Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.

The epidemiology of sepsis in the United States from 1979 through 2000

Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841 · see citing works

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116 · see citing works

Nonfilamentous C. albicans Mutants Are Avirulent

Lo, H.-J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., & Fink, G. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80358-x · Cited by 1,809 · see citing works

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

Clipstone, N. A., & Crabtree, G. R. (1992) · Nature · doi:10.1038/357695a0 · Cited by 1,635 · see citing works

Epidemiology and Outcome of Mould Infections in Hematopoietic Stem Cell Transplant Recipients

Marr, K. A., Carter, R. A., Crippa, F., Wald, A., & Corey, L. (2002) · Clinical Infectious Diseases · doi:10.1086/339202 · Cited by 1,446 · see citing works

Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia

Storb, R. F., Deeg, H. J., Whitehead, J., Appelbaum, F. R., Beatty, P. G., Bensinger, W., Buckner, C. D., Clift, R. A., Doney, K., Farewell, V. T., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198603203141201 · Cited by 1,411 · see citing works

Nosocomial Bloodstream Infections in United States Hospitals: A Three‐Year Analysis

Edmond, M. B., Wallace, S. E., McClish, D. K., Pfaller, M. A., Jones, R. N., & Wenzel, R. P. (1999) · Clinical Infectious Diseases · doi:10.1086/520192 · Cited by 1,387 · see citing works

Virulence factors of Candida albicans

Calderone, R. A., & Fonzi, W. A. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(01)02094-7 · Cited by 1,331 · see citing works

Bad Bugs Need Drugs: An Update on the Development Pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America

Talbot, G. H., Bradley, J. S., Edwards, J. E., Gilbert, D. N., Scheld, M., & Bartlett, J. G. (2006) · Clinical Infectious Diseases · doi:10.1086/499819 · Cited by 1,106 · see citing works

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.

Roe, S. M., Prodromou, C., O'Brien, R., Ladbury, J. E., Piper, P. W., & Pearl, L. H. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm980403y · Cited by 1,004 · see citing works

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

Griffith, J. P., Kim, J. L., Kim, E. E., Sintchak, M. D., Thomson, J. A., Fitzgibbon, M. J., Fleming, M. A., Caron, P. R., Hsiao, K., & Navia, M. A. (1995) · Cell · doi:10.1016/0092-8674(95)90439-5 · Cited by 834 · see citing works

Trends in the postmortem epidemiology of invasive fungal infections at a University Hospital

Groll, A. H., Shah, P. M., MENTZEL, C., Schneider, M., Just‐Nübling, G., & Huebner, K. (1996) · Journal of Infection · doi:10.1016/s0163-4453(96)92700-0 · Cited by 779 · see citing works

Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex

Kissinger, C. R., Parge, H. E., Knighton, D. R., Lewis, C. T., Pelletier, L. A., Tempczyk, A., Kalish, V. J., Tucker, K. D., Showalter, R. E., Moomaw, E. W., et al. (1995) · Nature · doi:10.1038/378641a0 · Cited by 762 · see citing works

A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)

Kidd, S. E., Hagen, F., Tscharke, R. L., Huynh, M., Bartlett, K. H., Fyfe, M. W., MacDougall, L., Boekhout, T., Kwon-Chung, K. J., & Meyer, W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402981101 · Cited by 758 · see citing works

Calcineurin: a calcium- and calmodulin-binding protein of the nervous system.

Klee, C. B., Crouch, T. H., & Krinks, M. H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6270 · Cited by 738 · see citing works

Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi

Cowen, L. E., & Lindquist, S. (2005) · Science · doi:10.1126/science.1118370 · Cited by 698 · see citing works

Trends in Mortality Due to Invasive Mycotic Diseases in the United States, 1980–1997

McNeil, M. M., Nash, S. L., Hajjeh, R. A., Phelan, M. A., Conn, L. A., Plikaytis, B. D., & Warnock, D. W. (2001) · Clinical Infectious Diseases · doi:10.1086/322606 · Cited by 657 · see citing works

PUTATIVE VIRULENCE FACTORS OF CANDIDA ALBICANS

Cutler, J. E. (1991) · Annual Review of Microbiology · doi:10.1146/annurev.mi.45.100191.001155 · Cited by 632 · see citing works

Candida albicans: A molecular revolution built on lessons from budding yeast

Berman, J., & Sudbery, P. E. (2002) · Nature Reviews Genetics · doi:10.1038/nrg948 · Cited by 578 · see citing works

Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number

Flavell, S. W., Cowan, C. W., Kim, T.-K., Greer, P. L., Lin, Y., Paradis, S., Griffith, E. C., Hu, L. S., Chen, C., & Greenberg, M. E. (2006) · Science · doi:10.1126/science.1122511 · Cited by 573 · see citing works

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

Dawson, T. M., Steiner, J. P., Dawson, V. L., DINERMAN, J. L., Uhl, G. R., & Snyder, S. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.9808 · Cited by 538 · see citing works

Calcineurin is required for virulence of Cryptococcus neoformans

Odom, A., Muir, S., Lim, E., Toffaletti, D. L., Perfect, J., & Heitman, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2576 · Cited by 516 · see citing works

NFAT and Osterix cooperatively regulate bone formation

Koga, T., Matsui, Y., Asagiri, M., Kodama, T., Crombrugghe, B. D., Nakashima, K., & Takayanagi, H. (2005) · Nature Medicine · doi:10.1038/nm1270 · Cited by 490 · see citing works

Inducible and Reversible Enhancement of Learning, Memory, and Long-Term Potentiation by Genetic Inhibition of Calcineurin

Malleret, G., Haditsch, U., Genoux, D., Jones, M. W., Bliss, T. V. P., Vanhoose, A. M., Weitlauf, C., Kandel, E. R., Winder, D. G., & Mansuy, I. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00264-1 · Cited by 470 · see citing works

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

Sussman, M. A., Lim, H. W., Gude, N. A., Taigen, T. L., Olson, E. N., Robbins, J. M., Colbert, M. C., Gualberto, A., Wieczorek, D. F., & Molkentin, J. D. (1998) · Science · doi:10.1126/science.281.5383.1690 · Cited by 461 · see citing works

Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway

Semsarian, C., Wu, M., Ju, Y., Marciniec, T., Yeoh, T., Allen, D. G., Harvey, R. P., & Graham, R. M. (1999) · Nature · doi:10.1038/23054 · Cited by 451 · see citing works

Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function

Heit, J. J., Apelqvist, Å., Gu, X., Winslow, M. M., Neilson, J. R., Crabtree, G. R., & Kim, S. K. (2006) · Nature · doi:10.1038/nature05097 · Cited by 445 · see citing works

Calcineurin acts through the<i>CRZ1/TCN1</i>-encoded transcription factor to regulate gene expression in yeast

Stathopoulos, A. M., & Cyert, M. S. (1997) · Genes &amp; Development · doi:10.1101/gad.11.24.3432 · Cited by 442 · see citing works

Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature

Graef, I. A., Chen, F., Chen, L., Kuo, A., & Crabtree, G. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00396-8 · Cited by 417 · see citing works

Genome-wide Analysis of Gene Expression Regulated by the Calcineurin/Crz1p Signaling Pathway in Saccharomyces cerevisiae

Yoshimoto, H., Saltsman, K., Gasch, A. P., Li, H. X., Ogawa, N., Botstein, D., Brown, P. O., & Cyert, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202718200 · Cited by 404 · see citing works

The <i>akuB</i> ^KU80 Mutant Deficient for Nonhomologous End Joining Is a Powerful Tool for Analyzing Pathogenicity in <i>Aspergillus fumigatus</i>

da Silva Ferreira, M. E., Kress, M. R. V. Z., Savoldi, M., Goldman, M. H. S., Härtl, A., Heinekamp, T., Brakhage, A. A., & Goldman, G. H. (2006) · Eukaryotic Cell · doi:10.1128/ec.5.1.207-211.2006 · Cited by 403 · see citing works

