Bone Marrow Precursor Cells from Aged Mice Generate CD4 T Cells That Function Well in Primary and Memory Responses
Open accessAbstract
Understanding how aging impacts the function of memory CD4 T cells is critical for designing effective vaccines. Our studies show that immunological memory generated during youth functions well into old age, whereas that generated later in life functions poorly. This is the result of declines in the function of naive CD4 T cells from aged individuals and contributes to reduced efficacy of vaccines in the elderly. To begin to identify the cause of this defect, we examined the function of memory T cells generated from bone marrow precursor cells (BMPC) from young or aged mice in young hosts. In two different models, memory cells derived from young and aged BMPC exhibit good ex vivo and in vivo function. Importantly, memory CD4 T cells generated from aged BMPC exhibit potent cognate helper function for humoral responses, which are critical for effective immunization. These results indicate that there are no apparent age-related intrinsic defects in BMPC with regards to generation of functional memory T cells.
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CD4+ T cells produced from old hematopoietic stem cells work in young hosts but not old hosts.
“Haynes and colleagues (111) found that CD4 + T cells generated from old HSCs were functional in young but not old hosts”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [111]
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- Authors
- Eaton, S. M., Maue, A. C., Swain, S. L., & Haynes, L.
- Affiliations
- Trudeau Institute (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10-01
- Volume
- 181
- Issue
- 7
- Pages
- 4825-4831
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC2582190
- OpenAlex
- W2162518894
- Cited by
- 45
- References
- 33
- Citations by year
- 2026: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 5 · 2017: 3 · 2016: 2 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG02160, P01AG021600, R37AG025805, AG025805)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- immunosenescence, memory CD4+ T cells, bone marrow progenitor cells, aging, humoral immune response, memory T cell generation, aged mice
- MeSH terms
- Aging, Animals, Bone Marrow Cells, Cell Differentiation, Cell Line, Cells, Cultured, Immunologic Memory, Mice, Inbred C57BL, Mice, Transgenic, Radiation Chimera, Receptors, Antigen, T-Cell, Stem Cells, CD4-Positive T-Lymphocytes, Bone Marrow Transplantation, Immunophenotyping, Resting Phase, Cell Cycle, Mice, Congenic, Stem Cell Transplantation, Mice
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