Manglik, Aashish

Crystal structure of the human σ1 receptor

Schmidt, H. R., Zheng, S., Gurpinar, E., Koehl, A., Manglik, A., & Kruse, A. C. (2016) · Nature

Pharmacological Receptor Mechanisms and EffectsReceptor Mechanisms and Signaling

Cited by 482

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

Maute, R. L., Gordon, S. R., Mayer, A. T., McCracken, M. N., Natarajan, A., Ring, N. G., Kimura, R., Tsai, J. M., Manglik, A., Kruse, A. C., et al. (2015) · Proceedings of the National Academy of Sciences

Cancer Immunotherapy and BiomarkersMonoclonal and Polyclonal Antibodies Research

Cited by 347

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

Billesbølle, C. B., Azumaya, C. M., Kretsch, R. C., Powers, A. S., Gonen, S., Schneider, S., Arvedson, T., Dror, R. O., Cheng, Y., & Manglik, A. (2020) · Nature

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 344

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Staus, D. P., Strachan, R. T., Manglik, A., Pani, B., Kahsai, A. W., Kim, T. H., Wingler, L. M., Ahn, S., Chatterjee, A., Masoudi, A., et al. (2016) · Nature

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 330

Protein design and variant prediction using autoregressive generative models

Shin, J.-E., Riesselman, A. J., Kollasch, A. W., McMahon, C., Simon, E., Sander, C., Manglik, A., Kruse, A. C., & Marks, D. S. (2021) · Nature Communications

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 320

Goniometer-based femtosecond crystallography with X-ray free electron lasers

Cohen, A. E., Soltis, S. M., González, A., Aguila, L., Alonso-Mori, R., Barnes, C. O., Baxter, E. L., Brehmer, W., Brewster, A. S., Brunger, A. T., et al. (2014) · Proceedings of the National Academy of Sciences

Enzyme Structure and FunctionAdvanced X-ray Imaging Techniques

Cited by 144

Fusion protein strategies for cryo-EM study of G protein-coupled receptors

Zhang, K., Wu, H., Hoppe, N., Manglik, A., & Cheng, Y. (2022) · Nature Communications

Receptor Mechanisms and SignalingAdvanced Electron Microscopy Techniques and Applications

Cited by 91

Fusion protein strategies for cryo-EM study of G protein-coupled receptors

Zhang, K., Wu, H., Hoppe, N., Manglik, A., & Cheng, Y. (2021) · Nature Communications

Receptor Mechanisms and SignalingAdvanced Electron Microscopy Techniques and Applications

Cited by 91

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

Gupta, M., Azumaya, C. M., Moritz, M., Pourmal, S., Diallo, A., Merz, G. E., Jang, G., Bouhaddou, M., Fossati, A., Brilot, A. F., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

SARS-CoV-2 and COVID-19 ResearchAdvanced Electron Microscopy Techniques and Applications

Cited by 89

Molecular basis of proton-sensing by G protein-coupled receptors

Howard, M. K., Hoppe, N., Huang, X.-P., Macdonald, C. B., Mehrota, E., Rockefeller Grimes, P., Zahm, A., Trinidad, D. D., English, J., Coyote-Maestas, W., et al. (2024) · Cell

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 78

Molecular basis of proton sensing by G protein-coupled receptors

Howard, M. K., Hoppe, N., Huang, X.-P., Mitrovic, D., Billesbølle, C. B., Macdonald, C. B., Mehrotra, E., Rockefeller Grimes, P., Trinidad, D. D., Delemotte, L., et al. (2025) · Cell

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 77

Surface Proteomics Reveals CD72 as a Target for In Vitro –Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1 -Rearranged B-ALL

Nix, M. A., Mandal, K., Geng, H., Paranjape, N., Lin, Y.-H. T., Rivera, J. M., Marcoulis, M., White, K. L., Whitman, J. D., Bapat, S. P., et al. (2021) · Cancer Discovery

CAR-T cell therapy researchAcute Lymphoblastic Leukemia research

Cited by 72