NAD+ in COVID-19 and viral infections

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884 · see citing works

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263 · see citing works

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683 · see citing works

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

Patel, A., Lee, H. O., Jawerth, L. M., Maharana, S., Jahnel, M., Hein, M. Y., Stoynov, S., Mahamid, J., Saha, S., Franzmann, T. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.047 · Cited by 2,927 · see citing works

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750 · see citing works

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

Zhu, L., She, Z., Cheng, X., Qin, J., Zhang, X.-J., Cai, J., Lei, F., Wang, H., Xie, J., Wang, W., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.021 · Cited by 1,613 · see citing works

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482 · see citing works

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S.-I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.014 · Cited by 1,340 · see citing works

NAD ⁺ in aging, metabolism, and neurodegeneration

Verdin, E. (2015) · Science · doi:10.1126/science.aac4854 · Cited by 1,319 · see citing works

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.022 · Cited by 1,238 · see citing works

Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19

Herold, T., Jurinovic, V., Arnreich, C., Lipworth, B. J., Hellmuth, J. C., von Bergwelt-Baildon, M., Klein, M., & Weinberger, T. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.05.008 · Cited by 1,161 · see citing works

Why does COVID-19 disproportionately affect older people?

Mueller, A. L., McNamara, M. S., & Sinclair, D. A. (2020) · Aging · doi:10.18632/aging.103344 · Cited by 1,128 · see citing works

COVID-19: combining antiviral and anti-inflammatory treatments

Stebbing, J., Phelan, A., Griffin, I., Tucker, C., Oechsle, O., Smith, D., & Richardson, P. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30132-8 · Cited by 1,117 · see citing works

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

Kawahara, T. L. A., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., McCord, R. A., Ongaigui, K. C. L., Boxer, L. D., Chang, H. Y., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.052 · Cited by 1,090 · see citing works

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, M. E., Apte, R. S., Uchida, K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.013 · Cited by 930 · see citing works

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

Camacho-Pereira, J., Tarragó, M. G., Chini, C. C. S., Nin, V., Escande, C., Warner, G. M., Puranik, A. S., Schoon, R. A., Reid, J. M., Galina, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.006 · Cited by 901 · see citing works

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Rajman, L., Chwalek, K., & Sinclair, D. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.011 · Cited by 865 · see citing works

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Rodrigues, T. S., de Sá, K. S. G., Ishimoto, A. Y., Becerra, A., Oliveira, S., Almeida, L., Gonçalves, A. V., Perucello, D. B., Andrade, W. A., Castro, R., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201707 · Cited by 839 · see citing works

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

Bai, P., Cantó, C., Oudart, H., Brunyánszki, A., Cen, Y., Thomas, C., Yamamoto, H., Huber, A., Kiss, B., Houtkooper, R. H., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.004 · Cited by 837 · see citing works

Salidroside Attenuates Ventilation Induced Lung Injury via SIRT1-Dependent Inhibition of NLRP3 Inflammasome

Wang, Y., Xu, C.-F., Liu, Y.-J., Mao, Y.-F., Lv, Z., Li, S.-Y., Zhu, X.-Y., & Jiang, L. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477112 · Cited by 825 · see citing works

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

Jiang, H., Khan, S., Wang, Y., Charron, G., He, B., Sebastian, C., Du, J., Kim, R., Ge, E., Mostoslavsky, R., et al. (2013) · Nature · doi:10.1038/nature12038 · Cited by 697 · see citing works

The SARM1 toll/interleukin-1 receptor domain possesses intrinsic NAD(+) cleavage activity that promotes pathological axonal degeneration

Essuman, K., Summers, D. W., Sasaki, Y., Mao, X., DiAntonio, A., & Milbrandt, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.022 · Cited by 619 · see citing works

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Martens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-03421-7 · Cited by 588 · see citing works

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

Altmeyer, M., Neelsen, K. J., Teloni, F., Pozdnyakova, I., Pellegrino, S., Grøfte, M., Rask, M., Streicher, W. W., Jungmichel, S., Nielsen, M. L., et al. (2015) · Nature Communications · doi:10.1038/ncomms9088 · Cited by 581 · see citing works

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

Liu, L., Su, X., Quinn, W. J., Hui, S., Krukenberg, K., Frederick, D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.018 · Cited by 564 · see citing works

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

Nieto-Torres, J. L., DeDiego, M. L., Verdiá-Báguena, C., Jiménez-Guardeño, J. M., Regla-Nava, J. Á., Fernández‐Delgado, R., Castaño-Rodríguez, C., Alcaraz, A., Torres, J., Aguilella, V. M., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004077 · Cited by 560 · see citing works

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

Chen, I.-Y., Moriyama, M., Chang, M., & Ichinohe, T. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00050 · Cited by 548 · see citing works

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042357 · Cited by 545 · see citing works

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

Nieto-Torres, J. L., Verdiá-Báguena, C., Jiménez-Guardeño, J. M., Regla-Nava, J. Á., Castaño-Rodríguez, C., Fernández‐Delgado, R., Torres, J., Aguilella, V. M., & Enjuanes, L. (2015) · Virology · doi:10.1016/j.virol.2015.08.010 · Cited by 506 · see citing works

Severe acute respiratory syndrome Coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3‐dependent ubiquitination of ASC

Siu, K., Yuen, K., Castaño-Rodríguez, C., Ye, Z., Yeung, M. L., Fung, S., Yuan, S., Chan, C., Yuen, K., Enjuanes, L., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802418r · Cited by 504 · see citing works

NAD(+) in aging: molecular mechanisms and translational implications

Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.08.001 · Cited by 501 · see citing works

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

Minhas, P. S., Liu, L., Moon, P. K., Joshi, A. U., Dove, C., Mhatre, S., Contrepois, K., Wang, Q., Lee, B. A., Coronado, M., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0255-3 · Cited by 501 · see citing works

Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging

Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L.-J., Osborne, B., Joshi, S., Lu, Y., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.008 · Cited by 496 · cited 1× · see citing works

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Pan, P., Shen, M., Yu, Z., Ge, W., Chen, K., Tian, M., Xiao, F., Wang, Z., Wang, J., Jia, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25015-6 · Cited by 496 · see citing works

Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases

Kane, A. E., & Sinclair, D. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312498 · Cited by 490 · see citing works

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

Elhassan, Y. S., Kluckova, K., Fletcher, R. S., Schmidt, M. S., Garten, A., Doig, C. L., Cartwright, D. M., Oakey, L., Burley, C. V., Jenkinson, N., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.043 · Cited by 448 · see citing works

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S.-I., et al. (2021) · Science · doi:10.1126/science.abe9985 · Cited by 439 · see citing works

De novo NAD+ synthesis enhances mitochondrial function and improves health

Katsyuba, E., Mottis, A., Ziętak, M., Franco, F., van der Velpen, V., Gariani, K., Ryu, D., Cialabrini, L., Matilainen, O., Liscio, P., et al. (2018) · Nature · doi:10.1038/s41586-018-0645-6 · Cited by 436 · see citing works

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

He, M., Chiang, H.-H., Luo, H., Zheng, Z., Qiao, Q., Wang, L., Tan, M., Ohkubo, R., Mu, W.-C., Zhao, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.009 · Cited by 425 · see citing works

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

Leung, A. K. L., Vyas, S., Rood, J., Bhutkar, A. J., Sharp, P. A., & Chang, P. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.015 · Cited by 420 · see citing works

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

Covarrubias, A. J., Kale, A., Perrone, R., Lopez-Dominguez, J. A., Pisco, A. O., Kasler, H. G., Schmidt, M. S., Heckenbach, I., Kwok, R., Wiley, C. D., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00305-3 · Cited by 420 · see citing works

SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes

Shi, C.-S., Nabar, N. R., Huang, N., & Kehrl, J. H. (2019) · Cell Death Discovery · doi:10.1038/s41420-019-0181-7 · Cited by 402 · see citing works

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

Picciotto, N. E., Gano, L. B., Johnson, L. C., Martens, C. R., Sindler, A. L., Mills, K. F., Imai, S., & Seals, D. R. (2016) · Aging Cell · doi:10.1111/acel.12461 · Cited by 396 · see citing works

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

Tarragó, M. G., Chini, C. C. S., Kanamori, K. S., Warner, G. M., Caride, A., de Oliveira, G. C., Rud, M., Samani, A., Hein, K. Z., Huang, R., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.016 · Cited by 384 · see citing works

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

Frederick, D. W., Loro, E., Liu, L., Davila, A., Chellappa, K., Silverman, I. M., Quinn, W. J., Gosai, S. J., Tichy, E. D., Davis, J. G., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.005 · Cited by 367 · see citing works

Translation inhibition and stress granules in the antiviral immune response

McCormick, C., & Khaperskyy, D. A. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.63 · Cited by 354 · see citing works

Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis

Castaño-Rodríguez, C., Honrubia, J. M., Gutierrez-Alvarez, F. J., DeDiego, M. L., Nieto-Torres, J. L., Jiménez-Guardeño, J. M., Regla-Nava, J. Á., Fernández‐Delgado, R., Verdiá-Báguena, C., Queralt-Martín, M., et al. (2018) · mBio · doi:10.1128/mbio.02325-17 · Cited by 311 · see citing works

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

Trammell, S. A. J., Weidemann, B. J., Chadda, A., Yorek, M. S., Holmes, A., Coppey, L. J., Obrosov, A., Kardon, R. H., Yorek, M. A., & Brenner, C. (2016) · Scientific Reports · doi:10.1038/srep26933 · Cited by 301 · see citing works

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation

Zhu, Y., Chen, G., Lv, F., Wang, X., Ji, X., Xu, Y., Sun, J., Wu, L. J., Zheng, Y., & Gao, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101676108 · Cited by 300 · see citing works

An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19

Ge, Y., Tian, T., Huang, S., Wan, F., Li, J., Li, S., Wang, X., Yang, H., Hong, L., Wu, N., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00568-6 · Cited by 300 · see citing works

Slc12a8 is a nicotinamide mononucleotide transporter

Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Cunningham, R., Sasaki, Y., Migaud, M. E., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0009-4 · Cited by 287 · cited 1× · see citing works

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

Iwata, H., Goettsch, C., Sharma, A., Ricchiuto, P., Goh, W. W. B., Halu, A., Yamada, I., Yoshida, H., Hara, T., Wei, M., et al. (2016) · Nature Communications · doi:10.1038/ncomms12849 · Cited by 283 · see citing works

Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

Xiao, N., Nie, M., Pang, H., Wang, B.-H., Hu, J.-L., Meng, X., Li, K., Ran, X.-R., Long, Q.-X., Deng, H.-J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21907-9 · Cited by 257 · see citing works

Inhibition of Hepatitis B Virus Replication by the Host Zinc Finger Antiviral Protein

Mao, R., Nie, H., Cai, D., Zhang, J., Liu, H., Yan, R., Cuconati, A., Block, T. M., Guo, J., & Guo, H. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003494 · Cited by 241 · see citing works

NAD + Repletion Reverses Heart Failure With Preserved Ejection Fraction

Tong, D., Schiattarella, G. G., Jiang, N., Altamirano, F. J., Szweda, P. A., Elnwasany, A., Lee, D. I., Yoo, H., Kass, D. A., Szweda, L. I., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.317046 · Cited by 240 · see citing works

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection

Fehr, A. R., Channappanavar, R., Jankevicius, G., Fett, C., Zhao, J., Athmer, J., Meyerholz, D. K., Ahel, I., & Perlman, S. M. (2016) · mBio · doi:10.1128/mbio.01721-16 · Cited by 234 · see citing works

Inhibition of Filovirus Replication by the Zinc Finger Antiviral Protein

Müller, S., Möller, P., Bick, M. J., Wurr, S., Becker, S., Günther, S., & Kümmerer, B. M. (2006) · Journal of Virology · doi:10.1128/jvi.01601-06 · Cited by 210 · see citing works

Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes

Hallakou‐Bozec, S., Vial, G., Kergoat, M., Fouqueray, P., Bolze, S., Borel, A., Fontaine, E. M., & Moller, D. E. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14277 · Cited by 208 · see citing works

