Heitman, Joseph

Calcineurin Target CrzA Regulates Conidial Germination, Hyphal Growth, and Pathogenesis of Aspergillus fumigatus

Cramer, R. A., Perfect, B. Z., Pinchai, N., Park, S., Perlin, D. S., Asfaw, Y. G., Heitman, J., Perfect, J. R., & Steinbach, W. J. (2008) · Eukaryotic Cell

Fungal and yeast genetics researchAntifungal resistance and susceptibility

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Coping with stress: calmodulin and calcineurin in model and pathogenic fungi

Kraus, P. R., & Heitman, J. (2003) · Biochemical and Biophysical Research Communications

Fungal and yeast genetics researchSignaling Pathways in Disease

Cited by 169

Synergistic Antifungal Activities of Bafilomycin A 1 , Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against Cryptococcus neoformans

Del Poeta, M., Cruz, M. C., Cardenas, M. E., Perfect, J. R., & Heitman, J. (2000) · Antimicrobial Agents and Chemotherapy

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 169

Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens

Park, H.-S., Lee, S. C., Cardenas, M. E., & Heitman, J. (2019) · Cell Host & Microbe

Fungal and yeast genetics researchSignaling Pathways in Disease

Cited by 168

Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR

Cruz, M. C., Goldstein, A. L., Blankenship, J., Del Poeta, M., Perfect, J. R., McCusker, J. H., Bennani, Y. L., Cardenas, M. E., & Heitman, J. (2001) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 159

Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans

Desjardins, C. A., Giamberardino, C., Sykes, S. M., Yu, C.-H., Tenor, J. L., Chen, Y., Yang, T., Jones, A. M., Sun, S., Haverkamp, M. R., et al. (2017) · Genome Research

Fungal Infections and StudiesPlant Pathogens and Fungal Diseases

Cited by 157

Calcineurin: a central controller of signalling in eukaryotes: Workshop on the Calcium/Calcineurin/NFAT Pathway: Regulation and Function

Aramburu, J., Heitman, J., & Crabtree, G. R. (2004) · The EMBO Reports

Signaling Pathways in DiseaseCalpain Protease Function and Regulation

Cited by 156

Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans

Cruz, M. C., Fox, D. S., & Heitman, J. (2001) · The EMBO Journal

Fungal Infections and StudiesFungal and yeast genetics research

Cited by 150

Good fungi gone bad: The corruption of calcineurin

Fox, D. S., & Heitman, J. (2002) · BioEssays

Signaling Pathways in DiseaseFungal and yeast genetics research

Cited by 137

Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.

Breuder, T., Hemenway, C. S., Movva, N. R., Cardenas, M. E., & Heitman, J. (1994) · Proceedings of the National Academy of Sciences

Signaling Pathways in DiseaseFungal and yeast genetics research

Cited by 135

The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of Candida albicans

Onyewu, C., Wormley, F. L., Perfect, J. R., & Heitman, J. (2004) · Infection and Immunity

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 121

Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1α

Hull, C. M., Davidson, R. C., & Heitman, J. (2002) · Genes & Development

Fungal and yeast genetics researchFungal Infections and Studies

Cited by 119

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Juvvadi, P. R., Fox, D., Bobay, B. G., Hoy, M. J., Gobeil, S. M. C., Venters, R. A., Chang, Z., Lin, J. J., Averette, A. F., Cole, D. C., et al. (2019) · Nature Communications

Signaling Pathways in DiseaseAntifungal resistance and susceptibility

Cited by 116

Calcineurin Inhibition or Mutation Enhances Cell Wall Inhibitors against Aspergillus fumigatus

Steinbach, W. J., Cramer, R. A., Perfect, B. Z., Henn, C., Nielsen, K., Heitman, J., & Perfect, J. R. (2007) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 108

Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis

Chen, Y.-L., Brand, A., Morrison, E. L., Silao, F. G. S., Bigol, U. G., Malbas, F. F., Nett, J. E., Andes, D. R., Solis, N. V., Filler, S. G., et al. (2011) · Eukaryotic Cell

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 107

5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus

Billmyre, R. B., Applen Clancey, S., Li, L. X., Doering, T. L., & Heitman, J. (2020) · Nature Communications

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 102

Estrogen Receptor Antagonists Are Anti-Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with Fluconazole In Vivo

Butts, A., Koselny, K., Chabrier-Roselló, Y., Semighini, C. P., Brown, J. C. S., Wang, X., Annadurai, S., DiDone, L., Tabroff, J., Childers, W. E., et al. (2014) · mBio

Fungal Infections and StudiesAntifungal resistance and susceptibility

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Dual action antifungal small molecule modulates multidrug efflux and TOR signaling

Shekhar-Guturja, T., Gunaherath, G. M. K. B., Wijeratne, E. M. K., Lambert, J.-P., Averette, A. F., Lee, S. C., Kim, T., Bahn, Y.-S., Tripodi, F., Ammar, R., et al. (2016) · Nature Chemical Biology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 101

Signal-transduction cascades as targets for therapeutic intervention by natural products

Cardenas, M. E., Sanfridson, A., Cutler, N. S., & Heitman, J. (1998) · Trends in Biotechnology

PI3K/AKT/mTOR signaling in cancerMicrobial Natural Products and Biosynthesis

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Convergent Evolution of Calcineurin Pathway Roles in Thermotolerance and Virulence in Candida glabrata

Chen, Y.-L., Konieczka, J. H., Springer, D. J., Bowen, S. E., Zhang, J., Silao, F. G. S., Bungay, A. A. C., Bigol, U. G., Nicolas, M. G., Abraham, S. N., et al. (2012) · G3 Genes|Genomes|Genetics

Fungal and yeast genetics researchAntifungal resistance and susceptibility

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Pheromones Stimulate Mating and Differentiation via Paracrine and Autocrine Signaling in Cryptococcus neoformans

Shen, W.-C., Davidson, R. C., Cox, G. M., & Heitman, J. (2002) · Eukaryotic Cell

Fungal and yeast genetics researchFungal Infections and Studies

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Highly recombinant VGII Cryptococcus gattii population develops clonal outbreak clusters through both sexual macroevolution and asexual microevolution

Billmyre, R. B., Croll, D., Li, W., Mieczkowski, P., Carter, D. A., Cuomo, C. A., Kronstad, J. W., & Heitman, J. (2014) · mBio

Fungal Infections and StudiesGenetic diversity and population structure

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Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii

Billmyre, R. B., Clancey, S. A., & Heitman, J. (2017) · eLife

Fungal Infections and StudiesEvolution and Genetic Dynamics

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An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens

Robbins, N., Spitzer, M., Yu, T., Cerone, R. P., Averette, A. K., Bahn, Y.-S., Heitman, J., Sheppard, D. C., Tyers, M., & Wright, G. D. (2015) · Cell Reports

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

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