Dependence Receptors: From Basic Research to Drug Development
Abstract
Discussion at a meeting in France focused on new insights into the biology of dependence receptors.
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Extrinsic apoptosis is mostly driven by either death receptors or dependence receptors.
“Extrinsic apoptosis is mostly driven by either of two types of plasma membrane receptors: (1) death receptors, whose activation depends on the binding of the cognate ligand(s), and (2) dependence receptors, whose activation occurs when the levels of their specific ligand drop below a specific threshold [267 269–271].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [271]
Death receptor activation depends on the binding of the cognate ligand(s).
“death receptors, whose activation depends on the binding of the cognate ligand(s)”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [271]
Dependence receptor activation occurs when the levels of their specific ligand drop below a specific threshold.
“dependence receptors, whose activation occurs when the levels of their specific ligand drop below a specific threshold [267 269–271].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [271]
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- Authors
- Mehlen, P., & Bredesen, D. E.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Buck Institute for Research on Aging (US)
- Corresponding author
- Mehlen, Patrick
- Bredesen, Dale E.
- Venue
- Science Signaling
- Published
- 2011-01-25
- Volume
- 4
- Issue
- 157
- Pages
- mr2-mr2
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- OpenAlex
- W1966863893
- Cited by
- 72
- References
- 43
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 10 · 2014: 7 · 2013: 6 · 2012: 6
- Type
- conference abstract
- Language
- en
- Open access
- closed
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- dependence receptors, trophic support, angiogenesis, carcinogenesis, neurodegeneration, drug development, receptor signaling
- MeSH terms
- Netrin Receptors, Humans, Ligands, Models, Biological, Receptors, Cell Surface, Drug Design, Cell Adhesion Molecules, Apoptosis, Caspases
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