Seino, Yutaka

Inhibition of gastric inhibitory polypeptide signaling prevents obesity

Miyawaki, K., Yamada, Y., Ban, N., Ihara, Y., Tsukiyama, K., Zhou, H., Fujimoto, S., Oku, A., Tsuda, K., Toyokuni, S., et al. (2002) · Nature Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 963

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

Yasuda, K., Miyake, K., Horikawa, Y., Hara, K., Osawa, H., Furuta, H., Hirota, Y., Mori, H., Jonsson, A., Sato, Y., et al. (2008) · Nature Genetics

Genetic Associations and EpidemiologyPancreatic function and diabetes

Cited by 776

GIP and GLP-1, the two incretin hormones: Similarities and differences

Seino, Y., Fukushima, M., & Yabe, D. (2010) · Journal of Diabetes Investigation

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 746

Report of the Committee on the classification and diagnostic criteria of diabetes mellitus: The Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus

Seino, Y., Nanjo, K., Tajima, N., Kadowaki, T., Kashiwagi, A., Araki, E., Ito, C., Inagaki, N., Iwamoto, Y., Kasuga, M., et al. (2010) · Diabetology International

Diabetes Management and ResearchDiabetes and associated disorders

Cited by 614

Over-expression of facilitative glucose transporter genes in human cancer

Yamamoto, T., Seino, Y., Fukumoto, H., Koh, G., Yano, H., Inagaki, N., Yamada, Y., Inoue, K., Manabe, T., & Imura, H. (1990) · Biochemical and Biophysical Research Communications

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 465

Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice

Miyawaki, K., Yamada, Y., Yano, H., Niwa, H., Ban, N., Ihara, Y., Kubota, A., Fujimoto, S., Kajikawa, M., Kuroe, A., et al. (1999) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 454

The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential

Fujita, H., Morii, T., Fujishima, H., Sato, T., Shimizu, T., Hosoba, M., Tsukiyama, K., Narita, T., Takahashi, T., Drucker, D. J., et al. (2014) · Kidney International

Chronic Kidney Disease and DiabetesDiabetes Treatment and Management

Cited by 336

β Cell Dysfunction Versus Insulin Resistance in the Pathogenesis of Type 2 Diabetes in East Asians

Yabe, D., Seino, Y., Fukushima, M., & Seino, S. (2015) · Current Diabetes Reports

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 328

The Murine Glucagon-Like Peptide-1 Receptor Is Essential for Control of Bone Resorption

Yamada, C., Yamada, Y., Tsukiyama, K., Yamada, K., Udagawa, N., Takahashi, N., Tanaka, K., Drucker, D. J., Seino, Y., & Inagaki, N. (2008) · Endocrinology

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 318

Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV Inhibitors

Hansotia, T., Baggio, L. L., Delmeire, D., Hinke, S. A., Yamada, Y., Tsukiyama, K., Seino, Y., Holst, J. J., Schuit, F., & Drucker, D. J. (2004) · Diabetes

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 309

Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure

Hansotia, T., Maida, A., Flock, G., Yamada, Y., Tsukiyama, K., Seino, Y., & Drucker, D. J. (2007) · Journal of Clinical Investigation

Diabetes Treatment and ManagementRegulation of Appetite and Obesity

Cited by 290

Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2/3a, randomised, controlled trial

Yamada, Y., Katagiri, H., Hamamoto, Y., Deenadayalan, S., Navarria, A., Nishijima, K., Seino, Y., Fukushima, Y., Hamamoto, Y., Hisatomi, A., et al. (2020) · The Lancet Diabetes & Endocrinology

Diabetes Treatment and ManagementDiabetes Management and Research

Cited by 228

Efficacy and safety of tirzepatide monotherapy compared with dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono): a double-blind, multicentre, randomised, phase 3 trial

Inagaki, N., Takeuchi, M., Oura, T., Imaoka, T., & Seino, Y. (2022) · The Lancet Diabetes & Endocrinology

Diabetes Treatment and ManagementDiabetes Management and Research

Cited by 226

Cdk5-dependent regulation of glucose-stimulated insulin secretion

Wei, F.-Y., Nagashima, K., Ohshima, T., Saheki, Y., Lu, Y.-F., Matsushita, M., Yamada, Y., Mikoshiba, K., Seino, Y., Matsui, H., et al. (2005) · Nature Medicine

Pancreatic function and diabetesIon channel regulation and function

Cited by 199

Gastric Inhibitory Polypeptide as an Endogenous Factor Promoting New Bone Formation after Food Ingestion

Tsukiyama, K., Yamada, Y., Yamada, C., Harada, N., Kawasaki, Y., Ogura, M., Bessho, K., Li, M., Amizuka, N., Sato, M., et al. (2006) · Molecular Endocrinology

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 198

Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside

MIURA, T., ICHIKI, H., IWAMOTO, N., KATO, M., KUBO, M., SASAKI, H., OKADA, M., ISHIDA, T., SEINO, Y., & TANIGAWA, K. (2001) · Biological and Pharmaceutical Bulletin

Natural Antidiabetic Agents StudiesMangiferin and Mango Extracts

Cited by 137

Safety and efficacy of semaglutide once weekly vs sitagliptin once daily, both as monotherapy in Japanese people with type 2 diabetes

Seino, Y., Terauchi, Y., Osonoi, T., Yabe, D., Abe, N., Nishida, T., Zacho, J., & Kaneko, S. (2018) · Diabetes, Obesity and Metabolism

Diabetes Treatment and ManagementDiabetes Management and Research

Cited by 127

Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis

Pamir, N., Lynn, F. C., Buchan, A. M. J., Ehses, J., Hinke, S. A., Pospisilik, J. A., Miyawaki, K., Yamada, Y., Seino, Y., McIntosh, C. H. S., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 126

Functional neuronal ionotropic glutamate receptors are expressed in the non-neuronal cell line MIN6.

Gonoi, T., Mizuno, N., Inagaki, N., Kuromi, H., Seino, Y., Miyazaki, J., & Seino, S. (1994) · Journal of Biological Chemistry

Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and Metabolism

Cited by 110

Effects of thorough mastication on postprandial plasma glucose concentrations in nonobese Japanese subjects

Suzuki, H., Fukushima, M., Okamoto, S., Takahashi, O., Shimbo, T., Kurose, T., Yamada, Y., Inagaki, N., Seino, Y., & Fukui, T. (2005) · Metabolism

Food composition and propertiesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 84

GLP-1 Receptor Signaling Differentially Modifies the Outcomes of Sterile vs Viral Pulmonary Inflammation in Male Mice

Sato, T., Shimizu, T., Fujita, H., Imai, Y., Drucker, D. J., Seino, Y., & Yamada, Y. (2020) · Endocrinology

Diabetes Treatment and ManagementNeuropeptides and Animal Physiology

Cited by 29

Efficacy and safety of oral semaglutide by baseline age in Japanese patients with type 2 diabetes: A subgroup analysis of the PIONEER 9 and 10 Japan trials

Yamada, Y., Yabe, D., Hertz, C. L., Horio, H., Nakamura, J., Nielsen, A. M., & Seino, Y. (2022) · Diabetes, Obesity and Metabolism

Diabetes Treatment and ManagementDiabetes Management and Research

Cited by 21

Twincretin as a potential therapeutic for the management of type 2 diabetes with obesity

Usui, R., Yabe, D., & Seino, Y. (2019) · Journal of Diabetes Investigation

Diabetes Treatment and ManagementPharmacology and Obesity Treatment

Cited by 20

The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice

Ahrén, B., Yamada, Y., & Seino, Y. (2021) · Frontiers in Endocrinology

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 15