Aging and Gene Expression in the Primate Brain
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It is well established that gene expression levels in many organisms change during the aging process, and the advent of DNA microarrays has allowed genome-wide patterns of transcriptional changes associated with aging to be studied in both model organisms and various human tissues. Understanding the effects of aging on gene expression in the human brain is of particular interest, because of its relation to both normal and pathological neurodegeneration. Here we show that human cerebral cortex, human cerebellum, and chimpanzee cortex each undergo different patterns of age-related gene expression alterations. In humans, many more genes undergo consistent expression changes in the cortex than in the cerebellum; in chimpanzees, many genes change expression with age in cortex, but the pattern of changes in expression bears almost no resemblance to that of human cortex. These results demonstrate the diversity of aging patterns present within the human brain, as well as how rapidly genome-wide patterns of aging can evolve between species; they may also have implications for the oxidative free radical theory of aging, and help to improve our understanding of human neurodegenerative diseases.
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Gene expression profiling studies of ageing mouse, rat, monkey and human brains have shown significant changes in the expression of synaptic genes.
“Gene expression profiling studies of ageing mouse, rat, monkey and human brains have shown significant changes in the expression of synaptic genes (7–13).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [11]
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- Authors
- Fraser, H. B., Khaitovich, P., Plotkin, J. B., Pääbo, S., & Eisen, M. B.
- Affiliations
- University of California, Berkeley (US)
- Max Planck Society (DE)
- Harvard University (US)
- Lawrence Berkeley National Laboratory (US)
- Corresponding author
- Fraser, Hunter B
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2005-08-02
- Volume
- 3
- Issue
- 9
- Pages
- e274
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC1181540
- OpenAlex
- W2090054883
- Cited by
- 172
- References
- 36
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 13 · 2018: 8 · 2017: 9 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 14 · 2012: 13
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of North Texas Digital Library (University of North Texas) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, cc-by)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Keywords
- brain aging, age-related gene expression, cerebral cortex, cerebellum, comparative genomics, neurodegeneration, gene expression changes, human brain evolution
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Animals, Cerebellum, Cerebral Cortex, Pan troglodytes, Humans, Middle Aged, Species Specificity, Gene Expression, Oligonucleotide Array Sequence Analysis
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