Debyser, Zeger

HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells

Cherepanov, P., Maertens, G., Proost, P., Devreese, B., Van Beeumen, J., Engelborghs, Y., De Clercq, E., & Debyser, Z. (2003) · Journal of Biological Chemistry

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 704

LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells

Maertens, G., Cherepanov, P., Pluymers, W., Busschots, K., De Clercq, E., Debyser, Z., & Engelborghs, Y. (2003) · Journal of Biological Chemistry

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 493

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

Christ, F., Voet, A., Marchand, A., Nicolet, S., Desimmie, B. A., Marchand, D., Bardiot, D., Van der Veken, N. J., Van Remoortel, B., Strelkov, S. V., et al. (2010) · Nature Chemical Biology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 479

Comparative Analysis of Adeno-Associated Viral Vector Serotypes 1, 2, 5, 7, And 8 in Mouse Brain

Taymans, J.-M., Vandenberghe, L. H., Haute, C. V. D., Thiry, I., Deroose, C. M., Mortelmans, L., Wilson, J. M., Debyser, Z., & Baekelandt, V. (2007) · Human Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 305

The Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding

Busschots, K., Vercammen, J., Emiliani, S., Benarous, R., Engelborghs, Y., Christ, F., & Debyser, Z. (2005) · Journal of Biological Chemistry

HIV Research and TreatmentVirus-based gene therapy research

Cited by 208

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

Heeman, B., Van den Haute, C., Aelvoet, S.-A., Valsecchi, F., Rodenburg, R. J., Reumers, V., Debyser, Z., Callewaert, G., Koopman, W. J. H., Willems, P. H. G. M., et al. (2011) · Journal of Cell Science

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 198

The BET Family of Proteins Targets Moloney Murine Leukemia Virus Integration near Transcription Start Sites

De Rijck, J., de Kogel, C., Demeulemeester, J., Vets, S., El Ashkar, S., Malani, N., Bushman, F. D., Landuyt, B., Husson, S. J., Busschots, K., et al. (2013) · Cell Reports

Virus-based gene therapy researchProtein Degradation and Inhibitors

Cited by 175

Optimized lentiviral vector production and purification procedure prevents immune response after transduction of mouse brain

Baekelandt, V, Eggermont, K., Michiels, M., Nuttin, B., & Debyser, Z. (2003) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 153

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

Desimmie, B. A., Schrijvers, R., Demeulemeester, J., Borrenberghs, D., Weydert, C., Thys, W., Vets, S., Van Remoortel, B., Hofkens, J., De Rijck, J., et al. (2013) · Retrovirology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 139

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV

Vranckx, L. S., Demeulemeester, J., Saleh, S., Boll, A., Vansant, G., Schrijvers, R., Weydert, C., Battivelli, E., Verdin, E., Cereseto, A., et al. (2016) · EBioMedicine

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 113

Viral Entry as the Primary Target for the Anti-HIV Activity of Chicoric Acid and Its Tetra-Acetyl Esters

Pluymers, W., Neamati, N., Pannecouque, C., Fikkert, V., Marchand, C., Burke, T. R., Pommier, Y., Schols, D., De Clercq, E., Debyser, Z., et al. (2000) · Molecular Pharmacology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 111

Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing

Maule, G., Casini, A., Montagna, C., Ramalho, A. S., De Boeck, K., Debyser, Z., Carlon, M. S., Petris, G., & Cereseto, A. (2019) · Nature Communications

CRISPR and Genetic EngineeringCystic Fibrosis Research Advances

Cited by 86

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif

Tesina, P., Čermáková, K., Hořejší, M., Procházková, K., Fábry, M., Sharma, S., Christ, F., Demeulemeester, J., Debyser, Z., Rijck, J. D., et al. (2015) · Nature Communications

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 74

rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice

Vidović, D., Carlon, M. S., da Cunha, M. F., Dekkers, J. F., Hollenhorst, M. I., Bijvelds, M. J. C., Ramalho, A. S., Van den Haute, C., Ferrante, M., Baekelandt, V., et al. (2016) · American Journal of Respiratory and Critical Care Medicine

Cystic Fibrosis Research AdvancesVirus-based gene therapy research

Cited by 74

Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection

Demeulemeester, J., De Rijck, J., Gijsbers, R., & Debyser, Z. (2015) · BioEssays

Virus-based gene therapy researchHIV Research and Treatment

Cited by 71

Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells

Bulcaen, M., Kortleven, P., Liu, R. B., Maule, G., Dreano, E., Kelly, M., Ensinck, M. M., Thierie, S., Smits, M., Ciciani, M., et al. (2024) · Cell Reports Medicine

Cystic Fibrosis Research AdvancesCRISPR and Genetic Engineering

Cited by 69

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase–LEDGF/p75 interaction

Serrao, E., Xu, Z.-L., Debnath, B., Christ, F., Debyser, Z., Long, Y.-Q., & Neamati, N. (2013) · Bioorganic & Medicinal Chemistry

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 47

HIV-1 Integrase Variants Retarget Viral Integration and Are Associated with Disease Progression in a Chronic Infection Cohort

Demeulemeester, J., Vets, S., Schrijvers, R., Madlala, P., De Maeyer, M., De Rijck, J., Ndung’u, T., Debyser, Z., & Gijsbers, R. (2014) · Cell Host & Microbe

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 43

GS-9822, a Preclinical LEDGIN Candidate, Displays a Block-and-Lock Phenotype in Cell Culture

Bruggemans, A., Vansant, G., Balakrishnan, M., Mitchell, M. L., Cai, R., Christ, F., & Debyser, Z. (2021) · Antimicrobial Agents and Chemotherapy

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 35

Single-cell imaging shows that the transcriptional state of the HIV-1 provirus and its reactivation potential depend on the integration site

Janssens, J., De Wit, F., Parveen, N., & Debyser, Z. (2022) · mBio

HIV Research and TreatmentVirus-based gene therapy research

Cited by 28

Immunological Ignorance Allows Long-Term Gene Expression After Perinatal Recombinant Adeno-Associated Virus-Mediated Gene Transfer to Murine Airways

Carlon, M. S., Vidović, D., Dooley, J., da Cunha, M. M., Maris, M., Lampi, Y., Toelen, J., Van den Haute, C., Baekelandt, V., Deprest, J., et al. (2014) · Human Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 19

New scaffolds of natural origin as Integrase–LEDGF/p75 interaction inhibitors: Virtual screening and activity assays

De Luca, L., Morreale, F., Christ, F., Debyser, Z., Ferro, S., & Gitto, R. (2013) · European Journal of Medicinal Chemistry

Computational Drug Discovery MethodsHIV/AIDS drug development and treatment

Cited by 17

New latency-promoting agents for a block-and-lock functional cure strategy

Pellaers, E., Denis, A., & Debyser, Z. (2024) · Current Opinion in HIV and AIDS

HIV Research and TreatmentVirus-based gene therapy research

Cited by 13