf, G., Giraldez, A. J., van Dijk, D., & Krishnaswamy, S. (2021) · Nature Biotechnology · doi:10.1038/s41587-020-00803-5 · Cited by 226 · see citing works
Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells
Almaça, J., Molina, J., Menegaz, D., Pronin, A. N., Tamayo, A., Slepak, V. Z., Berggren, P., & Caicedo, A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.072 · Cited by 199 · see citing works
Wang, P., Karakose, E., Liu, H., Swartz, E., Ackeifi, C., Zlatanic, V., Wilson, J., González, B. J., Bender, A., Takane, K. K., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.005 · Cited by 162 · see citing works
Self-citationSignals in the pancreatic islet microenvironment influence β‐cell proliferation
Aamodt, K. I., & Powers, A. C. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13031 · Cited by 154 · see citing works
Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions
Hart, N. J., & Powers, A. C. (2018) · Diabetologia · doi:10.1007/s00125-018-4772-2 · Cited by 141 · see citing works
Stress-impaired transcription factor expression and insulin secretion in transplanted human islets
Dai, C., Kayton, N. S., Shostak, A., Poffenberger, G., Cyphert, H. A., Aramandla, R., Thompson, C., Papagiannis, I. G., Emfinger, C., Shiota, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83657 · Cited by 109 · see citing works
Zhong, F., & Jiang, Y. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00101 · Cited by 110 · see citing works
β-Cell Maturation and Identity in Health and Disease
Salinno, C., Cota, P., Bastidas-Ponce, A., Tarquis-Medina, M., Lickert, H., & Bakhti, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215417 · Cited by 84 · see citing works
The Human Islet: Mini-Organ With Mega-Impact
Walker, J. T., Saunders, D. C., Briššová, M., & Powers, A. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab010 · Cited by 80 · see citing works
Gupta, D., Jetton, T., Larock, K., Monga, N., Satish, B., Lausier, J., Peshavaria, M., & Leahy, J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.781047 · Cited by 67 · see citing works
González‐Mariscal, I., Montoro, R. A., Doyle, M. E., Liu, Q., Rouse, M. D., O’Connell, J. F., Calvo, S. S.-C., Krzysik-Walker, S. M., Ghosh, S., Carlson, O. D., et al. (2018) · Diabetologia · doi:10.1007/s00125-018-4576-4 · Cited by 68 · see citing works
Ji, Y., Sun, S., Shrestha, N., Darragh, L. B., Shirakawa, J., Xing, Y., He, Y., Carboneau, L., Kim, H., An, D., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0396-z · Cited by 63 · see citing works
Self-citationAdvances in β cell replacement and regeneration strategies for treating diabetes
Benthuysen, J. R., Carrano, A. C., & Sander, M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87439 · Cited by 62 · see citing works
Montanari, E., Meier, R., Mahou, R., Seebach, J., Wandrey, C., Gerber-Lemaire, S., Buhler, L., & Gonelle-Gispert, C. (2017) · Stem cell research & therapeutics · doi:10.1186/s13287-017-0646-7 · Cited by 57 · see citing works
Targeting pancreatic β cells for diabetes treatment
Jain, C., Ansarullah, M., Bilekova, S., & Lickert, H. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00618-5 · Cited by 65 · see citing works
Human duct cells contribute to β cell compensation in insulin resistance