Candida albicans proteinases and host/pathogen interactions

Naglik, J., Albrecht, A., Bader, O., & Hube, B. (2004) · Cellular Microbiology · doi:10.1111/j.1462-5822.2004.00439.x · Cited by 399 · see citing works

Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: One in the presence and one in the absence of CsA

Friedman, J. S., & Weissman, I. L. (1991) · Cell · doi:10.1016/0092-8674(91)90123-g · Cited by 396 · see citing works

Cryptococcosis

Chayakulkeeree, M., & Perfect, J. R. (2006) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2006.07.001 · Cited by 396 · see citing works

Neurotrophins and Netrins Require Calcineurin/NFAT Signaling to Stimulate Outgrowth of Embryonic Axons

Graef, I. A., Wang, F., Charron, F., Chen, L., Neilson, J., Tessier-Lavigne, M., & Crabtree, G. R. (2003) · Cell · doi:10.1016/s0092-8674(03)00390-8 · Cited by 379 · see citing works

The direct cost and incidence of systemic fungal infections

Wilson, L. S., Reyes, C. M., Stolpman, M., Speckman, J., Allen, K., & Beney, J. (2002) · Value in Health · doi:10.1046/j.1524-4733.2002.51108.x · Cited by 374 · see citing works

Calcineurin A of <i>Candida albicans</i>: involvement in antifungal tolerance, cell morphogenesis and virulence

Sanglard, D., Ischer, F., Marchetti, O., Entenza, J., & Bille, J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03495.x · Cited by 350 · see citing works

Calcineurin is essential for survival during membrane stress in Candida albicans

Cruz, M. C., Goldstein, A. L., Blankenship, J. R., Del Poeta, M., Davis, D., Cardenas, M. E., Perfect, J. R., McCusker, J. H., & Heitman, J. (2002) · The EMBO Journal · doi:10.1093/emboj/21.4.546 · Cited by 342 · cited 1× · see citing works

Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress.

Cyert, M. S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01552-3 · Cited by 333 · see citing works

Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in <i>Saccharomyces cerevisiae</i>

Matheos, D. P., Kingsbury, T. J., Ahsan, U. S., & Cunningham, K. W. (1997) · Genes &amp; Development · doi:10.1101/gad.11.24.3445 · Cited by 332 · see citing works

A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis

Chang, C.-P., Neilson, J. R., Bayle, J. H., Gestwicki, J. E., Kuo, A., Stankunas, K., Graef, I. A., & Crabtree, G. R. (2004) · Cell · doi:10.1016/j.cell.2004.08.010 · Cited by 331 · see citing works

Trial of cyclosporin in corticosteroid-dependent chronic severe asthma

Alexander, A. G., Kay, A. B., & Barnes, N. C. (1992) · The Lancet · doi:10.1016/0140-6736(92)91646-p · Cited by 330 · see citing works

Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

Shirane, M., & Nakayama, K. I. (2002) · Nature Cell Biology · doi:10.1038/ncb894 · Cited by 319 · see citing works

Ergosterol Biosynthesis Inhibitors Become Fungicidal when Combined with Calcineurin Inhibitors against <i>Candida albicans</i> , <i>Candida glabrata</i> , and <i>Candida krusei</i>

Onyewu, C., Blankenship, J. R., Del Poeta, M., & Heitman, J. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.3.956-964.2003 · Cited by 282 · see citing works

International Surveillance of Bloodstream Infections Due to <i>Candida</i> Species: Frequency of Occurrence and Antifungal Susceptibilities of Isolates Collected in 1997 in the United States, Canada, and South America for the SENTRY Program

Pfaller, M. A., Jones, R. N., Doern, G. V., Sader, H. S., Hollis, R. J., Messer, S. A., & Group, F. T. S. P. (1998) · Journal of Clinical Microbiology · doi:10.1128/jcm.36.7.1886-1889.1998 · Cited by 281 · see citing works

Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexes

Huai, Q., Kim, H.-Y., Liu, Y., Zhao, Y., Mondragon, A., Liu, J. O., & Ke, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192206699 · Cited by 278 · see citing works

Calcineurin Controls Growth, Morphology, and Pathogenicity in <i>Aspergillus fumigatus</i>

Steinbach, W. J., Cramer, R. A., Perfect, B. Z., Asfaw, Y. G., Sauer, T. C., Najvar, L. K., Kirkpatrick, W. R., Patterson, T. F., Benjamin, D. K., Heitman, J., et al. (2006) · Eukaryotic Cell · doi:10.1128/ec.00139-06 · Cited by 264 · see citing works

Cryptococcus neoformans in Organ Transplant Recipients: Impact of Calcineurin‐Inhibitor Agents on Mortality

Singh, N., Alexander, B. D., Lortholary, O., Dromer, F., Gupta, K. L., John, G. T., Busto, R. D., Klintmalm, G. B. G., Somani, J., Lyon, G. M., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/511438 · Cited by 263 · see citing works

Candida albicans Hyphal Formation and the Expression of the Efg1-Regulated Proteinases Sap4 to Sap6 Are Required for the Invasion of Parenchymal Organs

Felk, A., Kretschmar, M., Albrecht, A., Schaller, M., Beinhauer, S., Nichterlein, T., Sanglard, D., Körting, H. C., Schäfer, W., & Hube, B. (2002) · Infection and Immunity · doi:10.1128/iai.70.7.3689-3700.2002 · Cited by 258 · see citing works

Dimorphism and virulence in Candida albicans

Mitchell, A. P. (1998) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(98)80116-1 · Cited by 256 · see citing works

Potent Synergism of the Combination of Fluconazole and Cyclosporine in <i>Candida albicans</i>

Marchetti, O., Moreillon, P., Glauser, M. P., Bille, J., & Sanglard, D. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.9.2373-2381.2000 · Cited by 252 · see citing works

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

Jin, L., & Harrison, S. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212504399 · Cited by 244 · see citing works

Trends in Risk Profiles for and Mortality Associated with Invasive Aspergillosis among Liver Transplant Recipients

Singh, N., Avery, R. K., Muñóz, P., Pruett, T. L., Alexander, B. D., Jacobs, R. A., Tollemar, J. G., Dominguez, E. A., Chen, Y., Paterson, D. L., et al. (2003) · Clinical Infectious Diseases · doi:10.1086/345441 · Cited by 240 · see citing works

Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation.

Stathopoulos-Gerontides, A., Guo, J. J., & Cyert, M. S. (1999) · Genes &amp; Development · doi:10.1101/gad.13.7.798 · Cited by 240 · see citing works

<i>CRZ1</i> , a target of the calcineurin pathway in <i>Candida albicans</i>

Karababa, M., Valentino, E., Pardini, G., Coste, A. T., Bille, J., & Sanglard, D. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.05037.x · Cited by 231 · see citing works

A Randomized Trial of Inhaled Cyclosporine in Lung-Transplant Recipients

Iacono, A. T., Johnson, B. A., Grgurich, W. F., Youssef, J. G., Corcoran, T. E., Smith-Seiler, D., Dauber, J. H., Smaldone, G. C., Zeevi, A., Yousem, S. A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa043204 · Cited by 227 · see citing works

Calcineurin: Structure, function, and inhibition

Hemenway, C. S., & Heitman, J. (1999) · Cell Biochemistry and Biophysics · doi:10.1007/bf02737887 · Cited by 227 · see citing works

Advances in combating fungal diseases: vaccines on the threshold

Cutler, J. E., Deepe, G. S., & Klein, B. S. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1537 · Cited by 223 · see citing works

The <i>Cryptococcus neoformans</i> MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function

Kraus, P. R., Fox, D. S., Cox, G. M., & Heitman, J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03508.x · Cited by 217 · see citing works

Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients

Drew, R. H., Ashley, E. D., Benjamin, D. K., Davis, R. D., Palmer, S. M., & Perfect, J. R. (2004) · Transplantation · doi:10.1097/01.tp.0000101516.08327.a9 · Cited by 198 · see citing works

Changes in the spectrum and risk factors for invasive candidiasis in liver transplant recipients: prospective, multicenter, case-controlled study1

Husain, S., Tollemar, J. G., Dominguez, E. A., Baumgarten, K. L., Humar, A., Paterson, D. L., Wagener, M. M., Kusne, S., & Singh, N. (2003) · Transplantation · doi:10.1097/01.tp.0000065178.93741.72 · Cited by 194 · see citing works

Calcineurin mediates alpha-adrenergic stimulation of Na+,K(+)-ATPase activity in renal tubule cells.

