Effects of aging on T cell function

How regulatory T cells work

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

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Germinal Centers

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Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

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Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines

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Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

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Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

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Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation

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Cytokine-mediated regulation of antimicrobial proteins

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Expanded CD4+ and CD8+ T cell clones in elderly humans

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Age-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses

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Differential contributions of central and effector memory T cells to recall responses

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CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

Haynes, L., Eaton, S. M., Burns, E. M., Randall, T. D., & Swain, S. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2433717100 · Cited by 270 · see citing works

Th17 T cells: Linking innate and adaptive immunity

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Antigen-independent changes in naive CD4 T cells with aging.

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Interleukin 2, but Not Other Common γ Chain–Binding Cytokines, Can Reverse the Defect in Generation of Cd4 Effector T Cells from Naive T Cells of Aged Mice

Haynes, L., Linton, P., Eaton, S. M., Tonkonogy, S. L., & Swain, S. L. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.1013 · Cited by 248 · see citing works

Age-related CD8 T Cell Clonal Expansions Constrict CD8 T Cell Repertoire and Have the Potential to Impair Immune Defense

Messaoudi, I., LeMaoult, J., Guevara-Patino, J. A., Metzner, B. M., & Nikolich‐Žugich, J. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040437 · Cited by 243 · see citing works

High Accumulation of T Regulatory Cells Prevents the Activation of Immune Responses in Aged Animals

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Unexpected expansions of CD8-bearing cells in old mice.

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CD4+CD25+Foxp3+ T Cells and CD4+CD25−Foxp3+ T Cells in Aged Mice

Nishioka, T., Shimizu, J., Iida, R., Yamazaki, S., & Sakaguchi, S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6586 · Cited by 220 · see citing works

Natural and Vaccine-Related Immunity to Streptococcus pneumoniae

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Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo

Haynes, L., Eaton, S. M., Burns, E. M., Rincon, M., & Swain, S. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5194 · Cited by 162 · see citing works

Specific Humoral Immunity in the Elderly: in vivo and in vitro Response to Vaccination

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Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice

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Age-Dependent Defects in TCR-Triggered Cytoskeletal Rearrangement in CD4+ T Cells

Garcia, G. G., & Miller, R. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.5021 · Cited by 90 · see citing works

Alterations in the human immune response to the hepatitis B vaccine among the elderly

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Nuclear factor‐κB‐dependent reversal of aging‐induced alterations in T cell cytokines

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Proinflammatory Adjuvants Enhance the Cognate Helper Activity of Aged CD4 T Cells

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The physiology of germinal centers.

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Idiosyncratic Alterations of TCR Size Distributions Affecting Both CD4 and CD8 T Cell Subsets in Aging Mice

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OX40-Enhanced Tumor Rejection and Effector T Cell Differentiation Decreases with Age

Ruby, C. E., & Weinberg, A. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.3.1481 · Cited by 42 · see citing works

Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties

Clambey, E. T., White, J., Kappler, J. W., & Marrack, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805465105 · Cited by 38 · see citing works

Suppressive effects of androgens on the immune system

Trigunaite, A., Dimo, J., & Jørgensen, T. N. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.02.004 · Cited by 551 · see citing works

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

Elyahu, Y., Hekselman, I., Eizenberg-Magar, I., Berner, O., Strominger, I., Schiller, M., Mittal, K., Nemirovsky, A., Eremenko, E., Vital, A., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw8330 · Cited by 324 · see citing works

Aging and Immune Function: Molecular Mechanisms to Interventions

Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339 · see citing works

Sex, the aging immune system, and chronic disease

Bupp, M. G. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.02.002 · Cited by 333 · see citing works

Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality

Zohar, T., Loos, C., Fischinger, S., Atyeo, C., Wang, C., Slein, M. D., Burke, J., Yu, J., Feldman, J., Hauser, B. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.052 · Cited by 297 · see citing works

The Confluence of Sex Hormones and Aging on Immunity

Gubbels Bupp, M. R., Potluri, T., Fink, A. L., & Klein, S. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01269 · Cited by 277 · see citing works

Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories

Nikolich-Žugich, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401174 · Cited by 259 · see citing works

Inflammaging and the Skin

Pilkington, S. M., Bulfone‐Paus, S., Griffiths, C. E. M., & Watson, R. E. B. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.006 · Cited by 229 · see citing works

Aging of immune system: immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults

Qin, L., Xie, J., Qiu, Z., Cao, W., Jiao, Y., Routy, J., & Li, T. (2016) · Aging · doi:10.18632/aging.100894 · Cited by 218 · see citing works

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1−/Δ7 mice

van der Lugt, B., van Beek, A. A., Aalvink, S., Meijer, B., Sovran, B., Vermeij, W. P., Brandt, R. M. C., de Vos, W. M., Savelkoul, H. F. J., Steegenga, W. T., et al. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0145-z · Cited by 217 · see citing works

Aging is associated with circulating cytokine dysregulation

Álvarez-Rodríguez, L., López-Hoyos, M., Muñoz-Cacho, P., & Martínez-Taboada, V. M. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.01.001 · Cited by 217 · see citing works

When aging reaches CD4+ T-cells: phenotypic and functional changes

Moro‐García, M. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00107 · Cited by 212 · see citing works

Age-related macular degeneration: A two-level model hypothesis

Rozing, M. P., Durhuus, J. A., Nielsen, M. K., Subhi, Y., Kirkwood, T. B. L., Westendorp, R. G., & Sørensen, T. L. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.100825 · Cited by 183 · see citing works

Gain and loss of T cell subsets in old age: age-related reshaping of the T cell repertoire.

Arnold, C. R., Wolf, J., Brunner, S., Herndler-Brandstetter, D., & Grubeck-Loebenstein, B. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9499-x · Cited by 170 · see citing works

Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine

An, D., Na, C., Bielawski, J., Hannun, Y. A., & Kasper, D. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001501107 · Cited by 167 · see citing works

Targeting macrophages rescues age‐related immune deficiencies in C57<scp>BL</scp>/6J geriatric mice

Jackaman, C., Radley‐Crabb, H. G., Soffe, Z., Shavlakadze, T., Grounds, M. D., & Nelson, D. J. (2013) · Aging Cell · doi:10.1111/acel.12062 · Cited by 162 · see citing works

Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03048-x · Cited by 156 · see citing works

The ageing B cell population: Composition and function

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The Decrease in Number and Change in Phenotype of Mucosal‐Associated Invariant T cells in the Elderly and Differences in Men and Women of Reproductive Age

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The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice

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T cell ageing: effects of age on development, survival & function.

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The Aging Immune System and Its Relationship with Cancer

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Reference values for peripheral blood lymphocyte subsets of healthy children in China

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A Role for Immature Myeloid Cells in Immune Senescence

Enioutina, E. Y., Bareyan, D., & Daynes, R. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002987 · Cited by 130 · see citing works

Pathogenic features of CD4+CD28– T cells in immune disorders

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Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease

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The aged lymphoid tissue environment fails to support naïve T cell homeostasis

Becklund, B. R., Purton, J. F., Ramsey, C., Favre, S., Vogt, T. K., Martin, C. E., Spasova, D. S., Sarkisyan, G., LeRoy, E., Tan, J. T., et al. (2016) · Scientific Reports · doi:10.1038/srep30842 · Cited by 126 · see citing works

Kidney Allocation and the Aging Immune Response

Tullius, S. G., & Milford, E. L. (2011) · New England Journal of Medicine · doi:10.1056/nejmc1103007 · Cited by 124 · see citing works

Association of Sex, Age, and Eastern Cooperative Oncology Group Performance Status With Survival Benefit of Cancer Immunotherapy in Randomized Clinical Trials

Yang, F., Markovic, S. N., Molina, J. R., Halfdanarson, T. R., Pagliaro, L. C., Chintakuntlawar, A. V., Li, R., Wei, J., Wang, L., Liu, B., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.12534 · Cited by 122 · see citing works