Structural Basis of Severe Acute Respiratory Syndrome Coronavirus ADP-Ribose-1″-Phosphate Dephosphorylation by a Conserved Domain of nsP3

Saikatendu, K. S., Joseph, J. S., Subramanian, V., Clayton, T., Griffith, M. T., Moy, K., Velasquez, J., Neuman, B. W., Buchmeier, M. J., Stevens, R. C., et al. (2005) · Structure · doi:10.1016/j.str.2005.07.022 · Cited by 201 · see citing works

The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression

Grunewald, M. E., Chen, Y., Kuny, C. V., Maejima, T., Lease, R., Ferraris, D. V., Aikawa, M., Sullivan, C. S., Perlman, S. M., & Fehr, A. R. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007756 · Cited by 201 · see citing works

Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6

Tsilioni, I., Taliou, A., Francis, K., & Theoharides, T. C. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.142 · Cited by 199 · see citing works

Hepatic NAD+ deficiency as a therapeutic target for non‐alcoholic fatty liver disease in ageing

Zhou, C., Yang, X., Hua, X., Liu, J., Fan, M.-B., Li, G., Song, J., Xu, T., Li, Z., Guan, Y., et al. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13513 · Cited by 198 · see citing works

The Plasma NAD + Metabolome Is Dysregulated in “Normal” Aging

Clement, J., Wong, M. W. K., Poljak, A., Sachdev, P. S., & Braidy, N. (2018) · Rejuvenation Research · doi:10.1089/rej.2018.2077 · Cited by 196 · see citing works

Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity

Heer, C. D., Sanderson, D. J., Voth, L. S., Alhammad, Y. M. O., Schmidt, M. S., Trammell, S. A. J., Perlman, S., Cohen, M. S., Fehr, A. R., & Brenner, C. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015138 · Cited by 192 · see citing works

A conserved NAD + binding pocket that regulates protein-protein interactions during aging

Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J. Y., Rajman, L. A., Qin, B., Lou, Z., Gorbunova, V. A., et al. (2017) · Science · doi:10.1126/science.aad8242 · Cited by 188 · see citing works

Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects

Traba, J., Kwarteng-Siaw, M., Okoli, T. C., Li, J., Huffstutler, R. D., Bray, A., Waclawiw, M. A., Han, K., Pelletier, M., Sauve, A. A., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83260 · Cited by 180 · see citing works

Interferon-Stimulated Poly(ADP-Ribose) Polymerases Are Potent Inhibitors of Cellular Translation and Virus Replication

Atasheva, S., Frolova, E. I., & Frolov, I. V. (2013) · Journal of Virology · doi:10.1128/jvi.03443-13 · Cited by 179 · see citing works

SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway

Xu, H., Akinyemi, I. A., Chitre, S., Loeb, J. C., Lednicky, J. A., McIntosh, M. T., & Bhaduri‐McIntosh, S. (2022) · Virology · doi:10.1016/j.virol.2022.01.003 · Cited by 178 · see citing works

Boosting NAD+ with a small molecule that activates NAMPT

Gardell, S. J., Hopf, M., Khan, A., Dispagna, M., Hampton Sessions, E., Falter, R., Kapoor, N., Brooks, J., Culver, J., Petucci, C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11078-z · Cited by 169 · see citing works

Observations on Mortality during the 1918 Influenza Pandemic

Luk, J., Gross, P. A., & Thompson, W. (2001) · Clinical Infectious Diseases · doi:10.1086/322662 · Cited by 159 · see citing works

Obesity Is Associated With Low NAD+/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins

Jukarainen, S., Heinonen, S., Rämö, J. T., Rinnankoski‐Tuikka, R., Rappou, E., Tümmers, M., Muniandy, M., Hakkarainen, A., Lundbom, J., Lundbom, N. M. I., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3095 · Cited by 152 · see citing works

The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease

Figley, M. D., & DiAntonio, A. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.02.012 · Cited by 145 · see citing works

Sirtuins Are Evolutionarily Conserved Viral Restriction Factors

Koyuncu, E., Budayeva, H. G., Miteva, Y., Ricci, D. P., Silhavy, T. J., Shenk, T. E., & Cristea, I. M. (2014) · mBio · doi:10.1128/mbio.02249-14 · Cited by 144 · see citing works

ADP-ribosyl–binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Abraham, R., Hauer, D., McPherson, R. L., Utt, A., Kirby, I. T., Cohen, M. S., Merits, A., Leung, A. K. L., & Griffin, D. E. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812130115 · Cited by 142 · see citing works

New PARP Gene with an Anti-Alphavirus Function

Atasheva, S., Akhrymuk, M., Frolova, E. I., & Frolov, I. V. (2012) · Journal of Virology · doi:10.1128/jvi.00733-12 · Cited by 139 · see citing works

Discovery, synthesis, and biological evaluation of thiazoloquin(az)olin(on)es as potent CD38 inhibitors

Haffner, C. D., Becherer, J. D., Boros, E. E., Cadilla, R., Carpenter, T., Cowan, D., Deaton, D. N., Guo, Y., Harrington, W., Henke, B. R., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm502009h · Cited by 137 · see citing works

The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase

Alhammad, Y. M. O., Kashipathy, M. M., Roy, A., Gagné, J., McDonald, P. R., Gao, P., Nonfoux, L., Battaile, K. P., Johnson, D. K., Holmstrom, E. D., et al. (2020) · Journal of Virology · doi:10.1128/jvi.01969-20 · Cited by 137 · see citing works

Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis

Jijon, H. B., Churchill, T. A., Malfair, D., Wessler, A., Jewell, L. D., Parsons, H. G., & Madsen, K. L. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.3.g641 · Cited by 135 · see citing works

The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition

Goodier, J. L., Pereira, G., Cheung, L. E., Rose, R. J., & Kazazian, H. H. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005252 · Cited by 131 · see citing works

Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies

Raaben, M., Koerkamp, M. J. A. G., Rottier, P. J. M., & de Haan, C. A. M. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00951.x · Cited by 123 · see citing works