Aperia, A., Ibarra, F. R., Svensson, L. B., Klee, C., & Greengard, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7394 · Cited by 193 · see citing works

Calcineurin Is Essential for <i>Candida albicans</i> Survival in Serum and Virulence

Blankenship, J. R., Wormley, F. L., Boyce, M. K., Schell, W. A., Filler, S. G., Perfect, J. R., & Heitman, J. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.3.422-430.2003 · Cited by 186 · see citing works

Penetration and damage of endothelial cells by Candida albicans

Filler, S. G., Swerdloff, J. N., Hobbs, C., & Luckett, P. M. (1995) · Infection and Immunity · doi:10.1128/iai.63.3.976-983.1995 · Cited by 184 · see citing works

Pathogenesis of Pulmonary Aspergillosis. Granulocytopenia Versus Cyclosporine and Methylprednisolone-Induced Immunosuppression

Berenguer, J., Allende, M. C., Lee, J. W., Garrett, K., Lyman, C., Ali, N. M., Bacher, J., Pizzo, P. A., & Walsh, T. J. (1995) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.152.3.7663787 · Cited by 183 · see citing works

Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12–FK506 in <i>Cryptococcus neoformans</i>

Fox, D. S., Cruz, M. C., Sia, R. A. L., Ke, H., Cox, G. M., Cardenas, M. E., & Heitman, J. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02295.x · Cited by 175 · see citing works

Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans

Görlach, J. M., Fox, D. S., Cutler, N. S., Cox, G. M., Perfect, J. R., & Heitman, J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.14.3618 · Cited by 172 · see citing works

Truncation and Activation of Calcineurin A by Calpain I in Alzheimer Disease Brain

Liu, F., Grundke, I., Iqbal, K., Oda, Y., Tomizawa, K., & Gong, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507475200 · Cited by 171 · see citing works

Synergistic Antifungal Activities of Bafilomycin A ₁ , Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against <i>Cryptococcus neoformans</i>

Del Poeta, M., Cruz, M. C., Cardenas, M. E., Perfect, J. R., & Heitman, J. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.3.739-746.2000 · Cited by 169 · see citing works

Genetic Architecture of Hsp90-Dependent Drug Resistance

Cowen, L. E., Carpenter, A. E., Matangkasombut, O., Fink, G. R., & Lindquist, S. (2006) · Eukaryotic Cell · doi:10.1128/ec.00274-06 · Cited by 159 · see citing works

The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein

John, A. R. O., Poeta, M. D., Perfect, J. R., & Heitman, J. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.1.156 · Cited by 153 · see citing works

Adhesins in Candida albicans.

Sundstrom, P. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)80062-9 · Cited by 151 · see citing works

Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans

Cruz, M. C., Fox, D. S., & Heitman, J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.5.1020 · Cited by 150 · see citing works

Anti-CandidaDrugs — The Biochemical Basis for Their Activity

BOSSCHE, H. V., Willemsens, G., & Marichal, P. (1987) · CRC Critical Reviews in Microbiology · doi:10.3109/10408418709104448 · Cited by 145 · see citing works

Good fungi gone bad: The corruption of calcineurin

Fox, D. S., & Heitman, J. (2002) · BioEssays · doi:10.1002/bies.10157 · Cited by 137 · see citing works

In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus

Steinbach, W. J., Schell, W. A., Blankenship, J. R., Onyewu, C., Heitman, J., & Perfect, J. R. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.5.1664-1669.2004 · Cited by 135 · see citing works

Essential Role of theCandida albicansTransglutaminase Substrate, Hyphal Wall Protein 1, in Lethal Oroesophageal Candidiasis in Immunodeficient Mice

Sundstrom, P., Balish, E., & Allen, C. M. (2002) · The Journal of Infectious Diseases · doi:10.1086/338836 · Cited by 134 · see citing works

Characterization and expression of the unique calmodulin gene of Aspergillus nidulans.

Rasmussen, C. D., Means, R. L., Lu, K. P., May, G. S., & Means, A. R. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77415-2 · Cited by 131 · see citing works

Immunosuppressive and Nonimmunosuppressive Cyclosporine Analogs Are Toxic to the Opportunistic Fungal PathogenCryptococcus neoformansvia Cyclophilin-Dependent Inhibition of Calcineurin

Cruz, M. C., Poeta, M. D., Wang, P., Wenger, R. M., Zenke, G., Quesniaux, V. F. J., Movva, N. R., Perfect, J. R., Cardenas, M. E., & Heitman, J. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.1.143-149.2000 · Cited by 129 · see citing works

Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans

Kojima, K., Bahn, Y., & Heitman, J. (2006) · Microbiology · doi:10.1099/mic.0.28571-0 · Cited by 125 · see citing works

Functional characterization of the Aspergillus fumigatus calcineurin

Ferreira, M. E. D. S., Heinekamp, T., Härtl, A., Brakhage, A. A., Semighini, C. P., Harris, S. D., Savoldi, M., de Gouvêa, P. F., Goldman, M. H. D. S., & Goldman, G. H. (2007) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2006.08.004 · Cited by 121 · see citing works

The CRH Family Coding for Cell Wall Glycosylphosphatidylinositol Proteins with a Predicted Transglycosidase Domain Affects Cell Wall Organization and Virulence of Candida albicans

Pardini, G., De Groot, P. W. J., Coste, A. T., Karababa, M., Klis, F. M., de Koster, C. G., & Sanglard, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606361200 · Cited by 121 · see citing works

Calcineurin Is Essential for Virulence in <i>Candida albicans</i>

Bader, T., Bodendorfer, B., Schröppel, K., & Morschhäuser, J. (2003) · Infection and Immunity · doi:10.1128/iai.71.9.5344-5354.2003 · Cited by 121 · see citing works

The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of <i>Candida albicans</i>

Onyewu, C., Wormley, F. L., Perfect, J. R., & Heitman, J. (2004) · Infection and Immunity · doi:10.1128/iai.72.12.7330-7333.2004 · Cited by 121 · see citing works

Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans

Wang, P., Cardenas, M. E., Cox, G. M., Perfect, J. R., & Heitman, J. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve109 · Cited by 117 · see citing works

Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species

Kontoyiannis, D. P. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg090 · Cited by 116 · see citing works

The calmodulin‐dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.

Rasmussen, C. D., Garen, C. R., Brining, S. K., Kincaid, R. L., Means, R. L., & Means, A. R. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06544.x · Cited by 115 · see citing works

Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site

Boustany, L. M., & Cyert, M. S. (2002) · Genes &amp; Development · doi:10.1101/gad.967602 · Cited by 115 · see citing works

Fluconazole plus Cyclosporine: a Fungicidal Combination Effective against Experimental Endocarditis Due to <i>Candida albicans</i>

Marchetti, O., Entenza, J. M., Sanglard, D., Bille, J., Glauser, M. P., & Moreillon, P. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.11.2932-2938.2000 · Cited by 113 · see citing works

Calcineurin Is Required forCandida albicansTo Survive Calcium Stress in Serum

Blankenship, J. R., & Heitman, J. (2005) · Infection and Immunity · doi:10.1128/iai.73.9.5767-5774.2005 · Cited by 111 · see citing works

Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin.

