Fraenkel, Ernest

Transcriptional Regulatory Networks in Saccharomyces cerevisiae

Lee, T. I., Rinaldi, N. J., Robert, F., Odom, D. T., Bar-Joseph, Z., Gerber, G. K., Hannett, N. M., Harbison, C. T., Thompson, C. M., Simon, I., et al. (2002) · Science

Gene Regulatory Network AnalysisFungal and yeast genetics research

Cited by 2,956

The whole-genome landscape of medulloblastoma subtypes

Northcott, P. A., Buchhalter, I., Morrissy, A. S., Hovestadt, V., Weischenfeldt, J., Ehrenberger, T., Gröbner, S., Segura-Wang, M., Zichner, T., Rudneva, V. A., et al. (2017) · Nature

Glioma Diagnosis and TreatmentCancer Genomics and Diagnostics

Cited by 1,112

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature

T-cell and B-cell ImmunologySignaling Pathways in Disease

Cited by 724

Tissue-specific transcriptional regulation has diverged significantly between human and mouse

Odom, D. T., Dowell, R. D., Jacobsen, E. S., Gordon, W., Danford, T. W., MacIsaac, K. D., Rolfe, P. A., Conboy, C. M., Gifford, D. K., & Fraenkel, E. (2007) · Nature Genetics

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 506

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Keenan, A. B., Jenkins, S. L., Jagodnik, K. M., Koplev, S., He, E., Torre, D., Wang, Z., Dohlman, A. B., Silverstein, M. C., Lachmann, A., et al. (2018) · Cell Systems

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

Cited by 423

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Tam, O. H., Rozhkov, N. V., Shaw, R., Kim, D., Hubbard, I., Fennessey, S., Propp, N., Phatnani, H., Kwan, J., Sareen, D., et al. (2019) · Cell Reports

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 327

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

Lim, R. G., Quan, C., Reyes-Ortiz, A. M., Lutz, S. E., Kedaigle, A. J., Gipson, T. A., Wu, J., Vatine, G. D., Stocksdale, J., Casale, M. S., et al. (2017) · Cell Reports

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 253

Developmental alterations in Huntington’s disease neural cells and pharmacological rescue in cells and mice

The HD iPSC Consortium, Lim, R. G., Salazar, L. L., Wilton, D. K., King, A. R., Stocksdale, J. T., Sharifabad, D., Lau, A. L., Stevens, B., Reidling, J. C., et al. (2017) · Nature Neuroscience

Genetic Neurodegenerative DiseasesPluripotent Stem Cells Research

Cited by 221

Revealing disease-associated pathways by network integration of untargeted metabolomics

Pirhaji, L., Milani, P., Leidl, M., Curran, T., Avila-Pacheco, J., Clish, C. B., White, F. M., Saghatelian, A., & Fraenkel, E. (2016) · Nature Methods

Bioinformatics and Genomic NetworksMetabolomics and Mass Spectrometry Studies

Cited by 167

Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation

Lim, R. G., Al-Dalahmah, O., Wu, J., Gold, M. P., Reidling, J. C., Tang, G., Adam, M., Dansu, D. K., Park, H.-J., Casaccia, P., et al. (2022) · Nature Communications

Genetic Neurodegenerative DiseasesNeurogenesis and neuroplasticity mechanisms

Cited by 84

The small molecule, genistein, increases hepcidin expression in human hepatocytes

Zhen, A. W., Nguyen, N. H., Gibert, Y., Motola, S., Buckett, P., Wessling-Resnick, M., Fraenkel, E., & Fraenkel, P. G. (2013) · Hepatology

Iron Metabolism and DisordersPlant Micronutrient Interactions and Effects

Cited by 74

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice

Area-Gomez, E., Larrea, D., Pera, M., Agrawal, R. R., Guilfoyle, D. N., Pirhaji, L., Shannon, K., Arain, H. A., Ashok, A., Chen, Q., et al. (2020) · Scientific Reports

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 55

Adaptive bias correction for improved subseasonal forecasting

Mouatadid, S., Orenstein, P., Flaspohler, G., Cohen, J., Oprescu, M., Fraenkel, E., & Mackey, L. (2023) · Nature Communications

Meteorological Phenomena and SimulationsClimate variability and models

Cited by 54

Subseasonal Prediction of Central European Summer Heatwaves with Linear and Random Forest Machine Learning Models

Weirich-Benet, E., Pyrina, M., Jiménez-Esteve, B., Fraenkel, E., Cohen, J., & Domeisen, D. I. V. (2023) · Artificial Intelligence for the Earth Systems

Climate variability and modelsMeteorological Phenomena and Simulations

Cited by 33

An improved map of conserved regulatory sites for Saccharomyces cerevisiae

MacIsaac, K. D., Wang, T., Gordon, D. B., Gifford, D. K., Stormo, G. D., & Fraenkel, E. (2006) · BMC Bioinformatics

Genomics and Chromatin DynamicsFungal and yeast genetics research

Cited by 9