Mehlen, Patrick

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 2,421

Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer

Fitamant, J., Guenebeaud, C., Coissieux, M.-M., Guix, C., Treilleux, I., Scoazec, J.-Y., Bachelot, T., Bernet, A., & Mehlen, P. (2008) · Proceedings of the National Academy of Sciences

Axon Guidance and Neuronal SignalingCell death mechanisms and regulation

Cited by 241

The dependence receptor UNC5H2 mediates apoptosis through DAP‐kinase

Llambi, F., Lourenço, F. C., Gozuacik, D., Guix, C., Pays, L., Del Rio, G., Kimchi, A., & Mehlen, P. (2005) · The EMBO Journal

Cell death mechanisms and regulationAxon Guidance and Neuronal Signaling

Cited by 173

Dependence receptors: a new paradigm in cell signaling and cancer therapy

Goldschneider, D., & Mehlen, P. (2010) · Oncogene

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 169

The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex

Mille, F., Thibert, C., Fombonne, J., Rama, N., Guix, C., Hayashi, H., Corset, V., Reed, J. C., & Mehlen, P. (2009) · Nature Cell Biology

Hedgehog Signaling Pathway StudiesCell death mechanisms and regulation

Cited by 154

The Dependence Receptor UNC5H2/B Triggers Apoptosis via PP2A-Mediated Dephosphorylation of DAP Kinase

Guenebeaud, C., Goldschneider, D., Castets, M., Guix, C., Chazot, G., Delloye-Bourgeois, C., Eisenberg-Lerner, A., Shohat, G., Zhang, M., Laudet, V., et al. (2010) · Molecular Cell

Cell death mechanisms and regulationAxon Guidance and Neuronal Signaling

Cited by 137

Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

Grandin, M., Meier, M., Delcros, J. G., Nikodemus, D., Reuten, R., Patel, T. R., Goldschneider, D., Orriss, G., Krahn, N., Boussouar, A., et al. (2016) · Cancer Cell

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 128

Dependence Receptors and Cancer: Addiction to Trophic Ligands

Gibert, B., & Mehlen, P. (2015) · Cancer Research

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 73

Dependence Receptors: From Basic Research to Drug Development

Mehlen, P., & Bredesen, D. E. (2011) · Science Signaling

Nerve injury and regenerationCell death mechanisms and regulation

Cited by 72

Dependence receptor UNC5D mediates nerve growth factor depletion–induced neuroblastoma regression

Zhu, Y., Li, Y., Haraguchi, S., Yu, M., Ohira, M., Ozaki, T., Nakagawa, A., Ushijima, T., Isogai, E., Koseki, H., et al. (2013) · Journal of Clinical Investigation

Cell death mechanisms and regulationNeuroblastoma Research and Treatments

Cited by 57

Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9

Fombonne, J., Bissey, P.-A., Guix, C., Sadoul, R., Thibert, C., & Mehlen, P. (2012) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationHedgehog Signaling Pathway Studies

Cited by 56

Dependence receptors and colorectal cancer

Mehlen, P., & Tauszig-Delamasure, S. (2014) · Gut

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 44

Netrin-1 Expression Is an Independent Prognostic Factor for Poor Patient Survival in Brain Metastases

Harter, P. N., Zinke, J., Scholz, A., Tichy, J., Zachskorn, C., Kvasnicka, H. M., Goeppert, B., Delloye-Bourgeois, C., Hattingen, E., Senft, C., et al. (2014) · PLoS ONE

Brain Metastases and TreatmentGlioma Diagnosis and Treatment

Cited by 41

Inhibition of DNA methylation promotes breast tumor sensitivity to netrin‐1 interference

Grandin, M., Mathot, P., Devailly, G., Bidet, Y., Ghantous, A., Favrot, C., Gibert, B., Gadot, N., Puisieux, I., Herceg, Z., et al. (2016) · EMBO Molecular Medicine

Epigenetics and DNA MethylationCell death mechanisms and regulation

Cited by 39

Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer’s Disease

Spilman, P. R., Corset, V., Gorostiza, O., Poksay, K. S., Galvan, V., Zhang, J., Rao, R., Peters-Libeu, C., Vincelette, J., McGeehan, A., et al. (2016) · Journal of Alzheimer's Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 39

The Dependence Receptor TrkC Triggers Mitochondria-Dependent Apoptosis upon Cobra-1 Recruitment

Ichim, G., Genevois, A.-L., Ménard, M., Yu, L.-Y., Coelho-Aguiar, J. M., Llambi, F., Jarrosson-Wuilleme, L., Lefebvre, J., Tulasne, D., Dupin, E., et al. (2013) · Molecular Cell

Cell death mechanisms and regulationNerve injury and regeneration

Cited by 28

Notch receptor/ligand diversity: contribution to colorectal cancer stem cell heterogeneity

Brisset, M., Mehlen, P., Meurette, O., & Hollande, F. (2023) · Frontiers in Cell and Developmental Biology

Cancer Cells and MetastasisDevelopmental Biology and Gene Regulation

Cited by 20