Pruritus in Elderly Patients—Eruptions of Senescence

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Global Transcriptional Profiling Reveals Distinct Functions of Thymic Stromal Subsets and Age-Related Changes during Thymic Involution

Ki, S., Park, D., Selden, H. J., Seita, J., Chung, H., Kim, J., Iyer, V. R., & Ehrlich, L. I. R. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.070 · Cited by 116 · see citing works

Oral supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 enhances systemic immunity in elderly subjects

Moro‐García, M. A., Alonso‐Arias, R., BALTADJIEVA, M., Benítez, C. F., Barrial, M. A. F., Ruisánchez, E. D., Santos, R. A., Sánchez, M. Á., Miján, J. S., & López‐Larrea, C. (2012) · AGE · doi:10.1007/s11357-012-9434-6 · Cited by 114 · see citing works

Immunosenescence in wild animals: meta‐analysis and outlook

Peters, A., Delhey, K. J. V., Nakagawa, S., Aulsebrook, A. E., & Verhulst, S. (2019) · Ecology Letters · doi:10.1111/ele.13343 · Cited by 101 · see citing works

Autophagy, nutrition and immunology

Cuervo, A. M., & Macián, F. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.09.001 · Cited by 96 · see citing works

Relationship between functional ability in older people, immune system status, and intensity of response to CMV

Moro‐García, M. A., Alonso‐Arias, R., López‐Vázquez, A., Suárez-García, F. M., Solano-Jaurrieta, J. J., Baltar, J., & López‐Larrea, C. (2011) · AGE · doi:10.1007/s11357-011-9240-6 · Cited by 92 · see citing works

Dendritic cells and aging: consequences for autoimmunity

Agrawal, A., Sridharan, A., Prakash, S., & Agrawal, H. (2011) · Expert Review of Clinical Immunology · doi:10.1586/eci.11.77 · Cited by 89 · see citing works

Influenza-Induced Production of Interferon-Alpha is Defective in Geriatric Individuals

Canaday, D. H., Amponsah, N. A., Jones, L., Tisch, D. J., Hornick, T. R., & Ramachandra, L. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9374-9 · Cited by 89 · see citing works

Molecular Mechanisms Involved in the Aging of the T-cell Immune Response

Moro‐García, M. A., Alonso‐Arias, R., & López‐Larrea, C. (2012) · Current Genomics · doi:10.2174/138920212803759749 · Cited by 85 · see citing works

Nutrition, diet and immunosenescence

Maijó, M., Clements, S. J., Ivory, K., Nicoletti, C., & Carding, S. R. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.003 · Cited by 85 · see citing works

Impaired secretion of interferons by dendritic cells from aged subjects to influenza

Prakash, S., Agrawal, S., Cao, J., Gupta, S., & Agrawal, A. (2012) · AGE · doi:10.1007/s11357-012-9477-8 · Cited by 80 · see citing works

Key roles of autophagy in regulating T‐cell function

Botbol, Y. M., Guerrero‐Ros, I., & Macián, F. (2016) · European Journal of Immunology · doi:10.1002/eji.201545955 · Cited by 78 · see citing works

Erythroderma: a prospective study of 309 patients followed for 12 years in a tertiary center

Miyashiro, D., & Sanches, J. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-66040-7 · Cited by 75 · see citing works

Geriatric Dermatology Review: Major Changes in Skin Function in Older Patients and Their Contribution to Common Clinical Challenges

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Mycosis fungoides and Sézary syndrome: clinical presentation, diagnosis, staging, and therapeutic management

Miyashiro, D., & Sanches, J. A. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1141108 · Cited by 73 · see citing works

The Development of Next-generation PBMC Humanized Mice for Preclinical Investigation of Cancer Immunotherapeutic Agents

Morillon, Y. M., Sabzevari, A., Schlom, J., & Greiner, J. W. (2020) · Anticancer Research · doi:10.21873/anticanres.14540 · Cited by 72 · see citing works

The aged nonhematopoietic environment impairs natural killer cell maturation and function

