Bunnett, Nigel W.

Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome

Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology

Gastrointestinal motility and disordersMast cells and histamine

Cited by 1,475

Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome

Barbara, G., Wang, B., Stanghellini, V., de Giorgio, R., Cremon, C., Di Nardo, G., Trevisani, M., Campi, B., Geppetti, P., Tonini, M., et al. (2007) · Gastroenterology

Gastrointestinal motility and disordersMast cells and histamine

Cited by 783

Tachykinins and Their Receptors: Contributions to Physiological Control and the Mechanisms of Disease

Steinhoff, M. S., von Mentzer, B., Geppetti, P., Pothoulakis, C., & Bunnett, N. W. (2014) · Physiological Reviews

Neuropeptides and Animal PhysiologyPain Mechanisms and Treatments

Cited by 628

Role for protease activity in visceral pain in irritable bowel syndrome

Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation

Gastrointestinal motility and disordersPain Mechanisms and Treatments

Cited by 591

Endosomes: A legitimate platform for the signaling train

Murphy, J. E., Padilla, B. E., Hasdemir, B., Cottrell, G. S., & Bunnett, N. W. (2009) · Proceedings of the National Academy of Sciences

Cellular transport and secretionReceptor Mechanisms and Signaling

Cited by 373

Protease-activated receptors in inflammation, neuronal signaling and pain

Vergnolle, N., Wallace, J. L., Bunnett, N. W., & Hollenberg, M. D. (2001) · Trends in Pharmacological Sciences

Blood Coagulation and Thrombosis MechanismsProtease and Inhibitor Mechanisms

Cited by 369

The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice

Alemi, F., Poole, D. P., Chiu, J., Schoonjans, K., Cattaruzza, F., Grider, J. R., Bunnett, N. W., & Corvera, C. U. (2013) · Gastroenterology

Gastrointestinal motility and disordersDrug Transport and Resistance Mechanisms

Cited by 362

Mast Cell Tryptase Controls Paracellular Permeability of the Intestine

Jacob, C., Yang, P.-C., Darmoul, D., Amadesi, S., Saito, T., Cottrell, G. S., Coelho, A.-M., Singh, P., Grady, E. F., Perdue, M., et al. (2005) · Journal of Biological Chemistry

Mast cells and histamineGastrointestinal motility and disorders

Cited by 334

Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2

Kong, W., McConalogue, K., Khitin, L. M., Hollenberg, M. D., Payan, D. G., Böhm, S. K., & Bunnett, N. W. (1997) · Proceedings of the National Academy of Sciences

Blood Coagulation and Thrombosis MechanismsProtease and Inhibitor Mechanisms

Cited by 318

Mast cell tryptase and proteinase‐activated receptor 2 induce hyperexcitability of guinea‐pig submucosal neurons

Reed, D. E., Barajas‐Lopez, C., Cottrell, G., Velazquez‐Rocha, S., Dery, O., Grady, E. F., Bunnett, N. W., & Vanner, S. J. (2003) · The Journal of Physiology

Mast cells and histamineGastrointestinal motility and disorders

Cited by 192

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., et al. (2018) · Proceedings of the National Academy of Sciences

Gastrointestinal motility and disordersPain Mechanisms and Treatments

Cited by 185

Proteinase-Activated Receptor-2-Induced Colonic Inflammation in Mice: Possible Involvement of Afferent Neurons, Nitric Oxide, and Paracellular Permeability

Cenac, N., Garcia-Villar, R., Ferrier, L., Larauche, M., Vergnolle, N., Bunnett, N. W., Coelho, A.-M., Fioramonti, J., & Bueno, L. (2003) · The Journal of Immunology

Gastrointestinal motility and disordersBlood Coagulation and Thrombosis Mechanisms

Cited by 139

Pseudomonas aeruginosa Elastase Disables Proteinase-Activated Receptor 2 in Respiratory Epithelial Cells

Dulon, S., Leduc, D., Cottrell, G. S., D'Alayer, J., Hansen, K. K., Bunnett, N. W., Hollenberg, M. D., Pidard, D., & Chignard, M. (2005) · American Journal of Respiratory Cell and Molecular Biology

Blood Coagulation and Thrombosis MechanismsProtease and Inhibitor Mechanisms

Cited by 139

Protease-activated receptors in health and disease

Peach, C. J., Edgington-Mitchell, L. E., Bunnett, N. W., & Schmidt, B. L. (2023) · Physiological Reviews

Blood Coagulation and Thrombosis MechanismsProtease and Inhibitor Mechanisms

Cited by 116

Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P

Emanueli, C., Grady, E. F., Madeddu, P., Figini, M., Bunnett, N. W., Parisi, D., Regoli, D., & Geppetti, P. (1998) · Hypertension

Coagulation, Bradykinin, Polyphosphates, and AngioedemaRenin-Angiotensin System Studies

Cited by 114

Neuro-humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract

Bunnett, N. W. (2014) · The Journal of Physiology

Drug Transport and Resistance MechanismsGastrointestinal motility and disorders

Cited by 110

Sensitization of Peripheral Sensory Nerves by Mediators From Colonic Biopsies of Diarrhea-Predominant Irritable Bowel Syndrome Patients: A Role for PAR2

Valdez-Morales, E. E., Overington, J., Guerrero-Alba, R., Ochoa-Cortes, F., Ibeakanma, C. O., Spreadbury, I., Bunnett, N. W., Beyak, M., & Vanner, S. J. (2013) · American Journal of Gastroenterology

Gastrointestinal motility and disordersPain Mechanisms and Treatments

Cited by 107

Cathepsin S Is Activated During Colitis and Causes Visceral Hyperalgesia by a PAR2-Dependent Mechanism in Mice

Cattaruzza, F., Lyo, V., Jones, E., Pham, D., Hawkins, J., Kirkwood, K., Valdez–Morales, E., Ibeakanma, C., Vanner, S. J., Bogyo, M., et al. (2011) · Gastroenterology

Pain Mechanisms and TreatmentsProtease and Inhibitor Mechanisms

Cited by 103

Mechanisms of protease‐activated receptor 2‐evoked hyperexcitability of nociceptive neurons innervating the mouse colon

Kayssi, A., Amadesi, S., Bautista, F., Bunnett, N. W., & Vanner, S. (2007) · The Journal of Physiology

Pain Mechanisms and TreatmentsIon Channels and Receptors

Cited by 64

Protease-Activated Receptor 2, Dipeptidyl Peptidase I, and Proteases Mediate Clostridium difficile Toxin A Enteritis

Cottrell, G. S., Amadesi, S., Pikios, S., Camerer, E., Willardsen, J. A., Murphy, B. R., Caughey, G. H., Wolters, P. J., Coughlin, S. R., Peterson, A., et al. (2007) · Gastroenterology

Clostridium difficile and Clostridium perfringens researchBlood Coagulation and Thrombosis Mechanisms

Cited by 56

G-protein–coupled receptors are dynamic regulators of digestion and targets for digestive diseases

Canals, M., Poole, D. P., Veldhuis, N. A., Schmidt, B. L., & Bunnett, N. W. (2019) · Gastroenterology

Receptor Mechanisms and SignalingGastrointestinal motility and disorders

Cited by 35