Chini, Eduardo N.

Mitochondrial dysfunction in cell senescence and aging

Miwa, S., Kashyap, S., Chini, E., & von Zglinicki, T. (2022) · Journal of Clinical Investigation

Mitochondrial Function and PathologyTelomeres, Telomerase, and Senescence

Cited by 1,061

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

Camacho-Pereira, J., Tarragó, M. G., Chini, C. C. S., Nin, V., Escande, C., Warner, G. M., Puranik, A. S., Schoon, R. A., Reid, J. M., Galina, A., et al. (2016) · Cell Metabolism

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 901

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang‐Verzosa, G., et al. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceAdipokines, Inflammation, and Metabolic Diseases

Cited by 658

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

Palmer, A. K., Tchkonia, T., LeBrasseur, N. K., Chini, E. N., Xu, M., & Kirkland, J. L. (2015) · Diabetes

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 423

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

Tarragó, M. G., Chini, C. C. S., Kanamori, K. S., Warner, G. M., Caride, A., de Oliveira, G. C., Rud, M., Samani, A., Hein, K. Z., Huang, R., et al. (2018) · Cell Metabolism

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 384

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

Chini, C. C. S., Peclat, T. R., Warner, G. M., Kashyap, S., Espindola-Netto, J. M., de Oliveira, G. C., Gomez, L. S., Hogan, K. A., Tarragó, M. G., Puranik, A. S., et al. (2020) · Nature Metabolism

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 349

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38

Escande, C., Nin, V., Price, N. L., Capellini, V., Gomes, A. P., Barbosa, M. T., O’Neil, L., White, T. A., Sinclair, D. A., & Chini, E. N. (2013) · Diabetes

Sirtuins and Resveratrol in MedicineNatural Antidiabetic Agents Studies

Cited by 332

The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging

Chini, E. N., Chini, C. C. S., Espindola Netto, J. M., de Oliveira, G. C., & van Schooten, W. (2018) · Trends in Pharmacological Sciences

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 227

NAD and the aging process: role in life, death and everything in between

Chini, C. C. S., Tarragó, M. G., & Chini, E. N. (2017) · Molecular and Cellular Endocrinology

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 208

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline

Chini, C., Hogan, K. A., Warner, G. M., Tarragó, M. G., Peclat, T. R., Tchkonia, T., Kirkland, J. L., & Chini, E. (2019) · Biochemical and Biophysical Research Communications

Sirtuins and Resveratrol in MedicineTelomeres, Telomerase, and Senescence

Cited by 138

p21 induces a senescence program and skeletal muscle dysfunction

Englund, D. A., Jolliffe, A., Aversa, Z., Zhang, X., Sturmlechner, I., Sakamoto, A. E., Zeidler, J. D., Warner, G. M., McNinch, C., White, T. A., et al. (2023) · Molecular Metabolism

Telomeres, Telomerase, and SenescenceMuscle Physiology and Disorders

Cited by 90

Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation

Sahar, S., Nin, V., Barbosa, M. T., Chini, E. N., & Sassone-Corsi, P. (2011) · Aging

Circadian rhythm and melatoninSirtuins and Resveratrol in Medicine

Cited by 79

Dietary restriction: standing up for sirtuins

Baur, J. A., Chen, D., Chini, E. N., Chua, K., Cohen, H. Y., Cabo, R. D., Deng, C., Dimmeler, S., Gius, D., Guarente, L. P., et al. (2010) · Science

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 76