Desdouits, F., Siciliano, J. C., Greengard, P., & Girault, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2682 · Cited by 102 · see citing works

Structural and Biological Characterization of Chromofungin, the Antifungal Chromogranin A-(47–66)-derived Peptide

Lugardon, K., Chasserot‐Golaz, S., Kieffer, A., Maget‐Dana, R., Nullans, G., Kieffer, B., Aunis, D., & Metz‐Boutigue, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104670200 · Cited by 98 · see citing works

Role of Calcineurin in Stress Resistance, Morphogenesis, and Virulence of a <i>Candida albicans</i> Wild-Type Strain

Bader, T., Schröppel, K., Bentink, S., Agabian, N., Köhler, G., & Morschhäuser, J. (2006) · Infection and Immunity · doi:10.1128/iai.00142-06 · Cited by 81 · see citing works

Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor

Santos, M., & de Larrinoa, I. F. (2005) · Current Genetics · doi:10.1007/s00294-005-0003-8 · Cited by 78 · see citing works

Calcineurin and vacuolar-type H + -ATPase modulate macrophage effector functions

Conboy, I. M., Manoli, D. S., Mhaiskar, V., & Jones, P. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6324 · Cited by 76 · see citing works

Calcium- and Calcineurin-Independent Roles for Calmodulin in Cryptococcus neoformans Morphogenesis and High-Temperature Growth

Kraus, P. R., Nichols, C. B., & Heitman, J. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.6.1079-1087.2005 · Cited by 72 · see citing works

Cyclosporin A inhibits the growth of Cryptococcus neoformans in a murine model

Mody, C. H., Toews, G. B., & Lipscomb, M. F. (1988) · Infection and Immunity · doi:10.1128/iai.56.1.7-12.1988 · Cited by 69 · see citing works

Metaxin is required for tumor necrosis factor‐induced cell death

Wang, X., Ono, K., Kim, S. O., Kravchenko, V. V., Lin, S., & Han, J. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve135 · Cited by 68 · see citing works

Hph1p and Hph2p, Novel Components of Calcineurin-Mediated Stress Responses in Saccharomyces cerevisiae

Heath, V. L., Shaw, S. L., Roy, S., & Cyert, M. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.3.695-704.2004 · Cited by 68 · see citing works

Long-term Safety and Efficacy of Tacrolimus Ointment for the Treatment of Atopic Dermatitis in Children

Remitz, A., Harper, J. I., Rustin, M. H. A., Goldschmidt, W. F. M., Palatsi, R., Valk, P. V. D., Sharpe, G., Smith, C. H., DOBOZY, A., & Turjanmaa, K. (2007) · Acta Dermato Venereologica · doi:10.2340/00015555-0167 · Cited by 68 · see citing works

In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus Isolates from Transplant and Nontransplant Patients

Steinbach, W. J., Singh, N., Miller, J. L., Benjamin, D. K., Schell, W. A., Heitman, J., & Perfect, J. R. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.12.4922-4925.2004 · Cited by 66 · see citing works

Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p

Polizotto, R. S., & Cyert, M. S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200104078 · Cited by 63 · see citing works

FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818

Becker, J. W., Rotonda, J., McKeever, B. M., Chan, H., Marcy, A. I., Wiederrecht, G., Hermes, J. D., & Springer, J. P. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82129-9 · Cited by 62 · see citing works

Aerosol cyclosporin therapy in lung transplant recipients with bronchiolitis obliterans

Iacono, A. T., Corcoran, T. E., Griffith, B. P., Grgurich, W. F., Smith, D. A., Zeevi, A., Smaldone, G. C., McCurry, K. R., Johnson, B. A., & Dauber, J. H. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00058504 · Cited by 61 · see citing works

Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis.

Rotonda, J., Burbaum, J. J., Chan, H., Marcy, A. I., & Becker, J. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52995-1 · Cited by 61 · see citing works

Promoter sequences regulated by the calcineurin-activated transcription factor Crz1 in the yeast ENA1 gene

Mendizabal, I., Pascual-Ahuir, A., Serrano, R., & de Larrinoa, I. (2001) · Molecular Genetics and Genomics · doi:10.1007/s004380100474 · Cited by 57 · see citing works

Fungicidal Synergism of Fluconazole and Cyclosporine in Candida albicans Is Not Dependent on Multidrug Efflux Transporters Encoded by the CDR1 , CDR2 , CaMDR1 , and FLU1 Genes

Marchetti, O., Moreillon, P., Entenza, J. M., Vouillamoz, J., Glauser, M. P., Billé, J., & Sanglard, D. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.5.1565-1570.2003 · Cited by 57 · see citing works

THE ANTIMICROBIAL ACTIVITIES OF CYCLOSPORINE, FK506, AND RAPAMYCIN

High, K. P. (1994) · Transplantation · doi:10.1097/00007890-199457120-00001 · Cited by 57 · see citing works

THE ANTIMICROBIAL ACTIVITIES OF CYCLOSPORINE, FK506, AND RAPAMYCIN

High, K. P. (1994) · Transplantation · doi:10.1097/00007890-199406270-00001 · Cited by 56 · see citing works

Effects of cyclosporine in experimental cryptococcal meningitis

Perfect, J. R., & Durack, D. T. (1985) · Infection and Immunity · doi:10.1128/iai.50.1.22-26.1985 · Cited by 54 · see citing works

Cooperative regulation of cell proliferation by calcium and calmodulin in Aspergillus nidulans

Lu, K. P., Rasmussen, C. D., May, G. S., & Means, A. R. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.3.1584213 · Cited by 54 · see citing works

Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis.

Rotonda, J., Burbaum, J. J., Chan, H., et al. (1993) · PubMed · doi:10.2210/pdb1yat/pdb · Cited by 53 · see citing works

Invasive Aspergillosis in Mice Immunosuppressed with Cyclosporin A, Tacrolimus (FK506), or Sirolimus (Rapamycin)

High, K. P., & Washburn, R. G. (1997) · The Journal of Infectious Diseases · doi:10.1093/infdis/175.1.222 · Cited by 51 · see citing works

Antifungal attributes of immunosuppressive agents: new paradigms in management and elucidating the pathophysiologic basis of opportunistic mycoses in organ transplant recipients1

Singh, N., & Heitman, J. (2004) · Transplantation · doi:10.1097/01.tp.0000117252.75651.d6 · Cited by 50 · see citing works

Reversible blockade of experience-dependent plasticity by calcineurin in mouse visual cortex

Yang, Y., Fischer, Q. S., Zhang, Y., Baumgärtel, K., Mansuy, I. M., & Daw, N. W. (2005) · Nature Neuroscience · doi:10.1038/nn1464 · Cited by 47 · see citing works

Calcineurin-Binding Protein Cbp1 Directs the Specificity of Calcineurin-Dependent Hyphal Elongation during Mating in Cryptococcus neoformans

Fox, D. S., & Heitman, J. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.9.1526-1538.2005 · Cited by 47 · see citing works

Phospholipid-Binding Protein Cts1 Controls Septation and Functions Coordinately with Calcineurin in Cryptococcus neoformans

Fox, D. S., Cox, G. M., & Heitman, J. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.5.1025-1035.2003 · Cited by 47 · see citing works

Infliximab treatment in combination with cyclosporin A in patients with severe refractory rheumatoid arthritis

Temekonidis, T. I., Georgiadis, A. N., Alamanos, Y., Bougias, D. V., Voulgari, P. V., & Drosos, A. A. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.9.822 · Cited by 46 · see citing works

