Holehouse, Alex S.

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

Martin, E. W., Holehouse, A. S., Peran, I., Farag, M., Incicco, J. J., Bremer, A., Grace, C. R., Soranno, A., Pappu, R. V., & Mittag, T. (2020) · Science

RNA Research and SplicingProtein Structure and Dynamics

Cited by 1,147

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

Harmon, T. S., Holehouse, A. S., Rosen, M. K., & Pappu, R. V. (2017) · eLife

RNA Research and SplicingProtein Structure and Dynamics

Cited by 713

Conformational buffering underlies functional selection in intrinsically disordered protein regions

González-Foutel, N. S., Glavina, J., Borcherds, W. M., Safranchik, M., Barrera-Vilarmau, S., Sagar, A., Estaña, A., Barozet, A., Garrone, N. A., Fernandez-Ballester, G., et al. (2022) · Nature Structural & Molecular Biology

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 118

Sequence-to-conformation relationships of disordered regions tethered to folded domains of proteins

Mittal, A., Holehouse, A. S., Cohan, M. C., & Pappu, R. V. (2018) · Journal of Molecular Biology

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 72

Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms

Lambourne, L., Mattioli, K., Santoso, C., Sheynkman, G., Inukai, S., Kaundal, B., Berenson, A., Spirohn-Fitzgerald, K., Bhattacharjee, A., Rothman, E., et al. (2025) · Molecular Cell

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 42

A fuzzy complex in the negative arm regulates circadian clock robustness.

Hurley, J., Jankowski, M., Griffith, D., Shastry, D., Pelham, J., Ginell, G., Thomas, J., Karande, P., & Holehouse, A. (2022) · Nature Communications

Circadian rhythm and melatoninLight effects on plants

Cited by 23

The formation of a fuzzy complex in the negative arm regulates the robustness of the circadian clock

Jankowski, M. S., Griffith, D., Shastry, D. G., Pelham, J. F., Ginell, G. M., Thomas, J., Karande, P., Holehouse, A. S., & Hurley, J. M. (2022) · Nature Communications

Circadian rhythm and melatoninLight effects on plants

Cited by 23

Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator

Jankowski, M. S., Griffith, D., Shastry, D. G., Pelham, J. F., Ginell, G. M., Thomas, J., Karande, P., Holehouse, A. S., & Hurley, J. M. (2024) · Nature Communications

Circadian rhythm and melatoninLight effects on plants

Cited by 23

Disordered proteins interact with the chemical environment to tune their protective function during drying

KC, S., Nguyen, K., Nicholson, V., Walgren, A., Trent, T., Gollub, E., Romero, S., Holehouse, A. S., Sukenik, S., & Boothby, T. C. (2024) · eLife

Protein Structure and DynamicsTardigrade Biology and Ecology

Cited by 16

A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy

Townley, B. A., Buerer, L., Tsao, N., Bacolla, A., Mansoori, F., Rusanov, T., Clark, N. E., Goodarzi, N., Schmidt, N., Srivatsan, S. N., et al. (2023) · Molecular Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 15

Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure

Scholl, D., Boyd, T., Latham, A. P., Salazar, A., Khan, A., Boeynaems, S., Holehouse, A. S., Lander, G. C., Sali, A., Park, D., et al. (2024) · Nature Structural & Molecular Biology

Protein Structure and DynamicsRNA Research and Splicing

Cited by 14

The filamentous ultrastructure of the PopZ condensate is required for its cellular function

Scholl, D., Boyd, T., Latham, A. P., Salazar, A., Khan, A. M. A. M., Boeynaems, S., Holehouse, A. S., Lander, G. C., Sali, A., Park, D., et al. (2026) · Nature Structural & Molecular Biology

Protein Structure and DynamicsRNA Research and Splicing

Cited by 14

Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors

Chang, J.-F., Landmann, J. H., Chang, T.-C., Selli, M. E., Tenzin, Y., Warrington, J. M., Ritchey, J., Hsu, Y.-S., Slade, M., Gupta, D. K., et al. (2024) · Cancer Discovery

CAR-T cell therapy researchImmunotherapy and Immune Responses

Cited by 10

Protein surface chemistry encodes an adaptive tolerance to desiccation

Romero-Pérez, P. S., Moran, H. M., Cordone, D. P., Horani, A., Truong, A., Manriquez-Sandoval, E., Ramirez, J. F., Martinez, A., Gollub, E., Hunter, K., et al. (2025) · Cell Systems

Protein Structure and DynamicsAdvanced Proteomics Techniques and Applications

Cited by 9

Protein surface chemistry encodes an adaptive tolerance to desiccation

Romero-Pérez, P. S., Moran, H. M., Horani, A., Truong, A., Manriquez-Sandoval, E., Ramirez, J. F., Martinez, A., Gollub, E., Hunter, K., Lotthammer, J. M., et al. (2024) · Cell Systems

Protein Structure and DynamicsAdvanced Proteomics Techniques and Applications

Cited by 9

SHEPHARD: a modular and extensible software architecture for analyzing and annotating large protein datasets

Ginell, G. M., Flynn, A. J., & Holehouse, A. S. (2022) · Bioinformatics

Bioinformatics and Genomic NetworksGenomics and Phylogenetic Studies

Cited by 8

Disordered proteins interact with the chemical environment to tune their protective function during drying

KC, S., Nguyen, K. H., Nicholson, V., Walgren, A., Trent, T., Gollub, E., Romero-Perez, P. S., Holehouse, A. S., Sukenik, S., & Boothby, T. C. (2024) · eLife

Protein Structure and DynamicsTardigrade Biology and Ecology

Cited by 4