Brown, J. Mark

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell

Platelet Disorders and TreatmentsGut microbiota and health

Cited by 1,968

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

Roberts, A. B., Gu, X., Buffa, J. A., Hurd, A. G., Wang, Z., Zhu, W., Gupta, N., Skye, S. M., Cody, D. B., Levison, B. S., et al. (2018) · Nature Medicine

Gut microbiota and healthBlood Coagulation and Thrombosis Mechanisms

Cited by 552

Microbial modulation of cardiovascular disease

Brown, J. M., & Hazen, S. L. (2018) · Nature Reviews Microbiology

Gut microbiota and healthNutritional Studies and Diet

Cited by 440

The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases

Brown, J. M., & Hazen, S. L. (2015) · Annual Review of Medicine

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 438

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

Shih, D. M., Wang, Z., Lee, R., Meng, Y., Che, N., Charugundla, S., Qi, H., Wu, J., Pan, C., Brown, J. M., et al. (2015) · Journal of Lipid Research

Pharmacogenetics and Drug MetabolismLipid metabolism and disorders

Cited by 335

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Schugar, R. C., Shih, D. M., Warrier, M., Helsley, R. N., Burrows, A., Ferguson, D., Brown, A. L., Gromovsky, A. D., Heine, M., Chatterjee, A., et al. (2017) · Cell Reports

Gut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Cited by 291

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N‐oxide‐generating pathway, modulates platelet responsiveness and thrombosis risk

Zhu, W., Buffa, J. A., Wang, Z., Warrier, M., Schugar, R., Shih, D. M., Gupta, N., Gregory, J. C., Org, E., Fu, X., et al. (2018) · Journal of Thrombosis and Haemostasis

Blood Coagulation and Thrombosis MechanismsPlatelet Disorders and Treatments

Cited by 161

Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery

Brown, J. M., & Hazen, S. L. (2017) · Journal of Biological Chemistry

Gut microbiota and healthMetabolomics and Mass Spectrometry Studies

Cited by 108

Metaorganismal nutrient metabolism as a basis of cardiovascular disease

Brown, J. M., & Hazen, S. L. (2014) · Current Opinion in Lipidology

Gut microbiota and healthNutritional Studies and Diet

Cited by 80

Quantification of bile acids: a mass spectrometry platform for studying gut microbe connection to metabolic diseases

Choucair, I., Nemet, I., Li, L., Cole, M. A., Skye, S. M., Kirsop, J. D., Fischbach, M. A., Gogonea, V., Brown, J. M., Tang, W. H. W., et al. (2020) · Journal of Lipid Research

Gut microbiota and healthMetabolomics and Mass Spectrometry Studies

Cited by 77

Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3 ) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels—Brief Report

Shih, D. M., Zhu, W., Schugar, R. C., Meng, Y., Jia, X., Miikeda, A., Wang, Z., Zieger, M., Lee, R., Graham, M., et al. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology

Pharmacogenetics and Drug MetabolismBlood Coagulation and Thrombosis Mechanisms

Cited by 67

An in vivo multiplexed small-molecule screening platform

Grüner, B. M., Schulze, C. J., Yang, D., Ogasawara, D., Dix, M. M., Rogers, Z. N., Chuang, C.-H., McFarland, C. D., Chiou, S.-H., Brown, J. M., et al. (2016) · Nature Methods

Cancer Cells and MetastasisSingle-cell and spatial transcriptomics

Cited by 62

Gut microbial metabolites in Parkinson's disease: Association with lifestyle, disease characteristics, and treatment status

Voigt, R. M., Wang, Z., Brown, J. M., Engen, P. A., Naqib, A., Goetz, C. G., Hall, D. A., Metman, L. V., Shaikh, M., Forsyth, C. B., et al. (2022) · Neurobiology of Disease

Parkinson's Disease Mechanisms and TreatmentsGut microbiota and health

Cited by 51

Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer’s disease

Qiu, Y., Hou, Y., Gohel, D., Zhou, Y., Xu, J., Bykova, M., Yang, Y., Leverenz, J. B., Pieper, A. A., Nussinov, R., et al. (2024) · Cell Reports

Alzheimer's disease research and treatmentsGut microbiota and health

Cited by 40