Functional analysis of the calcineurin-encoding gene cnaA from Aspergillus oryzae: evidence for its putative role in stress adaptation

Juvvadi, P. R., Kuroki, Y., Arioka, M., Nakajima, H., & Kitamoto, K. (2003) · Archives of Microbiology · doi:10.1007/s00203-003-0546-3 · Cited by 44 · see citing works

Calcineurin Promotes the Expression of Monocyte Chemoattractant Protein-1 in Vascular Myocytes and Mediates Vascular Inflammation

Satonaka, H., Suzuki, E., Nishimatsu, H., Oba, S., Takeda, R., Goto, A., Omata, M., Fujita, T., Nagai, R., & Hirata, Y. (2004) · Circulation Research · doi:10.1161/01.res.0000118250.67032.5e · Cited by 43 · see citing works

A Fungal Achilles' Heel

Heitman, J. (2005) · Science · doi:10.1126/science.1119321 · Cited by 42 · see citing works

Treatment of Murine Cryptococcosis with Cyclosporin-A in Normal and Athymic Mice

Mody, C. H., Toews, G. B., & Lipscomb, M. F. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/139.1.8 · Cited by 42 · see citing works

Effects of Methylprednisolone and Cyclosporine A on Fungal Growth In Vitro

Bell, N. P., Karp, C. L., Alfonso, E. C., Schiffman, J., & Miller, D. (1999) · Cornea · doi:10.1097/00003226-199905000-00012 · Cited by 41 · see citing works

Regulation of aflatoxin production by Ca2+/calmodulin-dependent protein phosphorylation and dephosphorylation

Jayashree, T., Rao, J. P., & Subramanyam, C. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb08960.x · Cited by 37 · see citing works

Calcineurin Promotes Infection of the Cornea by Candida albicans and Can Be Targeted To Enhance Fluconazole Therapy

Onyewu, C., Afshari, N. A., & Heitman, J. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00393-06 · Cited by 36 · see citing works

Characterization of the recombinant C-terminal domain of dystrophin: phosphorylation by calmodulin-dependent protein kinase II and dephosphorylation by type 2B protein phosphatase

Walsh, M. P., Busaan, J. L., Fraser, E. D., Fu, S. Y., Pato, M. D., & Michalak, M. (1995) · Biochemistry · doi:10.1021/bi00016a030 · Cited by 33 · see citing works

Cryptococcus neoformans Isolates from Transplant Recipients Are Not Selected for Resistance to Calcineurin Inhibitors by Current Immunosuppressive Regimens

Blankenship, J. R., Singh, N., Alexander, B. D., & Heitman, J. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.1.464-467.2005 · Cited by 25 · see citing works

The Aspergillus niger cypA gene encodes a cyclophilin that mediates sensitivity to the immunosuppressant cyclosporin A

Derkx, P. M. F., & Madrid, S. M. (2001) · Molecular Genetics and Genomics · doi:10.1007/s004380100586 · Cited by 20 · see citing works

Dephosphorylation of Calponin by Type 2B Protein Phosphatase

Fraser, E. D., & Walsh, M. P. (1995) · Biochemistry · doi:10.1021/bi00028a026 · Cited by 18 · see citing works

Immunotherapy with Tacrolimus (FK506) Does Not Select for Resistance to Calcineurin Inhibitors inCandida albicansIsolates from Liver Transplant Patients

Reedy, J. L., Husain, S., Ison, M. G., Pruett, T. L., Singh, N., & Heitman, J. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.4.1573-1577.2006 · Cited by 18 · see citing works

Cloning and sequence analysis of cnaA gene encoding the catalytic subunit of calcineurin from Aspergillus oryzae

Juvvadi, P. R., Arioka, M., Nakajima, H., & Kitamoto, K. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10881.x · Cited by 14 · see citing works

SUMO Wrestles the Synapse

Beg, A. A., & Scheiffele, P. (2006) · Science · doi:10.1126/science.1124541 · Cited by 9 · see citing works

Alternative treatments for focal and segmental glomerular sclerosis.

Ponticelli, C. E., & Passerini, P. (2001) · PubMed · Cited by 8 · see citing works

Pharmacology of psoriasis.

Plummer, N. A. (1979) · PubMed · Cited by 1 · see citing works

The Fungal Cell Wall: Structure, Biosynthesis, and Function

Gow, N. A. R., Latge, J.-P., & Munro, C. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0035-2016 · Cited by 1,423 · see citing works

Antifungal Drug Resistance: Molecular Mechanisms in <i>Candida albicans</i> and Beyond

Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00199 · Cited by 801 · see citing works

Aspergillosis

Segal, B. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0808853 · Cited by 659 · see citing works

Mechanisms of Antifungal Drug Resistance

Cowen, L. E., Sanglard, D., Howard, S. J., Rogers, P. D., & Perlin, D. S. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019752 · Cited by 647 · see citing works

Efflux-Mediated Antifungal Drug Resistance

Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., Tanabe, K., Niimi, M., Goffeau, A., & Monk, B. C. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00051-08 · Cited by 608 · see citing works

Fungal Biofilm Resistance

Ramage, G., Rajendran, R., Sherry, L., & Williams, C. (2012) · International Journal of Microbiology · doi:10.1155/2012/528521 · Cited by 583 · see citing works

Regulatory circuitry governing fungal development, drug resistance, and disease.

Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00045-10 · Cited by 576 · see citing works

Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis

Kwon-Chung, K. J., Fraser, J. A., Doering, T. L., Wang, Z. A., Janbon, G., Idnurm, A., & Bahn, Y.-S. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019760 · Cited by 531 · see citing works

Chitin synthesis and fungal pathogenesis

Lenardon, M. D., Munro, C. A., & Gow, N. A. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.05.002 · Cited by 502 · see citing works

Architecture of the dynamic fungal cell wall

Gow, N. A. R., & Lenardon, M. D. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00796-9 · Cited by 447 · see citing works

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

Cowen, L. E., Singh, S. D., Köhler, J. R., Collins, C., Zaas, A. K., Schell, W. A., Aziz, H., Mylonakis, E., Perfect, J. R., Whitesell, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813394106 · Cited by 413 · see citing works

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

Singh, S. D., Robbins, N., Zaas, A. K., Schell, W. A., Perfect, J. R., & Cowen, L. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000532 · Cited by 362 · see citing works

PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

LaFayette, S. L., Collins, C., Zaas, A. K., Schell, W. A., Betancourt-Quiroz, M., Gunatilaka, A. A. L., Perfect, J. R., & Cowen, L. E. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001069 · Cited by 329 · see citing works

Hsp90 Orchestrates Temperature-Dependent Candida albicans Morphogenesis via Ras1-PKA Signaling

Shapiro, R. S., Uppuluri, P., Zaas, A. K., Collins, C., Senn, H., Perfect, J. R., Heitman, J., & Cowen, L. E. (2009) · Current Biology · doi:10.1016/j.cub.2009.03.017 · Cited by 311 · see citing works

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.

Cowen, L. E. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1835 · Cited by 311 · see citing works

Comparative genomics of MAP kinase and calcium–calcineurin signalling components in plant and human pathogenic fungi

Rispail, N., Soanes, D. M., Ant, C., Czajkowski, R., Grünler, A., Huguet, R., Pérez‐Nadales, E., Poli, A., Sartorel, E., Valiante, V., et al. (2009) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2009.01.002 · Cited by 312 · see citing works

Molecular mechanisms governing antifungal drug resistance

Lee, Y., Robbins, N., & Cowen, L. E. (2023) · npj Antimicrobials and Resistance · doi:10.1038/s44259-023-00007-2 · Cited by 304 · see citing works

Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.