Shehata, H. M., Hoebe, K., & Chougnet, C. A. (2015) · Aging Cell · doi:10.1111/acel.12303 · Cited by 69 · see citing works

The Gut Microbiome, Metformin, and Aging

Induri, S. N. R., Kansara, P., Thomas, S. C., Xu, F., Saxena, D. B., & Li, X. (2021) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051920-093829 · Cited by 66 · see citing works

Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8+ T Cells upon Stimulation with a TLR7 Ligand

Zacca, E. R., Crespo, M. I., Acland, R. P., Roselli, E., Núñez, N. G., Maccioni, M., Maletto, B. A., Pistoresi-Palencia, M. C., & Morón, G. (2015) · PLOS ONE · doi:10.1371/journal.pone.0140672 · Cited by 66 · see citing works

Expression of <i>p16</i>^<i>INK4a</i> as a biomarker of T‐cell aging in HIV‐infected patients prior to and during antiretroviral therapy

Nelson, J. A. E., Krishnamurthy, J., Menezes, P., Liu, Y., Hudgens, M. G., Sharpless, N. E., & Eron, J. J. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00856.x · Cited by 66 · see citing works

Values for αβ and γδ T‐lymphocytes and CD4+, CD8+, and CD56+ subsets in healthy adult subjects: Assessment by age and gender

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Ageing and immunity

Boraschi, D., Giudice, G. D., Dutel, C., Ivanoff, B., Rappuoli, R., & Grubeck‐Loebenstein, B. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.03.035 · Cited by 64 · see citing works

Increased Th17 differentiation in aged mice is significantly associated with high IL-1β level and low IL-2 expression

Lim, M., Lee, J. J., Park, J., Jhun, J., Moon, Y.-M., Cho, M., & Kim, H. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.10.006 · Cited by 63 · see citing works

Sex Steroid Ablation Enhances Hematopoietic Recovery following Cytotoxic Antineoplastic Therapy in Aged Mice

Dudakov, J. A., Goldberg, G. L., Reiseger, J. J., Vlahos, K., Chidgey, A. P., & Boyd, R. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900196 · Cited by 60 · see citing works

Reciprocal interactions between circadian clocks and aging

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Targeted Therapy With Immunoconjugates for Multiple Myeloma

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Factors associated with anti-human leukocyte antigen antibodies in patients supported with continuous-flow devices and effect on probability of transplant and post-transplant outcomes

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Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus

Malloy, A. M. W., Falsey, A. R., & Ruckwardt, T. J. (2013) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-38919-1_11 · Cited by 51 · see citing works

The impact of sex and age on T cell immunity and ischemic stroke outcomes

Ahnstedt, H. W., & McCullough, L. D. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.103960 · Cited by 51 · see citing works

CD8+ T cell differentiation in the aging immune system: until the last clone standing

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The effect of aging on the frequency, phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells: comparison of aged and young subjects

Zhou, M., Zou, R., Gan, H., Liang, Z., Li, F., Lin, T., Yanfei, L., Cai, X., He, F., & Shen, E. (2014) · Immunity & Ageing · doi:10.1186/1742-4933-11-12 · Cited by 46 · see citing works

Impaired Immune Response in Old Mice Suffering from Obesity and Premature Immunosenescence in Adulthood

Hunsche, C., Hernández, O., & la Fuente, M. D. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv082 · Cited by 46 · see citing works

Recipient sex and estradiol levels affect transplant outcomes in an age-specific fashion

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Dietary yeast β-glucan supplementation improves eggshell color and fertile eggs hatchability as well as enhances immune functions in breeder laying hens

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Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging

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Dietary Intake of Resveratrol Enhances the Adaptive Immunity of Aged Rats

Yuan, J., Lu, L., Zhang, Z., & Zhang, S. (2012) · Rejuvenation Research · doi:10.1089/rej.2012.1321 · Cited by 40 · see citing works

Age is not just a number: Naive T cells increase their ability to persist in the circulation over time

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Interruptions of cART limits CD4 T-cell recovery and increases the risk for opportunistic complications and death

