Kahn, C. Ronald

Identification and Importance of Brown Adipose Tissue in Adult Humans

Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine

Adipose Tissue and MetabolismCardiovascular Disease and Adiposity

Cited by 4,399

Critical nodes in signalling pathways: insights into insulin action

Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology

Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

Cited by 2,760

Type 2 diabetes mellitus

DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, J. J., Hu, F. B., Kahn, C. R., Raz, I., Shulman, G. I., et al. (2015) · Nature Reviews Disease Primers

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 2,611

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 2,235

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 1,952

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science

Genetics, Aging, and Longevity in Model OrganismsParathyroid Disorders and Treatments

Cited by 1,935

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

Hirschey, M. D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D. B., Grueter, C. A., Harris, C., Biddinger, S., Ilkayeva, O. R., et al. (2010) · Nature

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 1,687

Antioxidants prevent health-promoting effects of physical exercise in humans

Ristow, M., Zarse, K., Oberbach, A., Klöting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R., & Blüher, M. (2009) · Proceedings of the National Academy of Sciences

Exercise and Physiological ResponsesAntioxidant Activity and Oxidative Stress

Cited by 1,582

Adipose-derived circulating miRNAs regulate gene expression in other tissues

Thomou, T., Mori, M. A., Dreyfuss, J. M., Konishi, M., Sakaguchi, M., Wolfrum, C., Rao, T. N., Winnay, J. N., Garcia-Martin, R., Grinspoon, S. K., et al. (2017) · Nature

Extracellular vesicles in diseaseMicroRNA in disease regulation

Cited by 1,539

Developmental Origin of Fat: Tracking Obesity to Its Source

Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,508

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 1,296

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

Wong, S. L., Demers, M., Martinod, K., Gallant, M., Wang, Y., Goldfine, A. B., Kahn, C. R., & Wagner, D. D. (2015) · Nature Medicine

Neutrophil, Myeloperoxidase and Oxidative MechanismsWound Healing and Treatments

Cited by 1,264

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

Martin, B. C., Warram, J. H., Krolewski, A. S., Soeldner, J. S., Kahn, C. R., Martin, B. C., & Bergman, R. N. (1992) · The Lancet

Pancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 1,158

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,099

Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

Virkamäki, A., Ueki, K., & Kahn, C. R. (1999) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 854

A guide to analysis of mouse energy metabolism

Tschöp, M. H., Speakman, J. R., Arch, J. R. S., Auwerx, J., Brüning, J. C., Chan, L., Eckel, R. H., Farese, R. V., Galgani, J. E., Hambly, C., et al. (2012) · Nature Methods

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 813

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D., Mauvais-Jarvis, F., Lowell, B. B., Wojtaszewski, J. F. P., Hirshman, M. F., Virkamaki, A., Goodyear, L. J., et al. (2000) · Nature Medicine

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 743

Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production

Könner, A. C., Janoschek, R., Plum, L., Jordan, S. D., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G. S., et al. (2007) · Cell Metabolism

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 695

Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms

Ueki, K., Kondo, T., & Kahn, C. R. (2004) · Molecular and Cellular Biology

Adipokines, Inflammation, and Metabolic DiseasesCytokine Signaling Pathways and Interactions

Cited by 686

Cellular bioenergetics as a target for obesity therapy

Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery

Adipose Tissue and MetabolismRegulation of Appetite and Obesity

Cited by 591

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

Kleinridders, A., Cai, W., Cappellucci, L., Ghazarian, A., Collins, W. R., Vienberg, S. G., Pothos, E. N., & Kahn, C. R. (2015) · Proceedings of the National Academy of Sciences

Neurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and Treatments

Cited by 486

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

Jing, E., Emanuelli, B., Hirschey, M. D., Boucher, J., Lee, K. Y., Lombard, D., Verdin, E. M., & Kahn, C. R. (2011) · Proceedings of the National Academy of Sciences

Sirtuins and Resveratrol in MedicineMetabolism, Diabetes, and Cancer

Cited by 469

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

Biddinger, S. B., Hernandez-Ono, A., Rask-Madsen, C., Haas, J. T., Alemán, J. O., Suzuki, R., Scapa, E. F., Agarwal, C., Carey, M. C., Stephanopoulos, G., et al. (2008) · Cell Metabolism

Lipid metabolism and disordersCholesterol and Lipid Metabolism

Cited by 469

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

Zarse, K., Schmeisser, S., Groth, M., Priebe, S., Beuster, G., Kuhlow, D., Guthke, R., Platzer, M., Kahn, C. R., & Ristow, M. (2012) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

Cited by 430