Dirice, E., Jesus, D. F. D., Kahraman, S., Basile, G., Ng, R. W. S., Ouaamari, A. E., Teo, A. K. K., Bhatt, S., Hu, J., & Kulkarni, R. (2019) · JCI Insight · doi:10.1172/jci.insight.99576 · Cited by 59 · see citing works
Self-citationProtection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling
Lee, J.-H., Mellado‐Gil, J. M., Bahn, Y. J., Pathy, S. M., Zhang, Y. E., & Rane, S. G. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2365-8 · Cited by 59 · see citing works
Chen, H., Kleinberger, J. W., Takane, K. K., Salim, F. G., Fiaschi‐Taesch, N., Pappas, K., Parsons, R. E., Jiang, J., Zhang, Y., Liu, H., et al. (2015) · Diabetes · doi:10.2337/db15-0083 · Cited by 58 · see citing works
Self-citationPullen, T. J., Huising, M. O., & Rutter, G. A. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00041 · Cited by 57 · see citing works
Novel factors modulating human β‐cell proliferation
Shirakawa, J., & Kulkarni, R. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12731 · Cited by 56 · see citing works
Self-citationWisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells
Fernandez‐Ruiz, R., García, A., Esteban, Y., Mir-Coll, J., Serra-Navarro, B., Fontcuberta-PiSunyer, M., Broca, C., Armanet, M., Wojtusciszyn, A., Kram, V., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19657-1 · Cited by 55 · see citing works
Abbruzzese, J. L., Andersen, D. K., Borrebaeck, C. A. K., Chari, S. T., Costello, E., Cruz‐Monserrate, Z., Eibl, G., Engleman, E. G., Fisher, W. E., Habtezion, A., et al. (2018) · Pancreas · doi:10.1097/mpa.0000000000001037 · Cited by 54 · see citing works
Carboneau, L., Allan, J. A., Townsend, S. E., Kimple, M. E., BREYER, R. M., & GANNON, M. A. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.04.002 · Cited by 53 · see citing works
Zhao, Y. L., Jiang, Z., Delgado, E., Li, H., Zhou, H., Hu, W., Pérez‐Basterrechea, M., Janošťáková, A., Tan, Q., Wang, J., et al. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0078 · Cited by 54 · see citing works
Emerging diabetes therapies: Bringing back the β-cells
Basile, G., Qadir, F., Mauvais-Jarvis, F., Vetere, A., Shoba, V., Modell, A. E., Pastori, R., Russ, H., Wagner, B., & Domínguez-Bendala, J. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101477 · Cited by 47 · see citing works
Regenerating gene (REG) product and its potential clinical usage
Takasawa, S. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1123691 · Cited by 52 · see citing works
mTOR: A double-edged sword for diabetes
Tuo, Y., & Xiang, M. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0317-095rr · Cited by 50 · see citing works
Jiang, W., Peng, Y., & Yang, K. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6603 · Cited by 49 · see citing works
Keller, M. P., Paul, P. K., Rabaglia, M. E., Stapleton, D. S., Schueler, K. L., Broman, A. T., Ye, S., Leng, N., Brandon, C. J., Neto, E. C., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006466 · Cited by 43 · see citing works
Yang, Y., Wang, P., Zhang, C., Huang, F., Pang, G., Wei, C., Lv, C., Chhetri, G., Jiang, T., Liu, J., et al. (2020) · Liver International · doi:10.1111/liv.14697 · Cited by 45 · see citing works
Montemurro, C., Vadrevu, S., Gurlo, T., Butler, A. E., Vongbunyong, K. E., Petcherski, A., Shirihai, O. S., Satin, L. S., Braas, D., Butler, P. C., et al. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1361069 · Cited by 43 · see citing works
How, When, and Where Do Human β-Cells Regenerate?