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Extrathymic induction of Foxp3 + regulatory T cells declines with age in a T‐cell intrinsic manner

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CD4+ T Cell-Receptor Repertoire Diversity is Compromised in the Spleen but Not in the Bone Marrow of Aged Mice Due to Private and Sporadic Clonal Expansions

Shifrut, E., Baruch, K., Gal, H., Ndifon, W. O., Deczkowska, A., Schwartz, M., & Friedman, N. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00379 · Cited by 37 · see citing works

Management of Itch in the Elderly: A Review

Fourzali, K. M., & Yosipovitch, G. (2019) · Dermatology and Therapy · doi:10.1007/s13555-019-00326-1 · Cited by 36 · see citing works

Cytotoxic T-Cells in Peripheral Blood in Women with Endometriosis

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Aging and HIV infection

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Pubertal and adult windows of susceptibility to a high animal fat diet in Trp53-null mammary tumorigenesis

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Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation

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Pharmacological advantages of melatonin in immunosenescence by improving activity of T lymphocytes

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The Role of IL-17 Signaling in Regulation of the Liver–Brain Axis and Intestinal Permeability in Alcoholic Liver Disease

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Epigenetic Clock and Circadian Rhythms in Stem Cell Aging and Rejuvenation

Samoilova, E. M., Викторович, Б. В., Ekusheva, E. V., Zhang, C., Troitskiy, A. V., & Baklaushev, V. P. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11111050 · Cited by 32 · see citing works

Rejuvenating activity of salidroside (SDS): dietary intake of SDS enhances the immune response of aged rats

Lu, L., Yuan, J., & Zhang, S. (2012) · AGE · doi:10.1007/s11357-012-9394-x · Cited by 31 · see citing works

Septic shock in older people: a prospective cohort study

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IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice

Jackaman, C., Dye, D. E., & Nelson, D. J. (2014) · AGE · doi:10.1007/s11357-014-9655-y · Cited by 30 · see citing works

Age-associated alteration in Th17 cell response is related to endothelial cell senescence and atherosclerotic cerebral infarction.

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Pertussis Circulation Has Increased T-Cell Immunity during Childhood More than a Second Acellular Booster Vaccination in Dutch Children 9 Years of Age

Schure, R., de Rond, L., Öztürk, K., Hendrikx, L. H., Sanders, E. A. M., Berbers, G. A. M., & Buisman, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041928 · Cited by 29 · see citing works

Impaired thymic function and CD4+ T lymphopenia, but not mannose-binding lectin deficiency, are risk factors for Pneumocystis jirovecii pneumonia in kidney transplant recipients

Schürmann, M., Schürmann, D., Schindler, R., Meisel, C., Liman, P., Kruse, J. M., Enghard, P., König, J., Schmidt, D., Reinke, P., et al. (2013) · Transplant Immunology · doi:10.1016/j.trim.2013.05.003 · Cited by 29 · see citing works

Impact of Sex Steroid Ablation on Viral, Tumour and Vaccine Responses in Aged Mice

Heng, T. S. P., Reiseger, J. J., Fletcher, A. L., Leggatt, G. R., White, O. J., Vlahos, K., Frazer, I. H., Turner, S. J., & Boyd, R. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042677 · Cited by 28 · see citing works

The Roles of Immune Memory and Aging in Protective Immunity and Endogenous Reactivation of Tuberculosis

Guzzetta, G., & Kirschner, D. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060425 · Cited by 28 · see citing works

Should the cut‐off values of the lymphocyte to monocyte ratio for prediction of prognosis in diffuse large B ‐cell lymphoma be changed in elderly patients?

