Nixon, Colin

p53 status determines the role of autophagy in pancreatic tumour development

Rosenfeldt, M. T., O’Prey, J., Morton, J. P., Nixon, C., MacKay, G., Mrowinska, A., Au, A., Rai, T. S., Zheng, L., Ridgway, R., et al. (2013) · Nature

Autophagy in Disease and TherapyPancreatic and Hepatic Oncology Research

Cited by 713

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

Vizioli, M. G., Liu, T., Miller, K. N., Robertson, N. A., Gilroy, K., Lagnado, A. B., Perez-Garcia, A., Kiourtis, C., Dasgupta, N., Lei, X., et al. (2020) · Genes & Development

Telomeres, Telomerase, and SenescenceMitochondrial Function and Pathology

Cited by 359

A Stromal Lysolipid–Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression

Auciello, F. R., Bulusu, V., Oon, C., Tait-Mulder, J., Berry, M., Bhattacharyya, S., Tumanov, S., Allen-Petersen, B. L., Link, J., Kendsersky, N. D., et al. (2019) · Cancer Discovery

Sphingolipid Metabolism and SignalingPancreatic and Hepatic Oncology Research

Cited by 332

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

Cardaci, S., Zheng, L., MacKay, G., van den Broek, N. J. F., MacKenzie, E. D., Nixon, C., Stevenson, D., Tumanov, S., Bulusu, V., Kamphorst, J. J., et al. (2015) · Nature Cell Biology

Cancer, Hypoxia, and MetabolismCancer and biochemical research

Cited by 286

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

Bird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W.-Y., Jamieson, T., Govaere, O., Campbell, A. D., et al. (2018) · Science Translational Medicine

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 261

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

Flanagan, D. J., Pentinmikko, N., Luopajärvi, K., Willis, N. J., Gilroy, K., Raven, A. P., Mcgarry, L., Englund, J. I., Webb, A. T., Scharaw, S., et al. (2021) · Nature

Wnt/β-catenin signaling in development and cancerGenetic factors in colorectal cancer

Cited by 255

Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

Sakamaki, J.-I., Wilkinson, S., Hahn, M., Tasdemir, N., O’Prey, J., Clark, W., Hedley, A., Nixon, C., Long, J. S., New, M., et al. (2017) · Molecular Cell

Autophagy in Disease and TherapyProtein Degradation and Inhibitors

Cited by 249

CSF1R(+) macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype

Candido, J. B., Morton, J. P., Bailey, P., Campbell, A. D., Karim, S. A., Jamieson, T., Lapienyte, L., Gopinathan, A., Clark, W., McGhee, E. J., et al. (2018) · Cell Reports

Immune cells in cancerPancreatic and Hepatic Oncology Research

Cited by 224

Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma

Muthalagu, N., Monteverde, T., Raffo-Iraolagoitia, X., Wiesheu, R., Whyte, D., Hedley, A., Laing, S., Kruspig, B., Upstill-Goddard, R., Shaw, R., et al. (2020) · Cancer Discovery

Pancreatic and Hepatic Oncology Researchinterferon and immune responses

Cited by 182

LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest

Morton, J. P., Jamieson, N. B., Karim, S. A., Athineos, D., Ridgway, R. A., Nixon, C., McKay, C. J., Carter, R., Brunton, V. G., Frame, M. C., et al. (2010) · Gastroenterology

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 169

HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

Rai, T. S., Cole, J. J., Nelson, D. M., Dikovskaya, D., Faller, W. J., Vizioli, M. G., Hewitt, R. N., Anannya, O., McBryan, T., Manoharan, I., et al. (2014) · Genes & Development

Genomics and Chromatin DynamicsTelomeres, Telomerase, and Senescence

Cited by 162

The ERBB network facilitates KRAS-driven lung tumorigenesis

Kruspig, B., Monteverde, T., Neidler, S., Hock, A., Kerr, E., Nixon, C., Clark, W., Hedley, A., Laing, S., Coffelt, S. B., et al. (2018) · Science Translational Medicine

Lung Cancer Treatments and MutationsProtein Kinase Regulation and GTPase Signaling

Cited by 111

Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest

Dikovskaya, D., Cole, J. J., Mason, S. M., Nixon, C., Karim, S. A., McGarry, L., Clark, W., Hewitt, R. N., Sammons, M. A., Zhu, J., et al. (2015) · Cell Reports

Telomeres, Telomerase, and SenescenceMicrotubule and mitosis dynamics

Cited by 89

c‐Src drives intestinal regeneration and transformation

Cordero, J. B., Ridgway, R. A., Valeri, N., Nixon, C., Frame, M. C., Muller, W. J., Vidal, M., & Sansom, O. J. (2014) · The EMBO Journal

Protein Kinase Regulation and GTPase SignalingCancer Cells and Metastasis

Cited by 77

THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer

Blomme, A., Peter, C., Mui, E., Rodriguez Blanco, G., An, N., Mason, L. M., Jamieson, L. E., McGregor, G. H., Lilla, S., Ntala, C., et al. (2022) · EMBO Molecular Medicine

Prostate Cancer Treatment and ResearchCancer, Lipids, and Metabolism

Cited by 36

Aberrant expression of TopBP1 in breast cancer

Going, J. J., Nixon, C., Dornan, E. S., Boner, W., Donaldson, M. M., & Morgan, I. M. (2007) · Histopathology

BRCA gene mutations in cancerBreast Lesions and Carcinomas

Cited by 35

The RAC1 Target NCKAP1 Plays a Crucial Role in the Progression of Braf;Pten-Driven Melanoma in Mice

Swaminathan, K., Campbell, A., Papalazarou, V., Jaber-Hijazi, F., Nixon, C., McGhee, E., Strathdee, D., Sansom, O. J., & Machesky, L. M. (2021) · Journal of Investigative Dermatology

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 18

Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration

May, S., Müller, M., Livingstone, C. R., Skalka, G. L., Walsh, P. J., Nixon, C., Hedley, A., Shaw, R., Clark, W., Vande Voorde, J., et al. (2023) · Journal of Hepatology

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 13