Basile, G., Kulkarni, R. N., & Morgan, N. G. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1176-8 · Cited by 42 · see citing works
Self-citationIn vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR
Charbord, J., Ren, L., Sharma, R. B., Johansson, A., Ågren, R., Chu, L., Tworus, D., Schulz, N., Charbord, P., Stewart, A. F., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00391-x · Cited by 39 · see citing works
Self-citationReplicative capacity of β-cells and type 1 diabetes
Saunders, D. C., & Powers, A. C. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.03.014 · Cited by 39 · see citing works
Epidermal Growth Factor Receptor Signaling Regulates β Cell Proliferation in Adult Mice
Song, Z., Fusco, J. C., Zimmerman, R., Fischbach, S., Chen, C., Ricks, D. M., Prasadan, K. L., Shiota, C., Xiao, X., & Gittes, G. K. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.747840 · Cited by 39 · see citing works
Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass
Shirakawa, J., Jesus, D. F. D., & Kulkarni, R. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2017.13 · Cited by 39 · see citing works
Self-citationDeath versus dedifferentiation: The molecular bases of beta cell mass reduction in type 2 diabetes
Sun, T., & Han, X. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.12.002 · Cited by 40 · see citing works
Proproliferative and antiapoptotic action of exogenously introduced YAP in pancreatic β cells
Yuan, T., Rafizadeh, S., Azizi, Z., Lupše, B., Gorrepati, K. D. D., Awal, S., Oberholzer, J., Maedler, K., & Ardestani, A. D. (2016) · JCI Insight · doi:10.1172/jci.insight.86326 · Cited by 38 · see citing works
GPR142 prompts glucagon-like Peptide-1 release from islets to improve β cell function
Lin, H. V., Wang, J., Wang, J., Wei-ji, L., Wang, X., Alston, J. T., Thomas, M. K., Briere, D. A., Syed, S. K., & Efanov, A. M. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.02.008 · Cited by 35 · see citing works
Pancreatic β-cell failure, clinical implications, and therapeutic strategies in type 2 diabetes
Cui, D., Feng, X., Lei, S., Zhang, H., Hu, W., Yang, S., Yu, X., & Su, Z. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003034 · Cited by 36 · see citing works
Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats
Moullé, V. S. F., Vivot, K., Tremblay, C. C., Zarrouki, B., Ghislain, J. J., & Poitout, V. (2017) · Diabetologia · doi:10.1007/s00125-016-4197-8 · Cited by 34 · see citing works
Advances in drug discovery for human beta cell regeneration
Karaköse, E., Ackeifi, C. A., Wang, P., & Stewart, A. F. (2018) · Diabetologia · doi:10.1007/s00125-018-4639-6 · Cited by 33 · see citing works
Self-citationIdentification of potential markers for type 2 diabetes mellitus via bioinformatics analysis
Lu, Y., Li, Y., Li, G., & Lu, H. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11281 · Cited by 34 · see citing works
Nutrient regulation of pancreatic β-cell proliferation
Moullé, V. S. F., Ghislain, J. J., & Poitout, V. (2017) · Biochimie · doi:10.1016/j.biochi.2017.09.017 · Cited by 33 · see citing works
Danilova, T., & Lindahl, M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01457 · Cited by 31 · see citing works
Jara, M. A., Werneck‐de‐Castro, J. P., Lubaczeuski, C., Johnson, J. D., & Bernal‐Mizrachi, E. (2020) · Islets · doi:10.1080/19382014.2020.1762471 · Cited by 32 · see citing works
Self-citationTransient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation
Xiao, X., Fischbach, S., Song, Z., Gaffar, I. M., Zimmerman, R., Wiersch, J. C., Prasadan, K. L., Shiota, C., Guo, P., Ramachandran, S., et al. (2016) · Endocrinology · doi:10.1210/en.2015-1986 · Cited by 32 · see citing works
Galli, A., Maffioli, E., Sogne, E., Moretti, S., Cairano, E. S. D., Negri, A. L., Nonnis, S., Norata, G. D., Bonacina, F., Borghi, F., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-28019-3 · Cited by 31 · see citing works
Understanding generation and regeneration of pancreatic β cells from a single-cell perspective
Yu, X., & Xu, C. (2020) · Development · doi:10.1242/dev.179051 · Cited by 28 · see citing works
Islet Regeneration: Endogenous and Exogenous Approaches