Cowen, L. E., & Steinbach, W. J. (2008) · Eukaryotic Cell · doi:10.1128/ec.00041-08 · Cited by 285 · see citing works

Aspergillus fumigatus and Related SpeciesPreprint

Sugui, J. A., Kwon-Chung, K. J., Juvvadi, P. R., Latgé, J., & Steinbach, W. J. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019786 · Cited by 286 · see citing works

Echinocandins – structure, mechanism of action and use in antifungal therapy

Szymański, M., Chmielewska, S., Czyżewska, U., Malinowska, M., & Tylicki, A. (2022) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2022.2050224 · Cited by 281 · see citing works

Antifungal Drugs: The Current Armamentarium and Development of New Agents

Robbins, N., Wright, G. D., & Cowen, L. E. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0002-2016 · Cited by 271 · see citing works

Scedosporium and Lomentospora: an updated overview of underrated opportunists

Ramirez-Garcia, A., Pellon, A., Rementeria, A., Buldain, I., Barreto-Bergter, E., Rollin-Pinheiro, R., de Meirelles, J. V., Xisto, M. I. D. S., Ranque, S., Havlicek, V., et al. (2018) · Medical Mycology · doi:10.1093/mmy/myx113 · Cited by 264 · see citing works

Fungal echinocandin resistance

Walker, L. A., Gow, N. A. R., & Munro, C. A. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2009.09.003 · Cited by 267 · see citing works

Synergistic Effect of Calcineurin Inhibitors and Fluconazole against <i>Candida albicans</i> Biofilms

Uppuluri, P., Nett, J., Heitman, J., & Andes, D. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01397-07 · Cited by 228 · see citing works

Combinatorial strategies for combating invasive fungal infections

Spitzer, M., Robbins, N., & Wright, G. D. (2016) · Virulence · doi:10.1080/21505594.2016.1196300 · Cited by 218 · see citing works

Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal

Costa-de-Oliveira, S., & Rodrigues, A. G. (2020) · Microorganisms · doi:10.3390/microorganisms8020154 · Cited by 229 · see citing works

Candida albicans drug resistance—Another way to cope with stress

Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Tanabe, K., Niimi, M., & Monk, B. C. (2007) · Microbiology · doi:10.1099/mic.0.2007/010405-0 · Cited by 208 · see citing works

Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrata

Singh-Babak, S. D., Babak, T., Diezmann, S., Hill, J. A., Xie, J. L., Chen, Y.-L., Poutanen, S. M., Rennie, R. P., Heitman, J., & Cowen, L. E. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002718 · Cited by 204 · see citing works

Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens

Park, H.-S., Lee, S. C., Cardenas, M. E., & Heitman, J. (2019) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2019.08.004 · Cited by 168 · see citing works

Mucormycosis: its contemporary face and management strategies

Sun, H., & Singh, N. (2011) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(10)70316-9 · Cited by 174 · see citing works

Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach

Juvvadi, P. R., Lee, S. C., Heitman, J., & Steinbach, W. J. (2016) · Virulence · doi:10.1080/21505594.2016.1201250 · Cited by 172 · see citing works

Calcineurin Target CrzA Regulates Conidial Germination, Hyphal Growth, and Pathogenesis of <i>Aspergillus fumigatus</i>

Cramer, R. A., Perfect, B. Z., Pinchai, N., Park, S., Perlin, D. S., Asfaw, Y. G., Heitman, J., Perfect, J. R., & Steinbach, W. J. (2008) · Eukaryotic Cell · doi:10.1128/ec.00086-08 · Cited by 172 · see citing works

Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans

Cui, J., Ren, B., Tong, Y., Dai, H., & Zhang, L. (2015) · Virulence · doi:10.1080/21505594.2015.1039885 · Cited by 173 · see citing works

FKBP Ligands—Where We Are and Where to Go?

Kolos, J. M., Voll, A. M., Bauder, M., & Hausch, F. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01425 · Cited by 158 · see citing works

Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi

McCarthy, M. W., Kontoyiannis, D. P., Cornely, O. A., Perfect, J. R., & Walsh, T. J. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix130 · Cited by 169 · see citing works

Functional characterization of the <i>Aspergillus fumigatus</i> CRZ1 homologue, CrzA

Soriani, F. M., Malavazi, I., Da Silva Ferreira, M. E., Savoldi, M., Von Zeska Kress, M. R., De Souza Goldman, M. H., Loss, O., Bignell, E., & Goldman, G. H. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06122.x · Cited by 168 · see citing works

Antifungal drug resistance of oral fungi

Niimi, M., Firth, N. A., & Cannon, R. D. (2010) · Odontology · doi:10.1007/s10266-009-0118-3 · Cited by 169 · see citing works

Candida albicans and Candida glabrata : global priority pathogens

Katsipoulaki, M., Stappers, M. H. T., Malavia, D., Brunke, S., Hube, B., & Gow, N. A. R. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00021-23 · Cited by 174 · see citing works

Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites

Guo, Y., Crnkovic, C. M., Won, K., Yang, X., Lee, J. R., Orjala, J., Lee, H., & Jeong, H. (2018) · Drug Metabolism and Disposition · doi:10.1124/dmd.118.084772 · Cited by 161 · see citing works

ABC Transporter Cdr1p Contributes More than Cdr2p Does to Fluconazole Efflux in Fluconazole-Resistant Candida albicans Clinical Isolates

Holmes, A. R., Lin, Y.-H., Niimi, K., Lamping, E., Keniya, M. V., Niimi, M., Tanabe, K., Monk, B. C., & Cannon, R. D. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00463-08 · Cited by 160 · see citing works

Calcineurin-Responsive Zinc Finger Transcription Factor CRZ1 of Botrytis cinerea Is Required for Growth, Development, and Full Virulence on Bean Plants

Schumacher, J., Fernandez-de-Larrinoa, Í., & Tudzynski, B. (2008) · Eukaryotic Cell · doi:10.1128/ec.00426-07 · Cited by 155 · see citing works

Signalling pathways in the pathogenesis of Cryptococcus

Kozubowski, L., Lee, S. C., & Heitman, J. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01273.x · Cited by 150 · see citing works

Combination of fluconazole with non-antifungal agents: A promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent discovery

Liu, S., Hou, Y., Chen, X., Gao, Y., Li, H., & Sun, S. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2013.12.009 · Cited by 148 · see citing works

Tackling Fungal Resistance by Biofilm Inhibitors

Wu, S., Wang, Y., Liu, N., Dong, G., & Sheng, C. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01203 · Cited by 134 · see citing works

Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection

Ben‐Ami, R., Lewis, R. E., & Kontoyiannis, D. P. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08283.x · Cited by 132 · see citing works

Hsp90 orchestrates stress response signaling governing fungal drug resistance

Cowen, L. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000471 · Cited by 130 · see citing works

Proton transport and pH control in fungi

Kane, P. M. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-25304-6_3 · Cited by 131 · see citing works

Functional Characterization of an Aspergillus fumigatus Calcium Transporter (PmcA) that Is Essential for Fungal Infection

Dinamarco, T. M., Freitas, F. Z., Almeida, R. S., Brown, N. A., dos Reis, T. F., Ramalho, L. N. Z., Savoldi, M., Goldman, M. H. S., Bertolini, M. C., & Goldman, G. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037591 · Cited by 127 · see citing works

Preclinical evaluation of two 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging

Petřík, M., Franssen, G. M., Haas, H., Laverman, P., Hörtnagl, C., Schrettl, M., Helbok, A., Lass‐Flörl, C., & Decristoforo, C. (2012) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-012-2110-3 · Cited by 123 · see citing works

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Juvvadi, P. R., Fox, D., Bobay, B. G., Hoy, M. J., Gobeil, S. M. C., Venters, R. A., Chang, Z., Lin, J. J., Averette, A. F., Cole, D. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12199-1 · Cited by 116 · see citing works

Calcineurin as a multifunctional regulator: Unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesis

