Xu, H. Eric

Amyloid Beta: Structure, Biology and Structure-Based Therapeutic Development

Chen, G.-F., Xu, T.-H., Yan, Y., Zhou, Y.-R., Jiang, Y., Melcher, K., & Xu, H. E. (2017) · Acta Pharmacologica Sinica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,965

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Yin, W., Mao, C., Luan, X., Shen, D.-D., Shen, Q., Su, H., Wang, X., Zhou, F., Zhao, W., Gao, M., et al. (2020) · Science

SARS-CoV-2 and COVID-19 ResearchEnzyme Structure and Function

Cited by 1,219

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

Xu, H. E., Lambert, M. H., Montana, V. G., Parks, D. J., Blanchard, S. G., Brown, P. J., Sternbach, D. D., Lehmann, J. M., Wisely, G. B., Willson, T. M., et al. (1999) · Molecular Cell

Peroxisome Proliferator-Activated ReceptorsProtein Structure and Dynamics

Cited by 1,169

DWARF 53 acts as a repressor of strigolactone signalling in rice

Jiang, L., Liu, X., Xiong, G., Liu, H., Chen, F., Wang, L., Meng, X., Liu, G., Yu, H., Yuan, Y., et al. (2013) · Nature

Plant Parasitism and ResistancePlant Molecular Biology Research

Cited by 868

Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

Bledsoe, R. K., Montana, V. G., Stanley, T. B., Delves, C. J., Apolito, C. J., McKee, D. D., Consler, T. G., Parks, D. J., Stewart, E. L., Willson, T. M., et al. (2002) · Cell

Estrogen and related hormone effectsReceptor Mechanisms and Signaling

Cited by 818

A gate–latch–lock mechanism for hormone signalling by abscisic acid receptors

Melcher, K., Ng, L.-M., Zhou, X. E., Soon, F.-F., Xu, Y., Suino-Powell, K. M., Park, S.-Y., Weiner, J. J., Fujii, H., Chinnusamy, V., et al. (2009) · Nature

Plant Stress Responses and TolerancePlant Molecular Biology Research

Cited by 731

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

Kir, S., Beddow, S. A., Samuel, V. T., Miller, P., Previs, S. F., Suino-Powell, K., Xu, H. E., Shulman, G. I., Kliewer, S. A., & Mangelsdorf, D. J. (2011) · Science

Fibroblast Growth Factor ResearchMetabolism, Diabetes, and Cancer

Cited by 637

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

Potthoff, M. J., Boney-Montoya, J., Choi, M., He, T., Sunny, N. E., Satapati, S., Suino-Powell, K., Xu, H. E., Gerard, R. D., Finck, B. N., et al. (2011) · Cell Metabolism

Fibroblast Growth Factor ResearchMetabolism, Diabetes, and Cancer

Cited by 431

Structure and dynamics of the active human parathyroid hormone receptor-1

Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X. E., de Waal, P. W., Li, C.-Y., Kang, Y., Clark, L. J., Jean-Alphonse, F. G., et al. (2019) · Science

Receptor Mechanisms and SignalingProtein Structure and Dynamics

Cited by 256

Structure and Physiological Regulation of AMPK

Yan, Y., Zhou, X. E., Xu, H. E., & Melcher, K. (2018) · International Journal of Molecular Sciences

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 254

Covalent Peroxisome Proliferator-activated Receptor γ Adduction by Nitro-fatty Acids

Schopfer, F. J., Cole, M. P., Groeger, A. L., Chen, C.-S., Khoo, N. K. H., Woodcock, S. R., Golin-Bisello, F., Motanya, U. N., Li, Y., Zhang, J., et al. (2010) · Journal of Biological Chemistry

Peroxisome Proliferator-Activated ReceptorsFatty Acid Research and Health

Cited by 171

Molecular recognition of nitrated fatty acids by PPARγ

Li, Y., Zhang, J., Schopfer, F. J., Martynowski, D., Garcia-Barrio, M. T., Kovach, A., Suino-Powell, K., Baker, P. R. S., Freeman, B. A., Chen, Y. E., et al. (2008) · Nature Structural & Molecular Biology

Peroxisome Proliferator-Activated ReceptorsNuclear Receptors and Signaling

Cited by 168

Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors

Zhao, F., Zhou, Q., Cong, Z., Hang, K., Zou, X., Zhang, C., Chen, Y., Dai, A., Liang, A., Ming, Q., et al. (2022) · Nature Communications

Receptor Mechanisms and SignalingDiabetes Treatment and Management

Cited by 149

A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

Kim, D., Xiao, Z., Kwon, S., Sun, X., Ryerson, D., Tkac, D., Ma, P., Wu, S., Chiang, C., Zhou, E., et al. (2015) · The EMBO Journal

Adipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

Cited by 126

Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide

Li, W., Zhou, Q., Cong, Z., Yuan, Q., Li, W., Zhao, F., Xu, H. E., Zhao, L.-H., Yang, D., & Wang, M.-W. (2024) · Cell Discovery

Receptor Mechanisms and SignalingDiabetes Treatment and Management

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Structural basis of peptide recognition and activation of endothelin receptors

Ji, Y., Duan, J., Yuan, Q., He, X., Yang, G., Zhu, S., Wu, K., Hu, W., Gao, T., Cheng, X., et al. (2023) · Nature Communications

Receptor Mechanisms and SignalingNitric Oxide and Endothelin Effects

Cited by 31