Docherty, F. M., & Sussel, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073306 · Cited by 28 · see citing works
Zeng, W., Tang, J., Li, H., Xu, H., Lu, H., Peng, H., Lin, C., Gao, R., Lin, S., Lin, K., et al. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.03.013 · Cited by 27 · see citing works
Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells
Rosado-Olivieri, E. A., Aigha, I. I., Kenty, J. H.-R., & Melton, D. A. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.12.009 · Cited by 28 · see citing works
Li, Y., Wu, H., Liu, N., Cao, X., Yang, Z., Lü, B., Hu, R., Wang, X., & Wen, J. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3305 · Cited by 27 · see citing works
Đorđević, M., Grdović, N., Mihailović, M., Јovanović, J. A., Uskoković, A. S., Rajić, J., Đorđević, M., Tolić, A., Mišić, D. M., Šiler, B., et al. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112043 · Cited by 28 · see citing works
New Aspects of Diabetes Research and Therapeutic Development
Satin, L. S., Soleimanpour, S. A., & Walker, E. M. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000160 · Cited by 29 · see citing works
van de Bunt, M., Lako, M., Barrett, A., Gloyn, A., Hansson, M., McCarthy, M., Beer, N., & Honoré, C. (2016) · Islets · doi:10.1080/19382014.2016.1182276 · Cited by 25 · see citing works
Sisino, G., Zhou, A., Dahr, N., Sabirsh, A., Soundarapandian, M. M., Perera, R. J., Larsson-Lekholm, E., Magnone, M. C., Althage, M., & Tyrberg, B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182371 · Cited by 20 · see citing works
Zhang, X., Luo, S., Wang, M., Huang, Q. M., Fang, W., Li, J., Liu, T., Zhang, Y., Deng, Z., Liu, C.-L., et al. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.05.013 · Cited by 21 · see citing works
Self-citationAcinar to β-like cell conversion through inhibition of focal adhesion kinase
Dahiya, S., Saleh, M. W., Rodriguez, U. A., Rajasundaram, D., Arbujas, J. R., Hajihassani, A., Yang, K., Sehrawat, A., Kalsi, R. S., Yoshida, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47972-4 · Cited by 21 · see citing works
Mortlock, R. D., Georgia, S. K., & Finley, S. D. (2020) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-020-00647-8 · Cited by 19 · see citing works
Conversion of α-Cells to β-Cells in the Postpartum Mouse Pancreas Involves Lgr5 Progeny
Rodriguez, U. A., Socorro, M., Criscimanna, A., Martins, C. P., Mohamed, N., Hu, J., Prasadan, K. L., Gittes, G. K., & Esni, F. (2021) · Diabetes · doi:10.2337/db20-1059 · Cited by 18 · see citing works
Betatrophin in Diabetes Mellitus: the Epidemiological Evidence in Humans
Espes, D., Martinell, M., Liljebäck, H., & Carlsson, P. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0676-4 · Cited by 18 · see citing works
The role of ORMDL3/ATF6 in compensated beta cell proliferation during early diabetes
Yang, W., Sheng, F., Sun, B., Fischbach, S., & Xiao, X. (2019) · Aging · doi:10.18632/aging.101949 · Cited by 17 · see citing works
Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation
Shcheglova, E. G., Błaszczyk, K., & Borowiak, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.734597 · Cited by 16 · see citing works
Patti, M., Goldfine, A. B., Hu, J., Hoem, D., Molven, A., Goldsmith, J. D., Schwesinger, W. H., Rosa, S. L., Folli, F. B., & Kulkarni, R. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-1001-2 · Cited by 17 · see citing works
Self-citationDiabetogenic Effects of Immunosuppression: An Integrative Analysis
Bhat, M., Pasini, E., Das, A., Baciu, C., Angeli, M., Humar, A., Watt, K. D. S., & Allard, J. P. (2019) · Transplantation · doi:10.1097/tp.0000000000002815 · Cited by 17 · see citing works
Chronic Exposure to Palmitic Acid Down-Regulates AKT in Beta-Cells through Activation of mTOR
Aggarwal, R., Peng, Z., Zeng, N., Silva, J., He, L., Chen, J., Debebe, A., Tu, T., Alba, M. M., Chen, C.-Y., et al. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.09.008 · Cited by 16 · see citing works
Eguchi, N., Toribio, A. J., Alexander, M., Xu, I., Whaley, D. L., Hernandez, L. F., Dafoe, D. C., & Ichii, H. (2022) · Biomedicines · doi:10.3390/biomedicines10020472 · Cited by 16 · see citing works
