Balmain, Allan

TGF-β Signaling in Tumor Suppression and Cancer Progression

Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics

TGF-β signaling in diseasesMechanisms of cancer metastasis

Cited by 2,275

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., & Akhurst, R. J. (1996) · Cell

TGF-β signaling in diseasesCancer Cells and Metastasis

Cited by 628

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

Balmain, A., Ramsden, M., Bowden, G. T., & Smith, J. (1984) · Nature

Protein Kinase Regulation and GTPase SignalingCarcinogens and Genotoxicity Assessment

Cited by 529

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

Mao, J.-H., Perez-losada, J., Wu, D., DelRosario, R., Tsunematsu, R., Nakayama, K. I., Brown, K., Bryson, S., & Balmain, A. (2004) · Nature

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 390

A model for RAS mutation patterns in cancers: finding the sweet spot

Li, S., Balmain, A., & Counter, C. M. (2018) · Nature Reviews Cancer

Protein Kinase Regulation and GTPase SignalingCancer Genomics and Diagnostics

Cited by 384

TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest

Petritsch, C., Beug, H., Balmain, A., & Oft, M. (2000) · Genes & Development

TGF-β signaling in diseasesPI3K/AKT/mTOR signaling in cancer

Cited by 223

An expanded universe of cancer targets

Hahn, W. C., Bader, J. S., Braun, T. P., Califano, A., Clemons, P. A., Druker, B. J., Ewald, A. J., Fu, H., Jagu, S., Kemp, C. J., et al. (2021) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 213

KRAS4A directly regulates hexokinase 1

Amendola, C. R., Mahaffey, J. P., Parker, S. J., Ahearn, I. M., Chen, W.-C., Zhou, M., Court, H., Shi, J., Mendoza, S. L., Morten, M. J., et al. (2019) · Nature

Cancer, Hypoxia, and MetabolismProtein Kinase Regulation and GTPase Signaling

Cited by 203

K-Ras promotes tumorigenicity through suppression of non-canonical Wnt signaling

Wang, M.-T., Holderfield, M., Galeas, J., Delrosario, R., To, M. D., Balmain, A., & McCormick, F. (2015) · Cell

Protein Kinase Regulation and GTPase SignalingWnt/β-catenin signaling in development and cancer

Cited by 196

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

Dodagatta-Marri, E., Meyer, D. S., Reeves, M. Q., Paniagua, R., To, M. D., Binnewies, M., Broz, M. L., Mori, H., Wu, D., Adoumie, M., et al. (2019) · Journal for ImmunoTherapy of Cancer

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 177

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

Wang, Y. V., Leblanc, M., Fox, N., Mao, J.-H., Tinkum, K. L., Krummel, K., Engle, D., Piwnica-Worms, D., Piwnica-Worms, H., Balmain, A., et al. (2011) · Genes & Development

Hematopoietic Stem Cell TransplantationCancer-related Molecular Pathways

Cited by 53

Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus

Mahler, K. L., Fleming, J. L., Dworkin, A. M., Gladman, N., Cho, H.-Y., Mao, J.-H., Balmain, A., & Toland, A. E. (2008) · BMC Genomics

Genetic Mapping and Diversity in Plants and AnimalsGenetic Associations and Epidemiology

Cited by 18