Gene Knockout or Pharmacological Inhibition of Poly(ADP-Ribose) Polymerase-1 Prevents Lung Inflammation in a Murine Model of Asthma

Boulares, A. H., Zoltoski, A. J., Sherif, Z. A., Jolly, P. S., Massaro, D. J., & Smulson, M. E. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2001-0015oc · Cited by 123 · see citing works

Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3

Frick, D. N., Virdi, R. S., Vuksanovic, N., Dahal, N., & Silvaggi, N. R. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00309 · Cited by 115 · see citing works

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

Russo, L. C., Tomasin, R., Matos, I. D. A., Manucci, A. C., Sowa, S. T., Dale, K. L., Caldecott, K. W., Lehtiö, L., Schechtman, D., Meotti, F. C., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101041 · Cited by 115 · see citing works

The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation

Alhammad, Y. M. O., & Fehr, A. R. (2020) · Viruses · doi:10.3390/v12040384 · Cited by 110 · see citing works

Healthy aging and muscle function are positively associated with NAD+ abundance in humans

Janssens, G. E., Grevendonk, L., Perez, R. Z., Schomakers, B. V., de Vogel-van den Bosch, J., Geurts, J. M. W., van Weeghel, M., Schrauwen, P., Houtkooper, R. H., & Hoeks, J. (2022) · Nature Aging · doi:10.1038/s43587-022-00174-3 · Cited by 103 · see citing works

SIRT1 Alleviates LPS-Induced IL-1β Production by Suppressing NLRP3 Inflammasome Activation and ROS Production in Trophoblasts

Park, S., Shin, J., Bae, J., Han, D., Park, S., Shin, J., Lee, S. K., & Park, H. (2020) · Cells · doi:10.3390/cells9030728 · Cited by 98 · see citing works

Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells

Li, Y., Yang, X., He, Y., Wang, W., Zhang, J., Zhang, W., Jing, T., Wang, B., & Lin, R. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.11.002 · Cited by 97 · see citing works

Normal patterns of expression of glycosylphosphatidylinositol‐anchored proteins on different subsets of peripheral blood cells: A frame of reference for the diagnosis of paroxysmal nocturnal hemoglobinuria

Hernández‐Campo, P. M., Almeida, J., Sánchez, M. L., Malvezzi, M., & Órfão, A. (2006) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20087 · Cited by 94 · see citing works

Stress granule formation, disassembly, and composition are regulated by alphavirus ADP-ribosylhydrolase activity

Jayabalan, A. K., Adivarahan, S., Koppula, A., Abraham, R., Batish, M., Zenklusen, D. R., Griffin, D. E., & Leung, A. K. L. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021719118 · Cited by 91 · see citing works

Effects of Kynurenine Pathway Inhibition on NAD+ Metabolism and Cell Viability in Human Primary Astrocytes and Neurons

Braidy, N., Guillemin, G., & Grant, R. (2011) · International Journal of Tryptophan Research · doi:10.4137/ijtr.s7052 · Cited by 87 · see citing works

Activation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) by Inhibitors of Class III Histone Deacetylases: Identification of Sirtuin 1 as a Regulator of the KSHV Life Cycle

Li, Q., He, M., Zhou, F., Ye, F., & Gao, S. (2014) · Journal of Virology · doi:10.1128/jvi.00219-14 · Cited by 74 · see citing works

The coronavirus nucleocapsid protein is ADP-ribosylated

Grunewald, M. E., Fehr, A. R., Athmer, J., & Perlman, S. M. (2017) · Virology · doi:10.1016/j.virol.2017.11.020 · Cited by 72 · see citing works

Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase

Grady, S. L., Hwang, J., Vastag, L., Rabinowitz, J. D., & Shenk, T. E. (2012) · Journal of Virology · doi:10.1128/jvi.00495-12 · Cited by 71 · see citing works

Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults

Kaplon, R. E., Gano, L. B., & Seals, D. R. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00969.2013 · Cited by 70 · see citing works

Differential Regulation of P2X7 Receptor Activation by Extracellular Nicotinamide Adenine Dinucleotide and Ecto-ADP-Ribosyltransferases in Murine Macrophages and T Cells

Hong, S., Schwarz, N., Braß, A., Séman, M., Haag, F., Koch‐Nolte, F., Schilling, W. P., & Dubyak, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900120 · Cited by 63 · see citing works

SIRT1 stabilizes PML promoting its sumoylation

Campagna, M., Herranz, D., García, M. Á., Marcos-Villar, L., González, J., Gallego, P. P. F., Gutierrez, S., Collado, M., Serrano, M., Estéban, M., et al. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.77 · Cited by 63 · see citing works

Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes

Lee, H. J., Hong, Y., Jun, W., & Yang, S. J. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2015.3439 · Cited by 62 · see citing works

HIV Infection Decreases Intracellular Nicotinamide Adenine Dinucleotide [NAD]

Murray, M. F., Nghiem, M. N., & Srinivasan, A. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1945 · Cited by 62 · see citing works

A meta-analysis on the risk factors adjusted association between cardiovascular disease and COVID-19 severity

Xu, J., Xiao, W., Liang, X., Shi, L., Zhang, P., Wang, Y., Wang, Y., & Yang, H. (2021) · BMC Public Health · doi:10.1186/s12889-021-11051-w · Cited by 62 · see citing works

Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells

Kropotov, A., Kulikova, V., Nerinovski, K., Yakimov, A., Svetlova, M., Solovjeva, L., Sudnitsyna, J. S., Migaud, M. E., Khodorkovskiy, M., Ziegler, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031391 · Cited by 59 · see citing works

Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity

Brady, P. N., Goel, A., & Johnson, M. A. (2019) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00038-18 · Cited by 58 · see citing works

The Deacetylase SIRT1 Regulates the Replication Properties of Human Papillomavirus 16 E1 and E2

Das, D., Smith, N. W., Wang, X., & Morgan, I. M. (2017) · Journal of Virology · doi:10.1128/jvi.00102-17 · Cited by 55 · see citing works

CD38 in the age of COVID-19: a medical perspective

Horenstein, A., Faini, A., & Malavasi, F. (2021) · Physiological Reviews · doi:10.1152/physrev.00046.2020 · Cited by 53 · see citing works

Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis

Zingarelli, B., O’Connor, M. P., & Hake, P. W. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01726-6 · Cited by 52 · see citing works

The YXXΦ motif within the severe acute respiratory syndrome coronavirus (SARS-CoV) 3a protein is crucial for its intracellular transport

Minakshi, R., & Padhan, K. (2014) · Virology Journal · doi:10.1186/1743-422x-11-75 · Cited by 51 · see citing works

Inhibition of Poly(ADP-Ribose) Polymerase Prevents Allergen-Induced Asthma-Like Reaction in Sensitized Guinea Pigs

Suzuki, Y., Masini, E., Mazzocca, C., Cuzzocrea, S., Ciampa, A. R., Suzuki, H., & Bani, D. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.072546 · Cited by 49 · see citing works

Identification of the first noncompetitive SARM1 inhibitors

Loring, H. S., Parelkar, S. S., Mondal, S., & Thompson, P. R. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115644 · Cited by 48 · see citing works

Transcriptional Reprogramming and Resistance to Colonic Mucosal Injury in Poly(ADP-ribose) Polymerase 1 (PARP1)-deficient Mice

Larmonier, C. B., Shehab, K. W., Laubitz, D., Jamwal, D. R., Ghishan, F. K., & Kiela, P. R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.714386 · Cited by 45 · see citing works

Poly(ADP-ribose) polymerase-1 inhibition protects the brain against systemic inflammation

Czapski, G. A., Cąkała, M., Gajkowska, B., & Strosznajder, J. B. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.06.006 · Cited by 39 · see citing works

NAD+-consuming enzymes in immune defense against viral infection

Shang, J., Smith, M. R., Anmangandla, A., & Lin, H. (2021) · Biochemical Journal · doi:10.1042/bcj20210181 · Cited by 38 · see citing works

Absence of Poly(ADP-Ribose) Polymerase 1 Delays the Onset of Salmonella enterica Serovar Typhimurium-Induced Gut Inflammation

Altmeyer, M., Barthel, M., Eberhard, M., Rehrauer, H., Hardt, W., & Hottiger, M. O. (2010) · Infection and Immunity · doi:10.1128/iai.00211-10 · Cited by 34 · see citing works

Nicotinamide riboside regulates inflammation and mitochondrial markers in AML12 hepatocytes

Lee, H. J., & Yang, S. J. (2019) · Nutrition Research and Practice · doi:10.4162/nrp.2019.13.1.3 · Cited by 29 · see citing works

Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches?

Shimizu, J. F., Martins, D. O. S., McPhillie, M. J., Roberts, G. C., Zothner, C., Merits, A., Harris, M., & Jardim, A. C. G. (2020) · Acta Tropica · doi:10.1016/j.actatropica.2020.105490 · Cited by 26 · see citing works

Metabolic Regulators Nampt and Sirt6 Serially Participate in the Macrophage Interferon Antiviral Cascade

Dantoft, W., Robertson, K. A., Watkins, W. J., Strobl, B., & Ghazal, P. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00355 · Cited by 23 · see citing works

Stenoparib, an Inhibitor of Cellular Poly(ADP-Ribose) Polymerase, Blocks Replication of the SARS-CoV-2 and HCoV-NL63 Human Coronaviruses In Vitro

Stone, N. E., Jaramillo, S. A., Jones, A. N., Vazquez, A. J., Martz, M., Versluis, L. M., Raniere, M. O., Nunnally, H. E., Zarn, K. E., Nottingham, R. D., et al. (2021) · mBio · doi:10.1128/mbio.03495-20 · Cited by 22 · see citing works

Effect of Withania somnifer on CD38 expression on CD8+ T lymphocytes among patients of HIV infection

Maurya, S. P., Das, B. K., Singh, R., & Tyagi, S. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.04.003 · Cited by 18 · see citing works

Reduced Levels of NAD in Skeletal Muscle and Increased Physiologic Frailty Are Associated With Viral Coinfection in Asymptomatic Middle-Aged Adults

Tran, T., Pencina, K. M., Schultz, M. B., Li, Z., Ghattas, C., Lau, J., Sinclair, D. A., & Montano, M. A. (2022) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002852 · Cited by 13 · see citing works

Persistent SARS-CoV-2 Infection, EBV, HHV-6 and Other Factors May Contribute to Inflammation and Autoimmunity in Long COVID

Vojdani, A., Vojdani, E., Saidara, E., & Maes, M. H. J. (2023) · Viruses · doi:10.3390/v15020400 · Cited by 133 · see citing works

Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects

Okabe, K., Yaku, K., Uchida, Y., Fukamizu, Y., Sato, T., Sakurai, T., Tobe, K., & Nakagawa, T. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.868640 · Cited by 105 · see citing works

NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health

Alegre, G. F. S., & Pastore, G. M. (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00475-y · Cited by 101 · see citing works

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications

Kell, D. B., & Pretorius, E. (2022) · Biochemical Journal · doi:10.1042/bcj20220154 · Cited by 68 · see citing works

NAD+ metabolism-based immunoregulation and therapeutic potential

Fang, J., Chen, W., Hou, P., Liu, Z., Zuo, M., Liu, S., Feng, C., Han, Y., Li, P., Shi, Y., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01031-5 · Cited by 54 · see citing works

Disruption of glucose homeostasis by bacterial infection orchestrates host innate immunity through NAD+/NADH balance

Tang, J., Wang, X., Chen, S., Chang, T., Gu, Y., Zhang, F., Hou, J., Luo, Y., Li, M., Huang, J., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114648 · Cited by 44 · see citing works

Low-dose naltrexone and NAD+ for the treatment of patients with persistent fatigue symptoms after COVID-19

Isman, A., Nyquist, A., Strecker, B., Harinath, G., Lee, V., Zhang, X., & Zalzala, S. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100733 · Cited by 41 · see citing works

Nicotinamide Mononucleotide Restores NAD+ Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells

Ahmed, M., Riaz, U., Lv, H., Amjad, M., Ahmed, S., Ali, S., Ghani, M. U., Hua, G., & Yang, L. (2024) · Antioxidants · doi:10.3390/antiox14010039 · Cited by 38 · see citing works