Juvvadi, P. R., Lamoth, F., & Steinbach, W. J. (2014) · Fungal Biology Reviews · doi:10.1016/j.fbr.2014.02.004 · Cited by 116 · see citing works

A small protein that fights fungi: AFP as a new promising antifungal agent of biotechnological value

Meyer, V. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-1291-3 · Cited by 116 · see citing works

Cyclosporine modulates neutrophil functions via the SIRT6–HIF‐1α–glycolysis axis to alleviate severe ulcerative colitis

Lu, H., Lin, J., Xu, C., Sun, M., Zuo, K., Zhang, X., Li, M., Huang, H., Li, Z., Wu, W. H., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.334 · Cited by 111 · see citing works

The Calcineurin Signaling Network Evolves via Conserved Kinase-Phosphatase Modules that Transcend Substrate Identity

Goldman, A., Roy, J., Bodenmiller, B., Wanka, S., Landry, C. R., Aebersold, R., & Cyert, M. S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.012 · Cited by 109 · see citing works

MgCRZ1, a transcription factor ofMagnaporthe grisea, controls growth, development and is involved in full virulence

Zhang, H., Zhao, Q., Liu, K., Zhang, Z., Wang, Y., & Zheng, X. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01524.x · Cited by 109 · see citing works

Advancements and challenges in antifungal therapeutic development

Puumala, E., Fallah, S., Robbins, N., & Cowen, L. E. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00142-23 · Cited by 118 · see citing works

Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis

Chen, Y.-L., Brand, A., Morrison, E. L., Silao, F. G. S., Bigol, U. G., Malbas, F. F., Nett, J. E., Andes, D. R., Solis, N. V., Filler, S. G., et al. (2011) · Eukaryotic Cell · doi:10.1128/ec.00310-10 · Cited by 107 · see citing works

Recent Approaches to Antifungal Therapy for Invasive Mycoses

Mathew, B. P., & Nath, M. (2009) · ChemMedChem · doi:10.1002/cmdc.200800353 · Cited by 105 · see citing works

Microbial pathogens in the fungal kingdom

Heitman, J. (2011) · Fungal Biology Reviews · doi:10.1016/j.fbr.2011.01.003 · Cited by 104 · see citing works

Candida albicans Heat Shock Proteins and Hsps-Associated Signaling Pathways as Potential Antifungal Targets

Gong, Y., Li, T., Yu, C., & Sun, S. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00520 · Cited by 101 · see citing works

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling

Shekhar-Guturja, T., Gunaherath, G. M. K. B., Wijeratne, E. M. K., Lambert, J.-P., Averette, A. F., Lee, S. C., Kim, T., Bahn, Y.-S., Tripodi, F., Ammar, R., et al. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2165 · Cited by 101 · see citing works

Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-dioxygenase deficiency but corrected by kynurenines.

Iannitti, R., Carvalho, A., Cunha, C., Luca, A. D., Giovannini, G., Casagrande, A., Zelante, T., Vacca, C., Fallarino, F., Puccetti, P., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201207-1346oc · Cited by 104 · see citing works

Elucidating Drug Resistance in Human Fungal Pathogens

Xie, J. L., Polvi, E. J., Shekhar‐Guturja, T., & Cowen, L. E. (2014) · Future Microbiology · doi:10.2217/fmb.14.18 · Cited by 98 · see citing works

Antifungal Drug Discovery: The Process and Outcomes

Calderone, R., Sun, N., Gay‐Andrieu, F., Groutas, W. C., Weerawarna, P. M., Prasad, S., Alex, D., & Li, D. (2014) · Future Microbiology · doi:10.2217/fmb.14.32 · Cited by 98 · see citing works

Calcineurin Targets Involved in Stress Survival and Fungal Virulence

Hee-Soo, P., Chow, E. W. L., Fu, C., Soderblom, E. J., Moseley, M. A., Heitman, J., & Cardenas, M. E. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005873 · Cited by 94 · see citing works

Genetic and Genomic Architecture of the Evolution of Resistance to Antifungal Drug Combinations

Hill, J. A., Ammar, R., Torti, D., Nislow, C., & Cowen, L. E. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003390 · Cited by 93 · see citing works

Cryptococcal therapies and drug targets: the old, the new and the promising

Coelho, C., & Casadevall, A. (2016) · Cellular Microbiology · doi:10.1111/cmi.12590 · Cited by 94 · see citing works

Roles of Calcineurin and Crz1 in Antifungal Susceptibility and Virulence of <i>Candida glabrata</i>

Miyazaki, T., Yamauchi, S., Inamine, T., Nagayoshi, Y., Saijo, T., Izumikawa, K., Seki, M., Kakeya, H., Yamamoto, Y., Yanagihara, K., et al. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01364-09 · Cited by 88 · see citing works

Stress Signaling Pathways for the Pathogenicity of Cryptococcus

Bahn, Y.-S., & Jung, K.-W. (2013) · Eukaryotic Cell · doi:10.1128/ec.00218-13 · Cited by 84 · see citing works

The Fungal Cell Wall: Structure, Biosynthesis, and Function

Gow, N. A. R., Latgé, J., & Munro, C. A. (2017) · ASM Press eBooks · doi:10.1128/9781555819583.ch12 · Cited by 89 · see citing works

Pavlovian Conditioning of Immunological and Neuroendocrine Functions

Hadamitzky, M., Lückemann, L., Pacheco‐López, G., & Schedlowski, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00033.2018 · Cited by 87 · see citing works

Ultrasensitive Rapid Detection of Human Serum Antibody Biomarkers by Biomarker-Capturing Viral Nanofibers

Wang, Y., Ju, Z., Cao, B., Gao, X., Zhu, Y., Qiu, P., Xu, H., Pan, P., Bao, H., Wang, L., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b01074 · Cited by 83 · see citing works

Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in <i>Aspergillus fumigatus</i>

Juvvadi, P. R., Fortwendel, J. R., Rogg, L. E., Burns, K. A., Randell, S. H., & Steinbach, W. J. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07886.x · Cited by 80 · see citing works

The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance

Brown, N. A., & Goldman, G. H. (2016) · The Journal of Microbiology · doi:10.1007/s12275-016-5510-4 · Cited by 77 · see citing works

Antifungal mechanism of the combination of Cinnamomum verum and Pelargonium graveolens essential oils with fluconazole against pathogenic Candida strains

Essid, R., Hammami, M., Gharbi, D., Karkouch, I., Hamouda, T. B., Elkahoui, S., Limam, F., & Tabbene, O. (2017) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-017-8442-y · Cited by 78 · see citing works

Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence

Reedy, J. L., Filler, S. G., & Heitman, J. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2009.09.002 · Cited by 76 · see citing works

A LAPF/phafin1-like protein regulates TORC1 and lysosomal membrane permeabilization in response to endoplasmic reticulum membrane stress

Kim, A., & Cunningham, K. W. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-08-0581 · Cited by 67 · see citing works

Combining ChIP-chip and Expression Profiling to Model the MoCRZ1 Mediated Circuit for Ca2+/Calcineurin Signaling in the Rice Blast Fungus

Kim, S., Hu, J., Oh, Y., Park, J., Choi, J., Lee, Y., Dean, R. A., & Mitchell, T. K. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000909 · Cited by 72 · see citing works

Developmental regulators in Aspergillus fumigatus

Park, H.-S., & Yu, J. (2016) · The Journal of Microbiology · doi:10.1007/s12275-016-5619-5 · Cited by 71 · see citing works

Quantitative evaluation of cryptococcal pathogenesis and antifungal drugs using a silkworm infection model with Cryptococcus neoformans

Matsumoto, Y., Miyazaki, S., Fukunaga, D. H., Shimizu, K., Kawamoto, S., & Sekimizu, K. (2011) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2011.05186.x · Cited by 70 · see citing works

