Luo, Ji

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Engelman, J. A., Luo, J., & Cantley, L. C. (2006) · Nature Reviews Genetics

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 3,330

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science

DNA Repair MechanismsProtein Kinase Regulation and GTPase Signaling

Cited by 3,075

Drugging the undruggable RAS: Mission Possible?

Cox, A. D., Fesik, S. W., Kimmelman, A. C., Luo, J., & Der, C. J. (2014) · Nature Reviews Drug Discovery

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 1,997

Principles of cancer therapy: oncogene and non-oncogene addiction

Luo, J., Solimini, N. L., & Elledge, S. J. (2009) · Cell

Cancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism

Cited by 1,765

Targeting the PI3K-Akt pathway in human cancer

Luo, J., Manning, B. D., & Cantley, L. C. (2003) · Cancer Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 1,290

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

Luo, J., Emanuele, M. J., Li, D., Creighton, C. J., Schlabach, M. R., Westbrook, T. F., Wong, K.-K., & Elledge, S. J. (2009) · Cell

Protein Kinase Regulation and GTPase SignalingMicrotubule and mitosis dynamics

Cited by 1,017

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

Ma, C., Kesarwala, A. H., Eggert, T., Medina-Echeverz, J., Kleiner, D. E., Jin, P., Stroncek, D. F., Terabe, M., Kapoor, V., ElGindi, M., et al. (2016) · Nature

Liver Disease Diagnosis and TreatmentCancer, Lipids, and Metabolism

Cited by 766

KRAS mutation in pancreatic cancer

Luo, J. (2021) · Seminars in Oncology

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 360

Differential effector engagement by oncogenic KRAS

Yuan, T. L., Amzallag, A., Bagni, R., Yi, M., Afghani, S., Burgan, W., Fer, N., Strathern, L. A., Powell, K., Smith, B., et al. (2018) · Cell Reports

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 150

Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders

Steinebach, C., Ng, Y. L. D., Sosič, I., Lee, C.-S., Chen, S., Lindner, S., Vu, L. P., Bricelj, A., Haschemi, R., Monschke, M., et al. (2020) · Chemical Science

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 148

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

Lee, C.-S., Lee, L. C., Yuan, T. L., Chakka, S., Fellmann, C., Lowe, S. W., Caplen, N. J., McCormick, F., & Luo, J. (2019) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 126

Development of siRNA Payloads to Target KRAS -Mutant Cancer

Yuan, T. L., Fellmann, C., Lee, C.-S., Ritchie, C. D., Thapar, V., Lee, L. C., Hsu, D. J., Grace, D., Carver, J. O., Zuber, J., et al. (2014) · Cancer Discovery

RNA Interference and Gene DeliveryRNA Research and Splicing

Cited by 113

Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program

Mazzucco, A. E., Smogorzewska, A., Kang, C., Luo, J., Schlabach, M. R., Xu, Q., Patel, R., & Elledge, S. J. (2017) · Genes & Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 35