Redox Regulation and Metabolic Dependency of Zika Virus Replication: Inhibition by Nrf2-Antioxidant Response and NAD(H) Antimetabolites

Sahoo, B. R., Crook, A. A., Pattnaik, A., Torres-Gerena, A. D., Khalimonchuk, O., Powers, R., Franco, R., & Pattnaik, A. K. (2023) · Journal of Virology · doi:10.1128/jvi.01363-22 · Cited by 37 · see citing works

Neurovascular coupling impairment as a mechanism for cognitive deficits in COVID-19

Owens, C. D., Pinto, C. B., Detwiler, S., Olay, L., Pinaffi‐Langley, A. C. D. C., Mukli, P., Péterfi, A., Szarvas, Z., James, J. A., Galván, V., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae080 · Cited by 35 · see citing works

Tryptophan catabolism via the kynurenine pathway regulates infection and inflammation: from mechanisms to biomarkers and therapies

Zhang, J., Liu, Y., Zhi, X., Li, X., Tao, J., Cui, D., & Liu, T. F. (2024) · Inflammation Research · doi:10.1007/s00011-024-01878-5 · Cited by 33 · see citing works

Promoting healthy cardiovascular aging: emerging topics

Clayton, Z. S., Craighead, D. H., Darvish, S., Coppock, M. E., Ludwig, K., Brunt, V. E., Seals, D., & Rossman, M. J. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.27 · Cited by 19 · see citing works

Study of Albumin Oxidation in COVID-19 Pneumonia Patients: Possible Mechanisms and Consequences

Wybranowski, T., Napiórkowska-Mastalerz, M., Bosek, M., Pyskir, J., Ziomkowska, B., Cyrankiewicz, M., Pyskir, M., Pilaczyńska-Cemel, M., Rogańska, M., Kruszewski, S., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710103 · Cited by 26 · see citing works

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging

Chubanava, S., Karavaeva, I. E., Ehrlich, A. M., Justicia, R. M., Basse, A. L., Kulik, I., Dalbram, E., Ahwazi, D., Heaselgrave, S. R., Trôst, K., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.04.002 · Cited by 28 · see citing works

Emerging Role of Nicotinamide Riboside in Health and Diseases

Sharma, C., Donu, D., & Cen, Y. (2022) · Nutrients · doi:10.3390/nu14193889 · Cited by 24 · see citing works

Nicotinamide mononucleotide impacts HIV-1 infection by modulating immune activation in T lymphocytes and humanized mice

Mo, Y., Yue, M., Yim, L. Y., Zhou, R., Yu, C., Peng, Q., Zhou, Y., Luk, T., Lui, G. C.-Y., Huang, H., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104877 · Cited by 23 · see citing works

The Role of Acetyl-Carnitine and Rehabilitation in the Management of Patients with Post-COVID Syndrome: Case-Control Study

Scaturro, D., Vitagliani, F., Bella, V. E. D., Falco, V., Tomasello, S., Lauricella, L., & Mauro, G. L. (2022) · Applied Sciences · doi:10.3390/app12084084 · Cited by 20 · see citing works

Acute exercise boosts NAD+ metabolism of human peripheral blood mononuclear cells

Walzik, D., Joisten, N., Schenk, A., Trebing, S., Schaaf, K., Metcalfe, A. J., Spiliopoulou, P., Hiefner, J., McCann, A., Watzl, C., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.11.004 · Cited by 17 · see citing works

An Overview of the Circadian Clock in the Frame of Chronotherapy: From Bench to Bedside

Vandenberghe, A., Lefranc, M., & Furlan, A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071424 · Cited by 16 · see citing works

Vascular mechanisms leading to progression of mild cognitive impairment to dementia after COVID-19: Protocol and methodology of a prospective longitudinal observational study

Owens, C. D., Pinto, C. B., Mukli, P., Szarvas, Z., Péterfi, A., Detwiler, S., Olay, L., Olson, A. L., Li, G., Galván, V., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0289508 · Cited by 16 · see citing works

Gut Microbiota and Mitochondria: Health and Pathophysiological Aspects of Long COVID

Ailioaie, L. M., Ailioaie, C., & Litscher, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417198 · Cited by 16 · see citing works

Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial

Wu, C., Reynolds, W. C., Abril, I., McManus, A. J., Brenner, C., González-Irizarry, G., Gutiérrez-Martínez, L., Sun, O., Rosand, J. M., Tanzi, R. E., et al. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103633 · Cited by 14 · see citing works

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

Chini, C. C. S., Colman, L., Palmieri, E., Strange, J. L., Kashyap, S., Han, B., Benítez-Rosendo, A., Lopez, G. L. C., Rabelo, S. P., Mukherjee, S., et al. (2025) · Aging Cell · doi:10.1111/acel.70135 · Cited by 13 · see citing works

NAD+-boosting compounds enhance nitric oxide production and prevent oxidative stress in endothelial cells exposed to plasma from patients with COVID-19

Freeberg, K. A., Ludwig, K. R., Chonchol, M., Seals, D. R., & Rossman, M. J. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.08.003 · Cited by 13 · see citing works

Beyond Pellagra—Research Models and Strategies Addressing the Enduring Clinical Relevance of NAD Deficiency in Aging and Disease

Feuz, M. B., Meyer‐Ficca, M. L., & Meyer, R. G. (2023) · Cells · doi:10.3390/cells12030500 · Cited by 13 · see citing works

The DarT/DarG Toxin–Antitoxin ADP-Ribosylation System as a Novel Target for a Rational Design of Innovative Antimicrobial Strategies

Catara, G., Caggiano, R., & Palazzo, L. (2023) · Pathogens · doi:10.3390/pathogens12020240 · Cited by 12 · see citing works

SIRT1: A likely key for future therapeutic strategies for pain management

Ilari, S., Nucera, S., Passacatini, L. C., Caminiti, R., Mazza, V., Macrì, R., Serra, M. D. R., Scarano, F., Malafoglia, V., Palma, E., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107670 · Cited by 12 · see citing works