Koh, Y. W., Park, C. S., Yoon, D. H., Suh, C., & Huh, J. (2014) · European Journal Of Haematology · doi:10.1111/ejh.12354 · Cited by 27 · see citing works

Extrathymic development of murine T cells after bone marrow transplantation

Holland, A. M., Zakrzewski, J. L., Tsai, J. J.-Y., Hanash, A. M., Dudakov, J. A., Smith, O. M., West, M. L., Singer, N. V., Brill, J., Sun, J. C.-Y., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60630 · Cited by 27 · see citing works

Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques

Hale, L. P., Rajam, G., Carlone, G. M., Jiang, C., Owzar, K., Dugan, G. O., Caudell, D. L., Chao, N. J. A., Cline, J. M., Register, T. C., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210663 · Cited by 26 · see citing works

Antigenic challenge in the etiology of autoimmune disease in women

Rogers, M. A. M., Levine, D. A., Blumberg, N., Fisher, G. G., Kabeto, M. U., & Langa, K. M. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.08.001 · Cited by 26 · see citing works

Impact of the Epstein–Barr virus positivity on Hodgkin's lymphoma in a large cohort from a single institute in Korea

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Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation

Gardner, J. K., Cornwall, S. M. J., Musk, A. W., Alvarez, J., Mamotte, C. D. S., Jackaman, C., Nowak, A. K., & Nelson, D. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195313 · Cited by 26 · see citing works

Enhancement of adaptive immune responses of aged mice by dietary intake of β-glucans, with special emphasis on anti-aging activity

Song, L., Yuan, J., Ni, S., Zhou, Y., Wang, X., Chen, Y., & Zhang, S. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.10.019 · Cited by 25 · see citing works

Antibody dynamics after tick-borne encephalitis and measles–mumps–rubella vaccination in children post early thymectomy

Zlamy, M., Würzner, R., Holzmann, H., Kloss‐Brandstätter, A., Jeller, V., Zimmerhackl, L. B., & Prelog, M. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.10.002 · Cited by 25 · see citing works

Computational simulations to dissect the cell immune response dynamics for severe and critical cases of SARS-CoV-2 infection

Blanco‐Rodríguez, R., Du, X., & Hernandez-Vargas, E. A. (2021) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2021.106412 · Cited by 23 · see citing works

Immunity and the Endocrine System

Stelzer, I. A., & Arck, P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.19001-0 · Cited by 23 · see citing works

Long-Term CD4+ Cell Count in Response to Combination Antiretroviral Therapy

Luz, P. M., Grinsztejn, B. G. J., Velasque, L. D. S., Pacheco, A. G., Veloso, V. G., Moore, R. D., & Struchiner, C. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093039 · Cited by 22 · see citing works

Vaccine-Induced CD8+ T Cell Responses in Children: A Review of Age-Specific Molecular Determinants Contributing to Antigen Cross-Presentation

Beijnen, E. M. S., & van Haren, S. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.607977 · Cited by 22 · see citing works

A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells

Cruz, J. W., Damko, E., Modi, B., Tu, N., Meagher, K. A., Voronina, V. A., Gartner, H., Ehrlich, G. K., Rafique, A., Babb, R., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-48461-1 · Cited by 22 · see citing works

Regulatory T cells and TGF-β1 in clinically localized renal cell carcinoma: Comparison with age-matched healthy controls

Kim, C., Kim, Y., Kwon, T., Yoon, J. H., Kim, K. H., You, D., Hong, J. H., Ahn, H., & Jeong, I. G. (2014) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2014.11.004 · Cited by 21 · see citing works

Characteristics and Outcome of Patients Diagnosed With HIV at Older Age

Asher, I., Mahlab‐Guri, K., Elbirt, D., Bezalel, S. R., Maldarelli, F. M., Mor, O., Grossman, Z., & Sthoeger, Z. M. (2016) · Medicine · doi:10.1097/md.0000000000002327 · Cited by 22 · see citing works

T cell function in the aged: Lessons learned from animal models

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Dysregulation of T-Cell Function in the Elderly

Fülöp, T., Larbi, A., Wikby, A., Mocchegiani, E., Hirokawa, K., & Pawelec, G. (2005) · Drugs & Aging · doi:10.2165/00002512-200522070-00005 · Cited by 122 · see citing works

AGING WITH T CELLS

Pieren, D. K. J. (2021) · doi:10.33540/572

Aging, immunity and cancer

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T cell senescence

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