Kahn, C. Ronald

Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

Norris, A. W., Chen, L., Fisher, S. J., Szanto, I., Ristow, M., Jozsi, A. C., Hirshman, M. F., Rosen, E. D., Goodyear, L. J., Gonzalez, F. J., et al. (2003) · Journal of Clinical Investigation

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Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

Pospisilik, J. A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P. D., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., et al. (2007) · Cell

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

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Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism

Macotela, Y., Boucher, J., Tran, T. T., & Kahn, C. R. (2009) · Diabetes

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

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Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

Kendrick, A. A., Choudhury, M., Rahman, S. M., McCurdy, C. E., Friederich, M., Van Hove, J. L. K., Watson, P. A., Birdsey, N., Bao, J., Gius, D., et al. (2011) · Biochemical Journal

Sirtuins and Resveratrol in MedicineLiver Disease Diagnosis and Treatment

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Brown fat as a therapy for obesity and diabetes

Cypess, A. M., & Kahn, C. R. (2010) · Current Opinion in Endocrinology, Diabetes & Obesity

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Endocrine regulation of ageing

Russell, S. J., & Kahn, C. R. (2007) · Nature Reviews Molecular Cell Biology

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

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Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

Kim, J. K., Michael, M. D., Previs, S. F., Peroni, O. D., Mauvais-Jarvis, F., Neschen, S., Kahn, B. B., Kahn, C. R., & Shulman, G. I. (2000) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and Cancer

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Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

Belke, D. D., Betuing, S., Tuttle, M. J., Graveleau, C., Young, M. E., Pham, M., Zhang, D., Cooksey, R. C., McClain, D. A., Litwin, S. E., et al. (2002) · Journal of Clinical Investigation

Congenital heart defects researchCardiovascular Function and Risk Factors

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Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

Lee, K. Y., Russell, S. J., Ussar, S., Boucher, J., Vernochet, C., Mori, M. A., Smyth, G., Rourk, M., Cederquist, C., Rosen, E. D., et al. (2013) · Diabetes

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Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice

Almind, K., Manieri, M., Sivitz, W. I., Cinti, S., & Kahn, C. R. (2007) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

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Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation

Jing, E., O’Neill, B. T., Rardin, M. J., Kleinridders, A., Ilkeyeva, O. R., Ussar, S., Bain, J. R., Lee, K. Y., Verdin, E. M., Newgard, C. B., et al. (2013) · Diabetes

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Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

Ferris, H. A., Perry, R. J., Moreira, G. V., Shulman, G. I., Horton, J. D., & Kahn, C. R. (2017) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

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Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy

Ulanet, D. B., Ludwig, D. L., Kahn, C. R., & Hanahan, D. (2010) · Proceedings of the National Academy of Sciences

Growth Hormone and Insulin-like Growth FactorsMetabolism, Diabetes, and Cancer

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Diet, genetics, and the gut microbiome drive dynamic changes in plasma metabolites

Fujisaka, S., Avila-Pacheco, J., Soto, M., Kostic, A., Dreyfuss, J. M., Pan, H., Ussar, S., Altindis, E., Li, N., Bry, L., et al. (2018) · Cell Reports

Gut microbiota and healthMetabolomics and Mass Spectrometry Studies

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Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets

Cheng, K., Ho, K., Stokes, R., Scott, C., Lau, S. M., Hawthorne, W. J., O’Connell, P. J., Loudovaris, T., Kay, T. W., Kulkarni, R. N., et al. (2010) · Journal of Clinical Investigation

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FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

O-Sullivan, I., Zhang, W., Wasserman, D. H., Liew, C. W., Liu, J., Paik, J., DePinho, R. A., Stolz, D. B., Kahn, C. R., Schwartz, M. W., et al. (2015) · Nature Communications

FOXO transcription factor regulationMetabolism, Diabetes, and Cancer

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Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins

Softic, S., Meyer, J. G., Wang, G.-X., Gupta, M. K., Batista, T. M., Lauritzen, H. P. M. M., Fujisaka, S., Serra, D., Herrero, L., Willoughby, J., et al. (2019) · Cell Metabolism

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Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin

Tseng, Y.-H., Butte, A. J., Kokkotou, E., Yechoor, V. K., Taniguchi, C. M., Kriauciunas, K. M., Cypess, A. M., Niinobe, M., Yoshikawa, K., Patti, M. E., et al. (2005) · Nature Cell Biology

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Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism

Soto, M., Herzog, C., Pacheco, J. A., Fujisaka, S., Bullock, K., Clish, C. B., & Kahn, C. R. (2018) · Molecular Psychiatry

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Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

Asilmaz, E., Cohen, P., Miyazaki, M., Dobrzyn, P., Ueki, K., Fayzikhodjaeva, G., Soukas, A. A., Kahn, C. R., Ntambi, J. M., Socci, N. D., et al. (2004) · Journal of Clinical Investigation

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Loss of Skeletal Muscle HIF-1α Results in Altered Exercise Endurance

Mason, S. D., Howlett, R. A., Kim, M. J., Olfert, I. M., Hogan, M. C., McNulty, W., Hickey, R. P., Wagner, P. D., Kahn, C. R., Giordano, F. J., et al. (2004) · PLoS Biology

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Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

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TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism

Takahashi, H., Alves, C. R. R., Stanford, K. I., Middelbeek, R. J. W., Nigro, P., Ryan, R. E., Xue, R., Sakaguchi, M., Lynes, M. D., So, K., et al. (2019) · Nature Metabolism

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Skeletal Muscle-Selective Knockout of LKB1 Increases Insulin Sensitivity, Improves Glucose Homeostasis, and Decreases TRB3

Koh, H.-J., Arnolds, D. E., Fujii, N., Tran, T. T., Rogers, M. J., Jessen, N., Li, Y., Liew, C. W., Ho, R. C., Hirshman, M. F., et al. (2006) · Molecular and Cellular Biology

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