Dietary restriction: standing up for sirtuins
Open accessAbstract
We believe that L. Fontana, L. Partridge, and V. D. Longo should have included a\ndiscussion of sirtuins in their Review “Extending healthy life span—From yeast to humans”\n(16 April, p. 321). We also believe that some of the references used are misleading.\nThe authors state that the purpose of their Review is to “consider the role of nutrient-sensing\nsignaling pathways in mediating the beneficial effects of dietary restriction.” Yet there was\nno mention of the sirtuins, a family of critically important nutrient-sensing proteins that\npromote health span from yeast to mammals, as shown by more than 1000 peer-reviewed\npublications from labs around the world. The authors state that “[i]t is unlikely that a single,\nlinear pathway mediates the effects of dietary restriction in any organism,” and we agree.\nIndeed, the aging field now recognizes that healthy life span is under the influence of several\nnutrient-sensing pathways, and there is at least as much evidence for the involvement of\nsirtuins in the dietary restriction response as for any of the pathways discussed in the Review.
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Ageing delaying interventions such as CR, exercise or nutraceuticals as resveratrol induce mitochondrial biogenesis in humans and other organisms.
“ageing delaying interventions such as CR, exercise or nutraceuticals as resveratrol also induce mitochondrial biogenesis in humans and other organisms (Baur et al., 2010; Feige et al., 2008; Rodriguez-Bies et al., 2015).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Baur et al., 2010
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Cites
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- Authors
- Baur, J. A., Chen, D., Chini, E. N., Chua, K., Cohen, H. Y., Cabo, R. D., Deng, C., Dimmeler, S., Gius, D., Guarente, L. P., Helfand, S. L., Imai, S.-I., Itoh, H., Kadowaki, T., Koya, D., Leeuwenburgh, C., McBurney, M., Nabeshima, Y.-I., Neri, C., Oberdoerffer, P., Pestell, R. G., Rogina, B., Sadoshima, J., Sartorelli, V., Serrano, M., Sinclair, D. A., Steegborn, C., Tatar, M., Tissenbaum, H. A., Tong, Q., Tsubota, K., Vaquero, A., & Verdin, E.
- Affiliations
- University of Pennsylvania (US)
- University of California, Berkeley (US)
- Mayo Clinic (US)
- Stanford University (US)
- Bar-Ilan University (IL)
- National Institutes of Health (US)
- Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health, Bethesda, MD 20892, USA.
- Goethe University Frankfurt (DE)
- Vanderbilt University Medical Center (US)
- Massachusetts Institute of Technology (US)
- Brown University (US)
- Washington University in St. Louis (US)
- Keio University (JP)
- The University of Tokyo (JP)
- Kanazawa Medical University (JP)
- University of Florida (US)
- Department of Medicine and Biochemistry, Ottawa Health Research Institute, Ottawa, ON K1H 8L6, Canada.
- Foundation for Biomedical Research and Innovation (JP)
- INSERM, Unit 894, Laboratory of Neuronal Cell Biology and Pathology, 75014 Paris, France.
- Thomas Jefferson University (US)
- UConn Health (US)
- University of Medicine and Dentistry of New Jersey (US)
- Spanish National Cancer Research Centre (ES)
- Harvard University (US)
- University of Bayreuth (DE)
- University of Massachusetts Chan Medical School (US)
- Baylor College of Medicine (US)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- University of California, San Francisco (US)
- Corresponding author
- Guarente, Leonard P.
- Tatar, Marc
- ORCID
- Baur, Joseph A.
- Chen, Danica
- Chini, Eduardo N.
- Chua, Katrin
- Cohen, Haim Y.
- Cabo, Rafael de
- Dimmeler, Stefanie
- Gius, David
- Guarente, Leonard P.
- Imai, Shin-Ichiro
- Itoh, Hiroshi
- Kadowaki, Takashi
- Koya, Daisuke
- Leeuwenburgh, Christiaan
- McBurney, Michael
- Nabeshima, Yo-Ichi
- Oberdoerffer, Philipp
- Pestell, Richard G.
- Rogina, Blanka
- Sadoshima, Junichi
- Sartorelli, Vittorio
- Serrano, Manuel
- Sinclair, David A.
- Steegborn, Clemens
- Tatar, Marc
- Tong, Qiang
- Tsubota, Kazuo
- Vaquero, Alejandro
- Verdin, Eric
- Venue
- Science
- Published
- 2010-08-27
- Volume
- 329
- Issue
- 5995
- Pages
- 1012-1013
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3985480
- OpenAlex
- W1977043983
- Cited by
- 76
- References
- 11
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 7 · 2015: 5 · 2014: 9 · 2013: 12 · 2012: 8
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, public-domain)
- PMC
- Funders
- National Institutes of Health (Z99 DK999999)
- National Institute on Aging (P01AG027916, R01AG023039, R37AG024360, R01AG024360, R01AG028730, R01AG019719, R01AG023088, R00AG031182, P30AG028740)
- National Heart, Lung, and Blood Institute (R01HL067724, R01HL102738, R01HL091469)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- dietary restriction, sirtuins, lifespan extension, aging, longevity
- MeSH terms
- Aging, Animals, Humans, Longevity, Signal Transduction, Caloric Restriction, Sirtuins
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