Nicotinamide modulates gut microbial metabolic potential and accelerates recovery in mild-to-moderate COVID-19

Schreiber, S., Waetzig, G. H., López-Agudelo, V. A., Geisler, C., Schlicht, K., Franzenburg, S., di Giuseppe, R., Pape, D., Bahmer, T. J., Krawczak, M., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01290-1 · Cited by 12 · see citing works

Dysregulated nicotinamide adenine dinucleotide metabolome in patients hospitalized with COVID ‐19

Valderrábano, R. J., Wipper, B., Pencina, K. M., Migaud, M. E., Shang, Y. V., Latham, N. K., Montano, M. A., Cunningham, J. M., Wilson, L., Peng, L., et al. (2024) · Aging Cell · doi:10.1111/acel.14326 · Cited by 10 · see citing works

Urinary phenotyping of SARS-CoV-2 infection connects clinical diagnostics with metabolomics and uncovers impaired NAD+ pathway and SIRT1 activation

Lonati, C., Berezhnoy, G., Lawler, N. G., Masuda, R., Kulkarni, A., Sala, S., Nitschke, P., Zizmare, L., Bucci, D., Cannet, C., et al. (2023) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2023-1017 · Cited by 10 · see citing works

Maladaptive Immune Activation in Age-Related Decline of Muscle Function

Montano, M. A., & Correa‐de‐Araujo, R. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad036 · Cited by 7 · see citing works

Nicotinamide mononucleotide (NMN) alleviates the poly(I:C)-induced inflammatory response in human primary cell cultures

Sano, H. I., Kratz, A., Nishino, T., Imamura, H., Yoshida, Y., Shimizu, N., Kitano, H., & Yachie‐Kinoshita, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-38762-x · Cited by 7 · see citing works

Nampt: a new therapeutic target for modulating NAD+ levels in metabolic, cardiovascular, and neurodegenerative diseases

Manickam, R., Santhana, S., Xuan, W., Bisht, K. S., & Tipparaju, S. M. (2025) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2024-0400 · Cited by 6 · see citing works

Metformin is a potential therapeutic for COVID-19/LUAD by regulating glucose metabolism

Hou, Y., Yang, Z., Xiang, B., Liu, J., Geng, L., Xu, D., Zhan, M., Xu, Y., & Zhang, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-63081-0 · Cited by 6 · see citing works

Do vitamins halt the COVID-19-evoked pro-inflammatory cytokines involved in the development of neuropathic pain?

Al‐Khrasani, M., Essmat, N., Boldizsár, I., Varga, B. T., Chalabiani, Y., Abbood, S. K., Ernyey, A. J., Király, K. P., Máté, A., Riba, P., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118346 · Cited by 6 · see citing works

Renalase Challenges the Oxidative Stress and Fibroproliferative Response in COVID‐19

Stojanović, D. R., Stojanović, M., Milenković, J., Veličkov, A., Ignjatović, A., & Milojković, M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4032704 · Cited by 5 · see citing works

Metabolic support of trained immune responses in myeloid cells

Jarit-Cabanillas, A., Dunphy, G., Virga, F., den Bossche, J. V., & Sancho, D. (2026) · eLife · doi:10.7554/elife.108814 · Cited by 4 · see citing works

NAD+ Suppresses EV-D68 Infection by Enhancing Anti-Viral Effect of SIRT1

Wang, Y., Li, H., Huang, X., Huang, Y., Lv, M., Tang, H., Han, X., Liu, J., Liang, Y., Zang, G., et al. (2025) · Viruses · doi:10.3390/v17020175 · Cited by 3 · see citing works

Unveiling the role of the upper respiratory tract microbiome in susceptibility and severity to COVID-19

Lovison, O. V. A., Volpato, F. C. Z., Weber, L. G., Barth, A. L., Coitinho, A. S., & Martins, A. F. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1531084 · Cited by 3 · see citing works

Metabolic Activation of PARP as a SARS-CoV-2 Therapeutic Target—Is It a Bait for the Virus or the Best Deal We Could Ever Make with the Virus? Is AMBICA the Potential Cure?

Puthanveetil, P. (2023) · Biomolecules · doi:10.3390/biom13020374 · Cited by 3 · see citing works

Boosting NAD+ levels through fasting to aid in COVID-19 recovery

Dongoran, R. A., Mardiana, M., Huang, C., & Situmorang, J. H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1319106 · Cited by 3 · see citing works

Plant-Based Diet and Supplements Reduced COVID-19 Severity and Mortality in Elderly Patients with Multiple Comorbidities (Part 2: Exploring the Underlying Mechanisms of Successful Intervention)Preprint

Mulijono, D., Hutapea, A. M., Lister, I. N. E., Sudaryo, M. K., & Umniyati, H. (2024) · Preprints.org · doi:10.20944/preprints202403.0100.v1 · Cited by 3 · see citing works

Decoding NAD+ Metabolism in COVID-19: Implications for Immune Modulation and Therapy

Song, S., Gan, J., Long, Q., Gao, Z., & Zheng, Y. (2024) · Vaccines · doi:10.3390/vaccines13010001 · Cited by 2 · see citing works

Targeting mitochondrial metabolism with combined metabolic activators

Yang, H., Kong, X., Liao, X., Türkez, H., Borén, J., Uhlén, M., Altay, Ö., & Mardinoğlu, A. (2026) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2026.01.018 · Cited by 2 · see citing works

NAD⁺ circuits in aging, tissue repair and fibrosis

Izadpanah, R., Rappaport, J., & Alt, E. U. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103305 · Cited by 2 · see citing works

Perspective Chapter: Caste, Class, Race and Poverty – A Perspective from the Case of Pellagra

Williams, A. C., Badenoch, E. G., & Hill, L. J. (2024) · Sustainable development · doi:10.5772/intechopen.1005314 · Cited by 1 · see citing works

Oral MIB ‐626 (β Nicotinamide Mononucleotide) Safely Raises Blood Nicotinamide Adenine Dinucleotide Levels in Hospitalized Patients With COVID ‐19 and Acute Kidney Injury: A Randomized Controlled Trial

Pencina, K. M., Leaf, D. E., Valderrábano, R. J., Waikar, S. S., Mehta, T. S., Shang, Y. V., Latham, N. K., John, T., Volpi, E., Fusco, D. N., et al. (2025) · FASEB BioAdvances · doi:10.1096/fba.2025-00014 · Cited by 2 · see citing works

NAD + Homeostasis Attenuates Japanese Encephalitis Virus Infection Progression

Adugna, T., Tian, Z., Du, J., Niu, Q., Yang, J., Zhang, H., Song, Y., Chai, F., Zhang, Z., Guan, G., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202503827r · Cited by 1 · see citing works

Accumulation of Quinolinic Acid Modulates the Pulmonary Immune Response During Influenza Infection.

