Khaitovich, Philipp

The evolution of gene expression levels in mammalian organs

Brawand, D., Soumillon, M., Necsulea, A., Julien, P., Csárdi, G., Harrigan, P., Weier, M., Liechti, A., Aximu-Petri, A., Kircher, M., et al. (2011) · Nature

Genomics and Phylogenetic StudiesChromosomal and Genetic Variations

Cited by 1,248

Gene expression across mammalian organ development

Cardoso-Moreira, M., Halbert, J., Valloton, D., Velten, B., Chen, C., Shao, Y., Liechti, A., Ascenção, K., Rummel, C., Ovchinnikova, S., et al. (2019) · Nature

Developmental Biology and Gene RegulationGenomics and Phylogenetic Studies

Cited by 838

A genome-wide comparison of recent chimpanzee and human segmental duplications

Cheng, Z., Ventura, M., She, X., Khaitovich, P., Graves, T., Osoegawa, K., Church, D., DeJong, P., Wilson, R. K., Pääbo, S., et al. (2005) · Nature

Genomic variations and chromosomal abnormalitiesChromosomal and Genetic Variations

Cited by 398

Evolution of primate gene expression

Khaitovich, P., Enard, W., Lachmann, M., & Pääbo, S. (2006) · Nature Reviews Genetics

Evolution and Genetic DynamicsChromosomal and Genetic Variations

Cited by 341

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain

Somel, M., Guo, S., Fu, N., Yan, Z., Hu, H. Y., Xu, Y., Yuan, Y., Ning, Z., Hu, Y., Menzel, C., et al. (2010) · Genome Research

Genetics, Aging, and Longevity in Model OrganismsMicroRNA in disease regulation

Cited by 297

Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway

Jin, C., Li, J., Green, C. D., Yu, X., Tang, X., Han, D., Xian, B., Wang, D., Huang, X., Cao, X., et al. (2011) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 258

Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques

Liu, X., Somel, M., Tang, L., Yan, Z., Jiang, X., Guo, S., Yuan, Y., He, L., Oleksiak, A., Zhang, Y., et al. (2012) · Genome Research

Genetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanisms

Cited by 251

MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates

Somel, M., Liu, X., Tang, L., Yan, Z., Hu, H., Guo, S., Jiang, X., Zhang, X., Xu, G., Xie, G., et al. (2011) · PLoS Biology

MicroRNA in disease regulationDevelopmental Biology and Gene Regulation

Cited by 232

Widespread splicing changes in human brain development and aging

Mazin, P., Xiong, J., Liu, X., Yan, Z., Zhang, X., Li, M., He, L., Somel, M., Yuan, Y., Phoebe Chen, Y., et al. (2013) · Molecular Systems Biology

RNA Research and SplicingRNA regulation and disease

Cited by 216

Aging and Gene Expression in the Primate Brain

Fraser, H. B., Khaitovich, P., Plotkin, J. B., Pääbo, S., & Eisen, M. B. (2005) · PLoS Biology

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 172

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

Tyshkovskiy, A., Bozaykut, P., Borodinova, A. A., Gerashchenko, M. V., Ables, G. P., Garratt, M., Khaitovich, P., Clish, C. B., Miller, R. A., & Gladyshev, V. N. (2019) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 167

Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains

Khrameeva, E., Kurochkin, I., Han, D., Guijarro, P., Kanton, S., Santel, M., Qian, Z., Rong, S., Mazin, P., Sabirov, M., et al. (2020) · Genome Research

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 162

MicroRNA Expression and Regulation in Human, Chimpanzee, and Macaque Brains

Hu, H. Y., Guo, S., Xi, J., Yan, Z., Fu, N., Zhang, X., Menzel, C., Liang, H., Yang, H., Zhao, M., et al. (2011) · PLoS Genetics

MicroRNA in disease regulationChromosomal and Genetic Variations

Cited by 130

Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging

Wei, Y.-N., Hu, H.-Y., Xie, G.-C., Fu, N., Ning, Z.-B., Zeng, R., & Khaitovich, P. (2015) · Genome Biology

Genetics, Aging, and Longevity in Model OrganismsRNA Research and Splicing

Cited by 117

Lineage-Specific Expansions of Retroviral Insertions within the Genomes of African Great Apes but Not Humans and Orangutans

Yohn, C. T., Jiang, Z., McGrath, S. D., Hayden, K. E., Khaitovich, P., Johnson, M. E., Eichler, M. Y., McPherson, J. D., Zhao, S., Pääbo, S., et al. (2005) · PLoS Biology

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 104

Exceptional Evolutionary Divergence of Human Muscle and Brain Metabolomes Parallels Human Cognitive and Physical Uniqueness

Bozek, K., Wei, Y., Yan, Z., Liu, X., Xiong, J., Sugimoto, M., Tomita, M., Pääbo, S., Pieszek, R., Sherwood, C. C., et al. (2014) · PLoS Biology

Metabolomics and Mass Spectrometry StudiesPrimate Behavior and Ecology

Cited by 93

Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism

Liu, X., Han, D., Somel, M., Jiang, X., Hu, H., Guijarro, P., Zhang, N., Mitchell, A., Halene, T., Ely, J. J., et al. (2016) · PLOS Biology

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 87

Metabolome signature of autism in the human prefrontal cortex

Kurochkin, I., Khrameeva, E., Tkachev, A., Stepanova, V., Vanyushkina, A., Stekolshchikova, E., Li, Q., Zubkov, D., Shichkova, P., Halene, T., et al. (2019) · Communications Biology

Autism Spectrum Disorder ResearchMetabolomics and Mass Spectrometry Studies

Cited by 57

A Chronological Atlas of Natural Selection in the Human Genome during the Past Half-million Years

Zhou, H., Hu, S., Matveev, R., Yu, Q., Li, J., Khaitovich, P., Jin, L., Lachmann, M., Stoneking, M., Fu, Q., et al. (2015) · bioRxiv (Cold Spring Harbor Laboratory)

Forensic and Genetic ResearchPleistocene-Era Hominins and Archaeology

Cited by 28