Haynes, Laura

CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

Haynes, L., Eaton, S. M., Burns, E. M., Randall, T. D., & Swain, S. L. (2003) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 270

Effects of aging on T cell function

Haynes, L., & Maue, A. C. (2009) · Current Opinion in Immunology

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 244

Why Aging T Cells Fail: Implications for Vaccination

Haynes, L., & Swain, S. L. (2006) · Immunity

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 169

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

Tsukamoto, H., Clise-Dwyer, K., Huston, G. E., Duso, D. K., Buck, A. L., Johnson, L. L., Haynes, L., & Swain, S. L. (2009) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 166

Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo

Haynes, L., Eaton, S. M., Burns, E. M., Rincon, M., & Swain, S. L. (2004) · The Journal of Immunology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 162

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

Wang, B., Wang, L., Gasek, N. S., Zhou, Y., Kim, T., Guo, C., Jellison, E. R., Haynes, L., Yadav, S., Tchkonia, T., et al. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 145

The effect of age on the cognate function of CD4+ T cells

Haynes, L., & Eaton, S. M. (2005) · Immunological Reviews

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 116

Mitochondrial Ca2+ and membrane potential, an alternative pathway for interleukin 6 to regulate CD4 cell effector function

Yang, R., Lirussi, D., Thornton, T. M., Jelley-Gibbs, D. M., Diehl, S. A., Case, L. K., Madesh, M., Taatjes, D. J., Teuscher, C., Haynes, L., et al. (2015) · eLife

Mitochondrial Function and PathologyT-cell and B-cell Immunology

Cited by 91

Impact of age, caloric restriction, and influenza infection on mouse gut microbiome: an exploratory study of the role of age-related microbiome changes on influenza responses

Bartley, J. M., Zhou, X., Kuchel, G. A., Weinstock, G. M., & Haynes, L. (2017) · Frontiers in Immunology

Gut microbiota and healthAnimal Nutrition and Physiology

Cited by 87

Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

Wang, B., Wang, L., Gasek, N. S., Kuo, C.-L., Nie, J., Kim, T., Yan, P., Zhu, J., Torrance, B. L., Zhou, Y., et al. (2024) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 59

Bone Marrow Precursor Cells from Aged Mice Generate CD4 T Cells That Function Well in Primary and Memory Responses

Eaton, S. M., Maue, A. C., Swain, S. L., & Haynes, L. (2008) · The Journal of Immunology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 45