Pamart, G., Hennart, B., Ollivier, A., Kervoaze, G., Pichavant, M., Gosset, P., Rouzic, O. L., & Poulain-Godefroy, O. (2026) · International Journal of Tryptophan Research · doi:10.1177/11786469261423809 · Cited by 1 · see citing works

Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaques

Nguyen, C. T., Nakayama, M., Ishigaki, H., Kitagawa, Y., Kakino, A., Ohno, M., Shingai, M., Suzuki, Y., Sawamura, T., Kida, H., et al. (2024) · Virology · doi:10.1016/j.virol.2024.110052 · Cited by 1 · see citing works

The Connection Between PARP14 and SARS-CoV-2

Tauber, A. L., Schweiker, S. S., & Levonis, S. M. (2023) · Future Medicinal Chemistry · doi:10.4155/fmc-2023-0013

NAD + depletion and altered mitochondrial function are key to the establishment of placental dysfunction in an inflammatory-driven subclass of preeclampsiaPreprint

Jahan, F., Vasam, G., Cariaco, Y., Nik-Akhtar, A., Green, A., Menzies, K. J., & Bainbridge, S. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.09.556974

Covidsomnia: is the sirtuin1-NAD + axis the clue of the matter?

Mormile, R., & Mormile, C. (2024) · Sleep and Biological Rhythms · doi:10.1007/s41105-024-00518-z

Plant-Based Diet and Supplements Reduced COVID-19 Severity and Mortality in Elderly Patients with Multiple Comorbidities (Part 2: Exploring the Underlying Mechanisms of Successful Intervention)Preprint

Mulijono, D., Hutapea, A. M., Lister, I. N. E., Sudaryo, M. K., & Umniyati, H. (2024) · Preprints.org · doi:10.20944/preprints202403.0100.v2

Linking Disulfide Levels and NAD+ Metabolism with Alzheimer’s Disease for Diagnostic Modeling and Target Drug Analysis

Wang, Y., Su, L., Zhang, Y., & Wei, H. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2304085

Coenzyme I Drug

Jiang, Q., Luo, L., Jiang, Z., Qin, Y., Wang, L., Wang, K., & Wang, W. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_48

Coronavirus research topics, tracking twenty years of research

Aryani, A., Wang, J. B., Salvador‐Carulla, L., Woo, J., Cheung, C., Wu, Z., Yin, H., Xiao, J., Lambert, É., Howitt, J. A., et al. (2025) · Scientific Data · doi:10.1038/s41597-025-04992-z

PARP10 condensation inhibits viral infection via targeting NAD + homeostasisPreprint

Chen, X., Xu, Q. K., Liu, Y., Zhu, Z., Wang, Z., Zhang, Y., Chen, Q., Tian, L., Yao, Z., Shi, Z., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.22.696120

Identification of B-cell senescence-related key genes and mechanisms in Alzheimer's disease through transcriptomic sequencing combined with Mendelian randomization analysis and experimental verification

Yuan, R., Liao, G., Su, S., Shan, J., & Tang, S. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261477008

Microvascular Dysfunction and Redox Imbalance in Long COVID

Lewandowska, A., Sawicka, D., Jóźwiak, A., Jędrzejewska, A., Braczko, A., Romanowska‐Kocejko, M., Żarczyńska-Buchowiecka, M., Kutryb-Zając, B. A., Hellmann, M., & Mierzejewska, P. (2026) · Microcirculation · doi:10.1111/micc.70085

Dose‐related propofol resistance in COVID‐19 patients: Altered drug plasma levels, mechanistic insights from neuronal‐derived extracellular vesicles and miRNA analysis

Curci, D., Bidoli, C., Gerdol, M., Winston, C. N., Rissman, R. A., Decorti, G., Fabretto, A., Taddio, A., Stocco, G., Pognuz, E. R., et al. (2026) · British Journal of Clinical Pharmacology · doi:10.1002/bcp.70813

scH16S‐Seq Maps Klebsiella pneumoniae ‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Li, Y., Yu, Y., Qin, F., Li, S., Li, X., Liu, P., Liu, J., Liu, H., Jing, S., Zou, J., et al. (2026) · Advanced Science · doi:10.1002/advs.78127

NAD+ metabolism-based immunoregulation and therapeutic potential

Fang, J., Chen, W., Hou, P., Liu, Z., Zuo, M., Liu, S., Feng, C., Han, Y., Li, P., Shi, Y., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01031-5 · Cited by 54 · see citing works

Viral infection as an NAD+ battlefield

Brenner, C. (2022) · Nature Metabolism · doi:10.1038/s42255-021-00507-3 · Cited by 36 · see citing works

NAD+-consuming enzymes in immune defense against viral infection

Shang, J., Smith, M. R., Anmangandla, A., & Lin, H. (2021) · Biochemical Journal · doi:10.1042/bcj20210181 · Cited by 38 · see citing works

Decoding NAD+ Metabolism in COVID-19: Implications for Immune Modulation and Therapy

Song, S., Gan, J., Long, Q., Gao, Z., & Zheng, Y. (2024) · Vaccines · doi:10.3390/vaccines13010001 · Cited by 2 · see citing works

Insights into the modulation of the interferon response and NAD+in the context of COVID-19

Habeichi, N. J., Tannous, C., Yabluchanskiy, A., Altara, R., Mericskay, M., Booz, G. W., & Zouein, F. A. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.1961768 · Cited by 10 · see citing works