Kahn, C. Ronald

Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

Otani, K., Kulkarni, R. N., Baldwin, A. C., Krutzfeldt, J., Ueki, K., Stoffel, M., Kahn, C. R., & Polonsky, K. S. (2004) · American Journal of Physiology-Endocrinology and Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 185

Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation

Tseng, Y.-H., Kriauciunas, K. M., Kokkotou, E., & Kahn, C. R. (2004) · Molecular and Cellular Biology

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 173

Differential role of insulin/IGF-1 receptor signaling in muscle growth and glucose homeostasis

O’Neill, B. T., Lauritzen, H. P. M. M., Hirshman, M. F., Smyth, G., Goodyear, L. J., & Kahn, C. R. (2015) · Cell Reports

Metabolism, Diabetes, and CancerGrowth Hormone and Insulin-like Growth Factors

Cited by 171

FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy

O’Neill, B. T., Bhardwaj, G., Penniman, C. M., Krumpoch, M. T., Suarez Beltran, P. A., Klaus, K., Poro, K., Li, M., Pan, H., Dreyfuss, J. M., et al. (2019) · Diabetes

Muscle Physiology and DisordersFOXO transcription factor regulation

Cited by 167

Hepatocyte Stress Increases Expression of Yes‐Associated Protein and Transcriptional Coactivator With PDZ‐Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis

Mooring, M., Fowl, B. H., Lum, S. Z. C., Liu, Y., Yao, K., Softic, S., Kirchner, R., Bernstein, A., Singhi, A. D., Jay, D. G., et al. (2020) · Hepatology

Liver physiology and pathologyHippo pathway signaling and YAP/TAZ

Cited by 162

Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function

Boucher, J., Softic, S., El Ouaamari, A., Krumpoch, M. T., Kleinridders, A., Kulkarni, R. N., O’Neill, B. T., & Kahn, C. R. (2016) · Diabetes

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 154

Positive and Negative Regulation of Phosphoinositide 3-Kinase-Dependent Signaling Pathways by Three Different Gene Products of the p85α Regulatory Subunit

Ueki, K., Algenstaedt, P., Mauvais-Jarvis, F., & Kahn, C. R. (2000) · Molecular and Cellular Biology

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 148

Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling

Boucher, J., Mori, M. A., Lee, K. Y., Smyth, G., Liew, C. W., Macotela, Y., Rourk, M., Bluher, M., Russell, S. J., & Kahn, C. R. (2012) · Nature Communications

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 142

Mitochondrial gene expression and increased oxidative metabolism: Role in increased lifespan of fat-specific insulin receptor knock-out mice

Katic, M., Kennedy, A. R., Leykin, I., Norris, A., McGettrick, A., Gesta, S., Russell, S. J., Bluher, M., Maratos‐Flier, E., & Kahn, C. R. (2007) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsAdipose Tissue and Metabolism

Cited by 141

Leptin regulation of Hsp60 impacts hypothalamic insulin signaling

Kleinridders, A., Lauritzen, H. P. M. M., Ussar, S., Christensen, J. H., Mori, M. A., Bross, P., & Kahn, C. R. (2013) · Journal of Clinical Investigation

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 130

Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease.

Goldfine, A. B., Bouche, C., Parker, R. A., Kim, C., Kerivan, A., Soeldner, J. S., Martin, B. C., Warram, J. H., & Kahn, C. R. (2003) · Proceedings of the National Academy of Sciences

Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Cited by 99

Cross-talk between Insulin and Wnt Signaling in Preadipocytes

Palsgaard, J., Emanuelli, B., Winnay, J. N., Sumara, G., Karsenty, G., & Kahn, C. R. (2012) · Journal of Biological Chemistry

Wnt/β-catenin signaling in development and cancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 98

Differential Roles of Insulin Receptor Substrates in the Anti-apoptotic Function of Insulin-like Growth Factor-1 and Insulin

Tseng, Y.-H., Ueki, K., Kriauciunas, K. M., & Kahn, C. R. (2002) · Journal of Biological Chemistry

Growth Hormone and Insulin-like Growth FactorsMetabolism, Diabetes, and Cancer

Cited by 96

Regulation of Vascular Endothelial Growth Factor Expression and Vascularization in the Myocardium by Insulin Receptor and PI3K/Akt Pathways in Insulin Resistance and Ischemia

He, Z., Opland, D. M., Way, K. J., Ueki, K., Bodyak, N., Kang, P. M., Izumo, S., Kulkarni, R. N., Wang, B., Liao, R., et al. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology

Angiogenesis and VEGF in CancerCardiac Ischemia and Reperfusion

Cited by 94

Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFκB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance

Sajan, M. P., Standaert, M. L., Rivas, J., Miura, A., Kanoh, Y., Soto, J., Taniguchi, C. M., Kahn, C. R., & Farese, R. V. (2009) · Diabetologia

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 60

Insulin/IGF1 signalling mediates the effects of β2‐adrenergic agonist on muscle proteostasis and growth

Gonçalves, D. A., Silveira, W. A., Manfredi, L. H., Graça, F. A., Armani, A., Bertaggia, E., O´Neill, B. T., Lautherbach, N., Machado, J., Nogara, L., et al. (2019) · Journal of Cachexia, Sarcopenia and Muscle

Muscle Physiology and DisordersMuscle metabolism and nutrition

Cited by 56

Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity

Vienberg, S. G., Kleinridders, A., Suzuki, R., & Kahn, C. R. (2015) · Molecular Metabolism

Lipid metabolism and disordersLipid metabolism and biosynthesis

Cited by 33

Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan

Merry, T. L., Kuhlow, D., Laube, B., Pöhlmann, D., Pfeiffer, A. F. H., Kahn, C. R., Ristow, M., & Zarse, K. (2017) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and Cancer

Cited by 30

Signal transducer and activator of transcription 3 and the phosphatidylinositol 3‐kinase regulatory subunits p55α and p50α regulate autophagy in vivo

Pensa, S., Lloyd‐Lewis, B., Sargeant, T. J., Resemann, H. K., Kahn, C. R., & Watson, C. J. (2014) · The FEBS Journal

Autophagy in Disease and TherapyCytokine Signaling Pathways and Interactions

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