Fine-tuning of microRNAs in Type 2 Diabetes Mellitus
Rosado, J. A., Diez-Bello, R., Salido, G. M., & Jardín, I. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867325666171205163944 · Cited by 16 · see citing works
Txnip deficiency promotes β-cell proliferation in the HFD-induced obesity mouse model
Lei, Z., Chen, Y., Wang, J., Zhang, Y., Shi, W., Wang, X., Xing, D., Li, D., & Jiao, X. (2022) · Endocrine Connections · doi:10.1530/ec-21-0641 · Cited by 15 · see citing works
TRPM7 kinase is required for insulin production and compensatory islet responses during obesity
Khajavi, N., Beck, A., Riçku, K., Beyerle, P., Jacob, K., Syamsul, S. F., Belkacemi, A., Reinach, P. S., Schreier, P. C. F., Salah, H., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.163397 · Cited by 14 · see citing works
Chernysheva, M. B., Ruchko, E. S., Karimova, M. V., Vorotelyak, E. A., & Vasiliev, А. V. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1424278 · Cited by 15 · see citing works
Maachi, H., Ghislain, J. J., Tremblay, C. C., & Poitout, V. (2021) · Scientific Reports · doi:10.1038/s41598-021-90643-3 · Cited by 14 · see citing works
Scholz, O., Otter, S., Welters, A., Wörmeyer, L., Dolenšek, J., Klemen, M. S., Pohorec, V., Eberhard, D., Mrugala, J., Hamacher, A. B., et al. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.05.011 · Cited by 13 · see citing works
Yang, Y., Wang, B., Dong, H., Lin, H., Ho, M. Y.-M., Hu, K., Zhang, N., Ma, J., Xie, R., Cheng, K. K. Y., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2401218121 · Cited by 11 · see citing works
Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas
Socorro, M., Criscimanna, A., Riva, P., Tandon, M., Prasadan, K. L., Guo, P., Humar, A., Husain, S. Z., Leach, S. D., Gittes, G. K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17884-z · Cited by 12 · see citing works
Yu, H., Hu, W., Song, X. H., & Zhao, Y. L. (2020) · Cells · doi:10.3390/cells9061350 · Cited by 12 · see citing works
Oliveira, J. A. P., Camacho-Ramírez, A., Salas-Alvarez, J., Campos-Martinez, F. J., Lechuga-Sancho, A. M., Gomar, D. A., Blandino-Rosano, M., & Pérez-Arana, G.-M. (2019) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2019.01.007 · Cited by 12 · see citing works
In vivo generation and regeneration of β cells in zebrafish
Yang, B., Covington, B. A., & Chen, W. (2020) · Cell Regeneration · doi:10.1186/s13619-020-00052-6 · Cited by 12 · see citing works
Goode, R. A., Hum, J. M., & Kalwat, M. A. (2022) · Endocrinology · doi:10.1210/endocr/bqac193 · Cited by 11 · see citing works
Gsα-dependent signaling is required for postnatal establishment of a functional β-cell mass
Serra-Navarro, B., Fernandez‐Ruiz, R., García, A., Pradas-Juni, M., Fernández‐Rebollo, E., Esteban, Y., Mir-Coll, J., Mathieu, J., Dalle, S., Hahn, M., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101264 · Cited by 11 · see citing works
Karlsson, D., Ahnmark, A., Sabirsh, A., Andréasson, A., Gennemark, P., Sandinge, A.-S., Chen, L., Tyrberg, B., Lindén, D., & Winzell, M. S. (2022) · Biomedicines · doi:10.3390/biomedicines10020203 · Cited by 11 · see citing works
Lessons from neonatal β-cell epigenomic for diabetes prevention and treatment
Abderrahmani, A., Jacovetti, C., & Regazzi, R. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.03.002 · Cited by 11 · see citing works
TBK1 regulates regeneration of pancreatic β-cells
Jia, Y., Jeeva, S., Xu, J., Heppelmann, C. J. H., Jang, J. S., Slama, M. Q., Tapadar, S., Oyelere, A. K., Kang, S., Matveyenko, A. V., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76600-6 · Cited by 11 · see citing works
Assefa, Z., Akbib, S., Lavens, A., Stangé, G. M., Ling, Z., Hellemans, K., & PIPELEERS, D. G. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00070.2016 · Cited by 10 · see citing works
Recombinant protein CCN5/WISP2 promotes islet cell proliferation and survival in vitro
Kaddour, N., Zhang, D., Gao, Z., & Liu, J. (2019) · Growth Factors · doi:10.1080/08977194.2019.1652400 · Cited by 10 · see citing works
Advanced therapy to cure diabetes: mission impossible is now possible?
