Poellinger, Lorenz

Hypoxia requires Notch signaling to maintain the undifferentiated cell state

Gustafsson, M. V., Zheng, X., Pereira, T., Gradin, K., Jin, S., Lundkvist, J., Ruas, J. L., Poellinger, L., Lendahl, U., & Bondesson, M. (2005) · Developmental Cell

Developmental Biology and Gene RegulationCancer, Hypoxia, and Metabolism

Cited by 1,109

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

Sahlgren, C., Gustafsson, M. V., Jin, S., Poellinger, L., & Lendahl, U. (2008) · Proceedings of the National Academy of Sciences

Cancer Cells and MetastasisDevelopmental Biology and Gene Regulation

Cited by 823

Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

Holmquist-Mengelbier, L., Fredlund, E., Löfstedt, T., Noguera, R., Navarro, S., Nilsson, H., Pietras, A., Vallon-Christersson, J., Borg, Å., Gradin, K., et al. (2006) · Cancer Cell

Cancer, Hypoxia, and MetabolismNeuroblastoma Research and Treatments

Cited by 735

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

Makino, Y., Cao, R., Svensson, K., Bertilsson, G., Asman, M., Tanaka, H., Cao, Y., Berkenstam, A., & Poellinger, L. (2001) · Nature

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 705

Stabilization of HIF-1α is critical to improve wound healing in diabetic mice

Botusan, I. R., Sunkari, V. G., Savu, O., Catrina, A. I., Grünler, J., Lindberg, S., Pereira, T., Ylä-Herttuala, S., Poellinger, L., Brismar, K., et al. (2008) · Proceedings of the National Academy of Sciences

Wound Healing and TreatmentsCancer, Hypoxia, and Metabolism

Cited by 533

Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor

Gradin, K., McGuire, J., Wenger, R. H., Kvietikova, I., Whitelaw, M. L., Toftgård, R., Tora, L., Gassmann, M., & Poellinger, L. (1996) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismToxic Organic Pollutants Impact

Cited by 470

S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate

Tyrakis, P. A., Palazon, A., Macias, D., Lee, K. L., Phan, A. T., Veliça, P., You, J., Chia, G. S., Sim, J., Doedens, A., et al. (2016) · Nature

T-cell and B-cell ImmunologyCancer, Hypoxia, and Metabolism

Cited by 433

Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations

Loh, K. M., Ang, L. T., Zhang, J., Kumar, V., Ang, J., Auyeong, J. Q., Lee, K. L., Choo, S. H., Lim, C. Y. Y., Nichane, M., et al. (2014) · Cell Stem Cell

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 418

Activation of hypoxia-inducible factor 1α: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

Kallio, P. J., Pongratz, I., Gradin, K., McGuire, J., & Poellinger, L. (1997) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 415

Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype

Jögi, A., Øra, I., Nilsson, H., Lindeheim, Å., Makino, Y., Poellinger, L., Axelson, H., & Påhlman, S. (2002) · Proceedings of the National Academy of Sciences

Neuroblastoma Research and TreatmentsCancer, Hypoxia, and Metabolism

Cited by 399

A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors

Andersson, P., McGuire, J., Rubio, C., Gradin, K., Whitelaw, M. L., Pettersson, S., Hanberg, A., & Poellinger, L. (2002) · Proceedings of the National Academy of Sciences

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 310

Physiological activation of hypoxia inducible factor‐1 in human skeletal muscle

Ameln, H., Gustafsson, T., Sundberg, C. J., Okamoto, K., Jansson, E., Poellinger, L., & Makino, Y. (2005) · The FASEB Journal

Cancer, Hypoxia, and MetabolismCardiovascular and exercise physiology

Cited by 276

Definition of a Minimal Domain of the Dioxin Receptor That Is Associated with Hsp90 and Maintains Wild Type Ligand Binding Affinity and Specificity

Coumailleau, P., Poellinger, L., Gustafsson, J.-Å., & Whitelaw, M. L. (1995) · Journal of Biological Chemistry

Toxic Organic Pollutants ImpactHeat shock proteins research

Cited by 172

TCR Engagement Increases Hypoxia-Inducible Factor-1α Protein Synthesis via Rapamycin-Sensitive Pathway under Hypoxic Conditions in Human Peripheral T Cells

Nakamura, H., Makino, Y., Okamoto, K., Poellinger, L., Ohnuma, K., Morimoto, C., & Tanaka, H. (2005) · The Journal of Immunology

Cancer, Hypoxia, and MetabolismT-cell and B-cell Immunology

Cited by 158

Transcriptional Up-regulation of Inhibitory PAS Domain Protein Gene Expression by Hypoxia-inducible Factor 1 (HIF-1)

Makino, Y., Uenishi, R., Okamoto, K., Isoe, T., Hosono, O., Tanaka, H., Kanopka, A., Poellinger, L., Haneda, M., & Morimoto, C. (2007) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 120

Definition of a Dioxin Receptor Mutant That Is a Constitutive Activator of Transcription

McGuire, J., Okamoto, K., Whitelaw, M. L., Tanaka, H., & Poellinger, L. (2001) · Journal of Biological Chemistry

Toxic Organic Pollutants ImpactPeroxisome Proliferator-Activated Receptors

Cited by 102

Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP

Zheng, X., Zheng, X., Wang, X., Ma, Z., Gupta Sunkari, V, Botusan, I., Takeda, T., Björklund, A., Inoue, M., Catrina, S.-B., et al. (2012) · Cell Death & Disease

Endoplasmic Reticulum Stress and DiseasePancreatic function and diabetes

Cited by 99

Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer

Chien, W., Sun, Q.-Y., Lee, K. L., Ding, L.-W., Wuensche, P., Torres-Fernandez, L. A., Tan, S. Z., Tokatly, I., Zaiden, N., Poellinger, L., et al. (2015) · Molecular Oncology

Pancreatic and Hepatic Oncology ResearchProtein Tyrosine Phosphatases

Cited by 80

HIF-2α expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia

Nilsson, H., Jögi, A., Beckman, S., Harris, A. L., Poellinger, L., & Påhlman, S. (2005) · Experimental Cell Research

Neuroblastoma Research and TreatmentsCancer, Hypoxia, and Metabolism

Cited by 75

HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters

Suzuki, N., Vojnovic, N., Lee, K.-L., Yang, H., Gradin, K., & Poellinger, L. (2018) · Experimental Cell Research

Genomics and Chromatin DynamicsCancer, Hypoxia, and Metabolism

Cited by 21