Posaconazole Exhibits In Vitro and In Vivo Synergistic Antifungal Activity with Caspofungin or FK506 against Candida albicans

Chen, Y., Lehman, V. N., Averette, A. F., Perfect, J. R., & Heitman, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057672 · Cited by 69 · see citing works

Calcineurin Controls Hyphal Growth, Virulence, and Drug Tolerance of Candida tropicalis

Chen, Y., Yu, S.-J., Huang, H., Chang, Y.-L., Lehman, V. N., Silao, F. G. S., Bigol, U. G., Bungay, A. A. C., Averette, A. F., & Heitman, J. (2014) · Eukaryotic Cell · doi:10.1128/ec.00302-13 · Cited by 68 · see citing works

VdCrz1 is involved in microsclerotia formation and required for full virulence in Verticillium dahliae

Xiong, D., Wang, Y., Tang, C., Fang, Y., Zou, J., & Tian, C. (2015) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2015.07.011 · Cited by 66 · see citing works

Defects in Phosphate Acquisition and Storage Influence Virulence of Cryptococcus neoformans

Kretschmer, M., Reiner, E., Hu, G., Tam, N. M., Oliveira, D. L., Caza, M., Yeon, J. H., Kim, J., Kastrup, C. J., Jung, W. H., et al. (2014) · Infection and Immunity · doi:10.1128/iai.01607-14 · Cited by 65 · see citing works

Putative Calcium Channels CchA and MidA Play the Important Roles in Conidiation, Hyphal Polarity and Cell Wall Components in Aspergillus nidulans

Wang, S., Cao, J., Liu, X., Hu, H., Shi, J. R., Zhang, S., Keller, N. P., & Lü, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046564 · Cited by 64 · see citing works

Screening Repurposing Libraries for Identification of Drugs with Novel Antifungal Activity

Wall, G., & Lopez-Ribot, J. L. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00924-20 · Cited by 63 · see citing works

Reverse Genetics in Candida albicans Predicts ARF Cycling Is Essential for Drug Resistance and Virulence

Epp, E., Vanier, G., Harcus, D., Lee, A. Y., Jansen, G., Hallett, M., Sheppard, D. C., Thomas, D. Y., Munro, C. A., Mullick, A., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000753 · Cited by 61 · see citing works

Calcineurin Is Required for Pseudohyphal Growth, Virulence, and Drug Resistance in Candida lusitaniae

Zhang, J., Silao, F. G. S., Bigol, U. G., Bungay, A. A. C., Nicolas, M. G., Heitman, J., & Chen, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044192 · Cited by 61 · see citing works

The Involvement of the Mid1/Cch1/Yvc1 Calcium Channels in Aspergillus fumigatus Virulence

de Castro, P. A., Chiaratto, J., Winkelströter, L. K., Bom, V. L. P., Ramalho, L. N. Z., Goldman, M. H. S., Brown, N. A., & Goldman, G. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103957 · Cited by 60 · see citing works

Nonapoptotic Death of <i>Saccharomyces cerevisiae</i> Cells That Is Stimulated by Hsp90 and Inhibited by Calcineurin and Cmk2 in Response to Endoplasmic Reticulum Stresses

Dudgeon, D. D., Zhang, N., Ositelu, O. O., Kim, H., & Cunningham, K. W. (2008) · Eukaryotic Cell · doi:10.1128/ec.00291-08 · Cited by 59 · see citing works

Calcineurin Colocalizes with P-Bodies and Stress Granules during Thermal Stress in Cryptococcus neoformans

Kozubowski, L., Aboobakar, E. F., Cardenas, M. E., & Heitman, J. (2011) · Eukaryotic Cell · doi:10.1128/ec.05087-11 · Cited by 60 · see citing works

Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29

Shekhar‐Guturja, T., Tebung, W. A., Mount, H. O., Liu, N.-N., Köhler, J. R., Whiteway, M. S., & Cowen, L. E. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01959-16 · Cited by 59 · see citing works

Vacuolar H+-ATPase (V-ATPase) Promotes Vacuolar Membrane Permeabilization and Nonapoptotic Death in Stressed Yeast

Kim, H., Kim, A., & Cunningham, K. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.363390 · Cited by 60 · see citing works

Colutellin A, an immunosuppressive peptide from Colletotrichum dematium

Ren, Y., Strobel, G. A., Graff, J. C., Jutila, M. A., Park, S., Gosh, S., Teplow, D. B., Condron, M. M., Pang, E. S., Hess, W. M., et al. (2008) · Microbiology · doi:10.1099/mic.0.2008/017954-0 · Cited by 59 · see citing works

Calcineurin signaling: lessons from Candida species

Yu, S.-J., Chang, Y.-L., & Chen, Y. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov016 · Cited by 58 · see citing works

The transcription factor FgCrz1A is essential for fungal development, virulence, deoxynivalenol biosynthesis and stress responses in Fusarium graminearum

Chen, L., Tong, Q., Zhang, C., & Ding, K. (2018) · Current Genetics · doi:10.1007/s00294-018-0853-5 · Cited by 58 · see citing works

Phosphorylation of Calcineurin at a Novel Serine-Proline Rich Region Orchestrates Hyphal Growth and Virulence in Aspergillus fumigatus

Juvvadi, P. R., Gehrke, C., Fortwendel, J. R., Lamoth, F., Soderblom, E. J., Cook, E. C., Hast, M. A., Asfaw, Y. G., Moseley, M. A., Creamer, T. P., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003564 · Cited by 57 · see citing works

ChIP ‐seq reveals a role for CrzA in the A spergillus fumigatus high‐osmolarity glycerol response ( HOG ) signalling pathway

de Castro, P. A., Chen, C., Almeida, R. S., Freitas, F. Z., Bertolini, M. C., Morais, E. R., Brown, N. A., Ramalho, L. N. Z., Hagiwara, D., Mitchell, T. K., et al. (2014) · Molecular Microbiology · doi:10.1111/mmi.12785 · Cited by 56 · see citing works

Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA

Soriani, F. M., Malavazi, I., Savoldi, M., Espeso, E. A., Dinamarco, T. M., Bernardes, L. Â. D. S., Ferreira, M. E. S., Goldman, M. H. S., & Goldman, G. H. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-12 · Cited by 56 · see citing works

Conserved and Divergent Functions of the cAMP/PKA Signaling Pathway in Candida albicans and Candida tropicalis

Lin, C.-J., & Chen, Y.-L. (2018) · Journal of Fungi · doi:10.3390/jof4020068 · Cited by 55 · see citing works

Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach

Juvvadi, P. R., Lee, S. C., Heitman, J., & Steinbach, W. J. (2016) · Virulence · doi:10.1080/21505594.2016.1201250 · Cited by 172 · see citing works

On the Roles of Calcineurin in Fungal Growth and Pathogenesis

Chen, Y., Kozubowski, L., Cardenas, M. E., & Heitman, J. (2010) · Current Fungal Infection Reports · doi:10.1007/s12281-010-0027-5 · Cited by 39 · see citing works

Calcineurin as a multifunctional regulator: Unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesis

Juvvadi, P. R., Lamoth, F., & Steinbach, W. J. (2014) · Fungal Biology Reviews · doi:10.1016/j.fbr.2014.02.004 · Cited by 116 · see citing works

Good fungi gone bad: The corruption of calcineurin

Fox, D. S., & Heitman, J. (2002) · BioEssays · doi:10.1002/bies.10157 · Cited by 137 · see citing works

Calcineurin inhibitors impair the host innate immune response to invasive aspergillosis likely due to a calcineurin-dependant defect in fungal killing in alveolar macrophages

Shah, A., Herbst, S., Kannambath, S., Carby, M. R., Shaunak, S., & Armstrong-James, D. P. H. (2013) · Journal of Infection · doi:10.1016/j.jinf.2013.07.005