Rohban, R., Martins, C. P., & Esni, F. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1484859 · Cited by 10 · see citing works
Sionov, R. V., & Ahdut-HaCohen, R. (2023) · Biomedicines · doi:10.3390/biomedicines11092558 · Cited by 12 · see citing works
FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction
Tacto, C., Tahbaz, M., Salib, A., Wang, S., Cayabyab, F., Choi, J., Kim, K. A., Hamba, Y., Perez, H. D., Gershon, P. D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60188-4 · Cited by 8 · see citing works
Drug-induced regeneration of pancreatic beta cells: An approach to cellular therapeutic targets
Parsi, P., Saharkhiz, S., Farani, M. R., Bakhtiyari, S., & Alipourfard, I. (2025) · Cell Regeneration · doi:10.1186/s13619-025-00255-9 · Cited by 9 · see citing works
PROTECTIVE EFFECT OF SELENIUM ON DIABETIC NEPHROPATHY IN WISTAR RATS
Boussekine, S., Lekmine, S., Gasmi, S., Benkhedir, A., Saker, H., & Lidoughi, A. (2022) · Journal of Microbiology Biotechnology and Food Sciences · doi:10.55251/jmbfs.5960 · Cited by 8 · see citing works
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy
So, W., Liao, Y., Liu, W.-N., Rutter, G. A., & Han, W.-P. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202317928 · Cited by 5 · see citing works
Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells
Ye, C., & Driver, J. P. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00169 · Cited by 8 · see citing works
Interventions to improve β-cell mass and function
Mondal, P., Prasad, A., & Girdhar, K. (2017) · Annales d Endocrinologie · doi:10.1016/j.ando.2016.11.002 · Cited by 7 · see citing works
Møldrup, A., Lindberg, M. N., Galsgaard, E. D., Henriksen, U. L., Dalgaard, L. T., & Nielsen, J. H. (2020) · Acta Physiologica · doi:10.1111/apha.13454 · Cited by 8 · see citing works
ERK 5 plays an essential role in gestational beta‐cell proliferation
Chen, C., Wu, S., Lin, X., Wu, D., Fischbach, S., & Xiao, X. (2017) · Cell Proliferation · doi:10.1111/cpr.12410 · Cited by 8 · see citing works
Seferovic, M. D., Beamish, C. A., Mosser, R. E., Townsend, S. E., Pappan, K. L., Poitout, V., Aagaard, K. M., & GANNON, M. A. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00001.2018 · Cited by 8 · see citing works
- Authors
- Stewart, A. F., Hussain, M. A., García-Ocaña, A., Vasavada, R. C., Bhushan, A., Bernal-Mizrachi, E., & Kulkarni, R. N.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Johns Hopkins University (US)
- Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY
- University of California, San Francisco (US)
- Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI, and VA Ann Arbor Healthcare System, Ann Arbor, MI
- Joslin Diabetes Center (US)
- Corresponding author
- Stewart, Andrew F.
- Kulkarni, Rohit N.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2015-05-16
- Volume
- 64
- Issue
- 6
- Pages
- 1872-1885
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC4439562
- OpenAlex
- W2219097671
- Cited by
- 142
- References
- 120
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 14 · 2023: 5 · 2022: 14 · 2021: 14 · 2020: 13 · 2019: 14 · 2018: 15 · 2017: 18 · 2016: 14 · 2015: 6
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (5p60dk079637-02, P60-DK079637, DK-079637)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK 55023, DK077096, P60 DK-079637, R01DK084236, R01DK077096, R01 DK-67536, R01DK081472, U01DK089538, R01DK078060, UC4DK104211, R01DK103215, R01DK101591, R01DK073716, R01DK080996, R01DK055023, P30DK063720, R01 DK06735, P30DK020572, R01DK067536, P30DK020593)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Keywords
- pancreatic beta-cell proliferation, human beta cells, intracellular signaling, beta cell regeneration, type 1 diabetes, type 2 diabetes, JAK/STAT signaling, Ras/Raf/ERK signaling, cadherins, integrins, G protein-coupled receptors, TGF-beta signaling, stem cell differentiation, islet transplantation, cell cycle regulation
- MeSH terms
- Animals, Diabetes Mellitus, Humans, Insulin, Signal Transduction, Cell Proliferation, Insulin-Secreting Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
